Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUV0_LEIDO

TriTrypDb:

LdBPK_180550.1 , LdCL_180010400 , LDHU3_18.0690

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 6
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.515
CLV_NRD_NRD_1	298	300	PF00675	0.496
CLV_NRD_NRD_1	303	305	PF00675	0.468
CLV_NRD_NRD_1	307	309	PF00675	0.466
CLV_NRD_NRD_1	337	339	PF00675	0.579
CLV_NRD_NRD_1	48	50	PF00675	0.372
CLV_PCSK_FUR_1	299	303	PF00082	0.521
CLV_PCSK_KEX2_1	232	234	PF00082	0.647
CLV_PCSK_KEX2_1	278	280	PF00082	0.514
CLV_PCSK_KEX2_1	298	300	PF00082	0.399
CLV_PCSK_KEX2_1	301	303	PF00082	0.482
CLV_PCSK_KEX2_1	337	339	PF00082	0.579
CLV_PCSK_KEX2_1	48	50	PF00082	0.408
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.647
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.517
CLV_PCSK_PC7_1	298	304	PF00082	0.477
CLV_PCSK_SKI1_1	232	236	PF00082	0.519
CLV_PCSK_SKI1_1	321	325	PF00082	0.498
CLV_PCSK_SKI1_1	348	352	PF00082	0.459
CLV_PCSK_SKI1_1	49	53	PF00082	0.498
DEG_APCC_DBOX_1	249	257	PF00400	0.602
DEG_Nend_UBRbox_4	1	3	PF02207	0.467
DEG_SCF_FBW7_1	161	167	PF00400	0.495
DOC_CDC14_PxL_1	108	116	PF14671	0.383
DOC_CKS1_1	161	166	PF01111	0.529
DOC_CYCLIN_RxL_1	230	240	PF00134	0.483
DOC_MAPK_gen_1	231	237	PF00069	0.654
DOC_MAPK_gen_1	308	315	PF00069	0.589
DOC_MAPK_gen_1	337	346	PF00069	0.546
DOC_PP1_RVXF_1	346	353	PF00149	0.505
DOC_PP1_RVXF_1	91	98	PF00149	0.395
DOC_USP7_MATH_1	208	212	PF00917	0.710
DOC_USP7_MATH_1	226	230	PF00917	0.549
DOC_USP7_UBL2_3	274	278	PF12436	0.589
DOC_WW_Pin1_4	160	165	PF00397	0.547
DOC_WW_Pin1_4	214	219	PF00397	0.560
LIG_14-3-3_CanoR_1	128	133	PF00244	0.463
LIG_14-3-3_CanoR_1	151	159	PF00244	0.553
LIG_14-3-3_CanoR_1	250	254	PF00244	0.488
LIG_BRCT_BRCA1_1	166	170	PF00533	0.488
LIG_BRCT_BRCA1_1	342	346	PF00533	0.541
LIG_BRCT_BRCA1_2	342	348	PF00533	0.405
LIG_Clathr_ClatBox_1	253	257	PF01394	0.516
LIG_FHA_1	237	243	PF00498	0.641
LIG_FHA_1	56	62	PF00498	0.463
LIG_FHA_2	312	318	PF00498	0.542
LIG_FHA_2	83	89	PF00498	0.396
LIG_Integrin_isoDGR_2	195	197	PF01839	0.497
LIG_LIR_Gen_1	139	149	PF02991	0.528
LIG_LIR_Gen_1	217	226	PF02991	0.558
LIG_LIR_Gen_1	26	36	PF02991	0.428
LIG_LIR_Gen_1	349	355	PF02991	0.514
LIG_LIR_Gen_1	76	86	PF02991	0.419
LIG_LIR_Nem_3	139	144	PF02991	0.542
LIG_LIR_Nem_3	167	173	PF02991	0.589
LIG_LIR_Nem_3	217	222	PF02991	0.580
LIG_LIR_Nem_3	26	32	PF02991	0.439
LIG_LIR_Nem_3	349	355	PF02991	0.535
LIG_LIR_Nem_3	76	82	PF02991	0.427
LIG_PDZ_Class_1	350	355	PF00595	0.571
LIG_PTB_Apo_2	59	66	PF02174	0.303
LIG_PTB_Phospho_1	59	65	PF10480	0.304
LIG_REV1ctd_RIR_1	324	333	PF16727	0.475
LIG_SH2_CRK	105	109	PF00017	0.411
LIG_SH2_CRK	141	145	PF00017	0.501
LIG_SH2_GRB2like	65	68	PF00017	0.431
LIG_SH2_NCK_1	105	109	PF00017	0.357
LIG_SH2_NCK_1	141	145	PF00017	0.479
LIG_SH2_PTP2	79	82	PF00017	0.410
LIG_SH2_STAT5	141	144	PF00017	0.427
LIG_SH2_STAT5	190	193	PF00017	0.607
LIG_SH2_STAT5	65	68	PF00017	0.459
LIG_SH2_STAT5	79	82	PF00017	0.260
LIG_SH3_1	202	208	PF00018	0.573
LIG_SH3_3	158	164	PF00018	0.507
LIG_SH3_3	16	22	PF00018	0.462
LIG_SH3_3	202	208	PF00018	0.735
LIG_SUMO_SIM_par_1	128	135	PF11976	0.534
LIG_SUMO_SIM_par_1	233	240	PF11976	0.554
LIG_TRAF2_1	259	262	PF00917	0.585
LIG_WRC_WIRS_1	133	138	PF05994	0.533
MOD_CK1_1	131	137	PF00069	0.405
MOD_CK1_1	139	145	PF00069	0.371
MOD_CK1_1	180	186	PF00069	0.516
MOD_CK1_1	211	217	PF00069	0.635
MOD_CK1_1	252	258	PF00069	0.643
MOD_CK2_1	256	262	PF00069	0.580
MOD_CK2_1	311	317	PF00069	0.563
MOD_CK2_1	82	88	PF00069	0.388
MOD_GlcNHglycan	145	148	PF01048	0.425
MOD_GlcNHglycan	153	156	PF01048	0.442
MOD_GlcNHglycan	170	173	PF01048	0.430
MOD_GlcNHglycan	257	261	PF01048	0.579
MOD_GSK3_1	128	135	PF00069	0.396
MOD_GSK3_1	136	143	PF00069	0.359
MOD_GSK3_1	160	167	PF00069	0.483
MOD_GSK3_1	177	184	PF00069	0.495
MOD_GSK3_1	208	215	PF00069	0.604
MOD_GSK3_1	220	227	PF00069	0.546
MOD_GSK3_1	252	259	PF00069	0.582
MOD_N-GLC_1	136	141	PF02516	0.366
MOD_N-GLC_1	159	164	PF02516	0.474
MOD_N-GLC_1	180	185	PF02516	0.474
MOD_N-GLC_1	37	42	PF02516	0.572
MOD_NEK2_1	136	141	PF00069	0.446
MOD_NEK2_1	159	164	PF00069	0.526
MOD_NEK2_1	220	225	PF00069	0.500
MOD_NEK2_1	81	86	PF00069	0.454
MOD_NEK2_2	30	35	PF00069	0.317
MOD_PK_1	128	134	PF00069	0.423
MOD_PKA_1	43	49	PF00069	0.285
MOD_PKA_2	244	250	PF00069	0.507
MOD_Plk_1	37	43	PF00069	0.502
MOD_Plk_4	128	134	PF00069	0.437
MOD_Plk_4	136	142	PF00069	0.415
MOD_Plk_4	164	170	PF00069	0.455
MOD_Plk_4	249	255	PF00069	0.497
MOD_Plk_4	37	43	PF00069	0.427
MOD_ProDKin_1	160	166	PF00069	0.543
MOD_ProDKin_1	214	220	PF00069	0.554
MOD_SUMO_for_1	200	203	PF00179	0.525
MOD_SUMO_for_1	286	289	PF00179	0.561
MOD_SUMO_rev_2	227	234	PF00179	0.691
MOD_SUMO_rev_2	305	310	PF00179	0.583
MOD_SUMO_rev_2	88	95	PF00179	0.502
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.491
TRG_ENDOCYTIC_2	105	108	PF00928	0.411
TRG_ENDOCYTIC_2	141	144	PF00928	0.417
TRG_ENDOCYTIC_2	29	32	PF00928	0.498
TRG_ENDOCYTIC_2	79	82	PF00928	0.410
TRG_ER_diArg_1	297	299	PF00400	0.582
TRG_ER_diArg_1	301	304	PF00400	0.550
TRG_ER_diArg_1	336	338	PF00400	0.592
TRG_ER_diArg_1	48	50	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.466
TRG_PTS2	1	12	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN8	Leptomonas seymouri	48%	81%
A0A0S4J078	Bodo saltans	24%	76%
A0A1X0P6U2	Trypanosomatidae	30%	80%
A0A422NJ54	Trypanosoma rangeli	28%	79%
A4H9G3	Leishmania braziliensis	73%	100%
A4HXT0	Leishmania infantum	100%	100%
D0A062	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	79%
E9ARJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDY7	Leishmania major	91%	100%