Phosphatidic acid phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUU8_LEIDO

TriTrypDb:

LdBPK_180440.1 , LdCL_180009300 , LDHU3_18.0540

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WUU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUU8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008195	phosphatidate phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.685
CLV_NRD_NRD_1	225	227	PF00675	0.455
CLV_NRD_NRD_1	334	336	PF00675	0.346
CLV_NRD_NRD_1	91	93	PF00675	0.469
CLV_PCSK_KEX2_1	334	336	PF00082	0.346
CLV_PCSK_KEX2_1	90	92	PF00082	0.439
CLV_PCSK_SKI1_1	105	109	PF00082	0.411
CLV_PCSK_SKI1_1	241	245	PF00082	0.397
DEG_SPOP_SBC_1	175	179	PF00917	0.681
DOC_CKS1_1	192	197	PF01111	0.721
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.405
DOC_MAPK_DCC_7	342	352	PF00069	0.405
DOC_MAPK_gen_1	334	340	PF00069	0.522
DOC_MAPK_MEF2A_6	151	159	PF00069	0.676
DOC_PP1_RVXF_1	302	308	PF00149	0.355
DOC_PP1_RVXF_1	9	16	PF00149	0.575
DOC_PP2B_LxvP_1	350	353	PF13499	0.405
DOC_PP2B_PxIxI_1	66	72	PF00149	0.332
DOC_SPAK_OSR1_1	11	15	PF12202	0.494
DOC_USP7_MATH_1	139	143	PF00917	0.768
DOC_USP7_MATH_1	215	219	PF00917	0.761
DOC_USP7_MATH_1	220	224	PF00917	0.735
DOC_USP7_MATH_1	407	411	PF00917	0.588
DOC_WW_Pin1_4	131	136	PF00397	0.677
DOC_WW_Pin1_4	191	196	PF00397	0.729
DOC_WW_Pin1_4	213	218	PF00397	0.691
DOC_WW_Pin1_4	285	290	PF00397	0.312
LIG_14-3-3_CanoR_1	219	225	PF00244	0.714
LIG_14-3-3_CanoR_1	304	308	PF00244	0.393
LIG_14-3-3_CanoR_1	335	341	PF00244	0.546
LIG_14-3-3_CanoR_1	406	413	PF00244	0.593
LIG_14-3-3_CanoR_1	42	47	PF00244	0.438
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BIR_III_2	214	218	PF00653	0.724
LIG_BRCT_BRCA1_1	255	259	PF00533	0.356
LIG_BRCT_BRCA1_1	312	316	PF00533	0.346
LIG_BRCT_BRCA1_1	49	53	PF00533	0.399
LIG_FHA_1	131	137	PF00498	0.621
LIG_FHA_1	179	185	PF00498	0.717
LIG_FHA_1	230	236	PF00498	0.657
LIG_FHA_1	349	355	PF00498	0.320
LIG_FHA_1	394	400	PF00498	0.572
LIG_FHA_1	63	69	PF00498	0.442
LIG_FHA_2	197	203	PF00498	0.726
LIG_FHA_2	290	296	PF00498	0.312
LIG_LIR_Apic_2	45	49	PF02991	0.375
LIG_LIR_Apic_2	63	67	PF02991	0.215
LIG_LIR_Gen_1	256	267	PF02991	0.344
LIG_LIR_Gen_1	313	324	PF02991	0.285
LIG_LIR_Nem_3	256	262	PF02991	0.368
LIG_LIR_Nem_3	313	319	PF02991	0.285
LIG_LIR_Nem_3	339	344	PF02991	0.546
LIG_LRP6_Inhibitor_1	262	268	PF00058	0.271
LIG_Pex14_2	12	16	PF04695	0.546
LIG_Pex14_2	255	259	PF04695	0.356
LIG_PTB_Apo_2	281	288	PF02174	0.329
LIG_PTB_Phospho_1	281	287	PF10480	0.294
LIG_REV1ctd_RIR_1	13	21	PF16727	0.378
LIG_SH2_STAT3	287	290	PF00017	0.294
LIG_SH2_STAT5	21	24	PF00017	0.405
LIG_SH2_STAT5	325	328	PF00017	0.525
LIG_SH2_STAT5	367	370	PF00017	0.329
LIG_SH2_STAT5	77	80	PF00017	0.405
LIG_SH3_3	302	308	PF00018	0.372
LIG_Sin3_3	259	266	PF02671	0.271
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.691
LIG_SUMO_SIM_par_1	354	359	PF11976	0.344
LIG_SUMO_SIM_par_1	381	387	PF11976	0.296
MOD_CDC14_SPxK_1	216	219	PF00782	0.689
MOD_CDK_SPxK_1	213	219	PF00069	0.691
MOD_CK1_1	134	140	PF00069	0.774
MOD_CK1_1	142	148	PF00069	0.731
MOD_CK1_1	178	184	PF00069	0.713
MOD_CK1_1	191	197	PF00069	0.785
MOD_CK1_1	218	224	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.299
MOD_CK1_1	306	312	PF00069	0.261
MOD_CK1_1	336	342	PF00069	0.581
MOD_CK2_1	196	202	PF00069	0.731
MOD_Cter_Amidation	88	91	PF01082	0.394
MOD_GlcNHglycan	144	147	PF01048	0.524
MOD_GlcNHglycan	160	163	PF01048	0.424
MOD_GlcNHglycan	164	167	PF01048	0.475
MOD_GlcNHglycan	222	225	PF01048	0.479
MOD_GlcNHglycan	308	311	PF01048	0.546
MOD_GlcNHglycan	316	319	PF01048	0.292
MOD_GlcNHglycan	335	338	PF01048	0.207
MOD_GlcNHglycan	374	377	PF01048	0.356
MOD_GlcNHglycan	380	383	PF01048	0.309
MOD_GlcNHglycan	386	389	PF01048	0.262
MOD_GlcNHglycan	409	412	PF01048	0.442
MOD_GSK3_1	125	132	PF00069	0.655
MOD_GSK3_1	158	165	PF00069	0.701
MOD_GSK3_1	174	181	PF00069	0.666
MOD_GSK3_1	249	256	PF00069	0.395
MOD_GSK3_1	285	292	PF00069	0.312
MOD_GSK3_1	306	313	PF00069	0.406
MOD_LATS_1	40	46	PF00433	0.356
MOD_NEK2_1	158	163	PF00069	0.654
MOD_NEK2_1	32	37	PF00069	0.354
MOD_NEK2_1	333	338	PF00069	0.624
MOD_NEK2_1	372	377	PF00069	0.413
MOD_PIKK_1	137	143	PF00454	0.669
MOD_PIKK_1	249	255	PF00454	0.356
MOD_PKA_2	206	212	PF00069	0.770
MOD_PKA_2	218	224	PF00069	0.669
MOD_PKA_2	303	309	PF00069	0.346
MOD_PKA_2	333	339	PF00069	0.546
MOD_Plk_1	207	213	PF00069	0.690
MOD_Plk_2-3	208	214	PF00069	0.688
MOD_Plk_4	2	8	PF00069	0.636
MOD_Plk_4	336	342	PF00069	0.568
MOD_ProDKin_1	131	137	PF00069	0.677
MOD_ProDKin_1	191	197	PF00069	0.728
MOD_ProDKin_1	213	219	PF00069	0.691
MOD_ProDKin_1	285	291	PF00069	0.312
TRG_DiLeu_BaEn_1	154	159	PF01217	0.693
TRG_ER_diArg_1	273	276	PF00400	0.346
TRG_ER_diArg_1	333	335	PF00400	0.546
TRG_ER_diArg_1	90	92	PF00400	0.605
TRG_NLS_MonoExtN_4	225	230	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9E7	Leishmania braziliensis	53%	96%
A4H9F0	Leishmania braziliensis	53%	96%
A4HXR9	Leishmania infantum	99%	100%
E9ARI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	96%
Q4QDZ8	Leishmania major	79%	100%