RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUU6_LEIDO

TriTrypDb:

LdBPK_180590.1 , LdCL_180010800 , LDHU3_18.0740

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WUU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.619
CLV_PCSK_SKI1_1	201	205	PF00082	0.283
CLV_PCSK_SKI1_1	239	243	PF00082	0.269
CLV_PCSK_SKI1_1	3	7	PF00082	0.611
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DEG_SPOP_SBC_1	15	19	PF00917	0.535
DEG_SPOP_SBC_1	53	57	PF00917	0.587
DOC_CKS1_1	113	118	PF01111	0.643
DOC_CKS1_1	150	155	PF01111	0.655
DOC_CKS1_1	156	161	PF01111	0.596
DOC_CKS1_1	300	305	PF01111	0.640
DOC_CKS1_1	397	402	PF01111	0.629
DOC_PP1_RVXF_1	256	262	PF00149	0.433
DOC_PP4_FxxP_1	261	264	PF00568	0.473
DOC_USP7_MATH_1	104	108	PF00917	0.622
DOC_USP7_MATH_1	129	133	PF00917	0.620
DOC_USP7_MATH_1	15	19	PF00917	0.590
DOC_USP7_MATH_1	262	266	PF00917	0.584
DOC_USP7_MATH_1	275	279	PF00917	0.461
DOC_USP7_MATH_1	290	294	PF00917	0.583
DOC_USP7_MATH_1	336	340	PF00917	0.606
DOC_USP7_MATH_1	5	9	PF00917	0.686
DOC_USP7_MATH_1	69	73	PF00917	0.593
DOC_USP7_MATH_1	79	83	PF00917	0.510
DOC_WW_Pin1_4	112	117	PF00397	0.646
DOC_WW_Pin1_4	144	149	PF00397	0.615
DOC_WW_Pin1_4	155	160	PF00397	0.615
DOC_WW_Pin1_4	299	304	PF00397	0.777
DOC_WW_Pin1_4	318	323	PF00397	0.561
DOC_WW_Pin1_4	327	332	PF00397	0.737
DOC_WW_Pin1_4	34	39	PF00397	0.621
DOC_WW_Pin1_4	358	363	PF00397	0.614
DOC_WW_Pin1_4	375	380	PF00397	0.615
DOC_WW_Pin1_4	396	401	PF00397	0.630
DOC_WW_Pin1_4	62	67	PF00397	0.602
LIG_14-3-3_CanoR_1	140	148	PF00244	0.663
LIG_14-3-3_CanoR_1	20	26	PF00244	0.485
LIG_14-3-3_CanoR_1	3	12	PF00244	0.615
LIG_BRCT_BRCA1_1	108	112	PF00533	0.637
LIG_BRCT_BRCA1_1	183	187	PF00533	0.456
LIG_BRCT_BRCA1_1	92	96	PF00533	0.661
LIG_FHA_1	152	158	PF00498	0.614
LIG_FHA_1	252	258	PF00498	0.465
LIG_FHA_1	264	270	PF00498	0.532
LIG_FHA_2	207	213	PF00498	0.484
LIG_FHA_2	361	367	PF00498	0.623
LIG_Integrin_isoDGR_2	220	222	PF01839	0.269
LIG_LIR_Apic_2	299	303	PF02991	0.639
LIG_LIR_Apic_2	61	66	PF02991	0.617
LIG_LIR_Nem_3	226	231	PF02991	0.469
LIG_LIR_Nem_3	93	99	PF02991	0.593
LIG_MLH1_MIPbox_1	108	112	PF16413	0.639
LIG_SH2_CRK	113	117	PF00017	0.580
LIG_SH2_CRK	300	304	PF00017	0.640
LIG_SH2_CRK	63	67	PF00017	0.615
LIG_SH2_GRB2like	12	15	PF00017	0.627
LIG_SH2_NCK_1	113	117	PF00017	0.644
LIG_SH2_NCK_1	12	16	PF00017	0.670
LIG_SH2_NCK_1	294	298	PF00017	0.616
LIG_SH2_NCK_1	300	304	PF00017	0.552
LIG_SH2_NCK_1	357	361	PF00017	0.602
LIG_SH2_NCK_1	63	67	PF00017	0.574
LIG_SH2_STAP1	127	131	PF00017	0.585
LIG_SH2_STAP1	294	298	PF00017	0.593
LIG_SH2_STAT5	32	35	PF00017	0.647
LIG_SH2_STAT5	346	349	PF00017	0.591
LIG_SH2_STAT5	386	389	PF00017	0.583
LIG_SH2_STAT5	398	401	PF00017	0.564
LIG_SH3_3	145	151	PF00018	0.627
LIG_SH3_3	246	252	PF00018	0.594
LIG_SH3_3	282	288	PF00018	0.639
LIG_SH3_3	410	416	PF00018	0.691
LIG_UBA3_1	210	214	PF00899	0.496
MOD_CK1_1	10	16	PF00069	0.620
MOD_CK1_1	114	120	PF00069	0.713
MOD_CK1_1	223	229	PF00069	0.469
MOD_CK1_1	293	299	PF00069	0.628
MOD_CK1_1	31	37	PF00069	0.635
MOD_CK1_1	358	364	PF00069	0.572
MOD_CK1_1	55	61	PF00069	0.614
MOD_CK1_1	90	96	PF00069	0.666
MOD_CK2_1	206	212	PF00069	0.516
MOD_GlcNHglycan	104	107	PF01048	0.586
MOD_GlcNHglycan	108	111	PF01048	0.628
MOD_GlcNHglycan	116	119	PF01048	0.569
MOD_GlcNHglycan	127	130	PF01048	0.743
MOD_GlcNHglycan	131	134	PF01048	0.539
MOD_GlcNHglycan	174	177	PF01048	0.504
MOD_GlcNHglycan	225	228	PF01048	0.269
MOD_GlcNHglycan	234	238	PF01048	0.269
MOD_GlcNHglycan	273	276	PF01048	0.620
MOD_GlcNHglycan	282	285	PF01048	0.574
MOD_GlcNHglycan	338	341	PF01048	0.584
MOD_GlcNHglycan	81	84	PF01048	0.781
MOD_GSK3_1	102	109	PF00069	0.477
MOD_GSK3_1	125	132	PF00069	0.656
MOD_GSK3_1	140	147	PF00069	0.518
MOD_GSK3_1	151	158	PF00069	0.593
MOD_GSK3_1	21	28	PF00069	0.611
MOD_GSK3_1	271	278	PF00069	0.538
MOD_GSK3_1	3	10	PF00069	0.777
MOD_GSK3_1	356	363	PF00069	0.571
MOD_GSK3_1	54	61	PF00069	0.596
MOD_GSK3_1	85	92	PF00069	0.658
MOD_N-GLC_1	129	134	PF02516	0.560
MOD_N-GLC_1	15	20	PF02516	0.639
MOD_N-GLC_1	34	39	PF02516	0.636
MOD_N-GLC_1	46	51	PF02516	0.527
MOD_N-GLC_1	85	90	PF02516	0.657
MOD_NEK2_1	111	116	PF00069	0.649
MOD_NEK2_1	233	238	PF00069	0.582
MOD_NEK2_1	355	360	PF00069	0.582
MOD_NEK2_1	403	408	PF00069	0.777
MOD_NEK2_1	87	92	PF00069	0.671
MOD_PIKK_1	151	157	PF00454	0.631
MOD_PIKK_1	3	9	PF00454	0.618
MOD_PIKK_1	64	70	PF00454	0.647
MOD_PIKK_1	85	91	PF00454	0.632
MOD_Plk_4	206	212	PF00069	0.516
MOD_Plk_4	275	281	PF00069	0.624
MOD_Plk_4	28	34	PF00069	0.741
MOD_Plk_4	58	64	PF00069	0.620
MOD_Plk_4	7	13	PF00069	0.668
MOD_ProDKin_1	112	118	PF00069	0.645
MOD_ProDKin_1	144	150	PF00069	0.619
MOD_ProDKin_1	155	161	PF00069	0.612
MOD_ProDKin_1	299	305	PF00069	0.776
MOD_ProDKin_1	318	324	PF00069	0.562
MOD_ProDKin_1	327	333	PF00069	0.734
MOD_ProDKin_1	34	40	PF00069	0.623
MOD_ProDKin_1	358	364	PF00069	0.611
MOD_ProDKin_1	375	381	PF00069	0.617
MOD_ProDKin_1	396	402	PF00069	0.629
MOD_ProDKin_1	62	68	PF00069	0.604
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z4	Leptomonas seymouri	46%	86%
A4H9G7	Leishmania braziliensis	80%	99%
A4HXT4	Leishmania infantum	100%	100%
E9ARJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QDY3	Leishmania major	95%	99%