Tubulin--tyrosine ligase-like protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUU3_LEIDO

TriTrypDb:

LdBPK_180370.1 , LdCL_180008600 , LDHU3_18.0450

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WUU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUU3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016874	ligase activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.524
CLV_C14_Caspase3-7	425	429	PF00656	0.595
CLV_NRD_NRD_1	124	126	PF00675	0.248
CLV_NRD_NRD_1	157	159	PF00675	0.249
CLV_NRD_NRD_1	4	6	PF00675	0.533
CLV_NRD_NRD_1	402	404	PF00675	0.412
CLV_NRD_NRD_1	74	76	PF00675	0.247
CLV_PCSK_KEX2_1	124	126	PF00082	0.234
CLV_PCSK_KEX2_1	157	159	PF00082	0.290
CLV_PCSK_KEX2_1	4	6	PF00082	0.533
CLV_PCSK_KEX2_1	402	404	PF00082	0.414
CLV_PCSK_KEX2_1	84	86	PF00082	0.233
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.221
CLV_PCSK_SKI1_1	14	18	PF00082	0.367
CLV_PCSK_SKI1_1	142	146	PF00082	0.234
CLV_PCSK_SKI1_1	158	162	PF00082	0.327
CLV_PCSK_SKI1_1	308	312	PF00082	0.318
CLV_PCSK_SKI1_1	333	337	PF00082	0.332
CLV_PCSK_SKI1_1	340	344	PF00082	0.337
CLV_PCSK_SKI1_1	391	395	PF00082	0.273
CLV_PCSK_SKI1_1	81	85	PF00082	0.243
DEG_APCC_DBOX_1	268	276	PF00400	0.448
DEG_Nend_UBRbox_2	1	3	PF02207	0.696
DOC_CYCLIN_RxL_1	330	337	PF00134	0.473
DOC_CYCLIN_yClb5_NLxxxL_5	302	311	PF00134	0.530
DOC_MAPK_gen_1	124	132	PF00069	0.434
DOC_MAPK_gen_1	237	245	PF00069	0.434
DOC_MAPK_gen_1	4	13	PF00069	0.442
DOC_MAPK_MEF2A_6	237	245	PF00069	0.434
DOC_PP2B_LxvP_1	444	447	PF13499	0.535
DOC_PP2B_LxvP_1	451	454	PF13499	0.509
DOC_PP4_FxxP_1	110	113	PF00568	0.448
DOC_PP4_MxPP_1	133	136	PF00568	0.434
DOC_USP7_MATH_1	371	375	PF00917	0.434
DOC_USP7_MATH_1	422	426	PF00917	0.528
DOC_USP7_MATH_1	44	48	PF00917	0.457
DOC_USP7_UBL2_3	134	138	PF12436	0.448
DOC_USP7_UBL2_3	289	293	PF12436	0.434
DOC_USP7_UBL2_3	84	88	PF12436	0.434
DOC_WW_Pin1_4	369	374	PF00397	0.434
DOC_WW_Pin1_4	376	381	PF00397	0.434
LIG_14-3-3_CanoR_1	269	273	PF00244	0.434
LIG_14-3-3_CanoR_1	333	339	PF00244	0.473
LIG_deltaCOP1_diTrp_1	155	160	PF00928	0.524
LIG_deltaCOP1_diTrp_1	36	43	PF00928	0.327
LIG_EH1_1	335	343	PF00400	0.490
LIG_FHA_1	107	113	PF00498	0.434
LIG_FHA_1	127	133	PF00498	0.325
LIG_FHA_1	252	258	PF00498	0.466
LIG_FHA_1	6	12	PF00498	0.545
LIG_FHA_2	18	24	PF00498	0.309
LIG_FHA_2	31	37	PF00498	0.360
LIG_FHA_2	377	383	PF00498	0.434
LIG_FHA_2	72	78	PF00498	0.438
LIG_LIR_Apic_2	109	113	PF02991	0.435
LIG_LIR_Apic_2	211	216	PF02991	0.473
LIG_LIR_Gen_1	260	270	PF02991	0.434
LIG_LIR_Gen_1	276	287	PF02991	0.434
LIG_LIR_Gen_1	392	399	PF02991	0.434
LIG_LIR_Gen_1	40	49	PF02991	0.330
LIG_LIR_Nem_3	104	108	PF02991	0.438
LIG_LIR_Nem_3	115	119	PF02991	0.444
LIG_LIR_Nem_3	249	253	PF02991	0.447
LIG_LIR_Nem_3	260	265	PF02991	0.459
LIG_LIR_Nem_3	276	282	PF02991	0.434
LIG_LIR_Nem_3	290	294	PF02991	0.434
LIG_LIR_Nem_3	36	42	PF02991	0.330
LIG_LIR_Nem_3	392	397	PF02991	0.434
LIG_LIR_Nem_3	51	56	PF02991	0.375
LIG_OCRL_FandH_1	159	171	PF00620	0.518
LIG_PCNA_PIPBox_1	329	338	PF02747	0.518
LIG_PCNA_yPIPBox_3	329	340	PF02747	0.518
LIG_Pex14_1	156	160	PF04695	0.434
LIG_Pex14_2	106	110	PF04695	0.448
LIG_Pex14_2	119	123	PF04695	0.448
LIG_Pex14_2	413	417	PF04695	0.343
LIG_Rb_pABgroove_1	388	396	PF01858	0.512
LIG_SH2_CRK	250	254	PF00017	0.434
LIG_SH2_CRK	53	57	PF00017	0.509
LIG_SH2_NCK_1	294	298	PF00017	0.490
LIG_SH2_PTP2	244	247	PF00017	0.434
LIG_SH2_PTP2	279	282	PF00017	0.524
LIG_SH2_SRC	279	282	PF00017	0.524
LIG_SH2_STAP1	239	243	PF00017	0.448
LIG_SH2_STAP1	354	358	PF00017	0.434
LIG_SH2_STAT3	222	225	PF00017	0.434
LIG_SH2_STAT5	166	169	PF00017	0.524
LIG_SH2_STAT5	222	225	PF00017	0.434
LIG_SH2_STAT5	227	230	PF00017	0.434
LIG_SH2_STAT5	244	247	PF00017	0.434
LIG_SH2_STAT5	279	282	PF00017	0.497
LIG_SH2_STAT5	294	297	PF00017	0.380
LIG_SH2_STAT5	437	440	PF00017	0.428
LIG_SH3_3	212	218	PF00018	0.484
LIG_SH3_4	134	141	PF00018	0.448
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.308
LIG_TRAF2_1	404	407	PF00917	0.544
LIG_UBA3_1	331	340	PF00899	0.439
LIG_WW_3	453	457	PF00397	0.432
MOD_CK1_1	148	154	PF00069	0.448
MOD_CK1_1	202	208	PF00069	0.553
MOD_CK1_1	429	435	PF00069	0.520
MOD_CK2_1	30	36	PF00069	0.394
MOD_CK2_1	401	407	PF00069	0.434
MOD_CK2_1	458	464	PF00069	0.522
MOD_Cter_Amidation	235	238	PF01082	0.234
MOD_Cter_Amidation	400	403	PF01082	0.528
MOD_GlcNHglycan	169	172	PF01048	0.297
MOD_GlcNHglycan	192	195	PF01048	0.339
MOD_GlcNHglycan	204	207	PF01048	0.319
MOD_GlcNHglycan	297	300	PF01048	0.241
MOD_GlcNHglycan	403	406	PF01048	0.545
MOD_GSK3_1	30	37	PF00069	0.453
MOD_GSK3_1	369	376	PF00069	0.434
MOD_GSK3_1	422	429	PF00069	0.590
MOD_GSK3_1	71	78	PF00069	0.518
MOD_LATS_1	3	9	PF00433	0.613
MOD_N-GLC_1	369	374	PF02516	0.234
MOD_N-GLC_1	426	431	PF02516	0.576
MOD_N-GLC_1	458	463	PF02516	0.604
MOD_NEK2_1	145	150	PF00069	0.434
MOD_NEK2_1	167	172	PF00069	0.524
MOD_NEK2_1	17	22	PF00069	0.322
MOD_NEK2_1	246	251	PF00069	0.443
MOD_NEK2_1	257	262	PF00069	0.421
MOD_NEK2_1	311	316	PF00069	0.490
MOD_NEK2_1	366	371	PF00069	0.434
MOD_NEK2_1	433	438	PF00069	0.517
MOD_NEK2_2	208	213	PF00069	0.473
MOD_PIKK_1	148	154	PF00454	0.434
MOD_PIKK_1	426	432	PF00454	0.664
MOD_PIKK_1	446	452	PF00454	0.531
MOD_PKA_1	75	81	PF00069	0.564
MOD_PKA_2	17	23	PF00069	0.259
MOD_PKA_2	268	274	PF00069	0.446
MOD_PKA_2	3	9	PF00069	0.546
MOD_PKA_2	401	407	PF00069	0.434
MOD_Plk_1	275	281	PF00069	0.434
MOD_Plk_1	358	364	PF00069	0.518
MOD_Plk_1	44	50	PF00069	0.459
MOD_Plk_2-3	32	38	PF00069	0.441
MOD_Plk_4	126	132	PF00069	0.524
MOD_Plk_4	17	23	PF00069	0.319
MOD_Plk_4	208	214	PF00069	0.473
MOD_Plk_4	251	257	PF00069	0.490
MOD_Plk_4	275	281	PF00069	0.434
MOD_Plk_4	429	435	PF00069	0.526
MOD_Plk_4	44	50	PF00069	0.459
MOD_Plk_4	75	81	PF00069	0.518
MOD_ProDKin_1	369	375	PF00069	0.434
MOD_ProDKin_1	376	382	PF00069	0.434
MOD_SUMO_rev_2	155	162	PF00179	0.514
TRG_ENDOCYTIC_2	116	119	PF00928	0.434
TRG_ENDOCYTIC_2	244	247	PF00928	0.434
TRG_ENDOCYTIC_2	250	253	PF00928	0.434
TRG_ENDOCYTIC_2	279	282	PF00928	0.509
TRG_ENDOCYTIC_2	354	357	PF00928	0.434
TRG_ENDOCYTIC_2	53	56	PF00928	0.394
TRG_ER_diArg_1	123	125	PF00400	0.448
TRG_ER_diArg_1	156	158	PF00400	0.490
TRG_ER_diArg_1	25	28	PF00400	0.346
TRG_ER_diArg_1	4	7	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P402	Leptomonas seymouri	83%	100%
A0A1X0NFU6	Trypanosomatidae	35%	88%
A0A1X0NZP1	Trypanosomatidae	36%	90%
A0A1X0P705	Trypanosomatidae	65%	100%
A0A3R7MY56	Trypanosoma rangeli	65%	100%
A0A3S5IS28	Trypanosoma rangeli	25%	73%
A0A422N932	Trypanosoma rangeli	34%	100%
A0A422NPL9	Trypanosoma rangeli	24%	76%
A2APC3	Mus musculus	46%	100%
A4H9E1	Leishmania braziliensis	90%	98%
A4HXR2	Leishmania infantum	95%	99%
B6DTF7	Bodo saltans	64%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	69%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	89%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	74%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	71%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
O95922	Homo sapiens	39%	100%
P38160	Sus scrofa	25%	100%
P38584	Bos taurus	25%	100%
P38585	Mus musculus	24%	100%
Q0VC71	Bos taurus	39%	100%
Q23SI8	Tetrahymena thermophila (strain SB210)	38%	100%
Q3SXZ7	Homo sapiens	42%	100%
Q3SZH6	Bos taurus	45%	100%
Q4QE05	Leishmania major	93%	99%
Q564U4	Caenorhabditis elegans	41%	100%
Q5PPI9	Rattus norvegicus	39%	100%
Q641W7	Rattus norvegicus	45%	100%
Q8NG68	Homo sapiens	24%	100%
Q91V51	Mus musculus	39%	100%
Q9QXJ0	Rattus norvegicus	25%	100%
V5BVF5	Trypanosoma cruzi	23%	73%