RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUT6_LEIDO

TriTrypDb:

LdBPK_180170.1 , LdCL_180006700 , LDHU3_18.0190

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WUT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUT6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.578
CLV_NRD_NRD_1	138	140	PF00675	0.345
CLV_NRD_NRD_1	157	159	PF00675	0.225
CLV_PCSK_KEX2_1	156	158	PF00082	0.363
CLV_PCSK_KEX2_1	345	347	PF00082	0.638
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.617
CLV_PCSK_SKI1_1	113	117	PF00082	0.462
CLV_PCSK_SKI1_1	139	143	PF00082	0.380
CLV_PCSK_SKI1_1	158	162	PF00082	0.175
CLV_PCSK_SKI1_1	230	234	PF00082	0.737
CLV_PCSK_SKI1_1	342	346	PF00082	0.681
CLV_PCSK_SKI1_1	36	40	PF00082	0.370
DEG_SCF_TRCP1_1	328	334	PF00400	0.674
DOC_MAPK_gen_1	108	116	PF00069	0.521
DOC_MAPK_gen_1	156	164	PF00069	0.563
DOC_MAPK_gen_1	75	85	PF00069	0.563
DOC_MAPK_MEF2A_6	156	164	PF00069	0.585
DOC_PP1_RVXF_1	155	162	PF00149	0.563
DOC_PP4_FxxP_1	318	321	PF00568	0.595
DOC_USP7_MATH_1	134	138	PF00917	0.513
DOC_USP7_MATH_1	231	235	PF00917	0.698
DOC_USP7_MATH_1	302	306	PF00917	0.526
DOC_USP7_MATH_1	326	330	PF00917	0.725
DOC_WW_Pin1_4	12	17	PF00397	0.606
DOC_WW_Pin1_4	130	135	PF00397	0.513
DOC_WW_Pin1_4	202	207	PF00397	0.660
DOC_WW_Pin1_4	238	243	PF00397	0.537
DOC_WW_Pin1_4	99	104	PF00397	0.594
LIG_14-3-3_CanoR_1	139	144	PF00244	0.463
LIG_14-3-3_CanoR_1	246	254	PF00244	0.536
LIG_14-3-3_CanoR_1	270	276	PF00244	0.594
LIG_14-3-3_CanoR_1	278	288	PF00244	0.572
LIG_14-3-3_CanoR_1	312	319	PF00244	0.616
LIG_14-3-3_CterR_2	346	348	PF00244	0.619
LIG_Actin_WH2_2	23	38	PF00022	0.563
LIG_APCC_ABBA_1	141	146	PF00400	0.563
LIG_APCC_ABBAyCdc20_2	140	146	PF00400	0.563
LIG_BIR_III_4	79	83	PF00653	0.563
LIG_BRCT_BRCA1_1	10	14	PF00533	0.630
LIG_BRCT_BRCA1_1	340	344	PF00533	0.639
LIG_FHA_1	145	151	PF00498	0.513
LIG_FHA_1	203	209	PF00498	0.619
LIG_FHA_1	259	265	PF00498	0.682
LIG_FHA_1	283	289	PF00498	0.706
LIG_FHA_1	295	301	PF00498	0.576
LIG_FHA_1	330	336	PF00498	0.741
LIG_FHA_1	60	66	PF00498	0.590
LIG_FHA_1	87	93	PF00498	0.568
LIG_FHA_2	161	167	PF00498	0.563
LIG_LIR_Apic_2	316	321	PF02991	0.601
LIG_LIR_Gen_1	37	45	PF02991	0.513
LIG_LIR_Nem_3	133	138	PF02991	0.560
LIG_LIR_Nem_3	19	25	PF02991	0.438
LIG_LIR_Nem_3	37	42	PF02991	0.545
LIG_LIR_Nem_3	62	67	PF02991	0.563
LIG_SH2_CRK	135	139	PF00017	0.563
LIG_SH2_SRC	67	70	PF00017	0.513
LIG_SH2_STAT3	55	58	PF00017	0.563
LIG_SH2_STAT5	199	202	PF00017	0.692
LIG_SH2_STAT5	25	28	PF00017	0.554
LIG_SH3_3	236	242	PF00018	0.643
LIG_SUMO_SIM_par_1	119	127	PF11976	0.563
LIG_TRAF2_1	104	107	PF00917	0.593
LIG_WRC_WIRS_1	161	166	PF05994	0.563
MOD_CDK_SPK_2	202	207	PF00069	0.590
MOD_CK1_1	12	18	PF00069	0.512
MOD_CK1_1	220	226	PF00069	0.706
MOD_CK1_1	277	283	PF00069	0.693
MOD_CK1_1	329	335	PF00069	0.708
MOD_CK1_1	340	346	PF00069	0.628
MOD_CK1_1	56	62	PF00069	0.513
MOD_CK2_1	160	166	PF00069	0.563
MOD_CK2_1	231	237	PF00069	0.569
MOD_CK2_1	302	308	PF00069	0.526
MOD_GlcNHglycan	224	227	PF01048	0.602
MOD_GlcNHglycan	304	307	PF01048	0.535
MOD_GlcNHglycan	328	331	PF01048	0.706
MOD_GlcNHglycan	39	42	PF01048	0.392
MOD_GlcNHglycan	55	58	PF01048	0.243
MOD_GSK3_1	130	137	PF00069	0.513
MOD_GSK3_1	193	200	PF00069	0.589
MOD_GSK3_1	220	227	PF00069	0.690
MOD_GSK3_1	270	277	PF00069	0.677
MOD_GSK3_1	8	15	PF00069	0.712
MOD_N-GLC_1	144	149	PF02516	0.363
MOD_N-GLC_2	179	181	PF02516	0.363
MOD_NEK2_1	86	91	PF00069	0.563
MOD_NEK2_2	134	139	PF00069	0.513
MOD_PIKK_1	197	203	PF00454	0.601
MOD_PIKK_1	2	8	PF00454	0.619
MOD_PIKK_1	220	226	PF00454	0.541
MOD_PIKK_1	258	264	PF00454	0.613
MOD_PIKK_1	279	285	PF00454	0.641
MOD_PIKK_1	294	300	PF00454	0.566
MOD_PK_1	88	94	PF00069	0.629
MOD_PKA_1	139	145	PF00069	0.563
MOD_PKA_2	277	283	PF00069	0.633
MOD_PKA_2	311	317	PF00069	0.683
MOD_PKA_2	337	343	PF00069	0.751
MOD_PKB_1	336	344	PF00069	0.634
MOD_Plk_4	314	320	PF00069	0.536
MOD_Plk_4	45	51	PF00069	0.563
MOD_ProDKin_1	12	18	PF00069	0.599
MOD_ProDKin_1	130	136	PF00069	0.513
MOD_ProDKin_1	202	208	PF00069	0.660
MOD_ProDKin_1	238	244	PF00069	0.540
MOD_ProDKin_1	99	105	PF00069	0.594
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.513
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.563
TRG_ENDOCYTIC_2	135	138	PF00928	0.563
TRG_ER_diArg_1	156	158	PF00400	0.563
TRG_ER_diArg_1	335	338	PF00400	0.742
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9C3	Leishmania braziliensis	69%	100%
A4HXP4	Leishmania infantum	99%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O09032	Rattus norvegicus	24%	90%
P26378	Homo sapiens	24%	90%
Q4QE24	Leishmania major	90%	100%
Q61701	Mus musculus	24%	90%