Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUS7_LEIDO

TriTrypDb:

LdBPK_180240.1 , LdCL_180007300 , LDHU3_18.0290

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WUS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.623
CLV_C14_Caspase3-7	54	58	PF00656	0.628
CLV_C14_Caspase3-7	83	87	PF00656	0.579
CLV_NRD_NRD_1	184	186	PF00675	0.470
CLV_NRD_NRD_1	241	243	PF00675	0.405
CLV_NRD_NRD_1	308	310	PF00675	0.499
CLV_NRD_NRD_1	314	316	PF00675	0.456
CLV_NRD_NRD_1	50	52	PF00675	0.449
CLV_PCSK_KEX2_1	184	186	PF00082	0.470
CLV_PCSK_KEX2_1	254	256	PF00082	0.467
CLV_PCSK_KEX2_1	307	309	PF00082	0.502
CLV_PCSK_KEX2_1	50	52	PF00082	0.449
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.455
CLV_PCSK_SKI1_1	171	175	PF00082	0.453
CLV_PCSK_SKI1_1	184	188	PF00082	0.386
CLV_PCSK_SKI1_1	315	319	PF00082	0.433
DOC_MAPK_gen_1	101	111	PF00069	0.558
DOC_MAPK_MEF2A_6	229	236	PF00069	0.632
DOC_PP2B_LxvP_1	174	177	PF13499	0.642
DOC_PP2B_LxvP_1	204	207	PF13499	0.739
DOC_USP7_MATH_1	179	183	PF00917	0.628
DOC_USP7_MATH_1	218	222	PF00917	0.666
DOC_USP7_MATH_1	58	62	PF00917	0.680
LIG_14-3-3_CanoR_1	132	139	PF00244	0.594
LIG_14-3-3_CanoR_1	200	205	PF00244	0.647
LIG_14-3-3_CanoR_1	315	322	PF00244	0.690
LIG_14-3-3_CanoR_1	81	89	PF00244	0.577
LIG_Actin_WH2_2	270	288	PF00022	0.588
LIG_Actin_WH2_2	67	83	PF00022	0.618
LIG_CtBP_PxDLS_1	303	307	PF00389	0.647
LIG_FHA_1	14	20	PF00498	0.269
LIG_FHA_1	43	49	PF00498	0.621
LIG_FHA_1	66	72	PF00498	0.625
LIG_FHA_2	165	171	PF00498	0.735
LIG_FHA_2	81	87	PF00498	0.551
LIG_LIR_Apic_2	342	346	PF02991	0.677
LIG_LIR_Gen_1	152	162	PF02991	0.648
LIG_LIR_Gen_1	230	241	PF02991	0.622
LIG_LIR_Nem_3	113	118	PF02991	0.614
LIG_LIR_Nem_3	123	127	PF02991	0.612
LIG_LIR_Nem_3	152	158	PF02991	0.622
LIG_LIR_Nem_3	21	26	PF02991	0.349
LIG_LIR_Nem_3	230	236	PF02991	0.626
LIG_LIR_Nem_3	46	52	PF02991	0.737
LIG_LRP6_Inhibitor_1	236	242	PF00058	0.333
LIG_MAD2	197	205	PF02301	0.673
LIG_Pex14_1	115	119	PF04695	0.577
LIG_SH2_CRK	343	347	PF00017	0.596
LIG_SH2_PTP2	26	29	PF00017	0.369
LIG_SH2_PTP2	347	350	PF00017	0.627
LIG_SH2_SRC	347	350	PF00017	0.584
LIG_SH2_STAT5	10	13	PF00017	0.470
LIG_SH2_STAT5	118	121	PF00017	0.616
LIG_SH2_STAT5	26	29	PF00017	0.220
LIG_SH2_STAT5	331	334	PF00017	0.683
LIG_SH2_STAT5	347	350	PF00017	0.536
LIG_SH3_3	295	301	PF00018	0.705
LIG_SUMO_SIM_anti_2	387	394	PF11976	0.605
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.571
LIG_SUMO_SIM_par_1	107	113	PF11976	0.599
LIG_SUMO_SIM_par_1	172	178	PF11976	0.633
LIG_TRAF2_1	270	273	PF00917	0.658
LIG_TYR_ITIM	24	29	PF00017	0.292
MOD_CK1_1	110	116	PF00069	0.510
MOD_CK1_1	128	134	PF00069	0.518
MOD_CK1_1	164	170	PF00069	0.583
MOD_CK1_1	263	269	PF00069	0.654
MOD_CK1_1	321	327	PF00069	0.526
MOD_CK1_1	352	358	PF00069	0.487
MOD_CK1_1	69	75	PF00069	0.447
MOD_CK2_1	97	103	PF00069	0.684
MOD_GlcNHglycan	135	138	PF01048	0.420
MOD_GlcNHglycan	177	180	PF01048	0.508
MOD_GlcNHglycan	244	247	PF01048	0.463
MOD_GlcNHglycan	262	265	PF01048	0.685
MOD_GlcNHglycan	323	326	PF01048	0.519
MOD_GlcNHglycan	367	370	PF01048	0.634
MOD_GlcNHglycan	60	63	PF01048	0.618
MOD_GlcNHglycan	68	71	PF01048	0.492
MOD_GSK3_1	122	129	PF00069	0.430
MOD_GSK3_1	145	152	PF00069	0.511
MOD_GSK3_1	175	182	PF00069	0.640
MOD_GSK3_1	311	318	PF00069	0.542
MOD_GSK3_1	349	356	PF00069	0.455
MOD_GSK3_1	365	372	PF00069	0.616
MOD_GSK3_1	52	59	PF00069	0.570
MOD_GSK3_1	62	69	PF00069	0.686
MOD_N-GLC_1	362	367	PF02516	0.592
MOD_NEK2_1	126	131	PF00069	0.421
MOD_NEK2_1	133	138	PF00069	0.572
MOD_NEK2_1	275	280	PF00069	0.528
MOD_NEK2_1	339	344	PF00069	0.475
MOD_NEK2_1	66	71	PF00069	0.531
MOD_PIKK_1	315	321	PF00454	0.515
MOD_PIKK_1	69	75	PF00454	0.414
MOD_PKA_1	242	248	PF00069	0.526
MOD_PKA_1	315	321	PF00069	0.515
MOD_PKA_2	13	19	PF00069	0.304
MOD_PKA_2	131	137	PF00069	0.489
MOD_PKA_2	80	86	PF00069	0.475
MOD_PKA_2	96	102	PF00069	0.408
MOD_Plk_1	122	128	PF00069	0.454
MOD_Plk_4	145	151	PF00069	0.527
MOD_Plk_4	294	300	PF00069	0.764
MOD_Plk_4	62	68	PF00069	0.605
MOD_SUMO_rev_2	249	256	PF00179	0.605
TRG_DiLeu_BaEn_1	373	378	PF01217	0.550
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.551
TRG_ENDOCYTIC_2	118	121	PF00928	0.509
TRG_ENDOCYTIC_2	26	29	PF00928	0.369
TRG_ENDOCYTIC_2	347	350	PF00928	0.547
TRG_ER_diArg_1	306	309	PF00400	0.625
TRG_ER_diArg_1	49	51	PF00400	0.558
TRG_NES_CRM1_1	73	86	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P351	Leptomonas seymouri	27%	100%
A4H9C8	Leishmania braziliensis	64%	100%
A4HXQ0	Leishmania infantum	99%	100%
E9ARG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QE18	Leishmania major	86%	100%