LeishMANIAdb
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UDP-galactose transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UDP-galactose transporter
Gene product:
UDP-galactose transporter
Species:
Leishmania donovani
UniProt:
A0A3S7WUS3_LEIDO
TriTrypDb:
LdBPK_180400.1 , LdCL_180008900 , LDHU3_18.0490
Length:
563

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 9
GO:0016020 membrane 2 9
GO:0031090 organelle membrane 3 9
GO:0098588 bounding membrane of organelle 4 9
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3S7WUS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUS3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0008643 carbohydrate transport 5 2
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0071702 organic substance transport 4 3
GO:0006811 monoatomic ion transport 4 1
GO:0006820 monoatomic anion transport 5 1
GO:0009987 cellular process 1 1
GO:0015711 organic anion transport 5 1
GO:0015780 nucleotide-sugar transmembrane transport 3 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072334 UDP-galactose transmembrane transport 5 1
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:1901264 carbohydrate derivative transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 9
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 9
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 9
GO:0022857 transmembrane transporter activity 2 9
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 9
GO:0005459 UDP-galactose transmembrane transporter activity 6 1
GO:0015136 sialic acid transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 285 289 PF00656 0.264
CLV_C14_Caspase3-7 531 535 PF00656 0.261
CLV_NRD_NRD_1 231 233 PF00675 0.451
CLV_NRD_NRD_1 241 243 PF00675 0.428
CLV_NRD_NRD_1 312 314 PF00675 0.264
CLV_NRD_NRD_1 32 34 PF00675 0.251
CLV_PCSK_KEX2_1 241 243 PF00082 0.422
CLV_PCSK_KEX2_1 260 262 PF00082 0.192
CLV_PCSK_KEX2_1 34 36 PF00082 0.240
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.264
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.240
CLV_PCSK_PC7_1 30 36 PF00082 0.240
CLV_PCSK_SKI1_1 241 245 PF00082 0.367
CLV_PCSK_SKI1_1 404 408 PF00082 0.264
CLV_PCSK_SKI1_1 476 480 PF00082 0.473
DEG_SPOP_SBC_1 406 410 PF00917 0.458
DOC_CYCLIN_RxL_1 241 248 PF00134 0.537
DOC_CYCLIN_yClb1_LxF_4 276 282 PF00134 0.295
DOC_CYCLIN_yCln2_LP_2 266 272 PF00134 0.276
DOC_MAPK_gen_1 260 268 PF00069 0.460
DOC_MAPK_MEF2A_6 260 268 PF00069 0.464
DOC_MAPK_MEF2A_6 407 415 PF00069 0.464
DOC_MAPK_MEF2A_6 55 62 PF00069 0.489
DOC_MAPK_MEF2A_6 88 96 PF00069 0.601
DOC_MAPK_NFAT4_5 261 269 PF00069 0.464
DOC_MAPK_NFAT4_5 55 63 PF00069 0.451
DOC_PP1_RVXF_1 448 454 PF00149 0.292
DOC_PP2B_LxvP_1 266 269 PF13499 0.295
DOC_PP2B_LxvP_1 335 338 PF13499 0.307
DOC_PP4_FxxP_1 423 426 PF00568 0.295
DOC_PP4_FxxP_1 456 459 PF00568 0.264
DOC_USP7_MATH_1 11 15 PF00917 0.289
DOC_USP7_MATH_1 133 137 PF00917 0.657
DOC_USP7_MATH_1 202 206 PF00917 0.666
DOC_USP7_MATH_1 428 432 PF00917 0.286
DOC_USP7_MATH_1 76 80 PF00917 0.617
DOC_USP7_UBL2_3 558 562 PF12436 0.531
DOC_WW_Pin1_4 135 140 PF00397 0.686
DOC_WW_Pin1_4 192 197 PF00397 0.671
DOC_WW_Pin1_4 313 318 PF00397 0.470
DOC_WW_Pin1_4 407 412 PF00397 0.458
LIG_14-3-3_CanoR_1 203 208 PF00244 0.642
LIG_Actin_WH2_2 180 195 PF00022 0.627
LIG_BIR_II_1 1 5 PF00653 0.425
LIG_BIR_III_4 165 169 PF00653 0.687
LIG_BRCT_BRCA1_1 398 402 PF00533 0.425
LIG_BRCT_BRCA1_1 538 542 PF00533 0.396
LIG_BRCT_BRCA1_1 552 556 PF00533 0.228
LIG_BRCT_BRCA1_2 398 404 PF00533 0.307
LIG_BRCT_BRCA1_2 552 558 PF00533 0.260
LIG_eIF4E_1 42 48 PF01652 0.464
LIG_FHA_1 140 146 PF00498 0.717
LIG_FHA_1 179 185 PF00498 0.700
LIG_FHA_1 261 267 PF00498 0.489
LIG_FHA_1 289 295 PF00498 0.284
LIG_FHA_1 296 302 PF00498 0.315
LIG_FHA_1 325 331 PF00498 0.295
LIG_FHA_1 340 346 PF00498 0.264
LIG_FHA_1 354 360 PF00498 0.285
LIG_FHA_1 410 416 PF00498 0.451
LIG_FHA_1 42 48 PF00498 0.473
LIG_FHA_1 461 467 PF00498 0.288
LIG_FHA_1 487 493 PF00498 0.314
LIG_FHA_1 81 87 PF00498 0.574
LIG_GBD_Chelix_1 540 548 PF00786 0.244
LIG_LIR_Apic_2 421 426 PF02991 0.295
LIG_LIR_Gen_1 248 258 PF02991 0.534
LIG_LIR_Gen_1 394 405 PF02991 0.381
LIG_LIR_Gen_1 489 498 PF02991 0.311
LIG_LIR_Gen_1 553 561 PF02991 0.376
LIG_LIR_LC3C_4 23 27 PF02991 0.295
LIG_LIR_Nem_3 394 400 PF02991 0.326
LIG_LIR_Nem_3 489 493 PF02991 0.299
LIG_LIR_Nem_3 553 559 PF02991 0.364
LIG_LIR_Nem_3 66 72 PF02991 0.586
LIG_MLH1_MIPbox_1 398 402 PF16413 0.307
LIG_NRP_CendR_1 562 563 PF00754 0.424
LIG_PCNA_PIPBox_1 243 252 PF02747 0.544
LIG_Pex14_1 490 494 PF04695 0.307
LIG_Pex14_2 267 271 PF04695 0.343
LIG_Pex14_2 494 498 PF04695 0.261
LIG_REV1ctd_RIR_1 477 487 PF16727 0.259
LIG_SH2_CRK 234 238 PF00017 0.592
LIG_SH2_CRK 397 401 PF00017 0.295
LIG_SH2_CRK 442 446 PF00017 0.273
LIG_SH2_NCK_1 397 401 PF00017 0.307
LIG_SH2_NCK_1 442 446 PF00017 0.299
LIG_SH2_SRC 484 487 PF00017 0.253
LIG_SH2_SRC 536 539 PF00017 0.266
LIG_SH2_STAP1 397 401 PF00017 0.307
LIG_SH2_STAP1 484 488 PF00017 0.251
LIG_SH2_STAP1 509 513 PF00017 0.464
LIG_SH2_STAT5 176 179 PF00017 0.618
LIG_SH2_STAT5 250 253 PF00017 0.582
LIG_SH2_STAT5 401 404 PF00017 0.464
LIG_SH3_3 127 133 PF00018 0.683
LIG_SH3_3 164 170 PF00018 0.688
LIG_SH3_3 222 228 PF00018 0.646
LIG_SH3_3 471 477 PF00018 0.251
LIG_SUMO_SIM_anti_2 14 20 PF11976 0.328
LIG_SUMO_SIM_anti_2 23 29 PF11976 0.329
LIG_SUMO_SIM_anti_2 519 526 PF11976 0.276
LIG_SUMO_SIM_anti_2 93 98 PF11976 0.683
LIG_SUMO_SIM_par_1 23 29 PF11976 0.329
LIG_SUMO_SIM_par_1 322 327 PF11976 0.298
LIG_SUMO_SIM_par_1 431 436 PF11976 0.248
LIG_SUMO_SIM_par_1 546 553 PF11976 0.248
LIG_SUMO_SIM_par_1 95 103 PF11976 0.628
LIG_TRAF2_1 123 126 PF00917 0.680
LIG_UBA3_1 501 508 PF00899 0.276
MOD_CK1_1 135 141 PF00069 0.681
MOD_CK1_1 178 184 PF00069 0.624
MOD_CK1_1 391 397 PF00069 0.289
MOD_Cter_Amidation 311 314 PF01082 0.273
MOD_GlcNHglycan 101 105 PF01048 0.418
MOD_GlcNHglycan 135 138 PF01048 0.473
MOD_GlcNHglycan 148 151 PF01048 0.531
MOD_GlcNHglycan 200 203 PF01048 0.491
MOD_GlcNHglycan 205 208 PF01048 0.503
MOD_GlcNHglycan 254 257 PF01048 0.332
MOD_GlcNHglycan 390 393 PF01048 0.371
MOD_GlcNHglycan 456 459 PF01048 0.465
MOD_GlcNHglycan 525 528 PF01048 0.295
MOD_GlcNHglycan 530 533 PF01048 0.295
MOD_GSK3_1 135 142 PF00069 0.673
MOD_GSK3_1 171 178 PF00069 0.688
MOD_GSK3_1 192 199 PF00069 0.748
MOD_GSK3_1 295 302 PF00069 0.352
MOD_GSK3_1 388 395 PF00069 0.313
MOD_GSK3_1 405 412 PF00069 0.464
MOD_GSK3_1 523 530 PF00069 0.276
MOD_GSK3_1 76 83 PF00069 0.645
MOD_NEK2_1 182 187 PF00069 0.652
MOD_NEK2_1 198 203 PF00069 0.645
MOD_NEK2_1 236 241 PF00069 0.646
MOD_NEK2_1 254 259 PF00069 0.484
MOD_NEK2_1 300 305 PF00069 0.328
MOD_NEK2_1 353 358 PF00069 0.242
MOD_NEK2_1 393 398 PF00069 0.295
MOD_NEK2_1 466 471 PF00069 0.260
MOD_NEK2_1 528 533 PF00069 0.313
MOD_NEK2_2 245 250 PF00069 0.523
MOD_NEK2_2 411 416 PF00069 0.472
MOD_PIKK_1 293 299 PF00454 0.295
MOD_PIKK_1 466 472 PF00454 0.226
MOD_PKA_1 260 266 PF00069 0.464
MOD_PKA_2 202 208 PF00069 0.679
MOD_PKA_2 260 266 PF00069 0.464
MOD_PKA_2 29 35 PF00069 0.464
MOD_PKA_2 80 86 PF00069 0.583
MOD_Plk_2-3 159 165 PF00069 0.670
MOD_Plk_4 11 17 PF00069 0.327
MOD_Plk_4 20 26 PF00069 0.329
MOD_Plk_4 254 260 PF00069 0.475
MOD_Plk_4 319 325 PF00069 0.373
MOD_Plk_4 396 402 PF00069 0.307
MOD_Plk_4 418 424 PF00069 0.339
MOD_Plk_4 428 434 PF00069 0.346
MOD_Plk_4 43 49 PF00069 0.467
MOD_ProDKin_1 135 141 PF00069 0.687
MOD_ProDKin_1 192 198 PF00069 0.673
MOD_ProDKin_1 313 319 PF00069 0.470
MOD_ProDKin_1 407 413 PF00069 0.458
TRG_DiLeu_BaEn_1 93 98 PF01217 0.619
TRG_ENDOCYTIC_2 234 237 PF00928 0.626
TRG_ENDOCYTIC_2 240 243 PF00928 0.603
TRG_ENDOCYTIC_2 250 253 PF00928 0.567
TRG_ENDOCYTIC_2 397 400 PF00928 0.295
TRG_ENDOCYTIC_2 442 445 PF00928 0.312
TRG_ENDOCYTIC_2 484 487 PF00928 0.338
TRG_ER_diArg_1 240 242 PF00400 0.648
TRG_ER_diArg_1 33 36 PF00400 0.440
TRG_NES_CRM1_1 51 66 PF08389 0.499
TRG_Pf-PMV_PEXEL_1 190 194 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVQ8 Leptomonas seymouri 54% 100%
A4H9E4 Leishmania braziliensis 65% 99%
A4HD92 Leishmania braziliensis 28% 100%
A4HDA0 Leishmania braziliensis 28% 100%
A4HXR5 Leishmania infantum 99% 100%
E9ARH7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q5QHQ6 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS