CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUS2_LEIDO

TriTrypDb:

LdBPK_180130.1 , LdCL_180006200 , LDHU3_18.0140

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 9
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	21
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7WUS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUS2

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	21
GO:0042592	homeostatic process	3	21
GO:0048878	chemical homeostasis	4	21
GO:0050801	monoatomic ion homeostasis	5	21
GO:0055065	obsolete metal ion homeostasis	7	21
GO:0055080	monoatomic cation homeostasis	6	21
GO:0065007	biological regulation	1	21
GO:0065008	regulation of biological quality	2	21
GO:0072507	obsolete divalent inorganic cation homeostasis	7	21
GO:0098771	inorganic ion homeostasis	6	21

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.326
CLV_C14_Caspase3-7	352	356	PF00656	0.272
CLV_NRD_NRD_1	271	273	PF00675	0.479
CLV_NRD_NRD_1	362	364	PF00675	0.762
CLV_NRD_NRD_1	377	379	PF00675	0.643
CLV_NRD_NRD_1	686	688	PF00675	0.747
CLV_NRD_NRD_1	95	97	PF00675	0.266
CLV_PCSK_KEX2_1	271	273	PF00082	0.512
CLV_PCSK_KEX2_1	362	364	PF00082	0.617
CLV_PCSK_KEX2_1	376	378	PF00082	0.649
CLV_PCSK_KEX2_1	698	700	PF00082	0.699
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.649
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.716
CLV_PCSK_PC7_1	372	378	PF00082	0.613
CLV_PCSK_PC7_1	694	700	PF00082	0.751
CLV_PCSK_SKI1_1	233	237	PF00082	0.605
CLV_PCSK_SKI1_1	323	327	PF00082	0.557
CLV_PCSK_SKI1_1	459	463	PF00082	0.743
CLV_PCSK_SKI1_1	48	52	PF00082	0.462
CLV_PCSK_SKI1_1	527	531	PF00082	0.506
CLV_PCSK_SKI1_1	687	691	PF00082	0.782
CLV_PCSK_SKI1_1	698	702	PF00082	0.662
CLV_PCSK_SKI1_1	96	100	PF00082	0.336
DEG_APCC_DBOX_1	206	214	PF00400	0.224
DEG_APCC_DBOX_1	232	240	PF00400	0.395
DEG_SPOP_SBC_1	11	15	PF00917	0.540
DOC_CDC14_PxL_1	617	625	PF14671	0.310
DOC_CKS1_1	410	415	PF01111	0.455
DOC_CYCLIN_RxL_1	655	669	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	659	665	PF00134	0.531
DOC_MAPK_gen_1	286	294	PF00069	0.347
DOC_MAPK_gen_1	411	421	PF00069	0.489
DOC_MAPK_MEF2A_6	170	179	PF00069	0.324
DOC_MAPK_MEF2A_6	96	103	PF00069	0.444
DOC_PP1_RVXF_1	480	486	PF00149	0.435
DOC_PP4_MxPP_1	3	6	PF00568	0.581
DOC_USP7_MATH_1	10	14	PF00917	0.708
DOC_USP7_MATH_1	33	37	PF00917	0.406
DOC_USP7_MATH_1	385	389	PF00917	0.582
DOC_USP7_MATH_1	491	495	PF00917	0.437
DOC_USP7_MATH_1	628	632	PF00917	0.350
DOC_USP7_UBL2_3	220	224	PF12436	0.410
DOC_WW_Pin1_4	12	17	PF00397	0.634
DOC_WW_Pin1_4	248	253	PF00397	0.266
DOC_WW_Pin1_4	260	265	PF00397	0.252
DOC_WW_Pin1_4	362	367	PF00397	0.590
DOC_WW_Pin1_4	389	394	PF00397	0.502
DOC_WW_Pin1_4	409	414	PF00397	0.460
DOC_WW_Pin1_4	550	555	PF00397	0.514
DOC_WW_Pin1_4	663	668	PF00397	0.551
LIG_14-3-3_CanoR_1	233	239	PF00244	0.422
LIG_14-3-3_CanoR_1	606	615	PF00244	0.294
LIG_14-3-3_CanoR_1	638	646	PF00244	0.366
LIG_APCC_ABBA_1	146	151	PF00400	0.306
LIG_APCC_ABBA_1	214	219	PF00400	0.260
LIG_BRCT_BRCA1_1	580	584	PF00533	0.291
LIG_Clathr_ClatBox_1	348	352	PF01394	0.311
LIG_Clathr_ClatBox_1	434	438	PF01394	0.290
LIG_Clathr_ClatBox_1	72	76	PF01394	0.507
LIG_CtBP_PxDLS_1	662	666	PF00389	0.379
LIG_FHA_1	109	115	PF00498	0.304
LIG_FHA_1	117	123	PF00498	0.304
LIG_FHA_1	141	147	PF00498	0.250
LIG_FHA_1	344	350	PF00498	0.352
LIG_FHA_1	518	524	PF00498	0.311
LIG_FHA_1	55	61	PF00498	0.329
LIG_FHA_1	581	587	PF00498	0.261
LIG_FHA_1	625	631	PF00498	0.308
LIG_FHA_1	67	73	PF00498	0.294
LIG_FHA_1	75	81	PF00498	0.424
LIG_FHA_2	261	267	PF00498	0.315
LIG_FHA_2	311	317	PF00498	0.309
LIG_FHA_2	32	38	PF00498	0.384
LIG_FHA_2	434	440	PF00498	0.296
LIG_FHA_2	465	471	PF00498	0.392
LIG_FHA_2	638	644	PF00498	0.334
LIG_GBD_Chelix_1	109	117	PF00786	0.309
LIG_GBD_Chelix_1	136	144	PF00786	0.338
LIG_KLC1_Yacidic_2	76	81	PF13176	0.536
LIG_LIR_Apic_2	487	491	PF02991	0.449
LIG_LIR_Gen_1	512	523	PF02991	0.347
LIG_LIR_Gen_1	581	592	PF02991	0.250
LIG_LIR_Gen_1	607	616	PF02991	0.308
LIG_LIR_Gen_1	625	630	PF02991	0.261
LIG_LIR_Gen_1	76	86	PF02991	0.502
LIG_LIR_LC3C_4	143	146	PF02991	0.405
LIG_LIR_LC3C_4	324	328	PF02991	0.390
LIG_LIR_LC3C_4	535	538	PF02991	0.262
LIG_LIR_Nem_3	392	397	PF02991	0.539
LIG_LIR_Nem_3	429	434	PF02991	0.400
LIG_LIR_Nem_3	512	518	PF02991	0.325
LIG_LIR_Nem_3	581	587	PF02991	0.262
LIG_LIR_Nem_3	607	611	PF02991	0.309
LIG_LIR_Nem_3	62	68	PF02991	0.338
LIG_LIR_Nem_3	625	629	PF02991	0.263
LIG_LIR_Nem_3	76	82	PF02991	0.478
LIG_MAD2	572	580	PF02301	0.409
LIG_NRBOX	108	114	PF00104	0.324
LIG_Pex14_1	505	509	PF04695	0.313
LIG_SH2_CRK	488	492	PF00017	0.422
LIG_SH2_CRK	626	630	PF00017	0.316
LIG_SH2_CRK	65	69	PF00017	0.439
LIG_SH2_SRC	79	82	PF00017	0.536
LIG_SH2_STAP1	626	630	PF00017	0.323
LIG_SH2_STAP1	94	98	PF00017	0.467
LIG_SH2_STAT3	205	208	PF00017	0.216
LIG_SH2_STAT5	296	299	PF00017	0.246
LIG_SH2_STAT5	305	308	PF00017	0.417
LIG_SH2_STAT5	339	342	PF00017	0.390
LIG_SH2_STAT5	455	458	PF00017	0.501
LIG_SH2_STAT5	510	513	PF00017	0.313
LIG_SH2_STAT5	515	518	PF00017	0.315
LIG_SH2_STAT5	566	569	PF00017	0.425
LIG_SH2_STAT5	626	629	PF00017	0.282
LIG_SH2_STAT5	65	68	PF00017	0.355
LIG_SH2_STAT5	79	82	PF00017	0.536
LIG_SH3_2	477	482	PF14604	0.444
LIG_SH3_3	178	184	PF00018	0.289
LIG_SH3_3	474	480	PF00018	0.436
LIG_SH3_3	618	624	PF00018	0.358
LIG_SH3_3	674	680	PF00018	0.540
LIG_Sin3_3	110	117	PF02671	0.300
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.349
LIG_SUMO_SIM_par_1	118	124	PF11976	0.322
LIG_SUMO_SIM_par_1	234	240	PF11976	0.411
LIG_SUMO_SIM_par_1	433	439	PF11976	0.261
LIG_SUMO_SIM_par_1	535	542	PF11976	0.306
LIG_SUMO_SIM_par_1	57	62	PF11976	0.395
LIG_SUMO_SIM_par_1	581	589	PF11976	0.296
LIG_SUMO_SIM_par_1	643	648	PF11976	0.323
LIG_SUMO_SIM_par_1	661	666	PF11976	0.378
LIG_TRAF2_1	86	89	PF00917	0.536
LIG_TRFH_1	180	184	PF08558	0.324
LIG_TYR_ITSM	75	82	PF00017	0.536
LIG_UBA3_1	152	160	PF00899	0.300
LIG_UBA3_1	179	187	PF00899	0.324
LIG_UBA3_1	213	220	PF00899	0.336
LIG_WRC_WIRS_1	605	610	PF05994	0.374
LIG_WW_3	479	483	PF00397	0.440
MOD_CDC14_SPxK_1	369	372	PF00782	0.412
MOD_CDK_SPK_2	409	414	PF00069	0.389
MOD_CDK_SPxK_1	366	372	PF00069	0.411
MOD_CDK_SPxxK_3	248	255	PF00069	0.311
MOD_CK1_1	222	228	PF00069	0.419
MOD_CK1_1	310	316	PF00069	0.415
MOD_CK1_1	365	371	PF00069	0.554
MOD_CK1_1	550	556	PF00069	0.529
MOD_CK1_1	582	588	PF00069	0.400
MOD_CK1_1	631	637	PF00069	0.317
MOD_CK2_1	264	270	PF00069	0.319
MOD_CK2_1	31	37	PF00069	0.507
MOD_CK2_1	460	466	PF00069	0.535
MOD_CK2_1	468	474	PF00069	0.540
MOD_CK2_1	489	495	PF00069	0.478
MOD_CK2_1	542	548	PF00069	0.523
MOD_CMANNOS	46	49	PF00535	0.599
MOD_GlcNHglycan	223	227	PF01048	0.522
MOD_GlcNHglycan	352	355	PF01048	0.503
MOD_GlcNHglycan	39	43	PF01048	0.668
MOD_GlcNHglycan	588	591	PF01048	0.490
MOD_GlcNHglycan	61	64	PF01048	0.312
MOD_GlcNHglycan	617	620	PF01048	0.623
MOD_GlcNHglycan	668	671	PF01048	0.679
MOD_GSK3_1	116	123	PF00069	0.335
MOD_GSK3_1	260	267	PF00069	0.301
MOD_GSK3_1	362	369	PF00069	0.496
MOD_GSK3_1	381	388	PF00069	0.532
MOD_GSK3_1	460	467	PF00069	0.467
MOD_GSK3_1	55	62	PF00069	0.398
MOD_GSK3_1	578	585	PF00069	0.270
MOD_GSK3_1	6	13	PF00069	0.715
MOD_GSK3_1	600	607	PF00069	0.356
MOD_GSK3_1	624	631	PF00069	0.309
MOD_GSK3_1	661	668	PF00069	0.516
MOD_N-GLC_1	366	371	PF02516	0.754
MOD_NEK2_1	108	113	PF00069	0.302
MOD_NEK2_1	120	125	PF00069	0.294
MOD_NEK2_1	175	180	PF00069	0.429
MOD_NEK2_1	234	239	PF00069	0.305
MOD_NEK2_1	259	264	PF00069	0.315
MOD_NEK2_1	468	473	PF00069	0.532
MOD_NEK2_1	54	59	PF00069	0.323
MOD_NEK2_1	586	591	PF00069	0.285
MOD_NEK2_2	74	79	PF00069	0.536
MOD_PIKK_1	121	127	PF00454	0.324
MOD_PIKK_1	343	349	PF00454	0.308
MOD_PKA_2	631	637	PF00069	0.301
MOD_Plk_1	301	307	PF00069	0.465
MOD_Plk_1	310	316	PF00069	0.414
MOD_Plk_1	468	474	PF00069	0.509
MOD_Plk_1	624	630	PF00069	0.300
MOD_Plk_1	90	96	PF00069	0.432
MOD_Plk_2-3	464	470	PF00069	0.382
MOD_Plk_2-3	542	548	PF00069	0.530
MOD_Plk_2-3	604	610	PF00069	0.373
MOD_Plk_4	108	114	PF00069	0.273
MOD_Plk_4	116	122	PF00069	0.304
MOD_Plk_4	140	146	PF00069	0.332
MOD_Plk_4	175	181	PF00069	0.340
MOD_Plk_4	234	240	PF00069	0.364
MOD_Plk_4	301	307	PF00069	0.464
MOD_Plk_4	329	335	PF00069	0.330
MOD_Plk_4	427	433	PF00069	0.412
MOD_Plk_4	55	61	PF00069	0.351
MOD_Plk_4	74	80	PF00069	0.446
MOD_ProDKin_1	12	18	PF00069	0.511
MOD_ProDKin_1	248	254	PF00069	0.266
MOD_ProDKin_1	260	266	PF00069	0.252
MOD_ProDKin_1	362	368	PF00069	0.591
MOD_ProDKin_1	389	395	PF00069	0.503
MOD_ProDKin_1	409	415	PF00069	0.456
MOD_ProDKin_1	550	556	PF00069	0.514
MOD_ProDKin_1	663	669	PF00069	0.550
MOD_SUMO_rev_2	206	213	PF00179	0.275
MOD_SUMO_rev_2	452	462	PF00179	0.405
MOD_SUMO_rev_2	643	651	PF00179	0.424
MOD_SUMO_rev_2	691	700	PF00179	0.574
TRG_DiLeu_BaEn_1	209	214	PF01217	0.260
TRG_DiLeu_BaEn_2	134	140	PF01217	0.284
TRG_DiLeu_BaEn_2	426	432	PF01217	0.350
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.377
TRG_ENDOCYTIC_2	515	518	PF00928	0.303
TRG_ENDOCYTIC_2	626	629	PF00928	0.291
TRG_ENDOCYTIC_2	65	68	PF00928	0.391
TRG_ENDOCYTIC_2	79	82	PF00928	0.536
TRG_ER_diArg_1	271	273	PF00400	0.276
TRG_ER_diArg_1	377	380	PF00400	0.443
TRG_NES_CRM1_1	228	240	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K6	Leptomonas seymouri	60%	96%
A0A0N1IK76	Leptomonas seymouri	31%	93%
A0A0S4JDJ1	Bodo saltans	33%	74%
A0A1X0P6Q5	Trypanosomatidae	34%	94%
A0A1X0P7K4	Trypanosomatidae	38%	100%
A0A3R7M693	Trypanosoma rangeli	38%	100%
A0A3S7WUR9	Leishmania donovani	32%	94%
A0A422NWG4	Trypanosoma rangeli	32%	96%
A4H9B8	Leishmania braziliensis	76%	100%
A4H9B9	Leishmania braziliensis	31%	100%
A4HXN9	Leishmania infantum	99%	100%
A4HXP0	Leishmania infantum	32%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	95%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q32NY4	Mus musculus	25%	99%
Q3TWN3	Mus musculus	26%	80%
Q4QE28	Leishmania major	32%	100%
Q4QE29	Leishmania major	91%	98%
Q5U2P1	Rattus norvegicus	26%	80%
Q8NE01	Homo sapiens	24%	99%
Q9GYL2	Caenorhabditis elegans	23%	92%
Q9H8M5	Homo sapiens	26%	80%
V5B9W6	Trypanosoma cruzi	31%	96%
V5BEH2	Trypanosoma cruzi	37%	100%