CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUR9_LEIDO

TriTrypDb:

LdBPK_180140.1 , LdCL_180006300 , LDHU3_18.0150

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 11
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	25
GO:0005886	plasma membrane	3	8
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A0A3S7WUR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUR9

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	25
GO:0042592	homeostatic process	3	25
GO:0048878	chemical homeostasis	4	25
GO:0050801	monoatomic ion homeostasis	5	25
GO:0055065	obsolete metal ion homeostasis	7	25
GO:0055080	monoatomic cation homeostasis	6	25
GO:0065007	biological regulation	1	25
GO:0065008	regulation of biological quality	2	25
GO:0072507	obsolete divalent inorganic cation homeostasis	7	25
GO:0098771	inorganic ion homeostasis	6	25

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	717	721	PF00656	0.548
CLV_NRD_NRD_1	117	119	PF00675	0.241
CLV_NRD_NRD_1	244	246	PF00675	0.453
CLV_NRD_NRD_1	278	280	PF00675	0.531
CLV_NRD_NRD_1	54	56	PF00675	0.613
CLV_PCSK_KEX2_1	59	61	PF00082	0.592
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.612
CLV_PCSK_PC7_1	55	61	PF00082	0.523
CLV_PCSK_SKI1_1	268	272	PF00082	0.608
CLV_PCSK_SKI1_1	373	377	PF00082	0.547
CLV_PCSK_SKI1_1	528	532	PF00082	0.506
CLV_PCSK_SKI1_1	614	618	PF00082	0.517
CLV_PCSK_SKI1_1	671	675	PF00082	0.592
DEG_COP1_1	648	656	PF00400	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.628
DOC_CKS1_1	284	289	PF01111	0.326
DOC_CKS1_1	299	304	PF01111	0.223
DOC_CKS1_1	337	342	PF01111	0.308
DOC_CKS1_1	479	484	PF01111	0.354
DOC_CKS1_1	555	560	PF01111	0.533
DOC_CKS1_1	647	652	PF01111	0.292
DOC_CYCLIN_RxL_1	525	533	PF00134	0.272
DOC_CYCLIN_RxL_1	665	675	PF00134	0.386
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.294
DOC_CYCLIN_yCln2_LP_2	647	653	PF00134	0.410
DOC_MAPK_DCC_7	665	674	PF00069	0.233
DOC_MAPK_gen_1	12	20	PF00069	0.565
DOC_MAPK_gen_1	193	200	PF00069	0.424
DOC_MAPK_gen_1	241	249	PF00069	0.347
DOC_MAPK_gen_1	310	318	PF00069	0.362
DOC_MAPK_gen_1	454	463	PF00069	0.482
DOC_MAPK_gen_1	608	618	PF00069	0.359
DOC_MAPK_gen_1	685	693	PF00069	0.488
DOC_MAPK_MEF2A_6	12	20	PF00069	0.563
DOC_MAPK_MEF2A_6	264	271	PF00069	0.380
DOC_MAPK_MEF2A_6	379	386	PF00069	0.222
DOC_MAPK_MEF2A_6	611	619	PF00069	0.387
DOC_MAPK_MEF2A_6	665	674	PF00069	0.372
DOC_MAPK_NFAT4_5	264	272	PF00069	0.294
DOC_PP1_RVXF_1	482	488	PF00149	0.428
DOC_PP1_RVXF_1	669	675	PF00149	0.318
DOC_PP2B_LxvP_1	473	476	PF13499	0.425
DOC_PP4_FxxP_1	491	494	PF00568	0.487
DOC_PP4_FxxP_1	651	654	PF00568	0.388
DOC_USP7_MATH_1	10	14	PF00917	0.646
DOC_USP7_MATH_1	202	206	PF00917	0.321
DOC_USP7_MATH_1	3	7	PF00917	0.704
DOC_USP7_MATH_1	317	321	PF00917	0.401
DOC_USP7_MATH_1	364	368	PF00917	0.315
DOC_USP7_MATH_1	494	498	PF00917	0.379
DOC_USP7_UBL2_3	119	123	PF12436	0.526
DOC_USP7_UBL2_3	242	246	PF12436	0.356
DOC_USP7_UBL2_3	264	268	PF12436	0.417
DOC_WW_Pin1_4	102	107	PF00397	0.412
DOC_WW_Pin1_4	283	288	PF00397	0.347
DOC_WW_Pin1_4	298	303	PF00397	0.288
DOC_WW_Pin1_4	336	341	PF00397	0.417
DOC_WW_Pin1_4	478	483	PF00397	0.485
DOC_WW_Pin1_4	547	552	PF00397	0.519
DOC_WW_Pin1_4	554	559	PF00397	0.535
DOC_WW_Pin1_4	646	651	PF00397	0.412
DOC_WW_Pin1_4	692	697	PF00397	0.527
LIG_14-3-3_CanoR_1	193	199	PF00244	0.533
LIG_14-3-3_CanoR_1	468	474	PF00244	0.468
LIG_14-3-3_CanoR_1	60	65	PF00244	0.362
LIG_14-3-3_CanoR_1	608	618	PF00244	0.335
LIG_14-3-3_CanoR_1	685	694	PF00244	0.474
LIG_14-3-3_CanoR_1	7	14	PF00244	0.605
LIG_14-3-3_CanoR_1	703	711	PF00244	0.529
LIG_Actin_WH2_2	184	201	PF00022	0.294
LIG_AP2alpha_1	143	147	PF02296	0.340
LIG_APCC_ABBA_1	180	185	PF00400	0.302
LIG_APCC_ABBA_1	248	253	PF00400	0.260
LIG_BRCT_BRCA1_1	581	585	PF00533	0.537
LIG_BRCT_BRCA1_1	77	81	PF00533	0.277
LIG_BRCT_BRCA1_2	582	588	PF00533	0.387
LIG_FHA_1	125	131	PF00498	0.317
LIG_FHA_1	158	164	PF00498	0.304
LIG_FHA_1	175	181	PF00498	0.258
LIG_FHA_1	213	219	PF00498	0.425
LIG_FHA_1	233	239	PF00498	0.155
LIG_FHA_1	295	301	PF00498	0.342
LIG_FHA_1	470	476	PF00498	0.481
LIG_FHA_1	493	499	PF00498	0.429
LIG_FHA_1	56	62	PF00498	0.318
LIG_FHA_1	571	577	PF00498	0.560
LIG_FHA_1	83	89	PF00498	0.307
LIG_FHA_1	91	97	PF00498	0.450
LIG_FHA_2	284	290	PF00498	0.370
LIG_FHA_2	337	343	PF00498	0.445
LIG_FHA_2	400	406	PF00498	0.444
LIG_FHA_2	427	433	PF00498	0.308
LIG_FHA_2	555	561	PF00498	0.559
LIG_FHA_2	61	67	PF00498	0.341
LIG_IRF3_LxIS_1	125	131	PF10401	0.343
LIG_LIR_Apic_2	489	494	PF02991	0.452
LIG_LIR_Apic_2	521	525	PF02991	0.371
LIG_LIR_Apic_2	648	654	PF02991	0.360
LIG_LIR_Gen_1	142	150	PF02991	0.323
LIG_LIR_Gen_1	205	214	PF02991	0.428
LIG_LIR_Gen_1	301	308	PF02991	0.297
LIG_LIR_Gen_1	356	365	PF02991	0.306
LIG_LIR_Gen_1	455	464	PF02991	0.471
LIG_LIR_Gen_1	638	647	PF02991	0.319
LIG_LIR_LC3C_4	326	331	PF02991	0.393
LIG_LIR_Nem_3	142	146	PF02991	0.310
LIG_LIR_Nem_3	168	174	PF02991	0.253
LIG_LIR_Nem_3	205	210	PF02991	0.401
LIG_LIR_Nem_3	342	346	PF02991	0.426
LIG_LIR_Nem_3	356	362	PF02991	0.291
LIG_LIR_Nem_3	440	446	PF02991	0.366
LIG_LIR_Nem_3	447	452	PF02991	0.409
LIG_LIR_Nem_3	455	461	PF02991	0.401
LIG_LIR_Nem_3	638	642	PF02991	0.322
LIG_LIR_Nem_3	675	680	PF02991	0.355
LIG_LIR_Nem_3	78	84	PF02991	0.325
LIG_MLH1_MIPbox_1	582	586	PF16413	0.394
LIG_NRBOX	266	272	PF00104	0.365
LIG_Pex14_1	506	510	PF04695	0.316
LIG_Pex14_1	522	526	PF04695	0.322
LIG_Pex14_2	143	147	PF04695	0.346
LIG_Pex14_2	487	491	PF04695	0.332
LIG_REV1ctd_RIR_1	583	592	PF16727	0.353
LIG_RPA_C_Fungi	721	733	PF08784	0.529
LIG_SH2_CRK	667	671	PF00017	0.361
LIG_SH2_CRK	74	78	PF00017	0.329
LIG_SH2_GRB2like	511	514	PF00017	0.318
LIG_SH2_NCK_1	449	453	PF00017	0.622
LIG_SH2_NCK_1	458	462	PF00017	0.583
LIG_SH2_PTP2	526	529	PF00017	0.459
LIG_SH2_SRC	449	452	PF00017	0.655
LIG_SH2_STAP1	110	114	PF00017	0.356
LIG_SH2_STAP1	196	200	PF00017	0.257
LIG_SH2_STAP1	656	660	PF00017	0.375
LIG_SH2_STAT3	520	523	PF00017	0.506
LIG_SH2_STAT5	490	493	PF00017	0.366
LIG_SH2_STAT5	511	514	PF00017	0.372
LIG_SH2_STAT5	526	529	PF00017	0.351
LIG_SH2_STAT5	62	65	PF00017	0.424
LIG_SH2_STAT5	641	644	PF00017	0.484
LIG_SH3_2	479	484	PF14604	0.559
LIG_SH3_3	334	340	PF00018	0.488
LIG_SH3_3	458	464	PF00018	0.631
LIG_SH3_3	473	479	PF00018	0.505
LIG_SH3_3	693	699	PF00018	0.722
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.336
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.385
LIG_SUMO_SIM_anti_2	612	619	PF11976	0.540
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.271
LIG_SUMO_SIM_par_1	126	131	PF11976	0.301
LIG_SUMO_SIM_par_1	136	142	PF11976	0.326
LIG_SUMO_SIM_par_1	326	333	PF11976	0.344
LIG_TRAF2_2	559	564	PF00917	0.561
LIG_UBA3_1	114	119	PF00899	0.420
LIG_UBA3_1	284	290	PF00899	0.467
LIG_WRC_WIRS_1	636	641	PF05994	0.476
LIG_WW_3	481	485	PF00397	0.588
MOD_CDK_SPxK_1	478	484	PF00069	0.641
MOD_CDK_SPxxK_3	102	109	PF00069	0.235
MOD_CDK_SPxxK_3	283	290	PF00069	0.509
MOD_CK1_1	102	108	PF00069	0.255
MOD_CK1_1	194	200	PF00069	0.308
MOD_CK1_1	232	238	PF00069	0.423
MOD_CK1_1	311	317	PF00069	0.402
MOD_CK1_1	344	350	PF00069	0.538
MOD_CK1_1	367	373	PF00069	0.373
MOD_CK1_1	43	49	PF00069	0.592
MOD_CK1_1	489	495	PF00069	0.546
MOD_CK1_1	565	571	PF00069	0.682
MOD_CK1_1	599	605	PF00069	0.519
MOD_CK1_1	6	12	PF00069	0.558
MOD_CK2_1	283	289	PF00069	0.502
MOD_CK2_1	336	342	PF00069	0.519
MOD_CK2_1	474	480	PF00069	0.635
MOD_GlcNHglycan	101	104	PF01048	0.298
MOD_GlcNHglycan	167	170	PF01048	0.316
MOD_GlcNHglycan	218	221	PF01048	0.394
MOD_GlcNHglycan	310	313	PF01048	0.426
MOD_GlcNHglycan	319	322	PF01048	0.393
MOD_GlcNHglycan	410	414	PF01048	0.558
MOD_GlcNHglycan	655	659	PF01048	0.471
MOD_GlcNHglycan	704	707	PF01048	0.625
MOD_GlcNHglycan	728	731	PF01048	0.677
MOD_GlcNHglycan	77	80	PF01048	0.308
MOD_GlcNHglycan	8	11	PF01048	0.574
MOD_GSK3_1	124	131	PF00069	0.308
MOD_GSK3_1	187	194	PF00069	0.366
MOD_GSK3_1	212	219	PF00069	0.423
MOD_GSK3_1	294	301	PF00069	0.468
MOD_GSK3_1	363	370	PF00069	0.410
MOD_GSK3_1	399	406	PF00069	0.600
MOD_GSK3_1	474	481	PF00069	0.621
MOD_GSK3_1	494	501	PF00069	0.551
MOD_GSK3_1	562	569	PF00069	0.656
MOD_GSK3_1	576	583	PF00069	0.541
MOD_GSK3_1	6	13	PF00069	0.652
MOD_GSK3_1	681	688	PF00069	0.494
MOD_GSK3_1	709	716	PF00069	0.659
MOD_N-GLC_1	512	517	PF02516	0.487
MOD_N-GLC_1	547	552	PF02516	0.520
MOD_N-GLC_1	565	570	PF02516	0.519
MOD_NEK2_1	128	133	PF00069	0.319
MOD_NEK2_1	173	178	PF00069	0.289
MOD_NEK2_1	212	217	PF00069	0.458
MOD_NEK2_1	218	223	PF00069	0.456
MOD_NEK2_1	27	32	PF00069	0.594
MOD_NEK2_1	308	313	PF00069	0.429
MOD_NEK2_1	409	414	PF00069	0.554
MOD_NEK2_1	417	422	PF00069	0.665
MOD_NEK2_1	500	505	PF00069	0.453
MOD_NEK2_1	512	517	PF00069	0.417
MOD_NEK2_1	542	547	PF00069	0.611
MOD_NEK2_1	553	558	PF00069	0.711
MOD_NEK2_1	562	567	PF00069	0.654
MOD_NEK2_1	580	585	PF00069	0.557
MOD_NEK2_1	65	70	PF00069	0.382
MOD_NEK2_1	702	707	PF00069	0.641
MOD_NEK2_2	10	15	PF00069	0.400
MOD_NEK2_2	202	207	PF00069	0.375
MOD_PIKK_1	40	46	PF00454	0.482
MOD_PIKK_1	500	506	PF00454	0.456
MOD_PIKK_1	542	548	PF00454	0.709
MOD_PIKK_1	568	574	PF00454	0.797
MOD_PIKK_1	580	586	PF00454	0.635
MOD_PK_1	665	671	PF00069	0.458
MOD_PKA_1	55	61	PF00069	0.560
MOD_PKA_2	155	161	PF00069	0.423
MOD_PKA_2	294	300	PF00069	0.519
MOD_PKA_2	3	9	PF00069	0.631
MOD_PKA_2	686	692	PF00069	0.581
MOD_PKA_2	702	708	PF00069	0.685
MOD_PKA_2	718	724	PF00069	0.718
MOD_Plk_1	512	518	PF00069	0.506
MOD_Plk_1	599	605	PF00069	0.521
MOD_Plk_1	65	71	PF00069	0.312
MOD_Plk_2-3	445	451	PF00069	0.589
MOD_Plk_4	110	116	PF00069	0.375
MOD_Plk_4	124	130	PF00069	0.292
MOD_Plk_4	174	180	PF00069	0.346
MOD_Plk_4	202	208	PF00069	0.326
MOD_Plk_4	324	330	PF00069	0.491
MOD_Plk_4	34	40	PF00069	0.662
MOD_Plk_4	367	373	PF00069	0.385
MOD_Plk_4	486	492	PF00069	0.406
MOD_Plk_4	60	66	PF00069	0.467
MOD_Plk_4	697	703	PF00069	0.672
MOD_Plk_4	718	724	PF00069	0.765
MOD_ProDKin_1	102	108	PF00069	0.235
MOD_ProDKin_1	283	289	PF00069	0.433
MOD_ProDKin_1	298	304	PF00069	0.336
MOD_ProDKin_1	336	342	PF00069	0.529
MOD_ProDKin_1	478	484	PF00069	0.617
MOD_ProDKin_1	547	553	PF00069	0.668
MOD_ProDKin_1	554	560	PF00069	0.688
MOD_ProDKin_1	646	652	PF00069	0.510
MOD_ProDKin_1	692	698	PF00069	0.678
MOD_SUMO_for_1	263	266	PF00179	0.549
MOD_SUMO_rev_2	101	111	PF00179	0.260
MOD_SUMO_rev_2	234	244	PF00179	0.377
MOD_SUMO_rev_2	265	270	PF00179	0.381
MOD_SUMO_rev_2	275	281	PF00179	0.326
MOD_SUMO_rev_2	41	51	PF00179	0.468
MOD_SUMO_rev_2	532	537	PF00179	0.540
TRG_DiLeu_BaEn_1	243	248	PF01217	0.325
TRG_DiLeu_BaEn_1	266	271	PF01217	0.350
TRG_DiLeu_BaEn_1	718	723	PF01217	0.688
TRG_DiLeu_BaEn_3	387	393	PF01217	0.409
TRG_DiLeu_BaEn_4	233	239	PF01217	0.423
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.518
TRG_ENDOCYTIC_2	23	26	PF00928	0.502
TRG_ENDOCYTIC_2	449	452	PF00928	0.608
TRG_ENDOCYTIC_2	458	461	PF00928	0.534
TRG_ENDOCYTIC_2	488	491	PF00928	0.518
TRG_ENDOCYTIC_2	526	529	PF00928	0.334
TRG_ENDOCYTIC_2	62	65	PF00928	0.428
TRG_ENDOCYTIC_2	679	682	PF00928	0.373
TRG_ENDOCYTIC_2	74	77	PF00928	0.387
TRG_ER_diArg_1	153	156	PF00400	0.423
TRG_ER_diArg_1	313	316	PF00400	0.409
TRG_ER_diLys_1	742	745	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK76	Leptomonas seymouri	66%	99%
A0A0S4JDJ1	Bodo saltans	39%	79%
A0A0S4JGZ5	Bodo saltans	31%	90%
A0A1X0P6Q5	Trypanosomatidae	43%	100%
A0A1X0P7K4	Trypanosomatidae	30%	100%
A0A3Q8IL77	Leishmania donovani	30%	100%
A0A3R7M693	Trypanosoma rangeli	27%	100%
A0A3S7WUS2	Leishmania donovani	32%	100%
A0A422NWG4	Trypanosoma rangeli	40%	100%
A4H9B8	Leishmania braziliensis	32%	95%
A4H9B9	Leishmania braziliensis	79%	100%
A4HXN9	Leishmania infantum	32%	100%
A4HXP0	Leishmania infantum	100%	100%
A4IA41	Leishmania infantum	29%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2T0	Leishmania major	31%	100%
Q4QE28	Leishmania major	94%	100%
Q4QE29	Leishmania major	32%	100%
V5B9W6	Trypanosoma cruzi	41%	100%
V5BEH2	Trypanosoma cruzi	28%	100%