Rab-GTPase-TBC domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUR8_LEIDO

TriTrypDb:

LdBPK_171570.1 , LdCL_170022200 , LDHU3_17.2150

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.746
CLV_C14_Caspase3-7	122	126	PF00656	0.695
CLV_C14_Caspase3-7	252	256	PF00656	0.398
CLV_C14_Caspase3-7	418	422	PF00656	0.470
CLV_NRD_NRD_1	13	15	PF00675	0.522
CLV_NRD_NRD_1	248	250	PF00675	0.425
CLV_NRD_NRD_1	70	72	PF00675	0.519
CLV_NRD_NRD_1	78	80	PF00675	0.528
CLV_NRD_NRD_1	88	90	PF00675	0.587
CLV_PCSK_KEX2_1	13	15	PF00082	0.541
CLV_PCSK_KEX2_1	248	250	PF00082	0.425
CLV_PCSK_KEX2_1	70	72	PF00082	0.561
CLV_PCSK_KEX2_1	78	80	PF00082	0.508
CLV_PCSK_SKI1_1	14	18	PF00082	0.531
CLV_PCSK_SKI1_1	284	288	PF00082	0.366
CLV_PCSK_SKI1_1	315	319	PF00082	0.344
CLV_PCSK_SKI1_1	409	413	PF00082	0.468
CLV_PCSK_SKI1_1	477	481	PF00082	0.434
CLV_PCSK_SKI1_1	93	97	PF00082	0.681
DEG_MDM2_SWIB_1	38	46	PF02201	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.534
DEG_ODPH_VHL_1	132	144	PF01847	0.553
DEG_SPOP_SBC_1	119	123	PF00917	0.676
DOC_CYCLIN_yClb1_LxF_4	1	7	PF00134	0.517
DOC_MAPK_gen_1	474	481	PF00069	0.443
DOC_MAPK_gen_1	89	97	PF00069	0.738
DOC_PP1_RVXF_1	157	163	PF00149	0.344
DOC_PP1_RVXF_1	313	319	PF00149	0.344
DOC_PP1_RVXF_1	91	98	PF00149	0.698
DOC_PP2B_LxvP_1	108	111	PF13499	0.650
DOC_PP2B_LxvP_1	49	52	PF13499	0.546
DOC_PP4_FxxP_1	27	30	PF00568	0.588
DOC_USP7_MATH_1	135	139	PF00917	0.598
DOC_USP7_MATH_1	222	226	PF00917	0.443
DOC_USP7_MATH_1	450	454	PF00917	0.464
DOC_WW_Pin1_4	14	19	PF00397	0.452
DOC_WW_Pin1_4	402	407	PF00397	0.516
DOC_WW_Pin1_4	84	89	PF00397	0.677
LIG_14-3-3_CanoR_1	13	17	PF00244	0.583
LIG_14-3-3_CanoR_1	150	154	PF00244	0.350
LIG_14-3-3_CanoR_1	159	163	PF00244	0.324
LIG_14-3-3_CanoR_1	248	258	PF00244	0.415
LIG_14-3-3_CanoR_1	329	335	PF00244	0.491
LIG_Actin_WH2_2	458	476	PF00022	0.565
LIG_BIR_III_2	106	110	PF00653	0.693
LIG_BIR_III_2	163	167	PF00653	0.262
LIG_BIR_III_4	374	378	PF00653	0.532
LIG_BRCT_BRCA1_1	224	228	PF00533	0.449
LIG_CaM_IQ_9	276	291	PF13499	0.359
LIG_deltaCOP1_diTrp_1	67	73	PF00928	0.532
LIG_FHA_1	15	21	PF00498	0.541
LIG_FHA_1	325	331	PF00498	0.480
LIG_FHA_1	346	352	PF00498	0.405
LIG_FHA_1	386	392	PF00498	0.539
LIG_FHA_1	46	52	PF00498	0.447
LIG_FHA_2	120	126	PF00498	0.702
LIG_FHA_2	173	179	PF00498	0.430
LIG_FHA_2	453	459	PF00498	0.475
LIG_LIR_Apic_2	161	165	PF02991	0.398
LIG_LIR_Apic_2	24	30	PF02991	0.572
LIG_LIR_Apic_2	445	450	PF02991	0.332
LIG_LIR_Gen_1	230	240	PF02991	0.381
LIG_LIR_Gen_1	337	343	PF02991	0.422
LIG_LIR_Gen_1	39	50	PF02991	0.481
LIG_LIR_Nem_3	225	231	PF02991	0.383
LIG_LIR_Nem_3	233	239	PF02991	0.320
LIG_LIR_Nem_3	3	9	PF02991	0.477
LIG_LIR_Nem_3	337	342	PF02991	0.415
LIG_LIR_Nem_3	39	45	PF02991	0.365
LIG_NRBOX	293	299	PF00104	0.449
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.475
LIG_PDZ_Class_3	483	488	PF00595	0.447
LIG_Pex14_1	331	335	PF04695	0.449
LIG_Pex14_1	40	44	PF04695	0.469
LIG_Pex14_2	228	232	PF04695	0.449
LIG_Pex14_2	318	322	PF04695	0.363
LIG_Pex14_2	38	42	PF04695	0.495
LIG_PTB_Apo_2	185	192	PF02174	0.475
LIG_PTB_Phospho_1	185	191	PF10480	0.475
LIG_SH2_GRB2like	265	268	PF00017	0.359
LIG_SH2_NCK_1	183	187	PF00017	0.300
LIG_SH2_PTP2	339	342	PF00017	0.504
LIG_SH2_SRC	339	342	PF00017	0.329
LIG_SH2_STAP1	140	144	PF00017	0.458
LIG_SH2_STAP1	396	400	PF00017	0.528
LIG_SH2_STAT3	140	143	PF00017	0.526
LIG_SH2_STAT5	309	312	PF00017	0.328
LIG_SH2_STAT5	339	342	PF00017	0.478
LIG_SH2_STAT5	358	361	PF00017	0.401
LIG_SH2_STAT5	466	469	PF00017	0.440
LIG_SH3_1	420	426	PF00018	0.641
LIG_SH3_3	128	134	PF00018	0.575
LIG_SH3_3	420	426	PF00018	0.553
LIG_TRAF2_1	455	458	PF00917	0.503
LIG_TYR_ITIM	181	186	PF00017	0.300
LIG_TYR_ITIM	234	239	PF00017	0.475
MOD_CDC14_SPxK_1	87	90	PF00782	0.651
MOD_CDK_SPK_2	84	89	PF00069	0.704
MOD_CDK_SPxK_1	84	90	PF00069	0.709
MOD_CDK_SPxxK_3	402	409	PF00069	0.566
MOD_CK1_1	101	107	PF00069	0.649
MOD_CK1_1	118	124	PF00069	0.538
MOD_CK1_1	136	142	PF00069	0.578
MOD_CK1_1	158	164	PF00069	0.398
MOD_CK1_1	405	411	PF00069	0.568
MOD_CK2_1	181	187	PF00069	0.457
MOD_CK2_1	452	458	PF00069	0.495
MOD_CK2_1	80	86	PF00069	0.613
MOD_CK2_1	99	105	PF00069	0.689
MOD_Cter_Amidation	76	79	PF01082	0.566
MOD_GlcNHglycan	111	114	PF01048	0.737
MOD_GlcNHglycan	117	120	PF01048	0.685
MOD_GlcNHglycan	122	125	PF01048	0.639
MOD_GlcNHglycan	224	227	PF01048	0.473
MOD_GlcNHglycan	271	275	PF01048	0.451
MOD_GlcNHglycan	451	455	PF01048	0.546
MOD_GSK3_1	115	122	PF00069	0.493
MOD_GSK3_1	80	87	PF00069	0.638
MOD_GSK3_1	97	104	PF00069	0.685
MOD_N-GLC_1	351	356	PF02516	0.400
MOD_N-GLC_1	400	405	PF02516	0.367
MOD_NEK2_1	181	186	PF00069	0.466
MOD_NEK2_1	297	302	PF00069	0.359
MOD_NEK2_1	324	329	PF00069	0.426
MOD_NEK2_1	351	356	PF00069	0.385
MOD_NEK2_1	45	50	PF00069	0.439
MOD_NEK2_1	80	85	PF00069	0.577
MOD_NEK2_1	97	102	PF00069	0.720
MOD_NEK2_2	427	432	PF00069	0.614
MOD_PKA_2	12	18	PF00069	0.564
MOD_PKA_2	149	155	PF00069	0.364
MOD_PKA_2	158	164	PF00069	0.344
MOD_PKA_2	21	27	PF00069	0.495
MOD_PKA_2	88	94	PF00069	0.748
MOD_Plk_1	136	142	PF00069	0.559
MOD_Plk_1	155	161	PF00069	0.252
MOD_Plk_1	2	8	PF00069	0.527
MOD_Plk_1	324	330	PF00069	0.317
MOD_Plk_1	351	357	PF00069	0.360
MOD_Plk_1	427	433	PF00069	0.586
MOD_Plk_1	80	86	PF00069	0.585
MOD_Plk_2-3	369	375	PF00069	0.472
MOD_Plk_2-3	99	105	PF00069	0.722
MOD_Plk_4	181	187	PF00069	0.434
MOD_Plk_4	2	8	PF00069	0.498
MOD_Plk_4	297	303	PF00069	0.355
MOD_Plk_4	330	336	PF00069	0.432
MOD_ProDKin_1	14	20	PF00069	0.447
MOD_ProDKin_1	402	408	PF00069	0.514
MOD_ProDKin_1	84	90	PF00069	0.682
MOD_SUMO_rev_2	54	59	PF00179	0.580
TRG_AP2beta_CARGO_1	3	13	PF09066	0.507
TRG_DiLeu_BaEn_1	230	235	PF01217	0.398
TRG_DiLeu_BaEn_2	196	202	PF01217	0.344
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.328
TRG_ENDOCYTIC_2	183	186	PF00928	0.475
TRG_ENDOCYTIC_2	236	239	PF00928	0.427
TRG_ENDOCYTIC_2	244	247	PF00928	0.394
TRG_ENDOCYTIC_2	339	342	PF00928	0.504
TRG_ER_diArg_1	247	249	PF00400	0.449
TRG_ER_diArg_1	69	71	PF00400	0.545
TRG_ER_diArg_1	78	80	PF00400	0.531
TRG_NES_CRM1_1	362	374	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P848	Leptomonas seymouri	58%	100%
A0A0S4IV10	Bodo saltans	26%	84%
A0A1X0NSL3	Trypanosomatidae	32%	93%
A0A422NB36	Trypanosoma rangeli	31%	100%
A4H9A3	Leishmania braziliensis	78%	100%
A4HXM3	Leishmania infantum	99%	100%
C9ZPB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	90%
E9ARB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE44	Leishmania major	91%	100%
V5BEU9	Trypanosoma cruzi	33%	98%