Nuclear transport factor 2 (NTF2) domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUR4_LEIDO

TriTrypDb:

LdBPK_180300.1 , LdCL_180007900 , LDHU3_18.0380

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043229	intracellular organelle	3	2

Expansion

Sequence features

A0A3S7WUR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUR4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.652
CLV_NRD_NRD_1	311	313	PF00675	0.667
CLV_NRD_NRD_1	368	370	PF00675	0.772
CLV_NRD_NRD_1	377	379	PF00675	0.686
CLV_PCSK_KEX2_1	309	311	PF00082	0.651
CLV_PCSK_KEX2_1	368	370	PF00082	0.564
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.626
CLV_PCSK_SKI1_1	240	244	PF00082	0.733
CLV_PCSK_SKI1_1	380	384	PF00082	0.682
DEG_Nend_UBRbox_1	1	4	PF02207	0.503
DEG_SPOP_SBC_1	281	285	PF00917	0.360
DEG_SPOP_SBC_1	76	80	PF00917	0.408
DOC_CKS1_1	292	297	PF01111	0.521
DOC_CKS1_1	33	38	PF01111	0.388
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.575
DOC_USP7_MATH_1	157	161	PF00917	0.623
DOC_USP7_MATH_1	163	167	PF00917	0.672
DOC_USP7_MATH_1	248	252	PF00917	0.788
DOC_USP7_MATH_1	77	81	PF00917	0.448
DOC_USP7_UBL2_3	236	240	PF12436	0.719
DOC_USP7_UBL2_3	258	262	PF12436	0.792
DOC_USP7_UBL2_3	379	383	PF12436	0.760
DOC_USP7_UBL2_3	84	88	PF12436	0.485
DOC_WW_Pin1_4	132	137	PF00397	0.590
DOC_WW_Pin1_4	152	157	PF00397	0.646
DOC_WW_Pin1_4	246	251	PF00397	0.758
DOC_WW_Pin1_4	263	268	PF00397	0.496
DOC_WW_Pin1_4	291	296	PF00397	0.555
DOC_WW_Pin1_4	32	37	PF00397	0.388
LIG_14-3-3_CanoR_1	2	8	PF00244	0.496
LIG_FHA_1	111	117	PF00498	0.344
LIG_FHA_1	12	18	PF00498	0.383
LIG_FHA_1	133	139	PF00498	0.750
LIG_FHA_1	19	25	PF00498	0.358
LIG_FHA_1	225	231	PF00498	0.713
LIG_FHA_1	99	105	PF00498	0.356
LIG_FHA_2	282	288	PF00498	0.468
LIG_LIR_Gen_1	122	130	PF02991	0.621
LIG_LIR_Gen_1	320	331	PF02991	0.477
LIG_LIR_Nem_3	122	126	PF02991	0.521
LIG_LIR_Nem_3	269	275	PF02991	0.537
LIG_LIR_Nem_3	320	326	PF02991	0.470
LIG_NRBOX	52	58	PF00104	0.485
LIG_PDZ_Class_2	379	384	PF00595	0.682
LIG_SH2_CRK	123	127	PF00017	0.599
LIG_SH2_CRK	273	277	PF00017	0.434
LIG_SH2_NCK_1	123	127	PF00017	0.613
LIG_SH2_SRC	273	276	PF00017	0.466
LIG_SH2_STAP1	273	277	PF00017	0.434
LIG_SH2_STAT5	338	341	PF00017	0.492
LIG_SH2_STAT5	34	37	PF00017	0.357
LIG_SH3_3	21	27	PF00018	0.344
LIG_SH3_3	289	295	PF00018	0.518
LIG_SH3_4	258	265	PF00018	0.705
LIG_TRAF2_1	284	287	PF00917	0.511
LIG_TYR_ITIM	121	126	PF00017	0.559
LIG_TYR_ITIM	270	275	PF00017	0.501
MOD_CDK_SPxxK_3	132	139	PF00069	0.684
MOD_CK1_1	251	257	PF00069	0.728
MOD_CK1_1	55	61	PF00069	0.498
MOD_CK2_1	104	110	PF00069	0.499
MOD_CK2_1	200	206	PF00069	0.580
MOD_CK2_1	280	286	PF00069	0.497
MOD_GlcNHglycan	123	126	PF01048	0.604
MOD_GlcNHglycan	159	162	PF01048	0.667
MOD_GlcNHglycan	165	168	PF01048	0.687
MOD_GlcNHglycan	250	253	PF01048	0.704
MOD_GlcNHglycan	36	39	PF01048	0.436
MOD_GlcNHglycan	363	366	PF01048	0.702
MOD_GlcNHglycan	79	82	PF01048	0.427
MOD_GlcNHglycan	92	95	PF01048	0.444
MOD_GSK3_1	115	122	PF00069	0.368
MOD_GSK3_1	262	269	PF00069	0.756
MOD_GSK3_1	315	322	PF00069	0.612
MOD_GSK3_1	51	58	PF00069	0.434
MOD_GSK3_1	90	97	PF00069	0.449
MOD_NEK2_1	121	126	PF00069	0.559
MOD_NEK2_1	219	224	PF00069	0.768
MOD_NEK2_1	56	61	PF00069	0.439
MOD_PIKK_1	94	100	PF00454	0.403
MOD_PKA_1	310	316	PF00069	0.619
MOD_PKA_2	1	7	PF00069	0.564
MOD_PKA_2	224	230	PF00069	0.714
MOD_PKA_2	310	316	PF00069	0.665
MOD_PKA_2	367	373	PF00069	0.696
MOD_Plk_1	51	57	PF00069	0.436
MOD_Plk_4	19	25	PF00069	0.371
MOD_Plk_4	266	272	PF00069	0.666
MOD_Plk_4	334	340	PF00069	0.537
MOD_Plk_4	52	58	PF00069	0.460
MOD_ProDKin_1	132	138	PF00069	0.592
MOD_ProDKin_1	152	158	PF00069	0.647
MOD_ProDKin_1	246	252	PF00069	0.758
MOD_ProDKin_1	263	269	PF00069	0.488
MOD_ProDKin_1	291	297	PF00069	0.548
MOD_ProDKin_1	32	38	PF00069	0.388
MOD_SUMO_for_1	305	308	PF00179	0.592
MOD_SUMO_rev_2	283	289	PF00179	0.603
TRG_DiLeu_BaEn_1	52	57	PF01217	0.444
TRG_ENDOCYTIC_2	123	126	PF00928	0.585
TRG_ENDOCYTIC_2	272	275	PF00928	0.475
TRG_ER_diArg_1	310	312	PF00400	0.677
TRG_ER_diArg_1	368	371	PF00400	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH4	Leptomonas seymouri	53%	96%
A0A1X0P6X4	Trypanosomatidae	32%	76%
A0A422NWQ6	Trypanosoma rangeli	28%	82%
A4H9D4	Leishmania braziliensis	63%	94%
A4HXQ6	Leishmania infantum	98%	100%
D0A036	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
E9ARG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QE12	Leishmania major	85%	95%