RNA-binding_protein_27_putative/GeneDB:LmjF.18.00 30

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 27, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUR3_LEIDO

TriTrypDb:

LdBPK_180030.1 , LdCL_180005200 , LDHU3_18.0040

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.658
CLV_PCSK_KEX2_1	113	115	PF00082	0.631
CLV_PCSK_KEX2_1	296	298	PF00082	0.578
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.631
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.627
CLV_PCSK_SKI1_1	218	222	PF00082	0.694
CLV_PCSK_SKI1_1	271	275	PF00082	0.534
CLV_PCSK_SKI1_1	340	344	PF00082	0.559
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.628
DOC_MAPK_gen_1	113	123	PF00069	0.633
DOC_MAPK_gen_1	71	79	PF00069	0.476
DOC_PP1_RVXF_1	229	236	PF00149	0.563
DOC_PP1_RVXF_1	36	42	PF00149	0.581
DOC_PP2B_LxvP_1	126	129	PF13499	0.628
DOC_PP2B_LxvP_1	221	224	PF13499	0.432
DOC_PP2B_LxvP_1	331	334	PF13499	0.593
DOC_PP4_FxxP_1	54	57	PF00568	0.498
DOC_PP4_MxPP_1	133	136	PF00568	0.479
DOC_USP7_MATH_1	285	289	PF00917	0.581
DOC_USP7_MATH_1	316	320	PF00917	0.542
DOC_USP7_MATH_1	94	98	PF00917	0.753
DOC_WD40_RPTOR_TOS_1	327	332	PF00400	0.600
DOC_WW_Pin1_4	104	109	PF00397	0.566
DOC_WW_Pin1_4	207	212	PF00397	0.749
DOC_WW_Pin1_4	236	241	PF00397	0.563
DOC_WW_Pin1_4	53	58	PF00397	0.498
DOC_WW_Pin1_4	97	102	PF00397	0.766
LIG_14-3-3_CanoR_1	217	221	PF00244	0.650
LIG_14-3-3_CanoR_1	315	321	PF00244	0.525
LIG_APCC_ABBA_1	169	174	PF00400	0.598
LIG_APCC_ABBA_1	8	13	PF00400	0.417
LIG_Clathr_ClatBox_1	326	330	PF01394	0.683
LIG_FHA_1	105	111	PF00498	0.762
LIG_FHA_1	116	122	PF00498	0.609
LIG_FHA_1	188	194	PF00498	0.573
LIG_FHA_1	3	9	PF00498	0.565
LIG_FHA_1	315	321	PF00498	0.581
LIG_LIR_Apic_2	196	200	PF02991	0.612
LIG_LIR_Apic_2	53	57	PF02991	0.498
LIG_LIR_Gen_1	120	131	PF02991	0.539
LIG_LIR_Gen_1	170	180	PF02991	0.529
LIG_LIR_Gen_1	26	35	PF02991	0.474
LIG_LIR_Gen_1	264	275	PF02991	0.405
LIG_LIR_Nem_3	120	126	PF02991	0.531
LIG_LIR_Nem_3	170	175	PF02991	0.529
LIG_LIR_Nem_3	248	254	PF02991	0.505
LIG_LIR_Nem_3	26	30	PF02991	0.474
LIG_LIR_Nem_3	264	270	PF02991	0.299
LIG_LIR_Nem_3	304	308	PF02991	0.592
LIG_MYND_3	141	145	PF01753	0.558
LIG_NRBOX	188	194	PF00104	0.520
LIG_PDZ_Class_2	339	344	PF00595	0.629
LIG_SH2_GRB2like	66	69	PF00017	0.553
LIG_SH2_PTP2	9	12	PF00017	0.512
LIG_SH2_SRC	66	69	PF00017	0.484
LIG_SH2_STAP1	150	154	PF00017	0.435
LIG_SH2_STAT3	140	143	PF00017	0.443
LIG_SH2_STAT5	140	143	PF00017	0.579
LIG_SH2_STAT5	51	54	PF00017	0.562
LIG_SH2_STAT5	66	69	PF00017	0.418
LIG_SH2_STAT5	84	87	PF00017	0.515
LIG_SH2_STAT5	9	12	PF00017	0.480
LIG_SUMO_SIM_par_1	241	249	PF11976	0.554
LIG_SUMO_SIM_par_1	252	259	PF11976	0.385
LIG_SUMO_SIM_par_1	75	81	PF11976	0.599
LIG_TYR_ITIM	7	12	PF00017	0.507
MOD_CDK_SPxK_1	236	242	PF00069	0.589
MOD_CK1_1	210	216	PF00069	0.675
MOD_CK1_1	255	261	PF00069	0.512
MOD_CK1_1	288	294	PF00069	0.641
MOD_CK1_1	97	103	PF00069	0.743
MOD_Cter_Amidation	215	218	PF01082	0.659
MOD_GlcNHglycan	101	104	PF01048	0.739
MOD_GlcNHglycan	212	215	PF01048	0.730
MOD_GlcNHglycan	287	290	PF01048	0.581
MOD_GlcNHglycan	92	95	PF01048	0.762
MOD_GlcNHglycan	96	99	PF01048	0.769
MOD_GSK3_1	104	111	PF00069	0.671
MOD_GSK3_1	144	151	PF00069	0.657
MOD_GSK3_1	205	212	PF00069	0.618
MOD_GSK3_1	255	262	PF00069	0.470
MOD_GSK3_1	283	290	PF00069	0.591
MOD_GSK3_1	90	97	PF00069	0.711
MOD_N-GLC_1	2	7	PF02516	0.370
MOD_NEK2_1	175	180	PF00069	0.472
MOD_NEK2_1	193	198	PF00069	0.400
MOD_PIKK_1	187	193	PF00454	0.570
MOD_PIKK_1	205	211	PF00454	0.446
MOD_PIKK_1	259	265	PF00454	0.543
MOD_PIKK_1	297	303	PF00454	0.525
MOD_PIKK_1	87	93	PF00454	0.658
MOD_PKA_2	115	121	PF00069	0.621
MOD_PKA_2	216	222	PF00069	0.633
MOD_PKA_2	314	320	PF00069	0.391
MOD_PKB_1	114	122	PF00069	0.585
MOD_Plk_1	2	8	PF00069	0.441
MOD_Plk_4	193	199	PF00069	0.624
MOD_Plk_4	216	222	PF00069	0.641
MOD_ProDKin_1	104	110	PF00069	0.563
MOD_ProDKin_1	207	213	PF00069	0.749
MOD_ProDKin_1	236	242	PF00069	0.562
MOD_ProDKin_1	53	59	PF00069	0.498
MOD_ProDKin_1	97	103	PF00069	0.766
MOD_SUMO_rev_2	33	39	PF00179	0.477
TRG_ENDOCYTIC_2	172	175	PF00928	0.511
TRG_ENDOCYTIC_2	51	54	PF00928	0.593
TRG_ENDOCYTIC_2	9	12	PF00928	0.512
TRG_NES_CRM1_1	167	181	PF08389	0.593
TRG_NES_CRM1_1	26	40	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR6	Leptomonas seymouri	42%	99%
A0A1X0P7J4	Trypanosomatidae	29%	96%
A0A422NWM0	Trypanosoma rangeli	29%	96%
A4H9A9	Leishmania braziliensis	66%	100%
A4HXM9	Leishmania infantum	99%	100%
C9ZZY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A069	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ARE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QE39	Leishmania major	88%	100%
V5B9X5	Trypanosoma cruzi	30%	99%