Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUQ8_LEIDO

TriTrypDb:

LdBPK_171490.1 , LdCL_170021200 , LDHU3_17.2030

Length:

129

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.598
CLV_PCSK_FUR_1	94	98	PF00082	0.620
CLV_PCSK_KEX2_1	51	53	PF00082	0.555
CLV_PCSK_KEX2_1	96	98	PF00082	0.585
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.555
CLV_PCSK_SKI1_1	51	55	PF00082	0.634
CLV_PCSK_SKI1_1	75	79	PF00082	0.644
CLV_PCSK_SKI1_1	86	90	PF00082	0.644
DOC_PP1_RVXF_1	55	62	PF00149	0.600
DOC_PP4_FxxP_1	24	27	PF00568	0.642
DOC_PP4_FxxP_1	61	64	PF00568	0.553
DOC_USP7_MATH_1	27	31	PF00917	0.695
DOC_WW_Pin1_4	105	110	PF00397	0.686
DOC_WW_Pin1_4	12	17	PF00397	0.575
DOC_WW_Pin1_4	19	24	PF00397	0.558
DOC_WW_Pin1_4	32	37	PF00397	0.559
LIG_Actin_WH2_2	63	80	PF00022	0.595
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_CSL_BTD_1	106	109	PF09270	0.694
LIG_FHA_1	54	60	PF00498	0.561
LIG_FHA_1	78	84	PF00498	0.604
LIG_FHA_1	87	93	PF00498	0.533
LIG_LIR_Apic_2	22	27	PF02991	0.654
LIG_LIR_Nem_3	15	21	PF02991	0.625
LIG_SH2_PTP2	18	21	PF00017	0.703
LIG_SH2_STAT5	113	116	PF00017	0.553
LIG_SH2_STAT5	18	21	PF00017	0.670
LIG_SH2_STAT5	46	49	PF00017	0.609
LIG_SH3_3	103	109	PF00018	0.645
MOD_CDK_SPK_2	105	110	PF00069	0.686
MOD_CDK_SPK_2	12	17	PF00069	0.616
MOD_CK1_1	12	18	PF00069	0.576
MOD_CK2_1	39	45	PF00069	0.651
MOD_GlcNHglycan	89	92	PF01048	0.623
MOD_GSK3_1	27	34	PF00069	0.650
MOD_GSK3_1	8	15	PF00069	0.623
MOD_GSK3_1	96	103	PF00069	0.712
MOD_NEK2_1	123	128	PF00069	0.592
MOD_NEK2_1	7	12	PF00069	0.552
MOD_NEK2_1	77	82	PF00069	0.590
MOD_PIKK_1	100	106	PF00454	0.700
MOD_PKA_1	96	102	PF00069	0.638
MOD_PKA_2	96	102	PF00069	0.723
MOD_PKB_1	94	102	PF00069	0.638
MOD_Plk_1	123	129	PF00069	0.565
MOD_Plk_1	44	50	PF00069	0.633
MOD_Plk_4	123	129	PF00069	0.655
MOD_Plk_4	9	15	PF00069	0.550
MOD_ProDKin_1	105	111	PF00069	0.681
MOD_ProDKin_1	12	18	PF00069	0.577
MOD_ProDKin_1	19	25	PF00069	0.560
MOD_ProDKin_1	32	38	PF00069	0.554
TRG_ENDOCYTIC_2	18	21	PF00928	0.686
TRG_ER_diArg_1	93	96	PF00400	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P845	Leptomonas seymouri	67%	96%
A0A0S4J864	Bodo saltans	36%	100%
A0A1X0NSP0	Trypanosomatidae	55%	100%
A0A3R7MB48	Trypanosoma rangeli	52%	100%
A4H994	Leishmania braziliensis	85%	100%
A4HXL5	Leishmania infantum	100%	100%
C9ZPA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ARB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE52	Leishmania major	91%	99%