Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUQ4_LEIDO

TriTrypDb:

LdBPK_171000.1 , LdCL_170016000 , LDHU3_17.1430

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S7WUQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.454
CLV_C14_Caspase3-7	502	506	PF00656	0.704
CLV_C14_Caspase3-7	528	532	PF00656	0.759
CLV_NRD_NRD_1	574	576	PF00675	0.791
CLV_NRD_NRD_1	655	657	PF00675	0.674
CLV_NRD_NRD_1	660	662	PF00675	0.627
CLV_PCSK_FUR_1	7	11	PF00082	0.736
CLV_PCSK_KEX2_1	147	149	PF00082	0.485
CLV_PCSK_KEX2_1	654	656	PF00082	0.698
CLV_PCSK_KEX2_1	660	662	PF00082	0.626
CLV_PCSK_KEX2_1	9	11	PF00082	0.708
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.485
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.708
CLV_PCSK_PC7_1	650	656	PF00082	0.555
CLV_PCSK_SKI1_1	132	136	PF00082	0.597
CLV_PCSK_SKI1_1	147	151	PF00082	0.464
CLV_PCSK_SKI1_1	194	198	PF00082	0.626
CLV_PCSK_SKI1_1	655	659	PF00082	0.674
CLV_PCSK_SKI1_1	660	664	PF00082	0.624
CLV_Separin_Metazoa	629	633	PF03568	0.554
DEG_APCC_DBOX_1	123	131	PF00400	0.492
DEG_APCC_DBOX_1	147	155	PF00400	0.447
DEG_APCC_DBOX_1	309	317	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.775
DEG_SCF_FBW7_2	622	627	PF00400	0.622
DEG_SPOP_SBC_1	329	333	PF00917	0.454
DEG_SPOP_SBC_1	493	497	PF00917	0.600
DOC_CYCLIN_RxL_1	332	343	PF00134	0.438
DOC_CYCLIN_RxL_1	447	458	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.661
DOC_MAPK_gen_1	387	397	PF00069	0.366
DOC_MIT_MIM_1	614	622	PF04212	0.614
DOC_PP1_RVXF_1	266	272	PF00149	0.545
DOC_PP1_RVXF_1	333	340	PF00149	0.438
DOC_PP2B_LxvP_1	175	178	PF13499	0.661
DOC_PP2B_LxvP_1	309	312	PF13499	0.396
DOC_USP7_MATH_1	161	165	PF00917	0.618
DOC_USP7_MATH_1	20	24	PF00917	0.667
DOC_USP7_MATH_1	211	215	PF00917	0.631
DOC_USP7_MATH_1	305	309	PF00917	0.484
DOC_USP7_MATH_1	469	473	PF00917	0.779
DOC_USP7_MATH_1	483	487	PF00917	0.783
DOC_USP7_MATH_1	503	507	PF00917	0.679
DOC_USP7_MATH_1	530	534	PF00917	0.775
DOC_USP7_MATH_1	551	555	PF00917	0.776
DOC_USP7_MATH_1	571	575	PF00917	0.747
DOC_USP7_MATH_1	608	612	PF00917	0.541
DOC_WW_Pin1_4	204	209	PF00397	0.623
DOC_WW_Pin1_4	47	52	PF00397	0.608
DOC_WW_Pin1_4	620	625	PF00397	0.525
LIG_14-3-3_CanoR_1	105	109	PF00244	0.428
LIG_14-3-3_CanoR_1	268	272	PF00244	0.451
LIG_14-3-3_CanoR_1	279	288	PF00244	0.572
LIG_14-3-3_CanoR_1	387	393	PF00244	0.438
LIG_14-3-3_CanoR_1	430	439	PF00244	0.512
LIG_14-3-3_CanoR_1	546	555	PF00244	0.800
LIG_BIR_III_4	404	408	PF00653	0.438
LIG_BRCT_BRCA1_1	427	431	PF00533	0.373
LIG_BRCT_BRCA1_1	466	470	PF00533	0.753
LIG_BRCT_BRCA1_1	543	547	PF00533	0.692
LIG_Clathr_ClatBox_1	612	616	PF01394	0.549
LIG_deltaCOP1_diTrp_1	143	150	PF00928	0.509
LIG_eIF4E_1	144	150	PF01652	0.546
LIG_FHA_1	239	245	PF00498	0.462
LIG_FHA_1	268	274	PF00498	0.450
LIG_FHA_1	281	287	PF00498	0.544
LIG_FHA_1	331	337	PF00498	0.442
LIG_FHA_1	389	395	PF00498	0.391
LIG_FHA_1	485	491	PF00498	0.714
LIG_FHA_1	494	500	PF00498	0.503
LIG_FHA_1	578	584	PF00498	0.746
LIG_FHA_2	205	211	PF00498	0.667
LIG_FHA_2	418	424	PF00498	0.493
LIG_FHA_2	533	539	PF00498	0.650
LIG_FHA_2	621	627	PF00498	0.562
LIG_FHA_2	646	652	PF00498	0.469
LIG_FHA_2	94	100	PF00498	0.540
LIG_FXI_DFP_1	39	43	PF00024	0.626
LIG_LIR_Gen_1	22	30	PF02991	0.584
LIG_LIR_Gen_1	255	265	PF02991	0.553
LIG_LIR_Gen_1	85	95	PF02991	0.476
LIG_LIR_Nem_3	143	149	PF02991	0.536
LIG_LIR_Nem_3	255	261	PF02991	0.420
LIG_LIR_Nem_3	616	622	PF02991	0.529
LIG_LIR_Nem_3	85	90	PF02991	0.487
LIG_PCNA_yPIPBox_3	80	90	PF02747	0.557
LIG_Pex14_1	146	150	PF04695	0.400
LIG_Pex14_2	267	271	PF04695	0.483
LIG_SH2_CRK	87	91	PF00017	0.534
LIG_SH2_STAP1	254	258	PF00017	0.439
LIG_SH2_STAP1	494	498	PF00017	0.705
LIG_SH2_STAP1	87	91	PF00017	0.452
LIG_SH2_STAT3	639	642	PF00017	0.613
LIG_SH2_STAT5	238	241	PF00017	0.409
LIG_SH2_STAT5	368	371	PF00017	0.405
LIG_SH2_STAT5	53	56	PF00017	0.533
LIG_SH3_3	12	18	PF00018	0.676
LIG_SH3_3	239	245	PF00018	0.549
LIG_SH3_3	357	363	PF00018	0.508
LIG_SH3_3	477	483	PF00018	0.709
LIG_SH3_3	586	592	PF00018	0.689
LIG_SH3_3	92	98	PF00018	0.529
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.455
LIG_SUMO_SIM_par_1	495	502	PF11976	0.708
LIG_SUMO_SIM_par_1	611	616	PF11976	0.549
LIG_TRAF2_1	363	366	PF00917	0.409
LIG_TRAF2_1	461	464	PF00917	0.465
LIG_TRAF2_1	521	524	PF00917	0.839
LIG_TRAF2_1	57	60	PF00917	0.544
LIG_TRAF2_1	624	627	PF00917	0.577
LIG_TRAF2_1	633	636	PF00917	0.598
LIG_WRC_WIRS_1	264	269	PF05994	0.535
LIG_WRPW_2	251	254	PF00400	0.597
MOD_CDK_SPK_2	204	209	PF00069	0.623
MOD_CK1_1	198	204	PF00069	0.743
MOD_CK1_1	330	336	PF00069	0.473
MOD_CK1_1	340	346	PF00069	0.395
MOD_CK1_1	455	461	PF00069	0.534
MOD_CK1_1	486	492	PF00069	0.683
MOD_CK1_1	554	560	PF00069	0.757
MOD_CK2_1	431	437	PF00069	0.581
MOD_CK2_1	503	509	PF00069	0.755
MOD_CK2_1	532	538	PF00069	0.725
MOD_CK2_1	54	60	PF00069	0.562
MOD_CK2_1	608	614	PF00069	0.546
MOD_CK2_1	620	626	PF00069	0.473
MOD_CK2_1	645	651	PF00069	0.601
MOD_CK2_1	66	72	PF00069	0.416
MOD_GlcNHglycan	163	166	PF01048	0.614
MOD_GlcNHglycan	200	203	PF01048	0.702
MOD_GlcNHglycan	454	457	PF01048	0.575
MOD_GlcNHglycan	501	504	PF01048	0.728
MOD_GSK3_1	194	201	PF00069	0.710
MOD_GSK3_1	263	270	PF00069	0.422
MOD_GSK3_1	481	488	PF00069	0.672
MOD_GSK3_1	489	496	PF00069	0.589
MOD_GSK3_1	499	506	PF00069	0.633
MOD_GSK3_1	532	539	PF00069	0.720
MOD_GSK3_1	541	548	PF00069	0.722
MOD_GSK3_1	93	100	PF00069	0.521
MOD_N-GLC_1	171	176	PF02516	0.678
MOD_N-GLC_1	388	393	PF02516	0.391
MOD_N-GLC_1	608	613	PF02516	0.563
MOD_NEK2_1	104	109	PF00069	0.421
MOD_NEK2_1	189	194	PF00069	0.743
MOD_NEK2_1	267	272	PF00069	0.432
MOD_NEK2_1	328	333	PF00069	0.399
MOD_NEK2_1	337	342	PF00069	0.297
MOD_NEK2_1	388	393	PF00069	0.345
MOD_NEK2_1	411	416	PF00069	0.503
MOD_NEK2_1	431	436	PF00069	0.339
MOD_NEK2_1	452	457	PF00069	0.493
MOD_NEK2_1	499	504	PF00069	0.718
MOD_NEK2_1	54	59	PF00069	0.548
MOD_NEK2_1	547	552	PF00069	0.812
MOD_NEK2_1	593	598	PF00069	0.652
MOD_NEK2_1	643	648	PF00069	0.630
MOD_NEK2_1	66	71	PF00069	0.382
MOD_NEK2_2	211	216	PF00069	0.462
MOD_NEK2_2	263	268	PF00069	0.541
MOD_NEK2_2	305	310	PF00069	0.486
MOD_PIKK_1	189	195	PF00454	0.742
MOD_PIKK_1	337	343	PF00454	0.438
MOD_PIKK_1	444	450	PF00454	0.560
MOD_PIKK_1	455	461	PF00454	0.556
MOD_PIKK_1	515	521	PF00454	0.707
MOD_PIKK_1	578	584	PF00454	0.824
MOD_PIKK_1	93	99	PF00454	0.534
MOD_PKA_2	104	110	PF00069	0.482
MOD_PKA_2	267	273	PF00069	0.459
MOD_PKA_2	278	284	PF00069	0.603
MOD_PKA_2	545	551	PF00069	0.807
MOD_PKA_2	571	577	PF00069	0.749
MOD_PKA_2	667	673	PF00069	0.669
MOD_Plk_1	211	217	PF00069	0.624
MOD_Plk_1	388	394	PF00069	0.391
MOD_Plk_1	463	469	PF00069	0.651
MOD_Plk_1	530	536	PF00069	0.828
MOD_Plk_1	561	567	PF00069	0.736
MOD_Plk_1	578	584	PF00069	0.531
MOD_Plk_1	608	614	PF00069	0.567
MOD_Plk_1	643	649	PF00069	0.700
MOD_Plk_4	171	177	PF00069	0.716
MOD_Plk_4	179	185	PF00069	0.602
MOD_Plk_4	211	217	PF00069	0.464
MOD_Plk_4	351	357	PF00069	0.518
MOD_Plk_4	489	495	PF00069	0.778
MOD_Plk_4	49	55	PF00069	0.525
MOD_Plk_4	608	614	PF00069	0.567
MOD_Plk_4	97	103	PF00069	0.543
MOD_ProDKin_1	204	210	PF00069	0.619
MOD_ProDKin_1	47	53	PF00069	0.612
MOD_ProDKin_1	620	626	PF00069	0.520
TRG_DiLeu_BaEn_1	291	296	PF01217	0.508
TRG_DiLeu_BaEn_1	351	356	PF01217	0.546
TRG_DiLeu_BaEn_4	463	469	PF01217	0.651
TRG_DiLeu_BaEn_4	81	87	PF01217	0.563
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.615
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.559
TRG_ENDOCYTIC_2	254	257	PF00928	0.420
TRG_ENDOCYTIC_2	303	306	PF00928	0.425
TRG_ENDOCYTIC_2	87	90	PF00928	0.463
TRG_ER_diArg_1	654	656	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS3	Leptomonas seymouri	55%	100%
A0A3R7LWJ9	Trypanosoma rangeli	40%	100%
A4H936	Leishmania braziliensis	78%	100%
A4HXG8	Leishmania infantum	100%	100%
C9ZP54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AR63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QEA0	Leishmania major	94%	100%