Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUP8_LEIDO

TriTrypDb:

LdBPK_171540.1 , LdCL_170021800 , LDHU3_17.2110

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.479
CLV_NRD_NRD_1	176	178	PF00675	0.481
CLV_NRD_NRD_1	186	188	PF00675	0.478
CLV_NRD_NRD_1	38	40	PF00675	0.567
CLV_NRD_NRD_1	56	58	PF00675	0.303
CLV_NRD_NRD_1	73	75	PF00675	0.454
CLV_NRD_NRD_1	84	86	PF00675	0.472
CLV_PCSK_KEX2_1	107	109	PF00082	0.579
CLV_PCSK_KEX2_1	171	173	PF00082	0.507
CLV_PCSK_KEX2_1	40	42	PF00082	0.550
CLV_PCSK_KEX2_1	56	58	PF00082	0.331
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.606
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.584
CLV_PCSK_SKI1_1	173	177	PF00082	0.598
CLV_PCSK_SKI1_1	194	198	PF00082	0.588
DEG_APCC_DBOX_1	203	211	PF00400	0.524
DOC_CYCLIN_RxL_1	188	201	PF00134	0.505
DOC_USP7_MATH_1	229	233	PF00917	0.608
LIG_14-3-3_CanoR_1	171	176	PF00244	0.525
LIG_BRCT_BRCA1_1	5	9	PF00533	0.672
LIG_FHA_1	119	125	PF00498	0.483
LIG_FHA_2	179	185	PF00498	0.540
LIG_FHA_2	233	239	PF00498	0.650
LIG_LIR_Gen_1	6	17	PF02991	0.573
LIG_LIR_Nem_3	6	12	PF02991	0.564
LIG_PCNA_PIPBox_1	24	33	PF02747	0.548
LIG_PCNA_yPIPBox_3	24	33	PF02747	0.552
LIG_SH2_CRK	13	17	PF00017	0.508
LIG_SH2_STAT3	31	34	PF00017	0.541
LIG_SH2_STAT5	31	34	PF00017	0.452
LIG_SH2_STAT5	37	40	PF00017	0.430
LIG_TRAF2_1	128	131	PF00917	0.544
LIG_TRAF2_1	249	252	PF00917	0.700
LIG_TRAF2_1	99	102	PF00917	0.589
MOD_CK1_1	232	238	PF00069	0.620
MOD_CK1_1	79	85	PF00069	0.486
MOD_CK2_1	178	184	PF00069	0.547
MOD_CK2_1	245	251	PF00069	0.709
MOD_GlcNHglycan	247	250	PF01048	0.728
MOD_GlcNHglycan	70	73	PF01048	0.405
MOD_PIKK_1	229	235	PF00454	0.581
MOD_PIKK_1	85	91	PF00454	0.533
MOD_PKA_1	171	177	PF00069	0.510
MOD_PKA_1	85	91	PF00069	0.553
MOD_PKA_2	171	177	PF00069	0.560
MOD_Plk_1	118	124	PF00069	0.510
MOD_Plk_1	240	246	PF00069	0.573
MOD_Plk_4	171	177	PF00069	0.577
MOD_Plk_4	76	82	PF00069	0.602
MOD_SUMO_rev_2	184	189	PF00179	0.605
MOD_SUMO_rev_2	79	88	PF00179	0.503
TRG_DiLeu_BaEn_1	119	124	PF01217	0.577
TRG_DiLeu_BaEn_1	193	198	PF01217	0.607
TRG_DiLeu_BaEn_2	143	149	PF01217	0.604
TRG_ENDOCYTIC_2	13	16	PF00928	0.490
TRG_ER_diArg_1	145	148	PF00400	0.528
TRG_ER_diArg_1	38	41	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEK9	Leptomonas seymouri	73%	94%
A0A0S4J6Y0	Bodo saltans	32%	94%
A0A1X0NU37	Trypanosomatidae	48%	96%
A0A422NB62	Trypanosoma rangeli	46%	96%
A4H9A0	Leishmania braziliensis	90%	100%
A4HXM0	Leishmania infantum	100%	100%
C9ZPB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	75%
E9ARB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QE47	Leishmania major	98%	100%
V5BNY4	Trypanosoma cruzi	46%	96%