Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUM9_LEIDO

TriTrypDb:

LdBPK_171430.1 , LdCL_170020500 , LDHU3_17.1950

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.650
CLV_NRD_NRD_1	122	124	PF00675	0.615
CLV_NRD_NRD_1	428	430	PF00675	0.474
CLV_NRD_NRD_1	46	48	PF00675	0.599
CLV_PCSK_FUR_1	119	123	PF00082	0.616
CLV_PCSK_KEX2_1	121	123	PF00082	0.616
CLV_PCSK_KEX2_1	46	48	PF00082	0.599
CLV_PCSK_KEX2_1	522	524	PF00082	0.381
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.381
CLV_PCSK_SKI1_1	387	391	PF00082	0.602
CLV_PCSK_SKI1_1	451	455	PF00082	0.471
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DEG_SCF_FBW7_1	143	149	PF00400	0.689
DEG_SCF_TRCP1_1	135	140	PF00400	0.711
DOC_CKS1_1	143	148	PF01111	0.692
DOC_CKS1_1	91	96	PF01111	0.674
DOC_MAPK_gen_1	46	54	PF00069	0.609
DOC_MAPK_MEF2A_6	47	56	PF00069	0.565
DOC_PP4_FxxP_1	268	271	PF00568	0.595
DOC_PP4_FxxP_1	357	360	PF00568	0.606
DOC_USP7_MATH_1	259	263	PF00917	0.644
DOC_USP7_MATH_1	275	279	PF00917	0.528
DOC_USP7_MATH_1	303	307	PF00917	0.638
DOC_USP7_MATH_1	360	364	PF00917	0.639
DOC_USP7_MATH_1	479	483	PF00917	0.546
DOC_USP7_MATH_1	574	578	PF00917	0.504
DOC_USP7_MATH_1	63	67	PF00917	0.699
DOC_USP7_UBL2_3	430	434	PF12436	0.444
DOC_WW_Pin1_4	123	128	PF00397	0.617
DOC_WW_Pin1_4	142	147	PF00397	0.746
DOC_WW_Pin1_4	151	156	PF00397	0.629
DOC_WW_Pin1_4	188	193	PF00397	0.661
DOC_WW_Pin1_4	21	26	PF00397	0.590
DOC_WW_Pin1_4	212	217	PF00397	0.639
DOC_WW_Pin1_4	222	227	PF00397	0.628
DOC_WW_Pin1_4	242	247	PF00397	0.705
DOC_WW_Pin1_4	248	253	PF00397	0.673
DOC_WW_Pin1_4	294	299	PF00397	0.683
DOC_WW_Pin1_4	35	40	PF00397	0.613
DOC_WW_Pin1_4	352	357	PF00397	0.617
DOC_WW_Pin1_4	456	461	PF00397	0.548
DOC_WW_Pin1_4	486	491	PF00397	0.438
DOC_WW_Pin1_4	54	59	PF00397	0.586
DOC_WW_Pin1_4	90	95	PF00397	0.659
LIG_14-3-3_CanoR_1	304	310	PF00244	0.579
LIG_14-3-3_CanoR_1	497	507	PF00244	0.402
LIG_14-3-3_CanoR_1	579	585	PF00244	0.620
LIG_14-3-3_CanoR_1	59	67	PF00244	0.625
LIG_BRCT_BRCA1_1	305	309	PF00533	0.600
LIG_BRCT_BRCA1_1	333	337	PF00533	0.608
LIG_BRCT_BRCA1_1	353	357	PF00533	0.563
LIG_BRCT_BRCA1_1	481	485	PF00533	0.494
LIG_EVH1_2	320	324	PF00568	0.583
LIG_FHA_1	384	390	PF00498	0.569
LIG_FHA_1	436	442	PF00498	0.440
LIG_FHA_1	541	547	PF00498	0.417
LIG_FHA_2	28	34	PF00498	0.594
LIG_FHA_2	389	395	PF00498	0.641
LIG_FHA_2	77	83	PF00498	0.629
LIG_LIR_Apic_2	103	107	PF02991	0.616
LIG_LIR_Apic_2	261	266	PF02991	0.616
LIG_LIR_Apic_2	297	303	PF02991	0.634
LIG_LIR_Apic_2	340	345	PF02991	0.682
LIG_LIR_Apic_2	354	360	PF02991	0.557
LIG_LIR_Gen_1	482	493	PF02991	0.453
LIG_LIR_Gen_1	506	514	PF02991	0.390
LIG_LIR_Nem_3	34	40	PF02991	0.664
LIG_LIR_Nem_3	482	488	PF02991	0.458
LIG_LIR_Nem_3	506	510	PF02991	0.403
LIG_LIR_Nem_3	512	516	PF02991	0.387
LIG_LIR_Nem_3	520	524	PF02991	0.397
LIG_PDZ_Class_3	582	587	PF00595	0.538
LIG_PROFILIN_1	226	232	PF00235	0.628
LIG_PTB_Apo_2	214	221	PF02174	0.714
LIG_PTB_Phospho_1	214	220	PF10480	0.712
LIG_SH2_CRK	104	108	PF00017	0.599
LIG_SH2_CRK	263	267	PF00017	0.544
LIG_SH2_CRK	342	346	PF00017	0.548
LIG_SH2_NCK_1	263	267	PF00017	0.592
LIG_SH2_SRC	21	24	PF00017	0.593
LIG_SH2_SRC	263	266	PF00017	0.594
LIG_SH2_STAT3	194	197	PF00017	0.658
LIG_SH2_STAT3	524	527	PF00017	0.396
LIG_SH2_STAT5	220	223	PF00017	0.727
LIG_SH2_STAT5	351	354	PF00017	0.642
LIG_SH2_STAT5	499	502	PF00017	0.376
LIG_SH2_STAT5	524	527	PF00017	0.396
LIG_SH2_STAT5	55	58	PF00017	0.637
LIG_SH3_3	140	146	PF00018	0.630
LIG_SH3_3	149	155	PF00018	0.622
LIG_SH3_3	223	229	PF00018	0.758
LIG_SH3_3	412	418	PF00018	0.472
LIG_SH3_3	460	466	PF00018	0.593
LIG_SH3_3	487	493	PF00018	0.434
LIG_SH3_3	88	94	PF00018	0.637
LIG_WRC_WIRS_1	518	523	PF05994	0.345
LIG_WW_2	230	233	PF00397	0.655
LIG_WW_3	150	154	PF00397	0.633
MOD_CDK_SPK_2	54	59	PF00069	0.586
MOD_CDK_SPxxK_3	188	195	PF00069	0.648
MOD_CDK_SPxxK_3	90	97	PF00069	0.640
MOD_CK1_1	126	132	PF00069	0.648
MOD_CK1_1	133	139	PF00069	0.654
MOD_CK1_1	162	168	PF00069	0.652
MOD_CK1_1	199	205	PF00069	0.666
MOD_CK1_1	247	253	PF00069	0.637
MOD_CK1_1	308	314	PF00069	0.627
MOD_CK1_1	363	369	PF00069	0.817
MOD_CK1_1	38	44	PF00069	0.597
MOD_CK1_1	381	387	PF00069	0.548
MOD_CK1_1	398	404	PF00069	0.526
MOD_CK1_1	405	411	PF00069	0.553
MOD_CK1_1	486	492	PF00069	0.431
MOD_CK1_1	57	63	PF00069	0.734
MOD_CK1_1	6	12	PF00069	0.611
MOD_CK1_1	89	95	PF00069	0.678
MOD_CK1_1	96	102	PF00069	0.616
MOD_CK2_1	461	467	PF00069	0.502
MOD_CK2_1	566	572	PF00069	0.435
MOD_CK2_1	63	69	PF00069	0.650
MOD_CK2_1	76	82	PF00069	0.566
MOD_Cter_Amidation	44	47	PF01082	0.531
MOD_DYRK1A_RPxSP_1	212	216	PF00069	0.712
MOD_GlcNHglycan	111	114	PF01048	0.524
MOD_GlcNHglycan	135	138	PF01048	0.723
MOD_GlcNHglycan	139	142	PF01048	0.781
MOD_GlcNHglycan	160	164	PF01048	0.665
MOD_GlcNHglycan	170	173	PF01048	0.604
MOD_GlcNHglycan	198	201	PF01048	0.735
MOD_GlcNHglycan	281	284	PF01048	0.632
MOD_GlcNHglycan	313	316	PF01048	0.683
MOD_GlcNHglycan	362	365	PF01048	0.822
MOD_GlcNHglycan	405	408	PF01048	0.700
MOD_GlcNHglycan	469	472	PF01048	0.610
MOD_GlcNHglycan	48	51	PF01048	0.654
MOD_GlcNHglycan	533	536	PF01048	0.422
MOD_GlcNHglycan	576	579	PF01048	0.516
MOD_GlcNHglycan	61	64	PF01048	0.583
MOD_GlcNHglycan	82	86	PF01048	0.737
MOD_GlcNHglycan	98	101	PF01048	0.731
MOD_GSK3_1	126	133	PF00069	0.663
MOD_GSK3_1	142	149	PF00069	0.556
MOD_GSK3_1	208	215	PF00069	0.671
MOD_GSK3_1	218	225	PF00069	0.630
MOD_GSK3_1	244	251	PF00069	0.648
MOD_GSK3_1	255	262	PF00069	0.649
MOD_GSK3_1	275	282	PF00069	0.705
MOD_GSK3_1	292	299	PF00069	0.598
MOD_GSK3_1	305	312	PF00069	0.678
MOD_GSK3_1	333	340	PF00069	0.714
MOD_GSK3_1	360	367	PF00069	0.626
MOD_GSK3_1	381	388	PF00069	0.591
MOD_GSK3_1	393	400	PF00069	0.612
MOD_GSK3_1	401	408	PF00069	0.486
MOD_GSK3_1	479	486	PF00069	0.498
MOD_GSK3_1	536	543	PF00069	0.414
MOD_GSK3_1	57	64	PF00069	0.592
MOD_GSK3_1	86	93	PF00069	0.629
MOD_N-GLC_1	133	138	PF02516	0.608
MOD_N-GLC_1	255	260	PF02516	0.601
MOD_N-GLC_1	483	488	PF02516	0.446
MOD_N-GLC_1	503	508	PF02516	0.296
MOD_NEK2_1	196	201	PF00069	0.629
MOD_NEK2_1	337	342	PF00069	0.655
MOD_NEK2_1	397	402	PF00069	0.681
MOD_NEK2_1	435	440	PF00069	0.444
MOD_NEK2_1	473	478	PF00069	0.597
MOD_NEK2_1	61	66	PF00069	0.602
MOD_NEK2_1	76	81	PF00069	0.688
MOD_NEK2_1	95	100	PF00069	0.601
MOD_NEK2_2	63	68	PF00069	0.599
MOD_PIKK_1	102	108	PF00454	0.512
MOD_PIKK_1	210	216	PF00454	0.638
MOD_PIKK_1	244	250	PF00454	0.669
MOD_PIKK_1	292	298	PF00454	0.616
MOD_PIKK_1	76	82	PF00454	0.760
MOD_PIKK_1	86	92	PF00454	0.607
MOD_PK_1	15	21	PF00069	0.589
MOD_PK_1	273	279	PF00069	0.618
MOD_PKA_1	46	52	PF00069	0.523
MOD_PKA_2	303	309	PF00069	0.581
MOD_PKA_2	46	52	PF00069	0.771
MOD_PKA_2	96	102	PF00069	0.627
MOD_Plk_1	393	399	PF00069	0.656
MOD_Plk_1	483	489	PF00069	0.441
MOD_Plk_1	503	509	PF00069	0.285
MOD_Plk_1	560	566	PF00069	0.390
MOD_Plk_1	572	578	PF00069	0.528
MOD_Plk_4	421	427	PF00069	0.551
MOD_Plk_4	536	542	PF00069	0.389
MOD_Plk_4	560	566	PF00069	0.401
MOD_ProDKin_1	123	129	PF00069	0.617
MOD_ProDKin_1	142	148	PF00069	0.745
MOD_ProDKin_1	151	157	PF00069	0.630
MOD_ProDKin_1	188	194	PF00069	0.663
MOD_ProDKin_1	21	27	PF00069	0.588
MOD_ProDKin_1	212	218	PF00069	0.634
MOD_ProDKin_1	222	228	PF00069	0.623
MOD_ProDKin_1	242	248	PF00069	0.705
MOD_ProDKin_1	294	300	PF00069	0.685
MOD_ProDKin_1	35	41	PF00069	0.613
MOD_ProDKin_1	352	358	PF00069	0.617
MOD_ProDKin_1	456	462	PF00069	0.542
MOD_ProDKin_1	486	492	PF00069	0.431
MOD_ProDKin_1	54	60	PF00069	0.585
MOD_ProDKin_1	90	96	PF00069	0.659
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.476
TRG_ENDOCYTIC_2	507	510	PF00928	0.392
TRG_ER_diArg_1	120	123	PF00400	0.616
TRG_NES_CRM1_1	549	562	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I056	Leptomonas seymouri	51%	90%
A4H977	Leishmania braziliensis	70%	100%
E9AGQ1	Leishmania infantum	100%	100%
E9ARA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QE58	Leishmania major	94%	100%