IQ calmodulin-binding motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IQ calmodulin-binding motif containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUM7_LEIDO

TriTrypDb:

LdCL_170021300 , LDHU3_17.2040

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WUM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.466
CLV_C14_Caspase3-7	333	337	PF00656	0.489
CLV_C14_Caspase3-7	444	448	PF00656	0.581
CLV_NRD_NRD_1	182	184	PF00675	0.767
CLV_NRD_NRD_1	410	412	PF00675	0.481
CLV_NRD_NRD_1	469	471	PF00675	0.446
CLV_NRD_NRD_1	482	484	PF00675	0.440
CLV_NRD_NRD_1	513	515	PF00675	0.419
CLV_NRD_NRD_1	531	533	PF00675	0.372
CLV_NRD_NRD_1	559	561	PF00675	0.457
CLV_NRD_NRD_1	565	567	PF00675	0.432
CLV_NRD_NRD_1	642	644	PF00675	0.541
CLV_NRD_NRD_1	655	657	PF00675	0.490
CLV_NRD_NRD_1	685	687	PF00675	0.537
CLV_PCSK_KEX2_1	410	412	PF00082	0.483
CLV_PCSK_KEX2_1	482	484	PF00082	0.481
CLV_PCSK_KEX2_1	531	533	PF00082	0.488
CLV_PCSK_KEX2_1	559	561	PF00082	0.487
CLV_PCSK_KEX2_1	565	567	PF00082	0.457
CLV_PCSK_KEX2_1	627	629	PF00082	0.507
CLV_PCSK_KEX2_1	642	644	PF00082	0.543
CLV_PCSK_KEX2_1	655	657	PF00082	0.480
CLV_PCSK_KEX2_1	666	668	PF00082	0.441
CLV_PCSK_KEX2_1	684	686	PF00082	0.193
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.380
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.585
CLV_PCSK_PC7_1	681	687	PF00082	0.215
CLV_PCSK_SKI1_1	184	188	PF00082	0.676
CLV_PCSK_SKI1_1	304	308	PF00082	0.485
CLV_PCSK_SKI1_1	411	415	PF00082	0.503
CLV_PCSK_SKI1_1	559	563	PF00082	0.476
CLV_PCSK_SKI1_1	656	660	PF00082	0.486
CLV_PCSK_SKI1_1	89	93	PF00082	0.576
DEG_APCC_DBOX_1	129	137	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DEG_SPOP_SBC_1	309	313	PF00917	0.478
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.641
DOC_MAPK_gen_1	422	432	PF00069	0.565
DOC_MAPK_gen_1	494	502	PF00069	0.434
DOC_MAPK_MEF2A_6	425	434	PF00069	0.580
DOC_MAPK_RevD_3	500	515	PF00069	0.496
DOC_PP1_RVXF_1	449	456	PF00149	0.424
DOC_PP2B_LxvP_1	167	170	PF13499	0.625
DOC_PP2B_LxvP_1	353	356	PF13499	0.743
DOC_PP2B_LxvP_1	95	98	PF13499	0.633
DOC_PP4_FxxP_1	115	118	PF00568	0.585
DOC_PP4_FxxP_1	94	97	PF00568	0.585
DOC_USP7_MATH_1	126	130	PF00917	0.567
DOC_USP7_MATH_1	220	224	PF00917	0.678
DOC_USP7_MATH_1	70	74	PF00917	0.569
DOC_WW_Pin1_4	184	189	PF00397	0.709
DOC_WW_Pin1_4	2	7	PF00397	0.675
DOC_WW_Pin1_4	200	205	PF00397	0.610
DOC_WW_Pin1_4	291	296	PF00397	0.686
DOC_WW_Pin1_4	344	349	PF00397	0.505
DOC_WW_Pin1_4	93	98	PF00397	0.693
LIG_14-3-3_CanoR_1	110	116	PF00244	0.712
LIG_14-3-3_CanoR_1	122	128	PF00244	0.552
LIG_14-3-3_CanoR_1	234	238	PF00244	0.385
LIG_14-3-3_CanoR_1	24	28	PF00244	0.643
LIG_14-3-3_CanoR_1	261	270	PF00244	0.563
LIG_14-3-3_CanoR_1	499	508	PF00244	0.561
LIG_14-3-3_CanoR_1	631	639	PF00244	0.486
LIG_14-3-3_CanoR_1	667	672	PF00244	0.632
LIG_14-3-3_CanoR_1	84	89	PF00244	0.637
LIG_BRCT_BRCA1_1	264	268	PF00533	0.488
LIG_CaM_IQ_9	387	402	PF13499	0.448
LIG_CaM_IQ_9	486	501	PF13499	0.448
LIG_CaM_IQ_9	523	539	PF13499	0.376
LIG_CaM_IQ_9	546	562	PF13499	0.395
LIG_CaM_IQ_9	607	622	PF13499	0.473
LIG_deltaCOP1_diTrp_1	370	376	PF00928	0.547
LIG_FHA_1	123	129	PF00498	0.650
LIG_FHA_1	185	191	PF00498	0.679
LIG_FHA_1	242	248	PF00498	0.623
LIG_FHA_1	27	33	PF00498	0.610
LIG_FHA_2	176	182	PF00498	0.608
LIG_FHA_2	318	324	PF00498	0.497
LIG_FHA_2	331	337	PF00498	0.459
LIG_Integrin_RGD_1	298	300	PF01839	0.783
LIG_LIR_Apic_2	113	118	PF02991	0.583
LIG_LIR_Gen_1	109	118	PF02991	0.738
LIG_LIR_Gen_1	131	141	PF02991	0.536
LIG_LIR_Nem_3	109	115	PF02991	0.746
LIG_LIR_Nem_3	131	137	PF02991	0.539
LIG_LIR_Nem_3	528	533	PF02991	0.458
LIG_LIR_Nem_3	586	592	PF02991	0.577
LIG_LIR_Nem_3	87	91	PF02991	0.535
LIG_MYND_1	93	97	PF01753	0.580
LIG_PCNA_yPIPBox_3	75	89	PF02747	0.640
LIG_REV1ctd_RIR_1	453	463	PF16727	0.496
LIG_RPA_C_Fungi	478	490	PF08784	0.360
LIG_RPA_C_Fungi	638	650	PF08784	0.334
LIG_SH2_CRK	589	593	PF00017	0.290
LIG_SH2_SRC	362	365	PF00017	0.584
LIG_SH2_STAT3	533	536	PF00017	0.454
LIG_SH2_STAT5	269	272	PF00017	0.521
LIG_SH2_STAT5	305	308	PF00017	0.616
LIG_SH2_STAT5	362	365	PF00017	0.585
LIG_SH3_2	97	102	PF14604	0.583
LIG_SH3_3	205	211	PF00018	0.717
LIG_SH3_3	94	100	PF00018	0.581
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.585
LIG_SUMO_SIM_anti_2	606	611	PF11976	0.343
LIG_SUMO_SIM_par_1	305	317	PF11976	0.476
LIG_TRAF2_1	198	201	PF00917	0.623
LIG_TRAF2_1	246	249	PF00917	0.482
LIG_TRAF2_1	272	275	PF00917	0.621
LIG_TRAF2_1	322	325	PF00917	0.616
LIG_WRC_WIRS_1	112	117	PF05994	0.536
LIG_WRC_WIRS_1	222	227	PF05994	0.514
LIG_WRC_WIRS_1	27	32	PF05994	0.608
LIG_WRC_WIRS_1	88	93	PF05994	0.543
LIG_WRPW_2	91	94	PF00400	0.588
MOD_CDK_SPK_2	344	349	PF00069	0.505
MOD_CDK_SPxxK_3	291	298	PF00069	0.634
MOD_CK1_1	113	119	PF00069	0.664
MOD_CK1_1	124	130	PF00069	0.629
MOD_CK1_1	22	28	PF00069	0.582
MOD_CK1_1	241	247	PF00069	0.500
MOD_CK1_1	312	318	PF00069	0.463
MOD_CK1_1	54	60	PF00069	0.721
MOD_CK2_1	175	181	PF00069	0.661
MOD_CK2_1	310	316	PF00069	0.747
MOD_CK2_1	317	323	PF00069	0.650
MOD_CK2_1	344	350	PF00069	0.702
MOD_GlcNHglycan	115	118	PF01048	0.648
MOD_GlcNHglycan	162	165	PF01048	0.710
MOD_GlcNHglycan	175	178	PF01048	0.670
MOD_GlcNHglycan	228	231	PF01048	0.622
MOD_GlcNHglycan	240	243	PF01048	0.529
MOD_GlcNHglycan	384	387	PF01048	0.378
MOD_GlcNHglycan	418	421	PF01048	0.532
MOD_GlcNHglycan	443	446	PF01048	0.673
MOD_GlcNHglycan	572	576	PF01048	0.514
MOD_GlcNHglycan	633	636	PF01048	0.605
MOD_GSK3_1	122	129	PF00069	0.682
MOD_GSK3_1	169	176	PF00069	0.678
MOD_GSK3_1	19	26	PF00069	0.648
MOD_GSK3_1	192	199	PF00069	0.683
MOD_GSK3_1	216	223	PF00069	0.653
MOD_GSK3_1	308	315	PF00069	0.558
MOD_GSK3_1	338	345	PF00069	0.716
MOD_GSK3_1	416	423	PF00069	0.325
MOD_GSK3_1	435	442	PF00069	0.573
MOD_GSK3_1	47	54	PF00069	0.683
MOD_GSK3_1	571	578	PF00069	0.519
MOD_GSK3_1	627	634	PF00069	0.415
MOD_GSK3_1	80	87	PF00069	0.539
MOD_LATS_1	108	114	PF00433	0.532
MOD_LATS_1	120	126	PF00433	0.481
MOD_NEK2_1	141	146	PF00069	0.650
MOD_NEK2_1	157	162	PF00069	0.545
MOD_NEK2_1	19	24	PF00069	0.731
MOD_NEK2_1	216	221	PF00069	0.577
MOD_NEK2_1	330	335	PF00069	0.615
MOD_NEK2_1	372	377	PF00069	0.617
MOD_NEK2_1	414	419	PF00069	0.555
MOD_NEK2_1	525	530	PF00069	0.490
MOD_NEK2_2	60	65	PF00069	0.533
MOD_OFUCOSY	522	529	PF10250	0.435
MOD_PIKK_1	71	77	PF00454	0.580
MOD_PKA_1	627	633	PF00069	0.494
MOD_PKA_2	121	127	PF00069	0.669
MOD_PKA_2	23	29	PF00069	0.747
MOD_PKA_2	233	239	PF00069	0.387
MOD_PKA_2	262	268	PF00069	0.566
MOD_PKA_2	34	40	PF00069	0.583
MOD_PKA_2	348	354	PF00069	0.604
MOD_PKA_2	627	633	PF00069	0.563
MOD_Plk_1	141	147	PF00069	0.698
MOD_Plk_1	446	452	PF00069	0.483
MOD_Plk_2-3	196	202	PF00069	0.624
MOD_Plk_4	175	181	PF00069	0.749
MOD_Plk_4	548	554	PF00069	0.407
MOD_Plk_4	588	594	PF00069	0.495
MOD_ProDKin_1	184	190	PF00069	0.710
MOD_ProDKin_1	2	8	PF00069	0.675
MOD_ProDKin_1	200	206	PF00069	0.610
MOD_ProDKin_1	291	297	PF00069	0.690
MOD_ProDKin_1	344	350	PF00069	0.505
MOD_ProDKin_1	93	99	PF00069	0.696
TRG_ENDOCYTIC_2	589	592	PF00928	0.575
TRG_ENDOCYTIC_2	88	91	PF00928	0.531
TRG_ER_diArg_1	39	42	PF00400	0.756
TRG_ER_diArg_1	397	400	PF00400	0.304
TRG_ER_diArg_1	481	483	PF00400	0.485
TRG_ER_diArg_1	497	500	PF00400	0.187
TRG_ER_diArg_1	530	532	PF00400	0.500
TRG_ER_diArg_1	559	561	PF00400	0.386
TRG_ER_diArg_1	565	567	PF00400	0.448
TRG_ER_diArg_1	642	644	PF00400	0.559
TRG_ER_diArg_1	683	686	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D9	Leptomonas seymouri	45%	93%
A0A0S4J9A9	Bodo saltans	29%	78%
A0A1X0NSM4	Trypanosomatidae	27%	90%
A0A3R7K6T1	Trypanosoma rangeli	28%	93%
A4H995	Leishmania braziliensis	66%	100%
A4HXL6	Leishmania infantum	99%	100%
E9ARB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QE51	Leishmania major	90%	100%
V5DFR3	Trypanosoma cruzi	29%	100%