Acyl_CoA_binding_protein_putative/Pfam:PF00887

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUM4_LEIDO

TriTrypDb:

LdBPK_170700.1 , LdCL_170012700 , LDHU3_17.1030

Length:

Annotations

Annotations by Jardim et al.

Lipid Metabolism, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WUM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUM4

PDB structure(s): 5ijm_A , 7des_A , 7fc7_A , 7wfs_A , 7wfs_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	16
GO:0000166	nucleotide binding	3	16
GO:0005488	binding	1	16
GO:0008289	lipid binding	2	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0033218	amide binding	2	16
GO:0036094	small molecule binding	2	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0120227	acyl-CoA binding	3	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:1901567	fatty acid derivative binding	3	16
GO:1901681	sulfur compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	65	67	PF00675	0.251
CLV_PCSK_SKI1_1	37	41	PF00082	0.279
DOC_PP1_RVXF_1	27	33	PF00149	0.286
DOC_USP7_MATH_1	62	66	PF00917	0.412
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_FHA_2	38	44	PF00498	0.415
LIG_SH2_STAT5	12	15	PF00017	0.302
LIG_SH2_STAT5	78	81	PF00017	0.303
LIG_SH3_1	89	95	PF00018	0.497
LIG_SH3_3	89	95	PF00018	0.427
LIG_SUMO_SIM_par_1	81	87	PF11976	0.345
MOD_CMANNOS	60	63	PF00535	0.327
MOD_GlcNHglycan	1	4	PF01048	0.444
MOD_PIKK_1	84	90	PF00454	0.451
MOD_Plk_4	31	37	PF00069	0.348
MOD_SUMO_rev_2	71	77	PF00179	0.365
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F5	Leptomonas seymouri	81%	100%
A0A0N1PC41	Leptomonas seymouri	68%	93%
A0A0S4J1D0	Bodo saltans	79%	100%
A0A3Q8I9Q9	Leishmania donovani	88%	100%
A4H905	Leishmania braziliensis	75%	100%
A4H907	Leishmania braziliensis	82%	100%
A4HXD6	Leishmania infantum	88%	100%
A4HXD8	Leishmania infantum	100%	100%
C9ZU33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AR31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AR33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O01805	Caenorhabditis elegans	38%	100%
O04066	Ricinus communis	39%	100%
O09035	Mus musculus	44%	100%
O22643	Fritillaria agrestis	36%	100%
P07107	Bos taurus	40%	100%
P07108	Homo sapiens	41%	100%
P0C8L7	Hypsibius exemplaris	41%	100%
P11030	Rattus norvegicus	38%	100%
P12026	Sus scrofa	40%	100%
P31786	Mus musculus	37%	100%
P31824	Manduca sexta	37%	100%
P42281	Drosophila melanogaster	38%	100%
P45882	Anas platyrhynchos	37%	93%
P45883	Pelophylax ridibundus	41%	100%
P56702	Rattus norvegicus	46%	100%
P57752	Arabidopsis thaliana	42%	100%
P82934	Chaetophractus villosus	38%	100%
Q20507	Caenorhabditis elegans	44%	83%
Q39315	Brassica napus	37%	100%
Q3SZF0	Bos taurus	38%	100%
Q4QED0	Leishmania major	96%	100%
Q4QED2	Leishmania major	84%	100%
Q5FXM5	Dictyostelium discoideum	50%	100%
Q84SC3	Oryza sativa subsp. japonica	40%	100%
Q8N6N7	Homo sapiens	38%	100%
Q8WN94	Oryctolagus cuniculus	43%	100%
Q9D258	Mus musculus	36%	100%
Q9MZG3	Bos taurus	44%	100%
Q9PRL8	Gallus gallus	42%	100%
Q9TQX6	Canis lupus familiaris	38%	100%
Q9Y7Z3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
V5BE16	Trypanosoma cruzi	67%	99%