Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WUL8_LEIDO

TriTrypDb:

LdBPK_171270.1 , LdCL_170018900 , LDHU3_17.1780

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.745
CLV_NRD_NRD_1	143	145	PF00675	0.695
CLV_NRD_NRD_1	146	148	PF00675	0.594
CLV_NRD_NRD_1	22	24	PF00675	0.557
CLV_NRD_NRD_1	239	241	PF00675	0.782
CLV_NRD_NRD_1	540	542	PF00675	0.538
CLV_NRD_NRD_1	578	580	PF00675	0.640
CLV_PCSK_FUR_1	144	148	PF00082	0.617
CLV_PCSK_KEX2_1	142	144	PF00082	0.760
CLV_PCSK_KEX2_1	146	148	PF00082	0.608
CLV_PCSK_KEX2_1	206	208	PF00082	0.733
CLV_PCSK_KEX2_1	22	24	PF00082	0.592
CLV_PCSK_KEX2_1	540	542	PF00082	0.535
CLV_PCSK_KEX2_1	578	580	PF00082	0.640
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.745
CLV_PCSK_PC7_1	142	148	PF00082	0.689
CLV_PCSK_SKI1_1	10	14	PF00082	0.616
CLV_PCSK_SKI1_1	246	250	PF00082	0.692
CLV_PCSK_SKI1_1	485	489	PF00082	0.607
CLV_PCSK_SKI1_1	546	550	PF00082	0.435
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DEG_SPOP_SBC_1	157	161	PF00917	0.679
DEG_SPOP_SBC_1	219	223	PF00917	0.693
DEG_SPOP_SBC_1	337	341	PF00917	0.701
DEG_SPOP_SBC_1	355	359	PF00917	0.570
DEG_SPOP_SBC_1	379	383	PF00917	0.668
DOC_ANK_TNKS_1	206	213	PF00023	0.647
DOC_CKS1_1	581	586	PF01111	0.581
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.763
DOC_MAPK_DCC_7	251	260	PF00069	0.662
DOC_MAPK_gen_1	278	288	PF00069	0.766
DOC_MAPK_gen_1	464	471	PF00069	0.527
DOC_MAPK_MEF2A_6	251	260	PF00069	0.662
DOC_MAPK_MEF2A_6	479	488	PF00069	0.480
DOC_PP2B_LxvP_1	122	125	PF13499	0.591
DOC_USP7_MATH_1	157	161	PF00917	0.630
DOC_USP7_MATH_1	215	219	PF00917	0.809
DOC_USP7_MATH_1	322	326	PF00917	0.648
DOC_USP7_MATH_1	379	383	PF00917	0.713
DOC_USP7_MATH_1	387	391	PF00917	0.541
DOC_USP7_MATH_1	507	511	PF00917	0.613
DOC_USP7_MATH_1	79	83	PF00917	0.808
DOC_WW_Pin1_4	276	281	PF00397	0.831
DOC_WW_Pin1_4	348	353	PF00397	0.809
DOC_WW_Pin1_4	367	372	PF00397	0.481
DOC_WW_Pin1_4	402	407	PF00397	0.751
DOC_WW_Pin1_4	580	585	PF00397	0.574
DOC_WW_Pin1_4	81	86	PF00397	0.765
LIG_14-3-3_CanoR_1	153	162	PF00244	0.740
LIG_14-3-3_CanoR_1	23	29	PF00244	0.588
LIG_14-3-3_CanoR_1	449	456	PF00244	0.663
LIG_14-3-3_CanoR_1	52	57	PF00244	0.708
LIG_14-3-3_CanoR_1	560	564	PF00244	0.615
LIG_BRCT_BRCA1_1	590	594	PF00533	0.732
LIG_BRCT_MDC1_1	594	598	PF00533	0.490
LIG_deltaCOP1_diTrp_1	106	116	PF00928	0.691
LIG_FHA_1	132	138	PF00498	0.698
LIG_FHA_1	219	225	PF00498	0.698
LIG_FHA_1	310	316	PF00498	0.755
LIG_FHA_1	361	367	PF00498	0.721
LIG_FHA_1	368	374	PF00498	0.678
LIG_FHA_1	381	387	PF00498	0.506
LIG_FHA_1	4	10	PF00498	0.730
LIG_FHA_1	413	419	PF00498	0.677
LIG_FHA_1	466	472	PF00498	0.621
LIG_FHA_1	494	500	PF00498	0.583
LIG_FHA_1	52	58	PF00498	0.749
LIG_FHA_1	82	88	PF00498	0.787
LIG_FHA_2	31	37	PF00498	0.571
LIG_FHA_2	314	320	PF00498	0.657
LIG_FHA_2	443	449	PF00498	0.710
LIG_HP1_1	256	260	PF01393	0.731
LIG_LIR_Gen_1	113	124	PF02991	0.751
LIG_LIR_Nem_3	113	119	PF02991	0.698
LIG_LIR_Nem_3	501	505	PF02991	0.644
LIG_MYND_1	169	173	PF01753	0.572
LIG_NRBOX	533	539	PF00104	0.648
LIG_PTB_Apo_2	261	268	PF02174	0.676
LIG_PTB_Phospho_1	261	267	PF10480	0.731
LIG_SH2_CRK	267	271	PF00017	0.650
LIG_SH2_CRK	502	506	PF00017	0.560
LIG_SH2_NCK_1	267	271	PF00017	0.650
LIG_SH2_SRC	283	286	PF00017	0.734
LIG_SH2_STAP1	495	499	PF00017	0.543
LIG_SH2_STAT5	32	35	PF00017	0.783
LIG_SH2_STAT5	495	498	PF00017	0.587
LIG_SH3_1	578	584	PF00018	0.662
LIG_SH3_2	581	586	PF14604	0.684
LIG_SH3_3	250	256	PF00018	0.675
LIG_SH3_3	283	289	PF00018	0.717
LIG_SH3_3	349	355	PF00018	0.763
LIG_SH3_3	520	526	PF00018	0.759
LIG_SH3_3	578	584	PF00018	0.701
LIG_TRAF2_1	149	152	PF00917	0.687
LIG_TRAF2_1	316	319	PF00917	0.626
LIG_TRAF2_1	478	481	PF00917	0.590
LIG_TRAF2_1	90	93	PF00917	0.576
LIG_TRAF2_2	526	531	PF00917	0.478
MOD_CDK_SPK_2	276	281	PF00069	0.769
MOD_CDK_SPK_2	402	407	PF00069	0.602
MOD_CDK_SPxK_1	580	586	PF00069	0.577
MOD_CDK_SPxxK_3	402	409	PF00069	0.605
MOD_CK1_1	156	162	PF00069	0.740
MOD_CK1_1	218	224	PF00069	0.800
MOD_CK1_1	303	309	PF00069	0.791
MOD_CK1_1	317	323	PF00069	0.559
MOD_CK1_1	351	357	PF00069	0.746
MOD_CK1_1	367	373	PF00069	0.649
MOD_CK1_1	381	387	PF00069	0.627
MOD_CK1_1	405	411	PF00069	0.719
MOD_CK1_1	420	426	PF00069	0.809
MOD_CK1_1	451	457	PF00069	0.690
MOD_CK1_1	66	72	PF00069	0.693
MOD_CK2_1	142	148	PF00069	0.650
MOD_CK2_1	313	319	PF00069	0.693
MOD_CK2_1	442	448	PF00069	0.707
MOD_CK2_1	474	480	PF00069	0.494
MOD_CK2_1	514	520	PF00069	0.605
MOD_CK2_1	87	93	PF00069	0.581
MOD_Cter_Amidation	204	207	PF01082	0.654
MOD_GlcNHglycan	155	158	PF01048	0.740
MOD_GlcNHglycan	177	180	PF01048	0.667
MOD_GlcNHglycan	216	220	PF01048	0.655
MOD_GlcNHglycan	303	306	PF01048	0.748
MOD_GlcNHglycan	324	327	PF01048	0.625
MOD_GlcNHglycan	358	361	PF01048	0.781
MOD_GlcNHglycan	365	369	PF01048	0.698
MOD_GlcNHglycan	389	392	PF01048	0.696
MOD_GlcNHglycan	39	43	PF01048	0.714
MOD_GlcNHglycan	44	47	PF01048	0.740
MOD_GlcNHglycan	452	456	PF01048	0.613
MOD_GlcNHglycan	475	479	PF01048	0.541
MOD_GlcNHglycan	509	512	PF01048	0.633
MOD_GlcNHglycan	59	62	PF01048	0.754
MOD_GlcNHglycan	590	593	PF01048	0.763
MOD_GlcNHglycan	594	597	PF01048	0.703
MOD_GlcNHglycan	66	69	PF01048	0.643
MOD_GSK3_1	1	8	PF00069	0.661
MOD_GSK3_1	152	159	PF00069	0.709
MOD_GSK3_1	163	170	PF00069	0.469
MOD_GSK3_1	171	178	PF00069	0.616
MOD_GSK3_1	185	192	PF00069	0.737
MOD_GSK3_1	214	221	PF00069	0.689
MOD_GSK3_1	303	310	PF00069	0.728
MOD_GSK3_1	313	320	PF00069	0.750
MOD_GSK3_1	333	340	PF00069	0.622
MOD_GSK3_1	344	351	PF00069	0.706
MOD_GSK3_1	356	363	PF00069	0.805
MOD_GSK3_1	378	385	PF00069	0.687
MOD_GSK3_1	38	45	PF00069	0.709
MOD_GSK3_1	408	415	PF00069	0.706
MOD_GSK3_1	417	424	PF00069	0.741
MOD_GSK3_1	507	514	PF00069	0.664
MOD_GSK3_1	588	595	PF00069	0.481
MOD_GSK3_1	81	88	PF00069	0.723
MOD_N-GLC_1	183	188	PF02516	0.742
MOD_N-GLC_1	588	593	PF02516	0.662
MOD_NEK2_1	1	6	PF00069	0.753
MOD_NEK2_1	24	29	PF00069	0.585
MOD_NEK2_1	300	305	PF00069	0.794
MOD_NEK2_1	333	338	PF00069	0.667
MOD_NEK2_1	344	349	PF00069	0.693
MOD_NEK2_1	393	398	PF00069	0.742
MOD_NEK2_1	57	62	PF00069	0.781
MOD_NEK2_1	87	92	PF00069	0.581
MOD_PIKK_1	110	116	PF00454	0.661
MOD_PIKK_1	71	77	PF00454	0.626
MOD_PKA_1	142	148	PF00069	0.504
MOD_PKA_2	142	148	PF00069	0.650
MOD_PKA_2	152	158	PF00069	0.621
MOD_PKA_2	301	307	PF00069	0.742
MOD_PKA_2	333	339	PF00069	0.698
MOD_PKA_2	408	414	PF00069	0.646
MOD_PKA_2	448	454	PF00069	0.807
MOD_PKA_2	465	471	PF00069	0.705
MOD_PKA_2	51	57	PF00069	0.677
MOD_PKA_2	559	565	PF00069	0.615
MOD_Plk_1	317	323	PF00069	0.614
MOD_Plk_4	167	173	PF00069	0.697
MOD_Plk_4	344	350	PF00069	0.644
MOD_Plk_4	408	414	PF00069	0.759
MOD_Plk_4	501	507	PF00069	0.458
MOD_Plk_4	52	58	PF00069	0.683
MOD_Plk_4	533	539	PF00069	0.501
MOD_Plk_4	559	565	PF00069	0.527
MOD_Plk_4	66	72	PF00069	0.721
MOD_ProDKin_1	276	282	PF00069	0.834
MOD_ProDKin_1	348	354	PF00069	0.807
MOD_ProDKin_1	367	373	PF00069	0.484
MOD_ProDKin_1	402	408	PF00069	0.754
MOD_ProDKin_1	580	586	PF00069	0.577
MOD_ProDKin_1	81	87	PF00069	0.763
MOD_SUMO_for_1	478	481	PF00179	0.506
TRG_DiLeu_BaEn_1	533	538	PF01217	0.548
TRG_ENDOCYTIC_2	267	270	PF00928	0.768
TRG_ENDOCYTIC_2	283	286	PF00928	0.702
TRG_ENDOCYTIC_2	502	505	PF00928	0.581
TRG_ER_diArg_1	142	144	PF00400	0.714
TRG_ER_diArg_1	22	24	PF00400	0.557
TRG_ER_diArg_1	244	247	PF00400	0.587
TRG_ER_diArg_1	406	409	PF00400	0.642
TRG_ER_diArg_1	463	466	PF00400	0.713
TRG_ER_diArg_1	540	542	PF00400	0.618
TRG_ER_diArg_1	578	580	PF00400	0.716
TRG_NES_CRM1_1	533	547	PF08389	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN2	Leptomonas seymouri	30%	69%
A4H972	Leishmania braziliensis	55%	99%
A4HXJ4	Leishmania infantum	98%	100%
E9AR89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QE74	Leishmania major	82%	99%