UTP--glucose-1-phosphate uridylyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-sugar pyrophosphorylase

Species:

Leishmania donovani

UniProt:

A0A3S7WUL7_LEIDO

TriTrypDb:

LdBPK_171260.1 , LdCL_170018800 , LDHU3_17.1770

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUL7

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	1
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009225	nucleotide-sugar metabolic process	4	1
GO:0009226	nucleotide-sugar biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046349	amino sugar biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	5
GO:0070569	uridylyltransferase activity	5	11
GO:0000166	nucleotide binding	3	1
GO:0002134	UTP binding	4	1
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	1
GO:0005488	binding	1	1
GO:0017103	UTP:galactose-1-phosphate uridylyltransferase activity	7	1
GO:0019103	pyrimidine nucleotide binding	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0032553	ribonucleotide binding	3	1
GO:0032557	pyrimidine ribonucleotide binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043763	UTP:glucose-1-phosphate uridylyltransferase regulator activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	424	430	PF00089	0.425
CLV_NRD_NRD_1	218	220	PF00675	0.234
CLV_NRD_NRD_1	393	395	PF00675	0.530
CLV_NRD_NRD_1	466	468	PF00675	0.407
CLV_NRD_NRD_1	96	98	PF00675	0.455
CLV_PCSK_KEX2_1	237	239	PF00082	0.624
CLV_PCSK_KEX2_1	393	395	PF00082	0.530
CLV_PCSK_KEX2_1	465	467	PF00082	0.408
CLV_PCSK_KEX2_1	96	98	PF00082	0.455
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.624
CLV_PCSK_SKI1_1	101	105	PF00082	0.403
CLV_PCSK_SKI1_1	114	118	PF00082	0.271
CLV_PCSK_SKI1_1	394	398	PF00082	0.480
CLV_PCSK_SKI1_1	466	470	PF00082	0.415
DEG_APCC_DBOX_1	464	472	PF00400	0.364
DEG_COP1_1	375	383	PF00400	0.373
DOC_AGCK_PIF_1	425	430	PF00069	0.340
DOC_ANK_TNKS_1	466	473	PF00023	0.361
DOC_CDC14_PxL_1	88	96	PF14671	0.473
DOC_CKS1_1	16	21	PF01111	0.519
DOC_CKS1_1	517	522	PF01111	0.439
DOC_CYCLIN_RxL_1	176	187	PF00134	0.403
DOC_MAPK_gen_1	301	309	PF00069	0.296
DOC_MAPK_gen_1	465	475	PF00069	0.316
DOC_MAPK_HePTP_8	463	475	PF00069	0.358
DOC_MAPK_MEF2A_6	161	168	PF00069	0.484
DOC_MAPK_MEF2A_6	466	475	PF00069	0.331
DOC_PP2B_LxvP_1	186	189	PF13499	0.524
DOC_PP2B_LxvP_1	82	85	PF13499	0.406
DOC_PP4_FxxP_1	383	386	PF00568	0.352
DOC_PP4_FxxP_1	396	399	PF00568	0.373
DOC_PP4_FxxP_1	517	520	PF00568	0.393
DOC_PP4_FxxP_1	89	92	PF00568	0.455
DOC_USP7_MATH_1	103	107	PF00917	0.504
DOC_USP7_MATH_1	288	292	PF00917	0.390
DOC_USP7_MATH_1	332	336	PF00917	0.436
DOC_USP7_MATH_1	4	8	PF00917	0.513
DOC_USP7_MATH_1	71	75	PF00917	0.434
DOC_USP7_UBL2_3	216	220	PF12436	0.415
DOC_USP7_UBL2_3	434	438	PF12436	0.259
DOC_WW_Pin1_4	15	20	PF00397	0.356
DOC_WW_Pin1_4	350	355	PF00397	0.410
DOC_WW_Pin1_4	516	521	PF00397	0.429
LIG_14-3-3_CanoR_1	127	137	PF00244	0.486
LIG_14-3-3_CanoR_1	393	397	PF00244	0.449
LIG_14-3-3_CanoR_1	427	431	PF00244	0.338
LIG_14-3-3_CanoR_1	588	595	PF00244	0.469
LIG_14-3-3_CanoR_1	96	104	PF00244	0.434
LIG_Actin_WH2_2	181	197	PF00022	0.463
LIG_Actin_WH2_2	352	367	PF00022	0.448
LIG_Actin_WH2_2	456	471	PF00022	0.358
LIG_AP2alpha_2	319	321	PF02296	0.380
LIG_BRCT_BRCA1_1	264	268	PF00533	0.421
LIG_CtBP_PxDLS_1	281	285	PF00389	0.281
LIG_EVH1_2	85	89	PF00568	0.445
LIG_FHA_1	107	113	PF00498	0.523
LIG_FHA_1	143	149	PF00498	0.512
LIG_FHA_1	16	22	PF00498	0.344
LIG_FHA_1	175	181	PF00498	0.415
LIG_FHA_1	212	218	PF00498	0.429
LIG_FHA_1	275	281	PF00498	0.296
LIG_FHA_1	359	365	PF00498	0.254
LIG_FHA_1	487	493	PF00498	0.332
LIG_FHA_1	528	534	PF00498	0.395
LIG_FHA_1	602	608	PF00498	0.346
LIG_FHA_2	100	106	PF00498	0.389
LIG_FHA_2	167	173	PF00498	0.422
LIG_FHA_2	31	37	PF00498	0.492
LIG_FHA_2	421	427	PF00498	0.415
LIG_FHA_2	604	610	PF00498	0.414
LIG_GBD_Chelix_1	120	128	PF00786	0.209
LIG_LIR_Apic_2	382	386	PF02991	0.351
LIG_LIR_Apic_2	395	399	PF02991	0.379
LIG_LIR_Apic_2	515	520	PF02991	0.426
LIG_LIR_Gen_1	115	124	PF02991	0.424
LIG_LIR_Gen_1	162	172	PF02991	0.469
LIG_LIR_Gen_1	293	303	PF02991	0.337
LIG_LIR_Gen_1	325	334	PF02991	0.327
LIG_LIR_Gen_1	423	433	PF02991	0.331
LIG_LIR_Gen_1	76	87	PF02991	0.372
LIG_LIR_Nem_3	115	120	PF02991	0.424
LIG_LIR_Nem_3	145	150	PF02991	0.497
LIG_LIR_Nem_3	293	299	PF02991	0.327
LIG_LIR_Nem_3	325	331	PF02991	0.318
LIG_LIR_Nem_3	350	355	PF02991	0.394
LIG_LIR_Nem_3	423	428	PF02991	0.320
LIG_LIR_Nem_3	429	433	PF02991	0.285
LIG_LIR_Nem_3	457	463	PF02991	0.335
LIG_LIR_Nem_3	543	548	PF02991	0.309
LIG_LIR_Nem_3	76	82	PF02991	0.386
LIG_PTB_Apo_2	382	389	PF02174	0.344
LIG_PTB_Phospho_1	382	388	PF10480	0.384
LIG_SH2_CRK	130	134	PF00017	0.465
LIG_SH2_CRK	430	434	PF00017	0.279
LIG_SH2_CRK	545	549	PF00017	0.310
LIG_SH2_SRC	430	433	PF00017	0.293
LIG_SH2_STAP1	263	267	PF00017	0.301
LIG_SH2_STAP1	477	481	PF00017	0.307
LIG_SH2_STAT3	461	464	PF00017	0.408
LIG_SH2_STAT3	477	480	PF00017	0.459
LIG_SH2_STAT5	147	150	PF00017	0.422
LIG_SH2_STAT5	151	154	PF00017	0.422
LIG_SH2_STAT5	369	372	PF00017	0.331
LIG_SH2_STAT5	451	454	PF00017	0.303
LIG_SH2_STAT5	62	65	PF00017	0.315
LIG_SH3_3	132	138	PF00018	0.465
LIG_SH3_3	275	281	PF00018	0.269
LIG_SH3_3	297	303	PF00018	0.299
LIG_SH3_3	550	556	PF00018	0.442
LIG_SUMO_SIM_anti_2	408	417	PF11976	0.299
LIG_SUMO_SIM_par_1	495	501	PF11976	0.281
LIG_SUMO_SIM_par_1	529	534	PF11976	0.324
LIG_TYR_ITIM	128	133	PF00017	0.440
LIG_Vh1_VBS_1	166	184	PF01044	0.394
MOD_CDK_SPxK_1	516	522	PF00069	0.349
MOD_CK1_1	106	112	PF00069	0.515
MOD_CK1_1	170	176	PF00069	0.417
MOD_CK1_1	347	353	PF00069	0.437
MOD_CK1_1	358	364	PF00069	0.264
MOD_CK1_1	389	395	PF00069	0.485
MOD_CK1_1	506	512	PF00069	0.435
MOD_CK1_1	587	593	PF00069	0.493
MOD_CK2_1	30	36	PF00069	0.522
MOD_CK2_1	420	426	PF00069	0.408
MOD_CK2_1	476	482	PF00069	0.460
MOD_CK2_1	609	615	PF00069	0.521
MOD_CK2_1	99	105	PF00069	0.385
MOD_GlcNHglycan	105	108	PF01048	0.244
MOD_GlcNHglycan	204	207	PF01048	0.263
MOD_GlcNHglycan	243	246	PF01048	0.686
MOD_GlcNHglycan	286	289	PF01048	0.348
MOD_GlcNHglycan	316	319	PF01048	0.497
MOD_GlcNHglycan	506	509	PF01048	0.413
MOD_GlcNHglycan	621	624	PF01048	0.658
MOD_GSK3_1	138	145	PF00069	0.494
MOD_GSK3_1	166	173	PF00069	0.409
MOD_GSK3_1	241	248	PF00069	0.609
MOD_GSK3_1	276	283	PF00069	0.343
MOD_GSK3_1	284	291	PF00069	0.331
MOD_GSK3_1	512	519	PF00069	0.441
MOD_GSK3_1	609	616	PF00069	0.645
MOD_GSK3_1	95	102	PF00069	0.530
MOD_N-GLC_1	143	148	PF02516	0.246
MOD_N-GLC_1	232	237	PF02516	0.263
MOD_N-GLC_1	294	299	PF02516	0.302
MOD_N-GLC_1	486	491	PF02516	0.265
MOD_NEK2_1	112	117	PF00069	0.440
MOD_NEK2_1	128	133	PF00069	0.363
MOD_NEK2_1	202	207	PF00069	0.465
MOD_NEK2_1	211	216	PF00069	0.412
MOD_NEK2_1	294	299	PF00069	0.413
MOD_NEK2_1	364	369	PF00069	0.357
MOD_NEK2_1	373	378	PF00069	0.283
MOD_NEK2_1	475	480	PF00069	0.495
MOD_NEK2_1	503	508	PF00069	0.419
MOD_NEK2_1	600	605	PF00069	0.494
MOD_NEK2_2	129	134	PF00069	0.446
MOD_NEK2_2	232	237	PF00069	0.429
MOD_NEK2_2	546	551	PF00069	0.374
MOD_NEK2_2	571	576	PF00069	0.373
MOD_PIKK_1	476	482	PF00454	0.332
MOD_PKA_1	314	320	PF00069	0.383
MOD_PKA_2	373	379	PF00069	0.402
MOD_PKA_2	392	398	PF00069	0.385
MOD_PKA_2	426	432	PF00069	0.315
MOD_PKA_2	587	593	PF00069	0.500
MOD_PKA_2	71	77	PF00069	0.561
MOD_PKA_2	95	101	PF00069	0.455
MOD_Plk_1	143	149	PF00069	0.519
MOD_Plk_1	174	180	PF00069	0.463
MOD_Plk_1	232	238	PF00069	0.446
MOD_Plk_1	288	294	PF00069	0.437
MOD_Plk_1	481	487	PF00069	0.402
MOD_Plk_1	600	606	PF00069	0.349
MOD_Plk_1	99	105	PF00069	0.365
MOD_Plk_4	112	118	PF00069	0.424
MOD_Plk_4	143	149	PF00069	0.458
MOD_Plk_4	226	232	PF00069	0.449
MOD_Plk_4	262	268	PF00069	0.367
MOD_Plk_4	358	364	PF00069	0.296
MOD_Plk_4	365	371	PF00069	0.336
MOD_Plk_4	401	407	PF00069	0.280
MOD_Plk_4	420	426	PF00069	0.277
MOD_Plk_4	512	518	PF00069	0.470
MOD_Plk_4	527	533	PF00069	0.305
MOD_Plk_4	603	609	PF00069	0.399
MOD_ProDKin_1	15	21	PF00069	0.349
MOD_ProDKin_1	350	356	PF00069	0.399
MOD_ProDKin_1	516	522	PF00069	0.434
TRG_AP2beta_CARGO_1	457	467	PF09066	0.354
TRG_DiLeu_BaEn_1	305	310	PF01217	0.329
TRG_DiLeu_BaEn_2	263	269	PF01217	0.357
TRG_DiLeu_LyEn_5	83	88	PF01217	0.459
TRG_ENDOCYTIC_2	130	133	PF00928	0.469
TRG_ENDOCYTIC_2	263	266	PF00928	0.327
TRG_ENDOCYTIC_2	328	331	PF00928	0.330
TRG_ENDOCYTIC_2	430	433	PF00928	0.275
TRG_ENDOCYTIC_2	545	548	PF00928	0.311
TRG_ER_diArg_1	465	467	PF00400	0.280
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.498
TRG_PTS1	627	630	PF00515	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W2	Leptomonas seymouri	67%	98%
A0A0S4IQX2	Bodo saltans	36%	83%
A0A1X0NSQ3	Trypanosomatidae	52%	100%
A0A3R7KRK2	Trypanosoma rangeli	49%	100%
A2YGP6	Oryza sativa subsp. indica	33%	100%
A4H971	Leishmania braziliensis	83%	100%
A4HXJ3	Leishmania infantum	100%	100%
E9AR88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q09WE7	Glycine max	34%	100%
Q0GZS3	Cucumis melo	34%	100%
Q4QE75	Leishmania major	94%	100%
Q5W915	Pisum sativum	35%	100%
Q5Z8Y4	Oryza sativa subsp. japonica	33%	100%
Q9C5I1	Arabidopsis thaliana	35%	100%
V5DFP2	Trypanosoma cruzi	51%	100%