LeishMANIAdb
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Glycosyltransferase (GlcNAc), putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycosyltransferase (GlcNAc), putative
Gene product:
glycosyltransferase (GlcNAc), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WUL5_LEIDO
TriTrypDb:
LdBPK_171120.1 * , LdCL_170017200 , LDHU3_17.1560
Length:
638

Annotations

LeishMANIAdb annotations

Similar to other Golgi-localized eukaryotic glycosyltransferases. Orthologous to the slime mold hydroxyproline N-acetylglucosaminyltransferase GNT1.. The cluster merges at least 2 distinct lineages of glycosyltransferases, that might have diverged early.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3S7WUL5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUL5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016740 transferase activity 2 5
GO:0016757 glycosyltransferase activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 609 613 PF00656 0.254
CLV_NRD_NRD_1 119 121 PF00675 0.729
CLV_NRD_NRD_1 129 131 PF00675 0.756
CLV_NRD_NRD_1 20 22 PF00675 0.493
CLV_NRD_NRD_1 220 222 PF00675 0.572
CLV_NRD_NRD_1 26 28 PF00675 0.407
CLV_NRD_NRD_1 317 319 PF00675 0.559
CLV_NRD_NRD_1 524 526 PF00675 0.530
CLV_NRD_NRD_1 537 539 PF00675 0.377
CLV_NRD_NRD_1 548 550 PF00675 0.444
CLV_PCSK_FUR_1 117 121 PF00082 0.713
CLV_PCSK_KEX2_1 119 121 PF00082 0.729
CLV_PCSK_KEX2_1 12 14 PF00082 0.482
CLV_PCSK_KEX2_1 19 21 PF00082 0.446
CLV_PCSK_KEX2_1 220 222 PF00082 0.582
CLV_PCSK_KEX2_1 25 27 PF00082 0.372
CLV_PCSK_KEX2_1 317 319 PF00082 0.498
CLV_PCSK_KEX2_1 524 526 PF00082 0.521
CLV_PCSK_KEX2_1 537 539 PF00082 0.384
CLV_PCSK_KEX2_1 548 550 PF00082 0.478
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.504
CLV_PCSK_PC7_1 16 22 PF00082 0.551
CLV_PCSK_SKI1_1 153 157 PF00082 0.650
CLV_PCSK_SKI1_1 178 182 PF00082 0.550
CLV_PCSK_SKI1_1 220 224 PF00082 0.580
CLV_PCSK_SKI1_1 237 241 PF00082 0.387
CLV_PCSK_SKI1_1 248 252 PF00082 0.441
CLV_PCSK_SKI1_1 27 31 PF00082 0.278
CLV_PCSK_SKI1_1 298 302 PF00082 0.519
CLV_PCSK_SKI1_1 353 357 PF00082 0.475
CLV_PCSK_SKI1_1 382 386 PF00082 0.567
CLV_PCSK_SKI1_1 393 397 PF00082 0.350
CLV_PCSK_SKI1_1 436 440 PF00082 0.501
CLV_PCSK_SKI1_1 524 528 PF00082 0.552
CLV_Separin_Metazoa 545 549 PF03568 0.245
DEG_MDM2_SWIB_1 375 383 PF02201 0.350
DOC_CDC14_PxL_1 4 12 PF14671 0.696
DOC_CKS1_1 147 152 PF01111 0.475
DOC_CKS1_1 463 468 PF01111 0.352
DOC_CKS1_1 508 513 PF01111 0.352
DOC_CKS1_1 516 521 PF01111 0.271
DOC_CYCLIN_RxL_1 175 182 PF00134 0.352
DOC_CYCLIN_RxL_1 227 238 PF00134 0.234
DOC_CYCLIN_RxL_1 245 254 PF00134 0.288
DOC_CYCLIN_RxL_1 558 567 PF00134 0.221
DOC_CYCLIN_yCln2_LP_2 11 17 PF00134 0.753
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.352
DOC_MAPK_gen_1 25 33 PF00069 0.518
DOC_MAPK_gen_1 91 99 PF00069 0.409
DOC_PP1_RVXF_1 235 242 PF00149 0.317
DOC_PP2B_LxvP_1 15 18 PF13499 0.756
DOC_PP2B_LxvP_1 257 260 PF13499 0.304
DOC_PP4_FxxP_1 275 278 PF00568 0.367
DOC_PP4_FxxP_1 388 391 PF00568 0.352
DOC_SPAK_OSR1_1 374 378 PF12202 0.352
DOC_WW_Pin1_4 108 113 PF00397 0.459
DOC_WW_Pin1_4 122 127 PF00397 0.418
DOC_WW_Pin1_4 146 151 PF00397 0.519
DOC_WW_Pin1_4 196 201 PF00397 0.330
DOC_WW_Pin1_4 438 443 PF00397 0.354
DOC_WW_Pin1_4 462 467 PF00397 0.352
DOC_WW_Pin1_4 507 512 PF00397 0.385
DOC_WW_Pin1_4 515 520 PF00397 0.271
DOC_WW_Pin1_4 82 87 PF00397 0.465
LIG_14-3-3_CanoR_1 237 242 PF00244 0.324
LIG_14-3-3_CanoR_1 284 292 PF00244 0.280
LIG_14-3-3_CanoR_1 335 343 PF00244 0.371
LIG_14-3-3_CanoR_1 353 359 PF00244 0.236
LIG_14-3-3_CanoR_1 374 378 PF00244 0.373
LIG_14-3-3_CanoR_1 393 403 PF00244 0.276
LIG_14-3-3_CanoR_1 485 494 PF00244 0.275
LIG_14-3-3_CanoR_1 524 534 PF00244 0.382
LIG_AP2alpha_2 468 470 PF02296 0.352
LIG_BRCT_BRCA1_1 356 360 PF00533 0.356
LIG_BRCT_BRCA1_1 610 614 PF00533 0.293
LIG_BRCT_BRCA1_1 73 77 PF00533 0.360
LIG_BRCT_BRCA1_2 610 616 PF00533 0.293
LIG_Clathr_ClatBox_1 250 254 PF01394 0.352
LIG_Clathr_ClatBox_1 358 362 PF01394 0.338
LIG_deltaCOP1_diTrp_1 619 628 PF00928 0.412
LIG_FHA_1 111 117 PF00498 0.469
LIG_FHA_1 217 223 PF00498 0.372
LIG_FHA_1 229 235 PF00498 0.320
LIG_FHA_1 335 341 PF00498 0.351
LIG_FHA_1 390 396 PF00498 0.283
LIG_FHA_1 420 426 PF00498 0.334
LIG_FHA_1 569 575 PF00498 0.293
LIG_FHA_1 581 587 PF00498 0.293
LIG_FHA_2 147 153 PF00498 0.481
LIG_FHA_2 238 244 PF00498 0.377
LIG_FHA_2 292 298 PF00498 0.352
LIG_FHA_2 463 469 PF00498 0.367
LIG_FHA_2 516 522 PF00498 0.325
LIG_FHA_2 67 73 PF00498 0.467
LIG_LIR_Apic_2 139 145 PF02991 0.507
LIG_LIR_Apic_2 385 391 PF02991 0.352
LIG_LIR_Apic_2 88 93 PF02991 0.431
LIG_LIR_Gen_1 160 168 PF02991 0.261
LIG_LIR_Gen_1 204 214 PF02991 0.221
LIG_LIR_Gen_1 238 247 PF02991 0.388
LIG_LIR_Gen_1 364 370 PF02991 0.262
LIG_LIR_Gen_1 74 81 PF02991 0.453
LIG_LIR_Gen_1 92 101 PF02991 0.271
LIG_LIR_Nem_3 160 165 PF02991 0.261
LIG_LIR_Nem_3 204 209 PF02991 0.391
LIG_LIR_Nem_3 238 244 PF02991 0.325
LIG_LIR_Nem_3 3 7 PF02991 0.743
LIG_LIR_Nem_3 350 354 PF02991 0.270
LIG_LIR_Nem_3 362 368 PF02991 0.247
LIG_LIR_Nem_3 464 470 PF02991 0.275
LIG_LIR_Nem_3 488 494 PF02991 0.261
LIG_LIR_Nem_3 500 505 PF02991 0.261
LIG_LIR_Nem_3 510 516 PF02991 0.352
LIG_LIR_Nem_3 587 592 PF02991 0.346
LIG_LIR_Nem_3 74 80 PF02991 0.457
LIG_LIR_Nem_3 92 98 PF02991 0.282
LIG_MAD2 221 229 PF02301 0.352
LIG_MLH1_MIPbox_1 356 360 PF16413 0.350
LIG_PCNA_PIPBox_1 498 507 PF02747 0.352
LIG_Pex14_1 132 136 PF04695 0.512
LIG_Pex14_1 589 593 PF04695 0.352
LIG_Pex14_1 624 628 PF04695 0.289
LIG_Pex14_2 375 379 PF04695 0.275
LIG_Pex14_2 44 48 PF04695 0.405
LIG_Pex14_2 95 99 PF04695 0.310
LIG_Rb_pABgroove_1 175 183 PF01858 0.352
LIG_Rb_pABgroove_1 469 477 PF01858 0.293
LIG_SH2_CRK 142 146 PF00017 0.473
LIG_SH2_CRK 4 8 PF00017 0.744
LIG_SH2_CRK 505 509 PF00017 0.350
LIG_SH2_PTP2 191 194 PF00017 0.352
LIG_SH2_SRC 136 139 PF00017 0.486
LIG_SH2_STAP1 482 486 PF00017 0.275
LIG_SH2_STAT5 115 118 PF00017 0.523
LIG_SH2_STAT5 191 194 PF00017 0.350
LIG_SH2_STAT5 354 357 PF00017 0.261
LIG_SH2_STAT5 46 49 PF00017 0.566
LIG_SH2_STAT5 513 516 PF00017 0.391
LIG_SH2_STAT5 551 554 PF00017 0.304
LIG_SH3_1 505 511 PF00018 0.352
LIG_SH3_3 241 247 PF00018 0.352
LIG_SH3_3 337 343 PF00018 0.337
LIG_SH3_3 463 469 PF00018 0.275
LIG_SH3_3 493 499 PF00018 0.370
LIG_SH3_3 505 511 PF00018 0.330
LIG_SUMO_SIM_par_1 249 254 PF11976 0.352
LIG_TRAF2_1 564 567 PF00917 0.221
LIG_TRAF2_2 247 252 PF00917 0.280
LIG_WRC_WIRS_1 98 103 PF05994 0.500
MOD_CDK_SPK_2 507 512 PF00069 0.433
MOD_CDK_SPK_2 515 520 PF00069 0.319
MOD_CDK_SPxxK_3 146 153 PF00069 0.609
MOD_CK1_1 122 128 PF00069 0.690
MOD_CK1_1 160 166 PF00069 0.409
MOD_CK1_1 201 207 PF00069 0.441
MOD_CK1_1 216 222 PF00069 0.371
MOD_CK1_1 258 264 PF00069 0.459
MOD_CK1_1 49 55 PF00069 0.662
MOD_CK2_1 515 521 PF00069 0.396
MOD_CK2_1 66 72 PF00069 0.591
MOD_DYRK1A_RPxSP_1 507 511 PF00069 0.433
MOD_GlcNHglycan 103 106 PF01048 0.587
MOD_GlcNHglycan 215 218 PF01048 0.430
MOD_GlcNHglycan 22 25 PF01048 0.480
MOD_GlcNHglycan 482 485 PF01048 0.369
MOD_GlcNHglycan 51 54 PF01048 0.630
MOD_GlcNHglycan 552 555 PF01048 0.393
MOD_GlcNHglycan 601 604 PF01048 0.366
MOD_GSK3_1 157 164 PF00069 0.306
MOD_GSK3_1 192 199 PF00069 0.419
MOD_GSK3_1 201 208 PF00069 0.300
MOD_GSK3_1 47 54 PF00069 0.609
MOD_GSK3_1 525 532 PF00069 0.472
MOD_GSK3_1 580 587 PF00069 0.366
MOD_GSK3_1 67 74 PF00069 0.570
MOD_GSK3_1 97 104 PF00069 0.553
MOD_N-GLC_1 72 77 PF02516 0.600
MOD_NEK2_1 419 424 PF00069 0.474
MOD_NEK2_1 47 52 PF00069 0.634
MOD_NEK2_1 97 102 PF00069 0.570
MOD_NEK2_2 173 178 PF00069 0.430
MOD_NEK2_2 354 359 PF00069 0.334
MOD_NEK2_2 556 561 PF00069 0.433
MOD_PK_1 131 137 PF00069 0.651
MOD_PK_1 584 590 PF00069 0.366
MOD_PKA_1 119 125 PF00069 0.684
MOD_PKA_1 20 26 PF00069 0.650
MOD_PKA_2 119 125 PF00069 0.681
MOD_PKA_2 20 26 PF00069 0.604
MOD_PKA_2 283 289 PF00069 0.360
MOD_PKA_2 334 340 PF00069 0.433
MOD_PKA_2 373 379 PF00069 0.463
MOD_PKB_1 117 125 PF00069 0.656
MOD_Plk_1 201 207 PF00069 0.362
MOD_Plk_1 584 590 PF00069 0.420
MOD_Plk_1 597 603 PF00069 0.448
MOD_Plk_1 72 78 PF00069 0.602
MOD_Plk_4 131 137 PF00069 0.701
MOD_Plk_4 157 163 PF00069 0.306
MOD_Plk_4 311 317 PF00069 0.457
MOD_Plk_4 354 360 PF00069 0.321
MOD_ProDKin_1 108 114 PF00069 0.600
MOD_ProDKin_1 122 128 PF00069 0.523
MOD_ProDKin_1 146 152 PF00069 0.662
MOD_ProDKin_1 196 202 PF00069 0.402
MOD_ProDKin_1 438 444 PF00069 0.436
MOD_ProDKin_1 462 468 PF00069 0.433
MOD_ProDKin_1 507 513 PF00069 0.479
MOD_ProDKin_1 515 521 PF00069 0.319
MOD_ProDKin_1 82 88 PF00069 0.593
MOD_SUMO_for_1 617 620 PF00179 0.496
MOD_SUMO_rev_2 376 384 PF00179 0.335
MOD_SUMO_rev_2 408 417 PF00179 0.249
TRG_DiLeu_BaEn_4 620 626 PF01217 0.368
TRG_DiLeu_BaLyEn_6 295 300 PF01217 0.366
TRG_DiLeu_BaLyEn_6 569 574 PF01217 0.433
TRG_ENDOCYTIC_2 191 194 PF00928 0.430
TRG_ENDOCYTIC_2 365 368 PF00928 0.325
TRG_ENDOCYTIC_2 4 7 PF00928 0.703
TRG_ENDOCYTIC_2 513 516 PF00928 0.411
TRG_ENDOCYTIC_2 592 595 PF00928 0.398
TRG_ER_diArg_1 116 119 PF00400 0.666
TRG_ER_diArg_1 18 21 PF00400 0.644
TRG_ER_diArg_1 220 222 PF00400 0.472
TRG_ER_diArg_1 25 27 PF00400 0.516
TRG_ER_diArg_1 316 318 PF00400 0.360
TRG_ER_diArg_1 524 526 PF00400 0.448
TRG_ER_diArg_1 536 538 PF00400 0.217
TRG_ER_diArg_1 547 549 PF00400 0.341
TRG_NES_CRM1_1 249 262 PF08389 0.333
TRG_Pf-PMV_PEXEL_1 178 182 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 230 235 PF00026 0.343
TRG_Pf-PMV_PEXEL_1 248 252 PF00026 0.268
TRG_Pf-PMV_PEXEL_1 298 303 PF00026 0.366
TRG_Pf-PMV_PEXEL_1 525 529 PF00026 0.386

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4J993 Bodo saltans 24% 100%
A0A1X0NT28 Trypanosomatidae 40% 100%
A0A422NS11 Trypanosoma rangeli 40% 100%
A4H957 Leishmania braziliensis 78% 100%
A4HXH9 Leishmania infantum 99% 100%
C9ZP66 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AR74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QE89 Leishmania major 92% 100%
V5AZB4 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS