Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WUL3_LEIDO

TriTrypDb:

LdBPK_171290.1 , LdCL_170019100 , LDHU3_17.1800

Length:

714

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.617
CLV_NRD_NRD_1	314	316	PF00675	0.671
CLV_NRD_NRD_1	358	360	PF00675	0.664
CLV_NRD_NRD_1	466	468	PF00675	0.670
CLV_NRD_NRD_1	474	476	PF00675	0.573
CLV_NRD_NRD_1	580	582	PF00675	0.625
CLV_PCSK_KEX2_1	314	316	PF00082	0.671
CLV_PCSK_KEX2_1	358	360	PF00082	0.664
CLV_PCSK_KEX2_1	466	468	PF00082	0.655
CLV_PCSK_KEX2_1	474	476	PF00082	0.592
CLV_PCSK_KEX2_1	579	581	PF00082	0.737
CLV_PCSK_KEX2_1	585	587	PF00082	0.681
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.749
CLV_PCSK_PC7_1	576	582	PF00082	0.664
CLV_PCSK_SKI1_1	23	27	PF00082	0.680
CLV_PCSK_SKI1_1	535	539	PF00082	0.623
CLV_PCSK_SKI1_1	560	564	PF00082	0.631
CLV_PCSK_SKI1_1	580	584	PF00082	0.517
DEG_SPOP_SBC_1	297	301	PF00917	0.695
DEG_SPOP_SBC_1	508	512	PF00917	0.669
DOC_CKS1_1	318	323	PF01111	0.718
DOC_MAPK_MEF2A_6	199	208	PF00069	0.632
DOC_MAPK_MEF2A_6	552	561	PF00069	0.598
DOC_PP2B_LxvP_1	13	16	PF13499	0.610
DOC_PP4_FxxP_1	384	387	PF00568	0.613
DOC_PP4_MxPP_1	14	17	PF00568	0.558
DOC_USP7_MATH_1	298	302	PF00917	0.657
DOC_USP7_MATH_1	334	338	PF00917	0.684
DOC_USP7_MATH_1	343	347	PF00917	0.582
DOC_USP7_MATH_1	398	402	PF00917	0.707
DOC_USP7_MATH_1	421	425	PF00917	0.689
DOC_USP7_MATH_1	504	508	PF00917	0.672
DOC_USP7_MATH_1	509	513	PF00917	0.548
DOC_USP7_MATH_1	530	534	PF00917	0.624
DOC_USP7_MATH_1	649	653	PF00917	0.641
DOC_USP7_MATH_1	667	671	PF00917	0.559
DOC_USP7_MATH_1	683	687	PF00917	0.592
DOC_USP7_MATH_1	701	705	PF00917	0.531
DOC_WW_Pin1_4	16	21	PF00397	0.672
DOC_WW_Pin1_4	194	199	PF00397	0.695
DOC_WW_Pin1_4	277	282	PF00397	0.642
DOC_WW_Pin1_4	317	322	PF00397	0.715
DOC_WW_Pin1_4	341	346	PF00397	0.659
DOC_WW_Pin1_4	390	395	PF00397	0.720
DOC_WW_Pin1_4	500	505	PF00397	0.582
DOC_WW_Pin1_4	584	589	PF00397	0.606
DOC_WW_Pin1_4	597	602	PF00397	0.574
DOC_WW_Pin1_4	606	611	PF00397	0.640
DOC_WW_Pin1_4	616	621	PF00397	0.610
DOC_WW_Pin1_4	628	633	PF00397	0.617
DOC_WW_Pin1_4	65	70	PF00397	0.646
DOC_WW_Pin1_4	677	682	PF00397	0.743
LIG_14-3-3_CanoR_1	162	168	PF00244	0.621
LIG_14-3-3_CanoR_1	293	298	PF00244	0.651
LIG_14-3-3_CanoR_1	45	51	PF00244	0.601
LIG_14-3-3_CanoR_1	474	479	PF00244	0.656
LIG_14-3-3_CanoR_1	625	630	PF00244	0.691
LIG_14-3-3_CanoR_1	640	649	PF00244	0.624
LIG_Actin_WH2_2	25	41	PF00022	0.553
LIG_Actin_WH2_2	544	562	PF00022	0.596
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	510	514	PF00533	0.669
LIG_BRCT_BRCA1_1	630	634	PF00533	0.643
LIG_Clathr_ClatBox_1	52	56	PF01394	0.638
LIG_CSL_BTD_1	318	321	PF09270	0.716
LIG_deltaCOP1_diTrp_1	545	555	PF00928	0.586
LIG_eIF4E_1	556	562	PF01652	0.611
LIG_FHA_1	159	165	PF00498	0.588
LIG_FHA_1	237	243	PF00498	0.715
LIG_FHA_1	284	290	PF00498	0.709
LIG_FHA_1	297	303	PF00498	0.557
LIG_FHA_1	318	324	PF00498	0.708
LIG_FHA_1	484	490	PF00498	0.647
LIG_FHA_1	603	609	PF00498	0.651
LIG_FHA_1	660	666	PF00498	0.678
LIG_FHA_1	8	14	PF00498	0.506
LIG_FHA_2	103	109	PF00498	0.552
LIG_FHA_2	122	128	PF00498	0.664
LIG_FHA_2	195	201	PF00498	0.622
LIG_FHA_2	326	332	PF00498	0.623
LIG_FHA_2	432	438	PF00498	0.684
LIG_FHA_2	75	81	PF00498	0.615
LIG_HP1_1	110	114	PF01393	0.610
LIG_Integrin_isoDGR_2	141	143	PF01839	0.589
LIG_LIR_Apic_2	383	387	PF02991	0.609
LIG_LIR_Gen_1	48	55	PF02991	0.674
LIG_LIR_Gen_1	545	556	PF02991	0.661
LIG_LIR_Nem_3	165	171	PF02991	0.642
LIG_LIR_Nem_3	48	53	PF02991	0.675
LIG_LIR_Nem_3	545	551	PF02991	0.659
LIG_LYPXL_yS_3	556	559	PF13949	0.599
LIG_PDZ_Class_2	709	714	PF00595	0.622
LIG_PTB_Apo_2	492	499	PF02174	0.572
LIG_PTB_Apo_2	550	557	PF02174	0.583
LIG_PTB_Phospho_1	550	556	PF10480	0.580
LIG_Rb_pABgroove_1	111	119	PF01858	0.685
LIG_SH2_NCK_1	262	266	PF00017	0.690
LIG_SH2_STAT3	546	549	PF00017	0.599
LIG_SH2_STAT5	546	549	PF00017	0.599
LIG_SH3_3	14	20	PF00018	0.567
LIG_SH3_3	247	253	PF00018	0.708
LIG_SH3_3	315	321	PF00018	0.714
LIG_SH3_3	626	632	PF00018	0.621
LIG_SUMO_SIM_par_1	293	301	PF11976	0.696
LIG_SUMO_SIM_par_1	51	58	PF11976	0.640
LIG_TRAF2_1	434	437	PF00917	0.728
LIG_TRAF2_1	98	101	PF00917	0.640
LIG_UBA3_1	414	420	PF00899	0.632
MOD_CDK_SPK_2	194	199	PF00069	0.622
MOD_CDK_SPxxK_3	16	23	PF00069	0.684
MOD_CK1_1	121	127	PF00069	0.657
MOD_CK1_1	163	169	PF00069	0.618
MOD_CK1_1	172	178	PF00069	0.589
MOD_CK1_1	244	250	PF00069	0.709
MOD_CK1_1	270	276	PF00069	0.657
MOD_CK1_1	277	283	PF00069	0.575
MOD_CK1_1	296	302	PF00069	0.617
MOD_CK1_1	337	343	PF00069	0.684
MOD_CK1_1	353	359	PF00069	0.491
MOD_CK1_1	457	463	PF00069	0.700
MOD_CK1_1	477	483	PF00069	0.470
MOD_CK1_1	500	506	PF00069	0.652
MOD_CK1_1	507	513	PF00069	0.609
MOD_CK1_1	628	634	PF00069	0.688
MOD_CK1_1	65	71	PF00069	0.688
MOD_CK1_1	670	676	PF00069	0.720
MOD_CK1_1	96	102	PF00069	0.664
MOD_CK2_1	102	108	PF00069	0.549
MOD_CK2_1	125	131	PF00069	0.673
MOD_CK2_1	16	22	PF00069	0.588
MOD_CK2_1	301	307	PF00069	0.713
MOD_CK2_1	362	368	PF00069	0.520
MOD_CK2_1	431	437	PF00069	0.724
MOD_CK2_1	45	51	PF00069	0.671
MOD_CK2_1	683	689	PF00069	0.585
MOD_CK2_1	74	80	PF00069	0.665
MOD_GlcNHglycan	1	4	PF01048	0.645
MOD_GlcNHglycan	134	137	PF01048	0.675
MOD_GlcNHglycan	147	150	PF01048	0.562
MOD_GlcNHglycan	233	236	PF01048	0.676
MOD_GlcNHglycan	277	280	PF01048	0.720
MOD_GlcNHglycan	31	35	PF01048	0.622
MOD_GlcNHglycan	362	367	PF01048	0.510
MOD_GlcNHglycan	400	403	PF01048	0.708
MOD_GlcNHglycan	440	444	PF01048	0.642
MOD_GlcNHglycan	454	457	PF01048	0.608
MOD_GlcNHglycan	490	493	PF01048	0.665
MOD_GlcNHglycan	499	502	PF01048	0.611
MOD_GlcNHglycan	506	509	PF01048	0.546
MOD_GlcNHglycan	567	570	PF01048	0.657
MOD_GlcNHglycan	592	595	PF01048	0.814
MOD_GlcNHglycan	63	67	PF01048	0.694
MOD_GlcNHglycan	644	647	PF01048	0.619
MOD_GlcNHglycan	675	678	PF01048	0.699
MOD_GlcNHglycan	703	706	PF01048	0.620
MOD_GlcNHglycan	95	98	PF01048	0.690
MOD_GSK3_1	121	128	PF00069	0.691
MOD_GSK3_1	156	163	PF00069	0.629
MOD_GSK3_1	166	173	PF00069	0.568
MOD_GSK3_1	190	197	PF00069	0.628
MOD_GSK3_1	206	213	PF00069	0.602
MOD_GSK3_1	226	233	PF00069	0.699
MOD_GSK3_1	241	248	PF00069	0.591
MOD_GSK3_1	252	259	PF00069	0.603
MOD_GSK3_1	263	270	PF00069	0.625
MOD_GSK3_1	293	300	PF00069	0.661
MOD_GSK3_1	323	330	PF00069	0.699
MOD_GSK3_1	333	340	PF00069	0.595
MOD_GSK3_1	386	393	PF00069	0.715
MOD_GSK3_1	470	477	PF00069	0.660
MOD_GSK3_1	479	486	PF00069	0.561
MOD_GSK3_1	493	500	PF00069	0.579
MOD_GSK3_1	503	510	PF00069	0.578
MOD_GSK3_1	512	519	PF00069	0.527
MOD_GSK3_1	590	597	PF00069	0.759
MOD_GSK3_1	599	606	PF00069	0.634
MOD_GSK3_1	616	623	PF00069	0.522
MOD_GSK3_1	665	672	PF00069	0.711
MOD_GSK3_1	673	680	PF00069	0.648
MOD_N-GLC_1	445	450	PF02516	0.571
MOD_N-GLC_1	45	50	PF02516	0.670
MOD_N-GLC_1	494	499	PF02516	0.573
MOD_N-GLC_1	602	607	PF02516	0.554
MOD_N-GLC_1	670	675	PF02516	0.681
MOD_NEK2_1	160	165	PF00069	0.608
MOD_NEK2_1	170	175	PF00069	0.602
MOD_NEK2_1	190	195	PF00069	0.582
MOD_NEK2_1	230	235	PF00069	0.709
MOD_NEK2_1	236	241	PF00069	0.660
MOD_NEK2_1	310	315	PF00069	0.684
MOD_NEK2_1	323	328	PF00069	0.590
MOD_NEK2_1	338	343	PF00069	0.551
MOD_NEK2_1	452	457	PF00069	0.646
MOD_NEK2_1	478	483	PF00069	0.650
MOD_NEK2_1	484	489	PF00069	0.624
MOD_NEK2_1	493	498	PF00069	0.549
MOD_NEK2_1	516	521	PF00069	0.604
MOD_NEK2_1	64	69	PF00069	0.648
MOD_NEK2_1	665	670	PF00069	0.708
MOD_NEK2_1	93	98	PF00069	0.670
MOD_NEK2_2	509	514	PF00069	0.685
MOD_NEK2_2	620	625	PF00069	0.552
MOD_NEK2_2	659	664	PF00069	0.607
MOD_PIKK_1	172	178	PF00454	0.659
MOD_PIKK_1	520	526	PF00454	0.648
MOD_PIKK_1	530	536	PF00454	0.516
MOD_PK_1	293	299	PF00069	0.653
MOD_PK_1	625	631	PF00069	0.651
MOD_PKA_1	474	480	PF00069	0.656
MOD_PKA_2	121	127	PF00069	0.695
MOD_PKA_2	474	480	PF00069	0.656
MOD_PKA_2	639	645	PF00069	0.684
MOD_PKA_2	74	80	PF00069	0.652
MOD_PKB_1	625	633	PF00069	0.649
MOD_Plk_1	23	29	PF00069	0.670
MOD_Plk_1	353	359	PF00069	0.628
MOD_Plk_1	45	51	PF00069	0.671
MOD_Plk_1	494	500	PF00069	0.575
MOD_Plk_1	516	522	PF00069	0.646
MOD_Plk_2-3	325	331	PF00069	0.593
MOD_Plk_4	163	169	PF00069	0.631
MOD_Plk_4	474	480	PF00069	0.656
MOD_Plk_4	484	490	PF00069	0.577
MOD_Plk_4	509	515	PF00069	0.665
MOD_Plk_4	516	522	PF00069	0.582
MOD_ProDKin_1	16	22	PF00069	0.679
MOD_ProDKin_1	194	200	PF00069	0.696
MOD_ProDKin_1	277	283	PF00069	0.640
MOD_ProDKin_1	317	323	PF00069	0.716
MOD_ProDKin_1	341	347	PF00069	0.660
MOD_ProDKin_1	390	396	PF00069	0.715
MOD_ProDKin_1	500	506	PF00069	0.582
MOD_ProDKin_1	584	590	PF00069	0.608
MOD_ProDKin_1	597	603	PF00069	0.574
MOD_ProDKin_1	606	612	PF00069	0.639
MOD_ProDKin_1	616	622	PF00069	0.609
MOD_ProDKin_1	628	634	PF00069	0.618
MOD_ProDKin_1	65	71	PF00069	0.646
MOD_ProDKin_1	677	683	PF00069	0.740
MOD_SUMO_rev_2	96	105	PF00179	0.631
TRG_ENDOCYTIC_2	556	559	PF00928	0.599
TRG_ENDOCYTIC_2	694	697	PF00928	0.654
TRG_ER_diArg_1	357	359	PF00400	0.667
TRG_ER_diArg_1	474	476	PF00400	0.665
TRG_ER_diArg_1	579	581	PF00400	0.728
TRG_ER_diArg_1	624	627	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HXJ6	Leishmania infantum	99%	100%
E9AI56	Leishmania braziliensis	61%	100%
E9AR91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QE72	Leishmania major	90%	100%