Bis(5'-nucleosyl)-tetraphosphatase, symmetrical-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bis(5'-nucleosyl)-tetraphosphatase,symmetrical- li keprotein

Species:

Leishmania donovani

UniProt:

A0A3S7WUL2_LEIDO

TriTrypDb:

LdBPK_170640.1 , LdCL_170011800 , LDHU3_17.0940

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUL2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	6	1
GO:0008803	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.678
CLV_NRD_NRD_1	192	194	PF00675	0.427
CLV_NRD_NRD_1	252	254	PF00675	0.551
CLV_NRD_NRD_1	271	273	PF00675	0.366
CLV_NRD_NRD_1	313	315	PF00675	0.511
CLV_PCSK_KEX2_1	251	253	PF00082	0.639
CLV_PCSK_KEX2_1	270	272	PF00082	0.375
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.432
DEG_Nend_UBRbox_4	1	3	PF02207	0.454
DOC_MAPK_gen_1	47	57	PF00069	0.301
DOC_MAPK_gen_1	71	78	PF00069	0.310
DOC_USP7_MATH_1	130	134	PF00917	0.288
DOC_USP7_MATH_1	16	20	PF00917	0.586
DOC_USP7_MATH_1	232	236	PF00917	0.588
DOC_USP7_MATH_1	313	317	PF00917	0.529
DOC_USP7_MATH_1	83	87	PF00917	0.230
DOC_USP7_UBL2_3	237	241	PF12436	0.620
DOC_WW_Pin1_4	14	19	PF00397	0.602
DOC_WW_Pin1_4	308	313	PF00397	0.523
LIG_APCC_ABBAyCdc20_2	251	257	PF00400	0.478
LIG_BRCT_BRCA1_1	168	172	PF00533	0.569
LIG_FHA_1	291	297	PF00498	0.448
LIG_FHA_2	77	83	PF00498	0.351
LIG_LIR_Gen_1	169	180	PF02991	0.621
LIG_LIR_Gen_1	257	265	PF02991	0.330
LIG_LIR_Gen_1	96	106	PF02991	0.321
LIG_LIR_Nem_3	169	175	PF02991	0.611
LIG_LIR_Nem_3	257	261	PF02991	0.427
LIG_LIR_Nem_3	41	46	PF02991	0.258
LIG_PDZ_Class_1	313	318	PF00595	0.594
LIG_SH2_CRK	114	118	PF00017	0.316
LIG_SH2_CRK	43	47	PF00017	0.316
LIG_SH2_SRC	278	281	PF00017	0.386
LIG_SH2_STAT3	149	152	PF00017	0.293
LIG_SH2_STAT5	258	261	PF00017	0.459
LIG_SH3_2	310	315	PF14604	0.482
LIG_SH3_3	100	106	PF00018	0.410
LIG_SH3_3	299	305	PF00018	0.441
LIG_SH3_3	307	313	PF00018	0.441
LIG_TRAF2_1	200	203	PF00917	0.565
LIG_UBA3_1	65	71	PF00899	0.258
LIG_WW_3	311	315	PF00397	0.483
MOD_CDC14_SPxK_1	311	314	PF00782	0.495
MOD_CDK_SPxK_1	308	314	PF00069	0.490
MOD_CDK_SPxxK_3	308	315	PF00069	0.511
MOD_CK1_1	210	216	PF00069	0.680
MOD_CK1_1	223	229	PF00069	0.595
MOD_CK2_1	76	82	PF00069	0.316
MOD_Cter_Amidation	235	238	PF01082	0.559
MOD_GlcNHglycan	14	17	PF01048	0.659
MOD_GlcNHglycan	168	171	PF01048	0.559
MOD_GlcNHglycan	18	21	PF01048	0.537
MOD_GlcNHglycan	222	225	PF01048	0.610
MOD_GlcNHglycan	233	237	PF01048	0.531
MOD_GlcNHglycan	283	286	PF01048	0.436
MOD_GSK3_1	12	19	PF00069	0.587
MOD_GSK3_1	151	158	PF00069	0.552
MOD_GSK3_1	207	214	PF00069	0.650
MOD_GSK3_1	296	303	PF00069	0.425
MOD_NEK2_1	101	106	PF00069	0.328
MOD_NEK2_1	12	17	PF00069	0.599
MOD_NEK2_1	166	171	PF00069	0.555
MOD_NEK2_1	195	200	PF00069	0.660
MOD_NEK2_2	83	88	PF00069	0.247
MOD_PKB_1	216	224	PF00069	0.596
MOD_Plk_1	259	265	PF00069	0.322
MOD_Plk_4	297	303	PF00069	0.447
MOD_Plk_4	83	89	PF00069	0.293
MOD_ProDKin_1	14	20	PF00069	0.601
MOD_ProDKin_1	308	314	PF00069	0.527
TRG_DiLeu_BaEn_1	291	296	PF01217	0.381
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.272
TRG_ENDOCYTIC_2	114	117	PF00928	0.328
TRG_ENDOCYTIC_2	258	261	PF00928	0.477
TRG_ENDOCYTIC_2	43	46	PF00928	0.316
TRG_ER_diArg_1	177	180	PF00400	0.503
TRG_ER_diArg_1	250	253	PF00400	0.519
TRG_ER_diArg_1	271	273	PF00400	0.416
TRG_NES_CRM1_1	67	82	PF08389	0.272
TRG_NLS_Bipartite_1	252	274	PF00514	0.385
TRG_NLS_MonoCore_2	237	242	PF00514	0.595
TRG_NLS_MonoExtC_3	236	241	PF00514	0.595
TRG_NLS_MonoExtN_4	237	242	PF00514	0.572
TRG_NLS_MonoExtN_4	312	318	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD44	Leptomonas seymouri	57%	73%
A4H901	Leishmania braziliensis	71%	98%
A4HXD2	Leishmania infantum	100%	100%
B4F2I4	Proteus mirabilis (strain HI4320)	27%	100%
B6J646	Coxiella burnetii (strain CbuK_Q154)	24%	100%
C6DEY8	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	25%	100%
C9ZWV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AR27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q3JBF6	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	26%	100%
Q4QED6	Leishmania major	93%	98%