LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Histone H2B

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histone H2B
Gene product:
histone H2B
Species:
Leishmania donovani
UniProt:
A0A3S7WUK6_LEIDO
TriTrypDb:
LdBPK_171320.1 , LdCL_170019400 , LDHU3_17.1840
Length:
111

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Histone H2B

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0000786 nucleosome 3 23
GO:0005634 nucleus 5 21
GO:0032991 protein-containing complex 1 23
GO:0032993 protein-DNA complex 2 23
GO:0043226 organelle 2 21
GO:0043227 membrane-bounded organelle 3 21
GO:0043229 intracellular organelle 3 21
GO:0043231 intracellular membrane-bounded organelle 4 21
GO:0044815 DNA packaging complex 2 23
GO:0110165 cellular anatomical entity 1 21

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WUK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUK6

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 3
GO:0006334 nucleosome assembly 7 3
GO:0006338 chromatin remodeling 5 3
GO:0009987 cellular process 1 3
GO:0016043 cellular component organization 3 3
GO:0022607 cellular component assembly 4 3
GO:0034728 nucleosome organization 6 3
GO:0043933 protein-containing complex organization 4 3
GO:0065003 protein-containing complex assembly 5 3
GO:0065004 protein-DNA complex assembly 6 3
GO:0071824 protein-DNA complex subunit organization 5 3
GO:0071840 cellular component organization or biogenesis 2 3
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 23
GO:0003677 DNA binding 4 23
GO:0005198 structural molecule activity 1 23
GO:0005488 binding 1 23
GO:0005515 protein binding 2 23
GO:0030527 structural constituent of chromatin 2 23
GO:0046982 protein heterodimerization activity 4 23
GO:0046983 protein dimerization activity 3 23
GO:0097159 organic cyclic compound binding 2 23
GO:1901363 heterocyclic compound binding 2 23

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 18 20 PF00675 0.289
CLV_NRD_NRD_1 5 7 PF00675 0.666
CLV_PCSK_KEX2_1 22 24 PF00082 0.317
CLV_PCSK_KEX2_1 4 6 PF00082 0.619
CLV_PCSK_KEX2_1 74 76 PF00082 0.296
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.314
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.296
CLV_PCSK_PC7_1 70 76 PF00082 0.296
CLV_PCSK_SKI1_1 31 35 PF00082 0.327
CLV_PCSK_SKI1_1 45 49 PF00082 0.269
CLV_PCSK_SKI1_1 87 91 PF00082 0.382
DOC_MAPK_gen_1 19 29 PF00069 0.499
DOC_USP7_MATH_1 11 15 PF00917 0.396
DOC_USP7_MATH_1 21 25 PF00917 0.576
DOC_USP7_MATH_1 38 42 PF00917 0.604
DOC_USP7_UBL2_3 104 108 PF12436 0.388
DOC_USP7_UBL2_3 16 20 PF12436 0.541
LIG_14-3-3_CanoR_1 60 69 PF00244 0.525
LIG_BIR_II_1 1 5 PF00653 0.659
LIG_FHA_1 101 107 PF00498 0.499
LIG_FHA_1 44 50 PF00498 0.499
LIG_LIR_Nem_3 24 28 PF02991 0.502
LIG_SH2_STAT5 28 31 PF00017 0.506
LIG_SH2_STAT5 53 56 PF00017 0.601
LIG_SH3_3 85 91 PF00018 0.410
MOD_CK1_1 14 20 PF00069 0.579
MOD_CK1_1 43 49 PF00069 0.544
MOD_CK1_1 52 58 PF00069 0.614
MOD_GSK3_1 100 107 PF00069 0.498
MOD_GSK3_1 5 12 PF00069 0.652
MOD_NEK2_1 40 45 PF00069 0.502
MOD_NEK2_1 68 73 PF00069 0.406
MOD_PKA_1 5 11 PF00069 0.806
MOD_PKA_1 73 79 PF00069 0.502
MOD_PKA_2 5 11 PF00069 0.618
MOD_Plk_4 49 55 PF00069 0.502
TRG_DiLeu_BaEn_1 64 69 PF01217 0.406
TRG_ER_diArg_1 4 6 PF00400 0.686
TRG_NLS_Bipartite_1 4 23 PF00514 0.365
TRG_NLS_MonoCore_2 18 23 PF00514 0.520
TRG_NLS_MonoExtC_3 18 23 PF00514 0.502
TRG_NLS_MonoExtN_4 16 23 PF00514 0.502
TRG_NLS_MonoExtN_4 70 77 PF00514 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD10 Leptomonas seymouri 43% 78%
A0A0N1PDG4 Leptomonas seymouri 89% 100%
A0A0S4IT56 Bodo saltans 46% 76%
A0A1X0NWS2 Trypanosomatidae 39% 78%
A0A2R8Y619 Homo sapiens 49% 91%
A0A381MG06 Leishmania infantum 90% 100%
A0A3R7MD18 Trypanosoma rangeli 69% 100%
A0A3R7NJN4 Trypanosoma rangeli 73% 99%
A0A3S5H748 Leishmania donovani 90% 100%
A0A3S5H7I6 Leishmania donovani 43% 100%
A0A422N4F4 Trypanosoma rangeli 40% 85%
A0A422NDW8 Trypanosoma rangeli 73% 99%
A1CJ09 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 48% 79%
A1D8G9 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 48% 79%
A2QY49 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 48% 79%
A2WKP3 Oryza sativa subsp. indica 45% 73%
A2WKP5 Oryza sativa subsp. indica 45% 73%
A2WKS3 Oryza sativa subsp. indica 45% 73%
A2WKS5 Oryza sativa subsp. indica 47% 73%
A2WKS8 Oryza sativa subsp. indica 45% 73%
A2WKT1 Oryza sativa subsp. indica 47% 73%
A2WKT4 Oryza sativa subsp. indica 45% 72%
A2WWU2 Oryza sativa subsp. indica 47% 80%
A2XF66 Oryza sativa subsp. indica 47% 73%
A2Y7R3 Oryza sativa subsp. indica 47% 73%
A2YWI3 Oryza sativa subsp. indica 46% 74%
A3AGM4 Oryza sativa subsp. japonica 47% 73%
A3LXE6 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 48% 85%
A3LZZ1 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 43% 85%
A4H5W2 Leishmania braziliensis 75% 100%
A4H9W2 Leishmania braziliensis 75% 100%
A4HG62 Leishmania braziliensis 45% 78%
A4HU57 Leishmania infantum 86% 100%
A4HXJ9 Leishmania infantum 100% 100%
A4HY42 Leishmania infantum 90% 100%
A4I394 Leishmania infantum 43% 100%
A5DBG5 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 40% 86%
A5DJJ1 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 39% 86%
A5DWF0 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 49% 85%
D0A4I4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 99%
D0A4I7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 99%
D0A4I8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 99%
D0A7S0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 67%
E9AMY6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AR94 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9ARV5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AZI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
L7I1W3 Magnaporthe oryzae (strain Y34) 48% 81%
O22582 Gossypium hirsutum 47% 76%
O23629 Arabidopsis thaliana 45% 74%
O49118 Capsicum annuum 45% 77%
O60814 Homo sapiens 48% 88%
O65818 Solanum lycopersicum 45% 79%
O65819 Solanum lycopersicum 47% 81%
O65821 Solanum lycopersicum 45% 78%
O97484 Euplotes crassus 52% 98%
P02281 Xenopus laevis 51% 88%
P02283 Drosophila melanogaster 48% 90%
P02284 Patella granatina 48% 91%
P02285 Marthasterias glacialis 52% 92%
P02286 Asterias rubens 52% 91%
P02287 Psammechinus miliaris 50% 90%
P02288 Psammechinus miliaris 49% 90%
P02289 Strongylocentrotus purpuratus 48% 90%
P02290 Parechinus angulosus 49% 77%
P02291 Parechinus angulosus 48% 77%
P02292 Parechinus angulosus 48% 74%
P02293 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 85%
P02294 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 85%
P04255 Caenorhabditis elegans 48% 91%
P04913 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 88%
P05621 Triticum aestivum 46% 74%
P06145 Strongylocentrotus purpuratus 48% 79%
P06146 Lytechinus pictus 52% 78%
P06899 Homo sapiens 47% 88%
P06900 Xenopus laevis 47% 88%
P07794 Psammechinus miliaris 49% 90%
P07795 Psammechinus miliaris 50% 90%
P08993 Tetrahymena thermophila (strain SB210) 46% 91%
P08994 Tetrahymena thermophila (strain SB210) 45% 91%
P0C1H3 Gallus gallus 49% 88%
P0C1H4 Gallus gallus 49% 88%
P0C1H5 Gallus gallus 49% 88%
P0C1H6 Homo sapiens 37% 72%
P0CO02 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 47% 80%
P0CO03 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 47% 80%
P0CT13 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 48% 81%
P10853 Mus musculus 48% 88%
P10854 Mus musculus 48% 88%
P14001 Cairina moschata 49% 88%
P16867 Volvox carteri 48% 71%
P16868 Volvox carteri 48% 72%
P16887 Strongylocentrotus purpuratus 47% 77%
P16888 Strongylocentrotus purpuratus 50% 90%
P16889 Strongylocentrotus purpuratus 52% 90%
P16890 Strongylocentrotus purpuratus 53% 100%
P17271 Drosophila hydei 48% 90%
P19374 Platynereis dumerilii 48% 90%
P21897 Chironomus thummi thummi 49% 89%
P23527 Homo sapiens 47% 88%
P23754 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 48% 79%
P27326 Urechis caupo 47% 90%
P27795 Trypanosoma cruzi 79% 99%
P27807 Triticum aestivum 47% 73%
P27893 Leishmania enriettii 77% 100%
P30755 Zea mays 45% 74%
P30756 Zea mays 47% 74%
P30757 Sipunculus nudus 47% 90%
P33778 Homo sapiens 47% 88%
P35067 Acropora formosa 47% 89%
P35068 Tigriopus californicus 48% 90%
P35069 Tigriopus californicus 48% 90%
P37210 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 48% 81%
P40283 Arabidopsis thaliana 47% 74%
P40284 Entamoeba invadens 35% 83%
P48557 Holothuria tubulosa 47% 90%
P48989 Candida albicans (strain SC5314 / ATCC MYA-2876) 49% 85%
P49120 Zea mays 47% 81%
P50565 Chlamydomonas reinhardtii 48% 73%
P54345 Chlamydomonas reinhardtii 48% 71%
P54346 Chlamydomonas reinhardtii 48% 73%
P54347 Chlamydomonas reinhardtii 48% 73%
P54348 Zea mays 47% 72%
P57053 Homo sapiens 48% 88%
P58876 Homo sapiens 48% 88%
P59781 Drosophila erecta 48% 90%
P59782 Drosophila simulans 48% 90%
P62807 Homo sapiens 48% 88%
P62808 Bos taurus 48% 88%
P69069 Oncorhynchus mykiss 46% 90%
P69070 Salmo trutta 46% 90%
P70696 Mus musculus 49% 87%
P78567 Agaricus bisporus 47% 78%
P82887 Olisthodiscus luteus 48% 97%
P83863 Penaeus vannamei 48% 96%
P93354 Nicotiana tabacum 46% 76%
Q00715 Rattus norvegicus 49% 89%
Q00729 Rattus norvegicus 49% 87%
Q0CBD1 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 48% 79%
Q0U1A0 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 47% 79%
Q16778 Homo sapiens 47% 88%
Q1E5N0 Coccidioides immitis (strain RS) 48% 80%
Q1S9I9 Medicago truncatula 45% 75%
Q1SU99 Medicago truncatula 45% 80%
Q1SWQ1 Medicago truncatula 44% 75%
Q27442 Anopheles gambiae 48% 90%
Q27484 Caenorhabditis elegans 48% 90%
Q27749 Psammechinus miliaris 49% 81%
Q27750 Psammechinus miliaris 48% 78%
Q27876 Caenorhabditis elegans 48% 90%
Q27894 Caenorhabditis elegans 48% 90%
Q2HH38 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 47% 81%
Q2M2T1 Bos taurus 48% 88%
Q2PFX4 Macaca fascicularis 48% 88%
Q2U5A9 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 48% 79%
Q32L48 Bos taurus 47% 88%
Q41575 Triticum aestivum 43% 92%
Q43215 Triticum aestivum 45% 82%
Q43216 Triticum aestivum 47% 82%
Q43217 Triticum aestivum 45% 80%
Q43261 Zea mays 45% 73%
Q4HTT2 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 47% 81%
Q4JHM7 Leishmania donovani 86% 100%
Q4PEF8 Ustilago maydis (strain 521 / FGSC 9021) 48% 78%
Q4Q8P9 Leishmania major 45% 100%
Q4QDL6 Leishmania major 91% 100%
Q4QHP1 Leishmania major 87% 100%
Q4WWC5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 48% 79%
Q54LP8 Dictyostelium discoideum 39% 72%
Q59VP1 Candida albicans (strain SC5314 / ATCC MYA-2876) 48% 85%
Q5BJA5 Danio rerio 47% 90%
Q5QNW6 Homo sapiens 48% 88%
Q5R893 Pongo abelii 48% 88%
Q5RCP8 Pongo abelii 48% 88%
Q64475 Mus musculus 48% 88%
Q64478 Mus musculus 48% 88%
Q64524 Mus musculus 46% 88%
Q64525 Mus musculus 48% 88%
Q6BKW7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 43% 86%
Q6BRG2 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 48% 85%
Q6C4I7 Yarrowia lipolytica (strain CLIB 122 / E 150) 46% 80%
Q6CK60 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 48% 84%
Q6CMV8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 48% 84%
Q6DRA6 Homo sapiens 31% 68%
Q6F362 Oryza sativa subsp. japonica 47% 73%
Q6FM30 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 45% 85%
Q6FWM8 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 45% 86%
Q6PC60 Danio rerio 49% 88%
Q6ZBP3 Oryza sativa subsp. japonica 46% 74%
Q6ZWY9 Mus musculus 48% 88%
Q74ZL5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 48% 84%
Q75VN4 Zhangixalus schlegelii 49% 88%
Q76FD7 Drosophila sechellia 48% 90%
Q76FE5 Drosophila mauritiana 48% 90%
Q76FE9 Drosophila orena 48% 90%
Q76FF3 Drosophila teissieri 48% 90%
Q7GBK0 Oryza sativa subsp. japonica 45% 73%
Q7M400 Tetrahymena pyriformis 46% 92%
Q7M4G7 Patiria pectinifera 50% 91%
Q7Z9J4 Ajellomyces capsulatus 48% 80%
Q875B7 Podospora anserina 48% 81%
Q8CGP0 Mus musculus 50% 88%
Q8CGP1 Mus musculus 48% 88%
Q8CGP2 Mus musculus 48% 88%
Q8I1N0 Drosophila yakuba 48% 90%
Q8J1F8 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 48% 87%
Q8J1K2 Rosellinia necatrix 47% 82%
Q8N257 Homo sapiens 50% 88%
Q8WNR4 Bos taurus 40% 91%
Q93079 Homo sapiens 48% 88%
Q943L2 Oryza sativa subsp. japonica 47% 80%
Q94JE1 Oryza sativa subsp. japonica 45% 72%
Q94JJ4 Oryza sativa subsp. japonica 45% 73%
Q94JJ7 Oryza sativa subsp. japonica 45% 73%
Q96A08 Homo sapiens 46% 87%
Q99285 Pisum sativum 45% 92%
Q99877 Homo sapiens 48% 88%
Q99879 Homo sapiens 48% 88%
Q99880 Homo sapiens 48% 88%
Q9D2U9 Mus musculus 51% 88%
Q9D9Z7 Mus musculus 34% 90%
Q9FFC0 Arabidopsis thaliana 45% 77%
Q9LFF6 Arabidopsis thaliana 44% 80%
Q9LGH4 Oryza sativa subsp. japonica 48% 73%
Q9LGH8 Oryza sativa subsp. japonica 47% 73%
Q9LGI2 Oryza sativa subsp. japonica 45% 73%
Q9LQQ4 Arabidopsis thaliana 45% 75%
Q9LZ45 Arabidopsis thaliana 48% 84%
Q9LZT0 Arabidopsis thaliana 45% 77%
Q9MBF7 Lilium longiflorum 33% 70%
Q9PSW9 Gallus gallus 49% 88%
Q9SF55 Arabidopsis thaliana 49% 88%
Q9SI96 Arabidopsis thaliana 47% 74%
Q9U8C0 Leishmania major 87% 100%
Q9ZUS0 Arabidopsis thaliana 45% 80%
V5D812 Trypanosoma cruzi 41% 78%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS