LeishMANIAdb
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Mak10 subunit, NatC N(Alpha)-terminal acetyltransferase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mak10 subunit, NatC N(Alpha)-terminal acetyltransferase, putative
Gene product:
Mak10 subunit, NatC N(alpha)-terminal acetyltransferase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WUK2_LEIDO
TriTrypDb:
LdBPK_171080.1 , LdCL_170016700 , LDHU3_17.1500
Length:
741

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0031248 protein acetyltransferase complex 3 12
GO:0031414 N-terminal protein acetyltransferase complex 4 12
GO:0031417 NatC complex 5 12
GO:0032991 protein-containing complex 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902493 acetyltransferase complex 4 12
GO:1902494 catalytic complex 2 12
GO:1990234 transferase complex 3 12
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WUK2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUK2

Function

Biological processes
Term Name Level Count
GO:0006473 protein acetylation 6 12
GO:0006474 N-terminal protein amino acid acetylation 5 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0017196 N-terminal peptidyl-methionine acetylation 6 12
GO:0018193 peptidyl-amino acid modification 5 12
GO:0018206 peptidyl-methionine modification 6 12
GO:0019538 protein metabolic process 3 12
GO:0031365 N-terminal protein amino acid modification 5 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043543 protein acylation 5 12
GO:0044238 primary metabolic process 2 12
GO:0051604 protein maturation 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016740 transferase activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 275 279 PF00656 0.504
CLV_C14_Caspase3-7 576 580 PF00656 0.510
CLV_NRD_NRD_1 201 203 PF00675 0.405
CLV_NRD_NRD_1 346 348 PF00675 0.492
CLV_NRD_NRD_1 354 356 PF00675 0.437
CLV_NRD_NRD_1 406 408 PF00675 0.522
CLV_NRD_NRD_1 432 434 PF00675 0.436
CLV_NRD_NRD_1 589 591 PF00675 0.485
CLV_NRD_NRD_1 676 678 PF00675 0.492
CLV_NRD_NRD_1 682 684 PF00675 0.516
CLV_NRD_NRD_1 732 734 PF00675 0.518
CLV_PCSK_KEX2_1 217 219 PF00082 0.534
CLV_PCSK_KEX2_1 284 286 PF00082 0.420
CLV_PCSK_KEX2_1 346 348 PF00082 0.500
CLV_PCSK_KEX2_1 354 356 PF00082 0.450
CLV_PCSK_KEX2_1 406 408 PF00082 0.522
CLV_PCSK_KEX2_1 432 434 PF00082 0.436
CLV_PCSK_KEX2_1 544 546 PF00082 0.527
CLV_PCSK_KEX2_1 682 684 PF00082 0.556
CLV_PCSK_KEX2_1 734 736 PF00082 0.620
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.534
CLV_PCSK_PC1ET2_1 284 286 PF00082 0.420
CLV_PCSK_PC1ET2_1 544 546 PF00082 0.652
CLV_PCSK_PC1ET2_1 734 736 PF00082 0.597
CLV_PCSK_SKI1_1 137 141 PF00082 0.491
CLV_PCSK_SKI1_1 148 152 PF00082 0.537
CLV_PCSK_SKI1_1 203 207 PF00082 0.411
CLV_PCSK_SKI1_1 284 288 PF00082 0.441
CLV_PCSK_SKI1_1 394 398 PF00082 0.588
CLV_PCSK_SKI1_1 614 618 PF00082 0.637
CLV_PCSK_SKI1_1 99 103 PF00082 0.516
DEG_APCC_DBOX_1 136 144 PF00400 0.472
DEG_APCC_DBOX_1 345 353 PF00400 0.490
DEG_APCC_DBOX_1 589 597 PF00400 0.493
DEG_APCC_KENBOX_2 522 526 PF00400 0.499
DEG_Nend_UBRbox_3 1 3 PF02207 0.692
DEG_SPOP_SBC_1 150 154 PF00917 0.596
DEG_SPOP_SBC_1 188 192 PF00917 0.540
DEG_SPOP_SBC_1 667 671 PF00917 0.496
DOC_ANK_TNKS_1 681 688 PF00023 0.601
DOC_CKS1_1 264 269 PF01111 0.662
DOC_CYCLIN_yCln2_LP_2 114 120 PF00134 0.464
DOC_CYCLIN_yCln2_LP_2 163 166 PF00134 0.681
DOC_CYCLIN_yCln2_LP_2 508 514 PF00134 0.410
DOC_MAPK_gen_1 406 412 PF00069 0.428
DOC_MAPK_gen_1 544 550 PF00069 0.506
DOC_MAPK_gen_1 590 596 PF00069 0.517
DOC_MAPK_RevD_3 418 433 PF00069 0.470
DOC_MAPK_RevD_3 638 652 PF00069 0.468
DOC_PP1_RVXF_1 196 202 PF00149 0.392
DOC_PP2B_LxvP_1 163 166 PF13499 0.681
DOC_PP2B_LxvP_1 46 49 PF13499 0.545
DOC_PP4_MxPP_1 1 4 PF00568 0.725
DOC_USP7_MATH_1 172 176 PF00917 0.694
DOC_USP7_MATH_1 187 191 PF00917 0.504
DOC_USP7_MATH_1 272 276 PF00917 0.607
DOC_USP7_MATH_1 320 324 PF00917 0.450
DOC_USP7_MATH_1 334 338 PF00917 0.471
DOC_USP7_MATH_1 461 465 PF00917 0.588
DOC_USP7_MATH_1 573 577 PF00917 0.539
DOC_USP7_MATH_1 600 604 PF00917 0.540
DOC_USP7_MATH_1 626 630 PF00917 0.607
DOC_USP7_MATH_1 636 640 PF00917 0.594
DOC_USP7_MATH_1 666 670 PF00917 0.627
DOC_USP7_MATH_1 81 85 PF00917 0.642
DOC_WD40_RPTOR_TOS_1 496 501 PF00400 0.554
DOC_WW_Pin1_4 189 194 PF00397 0.518
DOC_WW_Pin1_4 263 268 PF00397 0.535
DOC_WW_Pin1_4 387 392 PF00397 0.542
LIG_14-3-3_CanoR_1 242 246 PF00244 0.612
LIG_14-3-3_CanoR_1 346 350 PF00244 0.362
LIG_14-3-3_CanoR_1 379 385 PF00244 0.498
LIG_14-3-3_CanoR_1 433 439 PF00244 0.644
LIG_14-3-3_CanoR_1 473 478 PF00244 0.570
LIG_14-3-3_CanoR_1 632 640 PF00244 0.622
LIG_Actin_WH2_2 373 390 PF00022 0.598
LIG_BRCT_BRCA1_1 532 536 PF00533 0.551
LIG_Clathr_ClatBox_1 296 300 PF01394 0.573
LIG_Clathr_ClatBox_1 417 421 PF01394 0.427
LIG_Clathr_ClatBox_1 604 608 PF01394 0.519
LIG_deltaCOP1_diTrp_1 13 22 PF00928 0.541
LIG_eIF4E_1 582 588 PF01652 0.540
LIG_eIF4E_1 66 72 PF01652 0.530
LIG_FHA_1 266 272 PF00498 0.542
LIG_FHA_1 448 454 PF00498 0.544
LIG_FHA_1 532 538 PF00498 0.612
LIG_FHA_1 689 695 PF00498 0.508
LIG_FHA_1 72 78 PF00498 0.634
LIG_FHA_2 12 18 PF00498 0.528
LIG_FHA_2 435 441 PF00498 0.647
LIG_FHA_2 502 508 PF00498 0.451
LIG_FXI_DFP_1 113 117 PF00024 0.547
LIG_LIR_Apic_2 337 343 PF02991 0.653
LIG_LIR_Apic_2 353 359 PF02991 0.376
LIG_LIR_Gen_1 110 120 PF02991 0.433
LIG_LIR_Gen_1 13 22 PF02991 0.657
LIG_LIR_Gen_1 158 168 PF02991 0.666
LIG_LIR_Gen_1 413 424 PF02991 0.514
LIG_LIR_Gen_1 440 449 PF02991 0.605
LIG_LIR_Gen_1 94 103 PF02991 0.545
LIG_LIR_Nem_3 110 116 PF02991 0.437
LIG_LIR_Nem_3 13 18 PF02991 0.610
LIG_LIR_Nem_3 158 164 PF02991 0.620
LIG_LIR_Nem_3 281 286 PF02991 0.530
LIG_LIR_Nem_3 292 296 PF02991 0.447
LIG_LIR_Nem_3 310 315 PF02991 0.285
LIG_LIR_Nem_3 413 419 PF02991 0.560
LIG_LIR_Nem_3 440 444 PF02991 0.617
LIG_LIR_Nem_3 94 98 PF02991 0.542
LIG_NRBOX 208 214 PF00104 0.551
LIG_NRBOX 67 73 PF00104 0.478
LIG_Pex14_1 513 517 PF04695 0.421
LIG_Pex14_2 201 205 PF04695 0.501
LIG_Pex14_2 308 312 PF04695 0.469
LIG_SH2_CRK 283 287 PF00017 0.522
LIG_SH2_CRK 340 344 PF00017 0.654
LIG_SH2_CRK 356 360 PF00017 0.399
LIG_SH2_CRK 361 365 PF00017 0.462
LIG_SH2_CRK 619 623 PF00017 0.601
LIG_SH2_GRB2like 514 517 PF00017 0.439
LIG_SH2_PTP2 95 98 PF00017 0.544
LIG_SH2_SRC 95 98 PF00017 0.544
LIG_SH2_STAP1 449 453 PF00017 0.531
LIG_SH2_STAP1 630 634 PF00017 0.507
LIG_SH2_STAP1 649 653 PF00017 0.481
LIG_SH2_STAT5 103 106 PF00017 0.404
LIG_SH2_STAT5 113 116 PF00017 0.315
LIG_SH2_STAT5 118 121 PF00017 0.386
LIG_SH2_STAT5 135 138 PF00017 0.395
LIG_SH2_STAT5 240 243 PF00017 0.540
LIG_SH2_STAT5 416 419 PF00017 0.437
LIG_SH2_STAT5 449 452 PF00017 0.528
LIG_SH2_STAT5 485 488 PF00017 0.415
LIG_SH2_STAT5 514 517 PF00017 0.473
LIG_SH2_STAT5 582 585 PF00017 0.560
LIG_SH2_STAT5 715 718 PF00017 0.505
LIG_SH2_STAT5 95 98 PF00017 0.449
LIG_SH3_2 317 322 PF14604 0.428
LIG_SH3_3 1 7 PF00018 0.711
LIG_SH3_3 261 267 PF00018 0.520
LIG_SH3_3 314 320 PF00018 0.454
LIG_SH3_3 716 722 PF00018 0.470
LIG_SUMO_SIM_anti_2 230 237 PF11976 0.511
LIG_SUMO_SIM_anti_2 499 504 PF11976 0.575
LIG_SUMO_SIM_par_1 475 482 PF11976 0.501
LIG_SUMO_SIM_par_1 592 598 PF11976 0.490
LIG_SUMO_SIM_par_1 603 608 PF11976 0.496
LIG_SUMO_SIM_par_1 88 94 PF11976 0.434
LIG_SxIP_EBH_1 544 554 PF03271 0.541
LIG_TRAF2_1 157 160 PF00917 0.553
LIG_TRFH_1 161 165 PF08558 0.657
LIG_TYR_ITIM 617 622 PF00017 0.594
LIG_UBA3_1 286 294 PF00899 0.441
LIG_UBA3_1 593 601 PF00899 0.500
LIG_WRC_WIRS_1 290 295 PF05994 0.558
LIG_WRC_WIRS_1 493 498 PF05994 0.463
MOD_CDK_SPxK_1 263 269 PF00069 0.534
MOD_CDK_SPxxK_3 387 394 PF00069 0.560
MOD_CK1_1 263 269 PF00069 0.534
MOD_CK1_1 292 298 PF00069 0.505
MOD_CK1_1 30 36 PF00069 0.559
MOD_CK1_1 448 454 PF00069 0.462
MOD_CK1_1 578 584 PF00069 0.475
MOD_CK1_1 603 609 PF00069 0.470
MOD_CK1_1 726 732 PF00069 0.544
MOD_CK1_1 79 85 PF00069 0.500
MOD_CK2_1 154 160 PF00069 0.505
MOD_CK2_1 172 178 PF00069 0.526
MOD_CK2_1 216 222 PF00069 0.538
MOD_CK2_1 44 50 PF00069 0.522
MOD_CK2_1 501 507 PF00069 0.427
MOD_GlcNHglycan 236 239 PF01048 0.490
MOD_GlcNHglycan 280 283 PF01048 0.620
MOD_GlcNHglycan 46 49 PF01048 0.545
MOD_GlcNHglycan 57 60 PF01048 0.496
MOD_GlcNHglycan 583 586 PF01048 0.508
MOD_GlcNHglycan 597 600 PF01048 0.502
MOD_GlcNHglycan 634 637 PF01048 0.556
MOD_GlcNHglycan 670 673 PF01048 0.668
MOD_GlcNHglycan 702 705 PF01048 0.651
MOD_GlcNHglycan 725 728 PF01048 0.609
MOD_GlcNHglycan 78 81 PF01048 0.465
MOD_GSK3_1 105 112 PF00069 0.582
MOD_GSK3_1 150 157 PF00069 0.467
MOD_GSK3_1 212 219 PF00069 0.516
MOD_GSK3_1 447 454 PF00069 0.486
MOD_GSK3_1 472 479 PF00069 0.492
MOD_GSK3_1 553 560 PF00069 0.514
MOD_GSK3_1 632 639 PF00069 0.578
MOD_LATS_1 97 103 PF00433 0.547
MOD_N-GLC_1 11 16 PF02516 0.615
MOD_N-GLC_1 128 133 PF02516 0.512
MOD_N-GLC_1 154 159 PF02516 0.629
MOD_N-GLC_1 334 339 PF02516 0.603
MOD_N-GLC_1 524 529 PF02516 0.463
MOD_N-GLC_2 23 25 PF02516 0.473
MOD_NEK2_1 109 114 PF00069 0.466
MOD_NEK2_1 151 156 PF00069 0.596
MOD_NEK2_1 212 217 PF00069 0.509
MOD_NEK2_1 234 239 PF00069 0.490
MOD_NEK2_1 410 415 PF00069 0.486
MOD_NEK2_1 419 424 PF00069 0.457
MOD_NEK2_1 434 439 PF00069 0.491
MOD_NEK2_1 531 536 PF00069 0.591
MOD_NEK2_1 553 558 PF00069 0.450
MOD_NEK2_1 668 673 PF00069 0.561
MOD_NEK2_1 688 693 PF00069 0.462
MOD_NEK2_1 728 733 PF00069 0.529
MOD_PIKK_1 107 113 PF00454 0.558
MOD_PIKK_1 501 507 PF00454 0.442
MOD_PKA_1 216 222 PF00069 0.590
MOD_PKA_1 735 741 PF00069 0.630
MOD_PKA_2 241 247 PF00069 0.513
MOD_PKA_2 345 351 PF00069 0.368
MOD_PKA_2 472 478 PF00069 0.531
MOD_PKA_2 557 563 PF00069 0.609
MOD_PKB_1 733 741 PF00069 0.608
MOD_Plk_1 11 17 PF00069 0.555
MOD_Plk_1 172 178 PF00069 0.635
MOD_Plk_1 28 34 PF00069 0.503
MOD_Plk_1 334 340 PF00069 0.601
MOD_Plk_1 445 451 PF00069 0.443
MOD_Plk_1 524 530 PF00069 0.574
MOD_Plk_1 578 584 PF00069 0.569
MOD_Plk_1 99 105 PF00069 0.542
MOD_Plk_4 109 115 PF00069 0.560
MOD_Plk_4 207 213 PF00069 0.468
MOD_Plk_4 260 266 PF00069 0.628
MOD_Plk_4 292 298 PF00069 0.515
MOD_Plk_4 334 340 PF00069 0.514
MOD_Plk_4 419 425 PF00069 0.509
MOD_Plk_4 451 457 PF00069 0.485
MOD_Plk_4 473 479 PF00069 0.511
MOD_Plk_4 537 543 PF00069 0.553
MOD_Plk_4 578 584 PF00069 0.558
MOD_Plk_4 600 606 PF00069 0.509
MOD_Plk_4 99 105 PF00069 0.557
MOD_ProDKin_1 189 195 PF00069 0.509
MOD_ProDKin_1 263 269 PF00069 0.534
MOD_ProDKin_1 387 393 PF00069 0.541
MOD_SUMO_for_1 26 29 PF00179 0.623
MOD_SUMO_for_1 72 75 PF00179 0.488
MOD_SUMO_rev_2 243 253 PF00179 0.611
MOD_SUMO_rev_2 47 56 PF00179 0.520
MOD_SUMO_rev_2 584 593 PF00179 0.541
TRG_DiLeu_BaEn_1 159 164 PF01217 0.666
TRG_DiLeu_BaEn_1 230 235 PF01217 0.442
TRG_DiLeu_BaEn_1 392 397 PF01217 0.478
TRG_DiLeu_BaEn_1 589 594 PF01217 0.455
TRG_DiLeu_BaEn_4 63 69 PF01217 0.621
TRG_DiLeu_BaLyEn_6 282 287 PF01217 0.403
TRG_DiLeu_BaLyEn_6 314 319 PF01217 0.425
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.502
TRG_ENDOCYTIC_2 113 116 PF00928 0.364
TRG_ENDOCYTIC_2 283 286 PF00928 0.451
TRG_ENDOCYTIC_2 361 364 PF00928 0.420
TRG_ENDOCYTIC_2 416 419 PF00928 0.506
TRG_ENDOCYTIC_2 514 517 PF00928 0.416
TRG_ENDOCYTIC_2 619 622 PF00928 0.589
TRG_ENDOCYTIC_2 95 98 PF00928 0.541
TRG_ER_diArg_1 198 201 PF00400 0.409
TRG_ER_diArg_1 354 356 PF00400 0.460
TRG_ER_diArg_1 405 407 PF00400 0.524
TRG_ER_diArg_1 432 434 PF00400 0.436
TRG_ER_diArg_1 681 683 PF00400 0.579
TRG_ER_diArg_1 732 735 PF00400 0.635
TRG_NES_CRM1_1 230 245 PF08389 0.465
TRG_NES_CRM1_1 288 300 PF08389 0.566
TRG_NES_CRM1_1 491 505 PF08389 0.470
TRG_Pf-PMV_PEXEL_1 285 289 PF00026 0.482
TRG_Pf-PMV_PEXEL_1 394 399 PF00026 0.489

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4Y3 Leptomonas seymouri 80% 100%
A0A0S4IMZ6 Bodo saltans 32% 100%
A0A1X0NSS7 Trypanosomatidae 52% 100%
A0A3R7M3C6 Trypanosoma rangeli 50% 100%
A4H953 Leishmania braziliensis 91% 100%
A4HXH5 Leishmania infantum 100% 100%
C9ZP62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AR70 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QE93 Leishmania major 98% 100%
V5D6H5 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS