Hydrolase-like_protein/GeneDB:LmjF.17.1040

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WUK0_LEIDO

TriTrypDb:

LdBPK_171140.1 , LdCL_170017500 , LDHU3_17.1610

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WUK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016787	hydrolase activity	2	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	403	405	PF00675	0.459
CLV_PCSK_KEX2_1	276	278	PF00082	0.264
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.313
CLV_PCSK_SKI1_1	269	273	PF00082	0.305
CLV_PCSK_SKI1_1	286	290	PF00082	0.179
CLV_PCSK_SKI1_1	324	328	PF00082	0.195
DEG_APCC_DBOX_1	285	293	PF00400	0.406
DEG_COP1_1	331	339	PF00400	0.387
DEG_SPOP_SBC_1	207	211	PF00917	0.412
DOC_CKS1_1	330	335	PF01111	0.344
DOC_CYCLIN_RxL_1	172	183	PF00134	0.278
DOC_MAPK_gen_1	273	281	PF00069	0.404
DOC_MAPK_MEF2A_6	49	57	PF00069	0.292
DOC_MIT_MIM_1	146	155	PF04212	0.195
DOC_PP1_RVXF_1	147	153	PF00149	0.195
DOC_PP2B_LxvP_1	10	13	PF13499	0.678
DOC_PP2B_LxvP_1	292	295	PF13499	0.362
DOC_PP2B_PxIxI_1	336	342	PF00149	0.215
DOC_PP4_FxxP_1	334	337	PF00568	0.195
DOC_USP7_MATH_1	398	402	PF00917	0.431
DOC_USP7_MATH_1	5	9	PF00917	0.734
DOC_USP7_UBL2_3	248	252	PF12436	0.384
DOC_USP7_UBL2_3	422	426	PF12436	0.690
DOC_WW_Pin1_4	185	190	PF00397	0.320
DOC_WW_Pin1_4	329	334	PF00397	0.257
DOC_WW_Pin1_4	58	63	PF00397	0.294
DOC_WW_Pin1_4	8	13	PF00397	0.578
LIG_14-3-3_CanoR_1	175	180	PF00244	0.298
LIG_14-3-3_CanoR_1	238	246	PF00244	0.295
LIG_14-3-3_CanoR_1	30	38	PF00244	0.453
LIG_14-3-3_CanoR_1	302	311	PF00244	0.340
LIG_14-3-3_CanoR_1	324	334	PF00244	0.471
LIG_14-3-3_CanoR_1	355	361	PF00244	0.334
LIG_14-3-3_CanoR_1	69	74	PF00244	0.417
LIG_Actin_WH2_1	365	383	PF00022	0.396
LIG_BIR_III_4	140	144	PF00653	0.408
LIG_FHA_1	123	129	PF00498	0.386
LIG_FHA_1	245	251	PF00498	0.339
LIG_FHA_1	325	331	PF00498	0.298
LIG_FHA_1	336	342	PF00498	0.251
LIG_FHA_1	35	41	PF00498	0.379
LIG_FHA_2	131	137	PF00498	0.313
LIG_FHA_2	220	226	PF00498	0.195
LIG_FHA_2	92	98	PF00498	0.348
LIG_LIR_Apic_2	331	337	PF02991	0.194
LIG_LIR_Gen_1	245	253	PF02991	0.410
LIG_LIR_Gen_1	383	392	PF02991	0.362
LIG_LIR_Gen_1	77	85	PF02991	0.425
LIG_LIR_Nem_3	112	116	PF02991	0.337
LIG_LIR_Nem_3	140	145	PF02991	0.406
LIG_LIR_Nem_3	23	28	PF02991	0.420
LIG_LIR_Nem_3	245	249	PF02991	0.344
LIG_LIR_Nem_3	383	387	PF02991	0.371
LIG_LIR_Nem_3	77	83	PF02991	0.315
LIG_NRBOX	69	75	PF00104	0.268
LIG_PDZ_Class_1	426	431	PF00595	0.695
LIG_SH2_CRK	118	122	PF00017	0.310
LIG_SH2_CRK	80	84	PF00017	0.475
LIG_SH2_PTP2	384	387	PF00017	0.445
LIG_SH2_SRC	116	119	PF00017	0.215
LIG_SH2_STAP1	116	120	PF00017	0.417
LIG_SH2_STAP1	214	218	PF00017	0.410
LIG_SH2_STAP1	242	246	PF00017	0.412
LIG_SH2_STAT5	113	116	PF00017	0.412
LIG_SH2_STAT5	132	135	PF00017	0.296
LIG_SH2_STAT5	335	338	PF00017	0.391
LIG_SH2_STAT5	367	370	PF00017	0.350
LIG_SH2_STAT5	384	387	PF00017	0.403
LIG_SH3_3	1	7	PF00018	0.708
LIG_SH3_3	104	110	PF00018	0.442
LIG_SH3_3	15	21	PF00018	0.575
LIG_SH3_3	327	333	PF00018	0.329
LIG_SH3_3	344	350	PF00018	0.289
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.237
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.428
LIG_SUMO_SIM_par_1	174	180	PF11976	0.300
LIG_TRAF2_1	223	226	PF00917	0.412
LIG_UBA3_1	199	208	PF00899	0.368
LIG_WRC_WIRS_1	42	47	PF05994	0.322
MOD_CDK_SPxxK_3	8	15	PF00069	0.644
MOD_CK1_1	183	189	PF00069	0.295
MOD_CK1_1	201	207	PF00069	0.358
MOD_CK1_1	328	334	PF00069	0.350
MOD_CK1_1	8	14	PF00069	0.675
MOD_CK2_1	124	130	PF00069	0.359
MOD_CK2_1	219	225	PF00069	0.369
MOD_Cter_Amidation	402	405	PF01082	0.379
MOD_GlcNHglycan	158	161	PF01048	0.392
MOD_GlcNHglycan	210	213	PF01048	0.380
MOD_GlcNHglycan	222	225	PF01048	0.405
MOD_GlcNHglycan	253	256	PF01048	0.366
MOD_GlcNHglycan	327	330	PF01048	0.415
MOD_GlcNHglycan	418	421	PF01048	0.681
MOD_GlcNHglycan	76	79	PF01048	0.457
MOD_GSK3_1	177	184	PF00069	0.276
MOD_GSK3_1	275	282	PF00069	0.237
MOD_GSK3_1	30	37	PF00069	0.512
MOD_GSK3_1	320	327	PF00069	0.425
MOD_N-GLC_1	320	325	PF02516	0.215
MOD_NEK2_1	155	160	PF00069	0.356
MOD_NEK2_1	177	182	PF00069	0.297
MOD_NEK2_1	275	280	PF00069	0.303
MOD_NEK2_1	311	316	PF00069	0.229
MOD_NEK2_1	372	377	PF00069	0.371
MOD_NEK2_1	380	385	PF00069	0.390
MOD_NEK2_1	74	79	PF00069	0.383
MOD_NEK2_2	124	129	PF00069	0.463
MOD_PIKK_1	309	315	PF00454	0.452
MOD_PK_1	304	310	PF00069	0.417
MOD_PKA_2	219	225	PF00069	0.195
MOD_PKA_2	237	243	PF00069	0.419
MOD_PKA_2	303	309	PF00069	0.407
MOD_PKA_2	380	386	PF00069	0.464
MOD_PKB_1	302	310	PF00069	0.215
MOD_Plk_2-3	130	136	PF00069	0.289
MOD_Plk_4	109	115	PF00069	0.347
MOD_Plk_4	177	183	PF00069	0.240
MOD_Plk_4	198	204	PF00069	0.360
MOD_Plk_4	335	341	PF00069	0.272
MOD_Plk_4	356	362	PF00069	0.299
MOD_Plk_4	372	378	PF00069	0.280
MOD_Plk_4	380	386	PF00069	0.417
MOD_Plk_4	69	75	PF00069	0.415
MOD_ProDKin_1	185	191	PF00069	0.320
MOD_ProDKin_1	329	335	PF00069	0.257
MOD_ProDKin_1	58	64	PF00069	0.294
MOD_ProDKin_1	8	14	PF00069	0.577
MOD_SUMO_rev_2	93	102	PF00179	0.159
TRG_AP2beta_CARGO_1	140	149	PF09066	0.195
TRG_DiLeu_BaEn_4	225	231	PF01217	0.412
TRG_ENDOCYTIC_2	118	121	PF00928	0.266
TRG_ENDOCYTIC_2	384	387	PF00928	0.456
TRG_ENDOCYTIC_2	42	45	PF00928	0.334
TRG_ENDOCYTIC_2	80	83	PF00928	0.333
TRG_ER_diArg_1	148	151	PF00400	0.218
TRG_ER_diArg_1	19	22	PF00400	0.333
TRG_ER_diArg_1	227	230	PF00400	0.370
TRG_ER_diArg_1	301	304	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.353
TRG_PTS1	428	431	PF00515	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	65%	100%
A0A0N0P3S4	Leptomonas seymouri	36%	100%
A0A0N1PA10	Leptomonas seymouri	30%	100%
A0A0N1PCQ2	Leptomonas seymouri	32%	100%
A0A0S4JQB3	Bodo saltans	30%	100%
A0A1X0NSR3	Trypanosomatidae	29%	96%
A0A1X0NSS6	Trypanosomatidae	33%	100%
A0A1X0NT85	Trypanosomatidae	33%	87%
A0A3Q8IAY1	Leishmania donovani	38%	100%
A0A3R7KKJ0	Trypanosoma rangeli	33%	100%
A0A3S5IRR1	Trypanosoma rangeli	37%	100%
A0A3S7WUJ3	Leishmania donovani	31%	91%
A0A3S7X1K2	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	30%	100%
A4H956	Leishmania braziliensis	33%	95%
A4H959	Leishmania braziliensis	79%	99%
A4H960	Leishmania braziliensis	37%	100%
A4HGL0	Leishmania braziliensis	29%	87%
A4HXH8	Leishmania infantum	31%	91%
A4HXI1	Leishmania infantum	99%	100%
A4HXI2	Leishmania infantum	38%	100%
A4I3N6	Leishmania infantum	32%	96%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	86%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
Q4Q8A8	Leishmania major	31%	96%
Q4QE86	Leishmania major	37%	100%
Q4QE87	Leishmania major	93%	100%
Q4QE90	Leishmania major	37%	100%
Q54528	Streptomyces purpurascens	26%	100%
Q54809	Streptomyces peucetius	27%	100%
Q55217	Streptomyces sp. (strain C5)	27%	100%
V5AZB9	Trypanosoma cruzi	31%	100%
V5BER0	Trypanosoma cruzi	32%	100%
V5BNU9	Trypanosoma cruzi	34%	100%