Hydrolase, alpha/beta fold family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WUJ3_LEIDO

TriTrypDb:

LdBPK_171110.1 , LdCL_170017100 , LDHU3_17.1550

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WUJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUJ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.356
CLV_NRD_NRD_1	267	269	PF00675	0.415
CLV_NRD_NRD_1	279	281	PF00675	0.528
CLV_NRD_NRD_1	40	42	PF00675	0.435
CLV_PCSK_KEX2_1	169	171	PF00082	0.427
CLV_PCSK_KEX2_1	267	269	PF00082	0.385
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.427
CLV_PCSK_SKI1_1	301	305	PF00082	0.326
DEG_APCC_DBOX_1	191	199	PF00400	0.431
DEG_SCF_TRCP1_1	94	99	PF00400	0.376
DOC_CKS1_1	104	109	PF01111	0.395
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.291
DOC_MAPK_gen_1	169	176	PF00069	0.289
DOC_MAPK_gen_1	267	277	PF00069	0.377
DOC_MAPK_gen_1	328	336	PF00069	0.417
DOC_MAPK_JIP1_4	200	206	PF00069	0.271
DOC_MAPK_MEF2A_6	268	277	PF00069	0.288
DOC_MAPK_MEF2A_6	328	336	PF00069	0.496
DOC_PP1_RVXF_1	299	306	PF00149	0.404
DOC_PP2B_LxvP_1	283	286	PF13499	0.318
DOC_USP7_MATH_1	244	248	PF00917	0.264
DOC_WW_Pin1_4	103	108	PF00397	0.342
DOC_WW_Pin1_4	115	120	PF00397	0.353
DOC_WW_Pin1_4	239	244	PF00397	0.527
LIG_14-3-3_CanoR_1	170	175	PF00244	0.286
LIG_14-3-3_CanoR_1	192	196	PF00244	0.339
LIG_14-3-3_CanoR_1	36	45	PF00244	0.405
LIG_Actin_WH2_2	191	209	PF00022	0.278
LIG_Actin_WH2_2	317	332	PF00022	0.253
LIG_BRCT_BRCA1_1	97	101	PF00533	0.334
LIG_Clathr_ClatBox_1	87	91	PF01394	0.190
LIG_FHA_1	104	110	PF00498	0.299
LIG_FHA_1	192	198	PF00498	0.402
LIG_FHA_2	126	132	PF00498	0.304
LIG_FHA_2	38	44	PF00498	0.381
LIG_FHA_2	48	54	PF00498	0.361
LIG_FHA_2	5	11	PF00498	0.481
LIG_FHA_2	97	103	PF00498	0.323
LIG_GBD_Chelix_1	61	69	PF00786	0.430
LIG_Integrin_RGD_1	221	223	PF01839	0.269
LIG_LIR_Apic_2	102	107	PF02991	0.391
LIG_LIR_Apic_2	182	188	PF02991	0.287
LIG_LIR_Gen_1	135	145	PF02991	0.367
LIG_LIR_Nem_3	116	120	PF02991	0.314
LIG_LIR_Nem_3	135	140	PF02991	0.389
LIG_LIR_Nem_3	29	34	PF02991	0.391
LIG_LIR_Nem_3	98	104	PF02991	0.400
LIG_NRBOX	76	82	PF00104	0.252
LIG_PDZ_Class_2	331	336	PF00595	0.505
LIG_Pex14_1	72	76	PF04695	0.247
LIG_PTB_Apo_2	80	87	PF02174	0.190
LIG_PTB_Phospho_1	80	86	PF10480	0.159
LIG_SH2_CRK	48	52	PF00017	0.444
LIG_SH2_GRB2like	287	290	PF00017	0.274
LIG_SH2_NCK_1	130	134	PF00017	0.337
LIG_SH2_PTP2	185	188	PF00017	0.286
LIG_SH2_PTP2	317	320	PF00017	0.435
LIG_SH2_SRC	287	290	PF00017	0.292
LIG_SH2_SRC	317	320	PF00017	0.455
LIG_SH2_STAT5	127	130	PF00017	0.284
LIG_SH2_STAT5	185	188	PF00017	0.298
LIG_SH2_STAT5	212	215	PF00017	0.491
LIG_SH2_STAT5	317	320	PF00017	0.389
LIG_SH2_STAT5	86	89	PF00017	0.261
LIG_SH3_1	104	110	PF00018	0.181
LIG_SH3_3	104	110	PF00018	0.181
LIG_SH3_3	300	306	PF00018	0.368
LIG_SH3_3	329	335	PF00018	0.317
LIG_SH3_3	51	57	PF00018	0.403
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.537
LIG_SUMO_SIM_par_1	193	199	PF11976	0.296
LIG_TYR_ITIM	46	51	PF00017	0.430
MOD_CDK_SPxxK_3	239	246	PF00069	0.289
MOD_CK1_1	179	185	PF00069	0.341
MOD_CK1_1	95	101	PF00069	0.331
MOD_CK2_1	257	263	PF00069	0.292
MOD_CK2_1	37	43	PF00069	0.328
MOD_Cter_Amidation	278	281	PF01082	0.471
MOD_GlcNHglycan	181	184	PF01048	0.444
MOD_GlcNHglycan	246	249	PF01048	0.353
MOD_GlcNHglycan	263	266	PF01048	0.367
MOD_GlcNHglycan	94	97	PF01048	0.340
MOD_GSK3_1	172	179	PF00069	0.264
MOD_GSK3_1	257	264	PF00069	0.480
MOD_GSK3_1	92	99	PF00069	0.332
MOD_NEK2_1	151	156	PF00069	0.332
MOD_NEK2_1	308	313	PF00069	0.373
MOD_NEK2_1	65	70	PF00069	0.366
MOD_NEK2_2	202	207	PF00069	0.283
MOD_PKA_2	191	197	PF00069	0.537
MOD_PKA_2	257	263	PF00069	0.444
MOD_PKA_2	92	98	PF00069	0.364
MOD_Plk_4	125	131	PF00069	0.300
MOD_Plk_4	65	71	PF00069	0.425
MOD_ProDKin_1	103	109	PF00069	0.342
MOD_ProDKin_1	115	121	PF00069	0.353
MOD_ProDKin_1	239	245	PF00069	0.530
TRG_ENDOCYTIC_2	317	320	PF00928	0.451
TRG_ENDOCYTIC_2	48	51	PF00928	0.338
TRG_ENDOCYTIC_2	86	89	PF00928	0.323
TRG_ER_diArg_1	266	268	PF00400	0.431
TRG_NES_CRM1_1	75	91	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	32%	78%
A0A0N0P3S4	Leptomonas seymouri	39%	92%
A0A0N1PA10	Leptomonas seymouri	42%	99%
A0A0N1PCQ2	Leptomonas seymouri	55%	100%
A0A0S4JQB3	Bodo saltans	38%	99%
A0A1X0NSR3	Trypanosomatidae	36%	75%
A0A1X0NSS6	Trypanosomatidae	41%	100%
A0A1X0NT85	Trypanosomatidae	28%	68%
A0A3Q8IAY1	Leishmania donovani	40%	100%
A0A3R7KKJ0	Trypanosoma rangeli	45%	100%
A0A3S5IRR1	Trypanosoma rangeli	32%	83%
A0A3S7WUK0	Leishmania donovani	31%	78%
A0A3S7X1K2	Leishmania donovani	41%	97%
A0A422NS41	Trypanosoma rangeli	39%	78%
A1JMX1	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	25%	100%
A4H956	Leishmania braziliensis	57%	100%
A4H959	Leishmania braziliensis	30%	100%
A4H960	Leishmania braziliensis	36%	100%
A4HGL0	Leishmania braziliensis	42%	100%
A4HXH8	Leishmania infantum	99%	100%
A4HXI1	Leishmania infantum	31%	100%
A4HXI2	Leishmania infantum	40%	100%
A4I3N6	Leishmania infantum	41%	100%
A4VQH7	Pseudomonas stutzeri (strain A1501)	27%	100%
A9W3H8	Methylorubrum extorquens (strain PA1)	27%	100%
B1ZB18	Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)	29%	100%
B7KWT4	Methylorubrum extorquens (strain CM4 / NCIMB 13688)	27%	100%
C5CN82	Variovorax paradoxus (strain S110)	26%	100%
C7CM33	Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)	27%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D5VGV3	Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059)	27%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q48MQ7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	29%	100%
Q4Q8A8	Leishmania major	43%	100%
Q4QE86	Leishmania major	40%	100%
Q4QE87	Leishmania major	30%	100%
Q4QE90	Leishmania major	88%	100%
Q54528	Streptomyces purpurascens	28%	100%
Q54809	Streptomyces peucetius	25%	100%
Q55217	Streptomyces sp. (strain C5)	25%	100%
V5AZB9	Trypanosoma cruzi	39%	78%
V5BER0	Trypanosoma cruzi	46%	100%
V5BNU9	Trypanosoma cruzi	27%	83%