Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUI7_LEIDO

TriTrypDb:

LdBPK_170980.1 , LdCL_170015800 , LDHU3_17.1410

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WUI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.473
CLV_C14_Caspase3-7	111	115	PF00656	0.446
CLV_C14_Caspase3-7	15	19	PF00656	0.401
CLV_C14_Caspase3-7	253	257	PF00656	0.513
CLV_C14_Caspase3-7	294	298	PF00656	0.435
CLV_MEL_PAP_1	220	226	PF00089	0.628
CLV_NRD_NRD_1	155	157	PF00675	0.629
CLV_NRD_NRD_1	494	496	PF00675	0.726
CLV_NRD_NRD_1	509	511	PF00675	0.619
CLV_NRD_NRD_1	559	561	PF00675	0.449
CLV_NRD_NRD_1	89	91	PF00675	0.613
CLV_PCSK_KEX2_1	155	157	PF00082	0.659
CLV_PCSK_KEX2_1	222	224	PF00082	0.675
CLV_PCSK_KEX2_1	353	355	PF00082	0.666
CLV_PCSK_KEX2_1	494	496	PF00082	0.751
CLV_PCSK_KEX2_1	509	511	PF00082	0.651
CLV_PCSK_KEX2_1	559	561	PF00082	0.489
CLV_PCSK_KEX2_1	89	91	PF00082	0.613
CLV_PCSK_KEX2_1	95	97	PF00082	0.616
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.627
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.535
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.650
CLV_PCSK_SKI1_1	32	36	PF00082	0.606
CLV_PCSK_SKI1_1	324	328	PF00082	0.633
CLV_PCSK_SKI1_1	416	420	PF00082	0.705
CLV_PCSK_SKI1_1	494	498	PF00082	0.690
CLV_PCSK_SKI1_1	502	506	PF00082	0.706
CLV_Separin_Metazoa	43	47	PF03568	0.355
DEG_COP1_1	528	536	PF00400	0.441
DOC_MAPK_gen_1	316	323	PF00069	0.479
DOC_MAPK_gen_1	509	521	PF00069	0.492
DOC_PP4_FxxP_1	311	314	PF00568	0.487
DOC_USP7_MATH_1	10	14	PF00917	0.394
DOC_USP7_MATH_1	119	123	PF00917	0.382
DOC_USP7_MATH_1	2	6	PF00917	0.485
DOC_USP7_MATH_1	228	232	PF00917	0.563
DOC_USP7_MATH_1	250	254	PF00917	0.441
DOC_USP7_MATH_1	461	465	PF00917	0.523
DOC_USP7_MATH_1	482	486	PF00917	0.444
DOC_USP7_MATH_1	527	531	PF00917	0.508
DOC_WW_Pin1_4	134	139	PF00397	0.463
DOC_WW_Pin1_4	141	146	PF00397	0.399
DOC_WW_Pin1_4	183	188	PF00397	0.559
DOC_WW_Pin1_4	235	240	PF00397	0.478
DOC_WW_Pin1_4	423	428	PF00397	0.432
LIG_14-3-3_CanoR_1	155	164	PF00244	0.409
LIG_14-3-3_CanoR_1	223	227	PF00244	0.386
LIG_14-3-3_CanoR_1	237	243	PF00244	0.374
LIG_14-3-3_CanoR_1	331	335	PF00244	0.452
LIG_14-3-3_CanoR_1	354	358	PF00244	0.361
LIG_14-3-3_CanoR_1	367	376	PF00244	0.410
LIG_14-3-3_CanoR_1	465	474	PF00244	0.500
LIG_14-3-3_CanoR_1	67	71	PF00244	0.445
LIG_14-3-3_CterR_2	559	561	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BIR_III_1	1	5	PF00653	0.501
LIG_BIR_III_3	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	121	125	PF00533	0.386
LIG_BRCT_BRCA1_1	231	235	PF00533	0.456
LIG_BRCT_BRCA1_1	472	476	PF00533	0.495
LIG_deltaCOP1_diTrp_1	159	164	PF00928	0.509
LIG_deltaCOP1_diTrp_1	304	311	PF00928	0.489
LIG_FHA_1	111	117	PF00498	0.505
LIG_FHA_1	261	267	PF00498	0.503
LIG_FHA_1	400	406	PF00498	0.513
LIG_FHA_1	521	527	PF00498	0.574
LIG_FHA_1	535	541	PF00498	0.269
LIG_FHA_2	106	112	PF00498	0.580
LIG_FHA_2	171	177	PF00498	0.462
LIG_FHA_2	267	273	PF00498	0.457
LIG_FHA_2	292	298	PF00498	0.474
LIG_FHA_2	434	440	PF00498	0.425
LIG_FHA_2	513	519	PF00498	0.568
LIG_LIR_Apic_2	308	314	PF02991	0.497
LIG_LIR_Apic_2	528	534	PF02991	0.461
LIG_LIR_Gen_1	172	183	PF02991	0.469
LIG_LIR_Gen_1	194	205	PF02991	0.497
LIG_LIR_Gen_1	256	267	PF02991	0.452
LIG_LIR_Gen_1	304	314	PF02991	0.497
LIG_LIR_Gen_1	436	443	PF02991	0.509
LIG_LIR_Nem_3	194	200	PF02991	0.502
LIG_LIR_Nem_3	256	262	PF02991	0.448
LIG_LIR_Nem_3	304	309	PF02991	0.490
LIG_LIR_Nem_3	374	380	PF02991	0.416
LIG_LIR_Nem_3	436	440	PF02991	0.437
LIG_LIR_Nem_3	80	86	PF02991	0.408
LIG_REV1ctd_RIR_1	324	333	PF16727	0.473
LIG_SH2_CRK	489	493	PF00017	0.434
LIG_SH2_CRK	531	535	PF00017	0.487
LIG_SH2_NCK_1	249	253	PF00017	0.487
LIG_SH2_NCK_1	489	493	PF00017	0.483
LIG_SH2_NCK_1	531	535	PF00017	0.456
LIG_SH2_STAP1	171	175	PF00017	0.440
LIG_SH2_STAT5	197	200	PF00017	0.486
LIG_SH2_STAT5	258	261	PF00017	0.409
LIG_SH2_STAT5	86	89	PF00017	0.424
LIG_SH3_3	402	408	PF00018	0.550
LIG_SH3_3	421	427	PF00018	0.395
LIG_SH3_3	516	522	PF00018	0.527
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.428
LIG_SUMO_SIM_anti_2	341	346	PF11976	0.427
LIG_TRAF2_1	468	471	PF00917	0.497
LIG_UBA3_1	207	211	PF00899	0.382
LIG_UBA3_1	216	222	PF00899	0.352
LIG_WRC_WIRS_1	49	54	PF05994	0.445
MOD_CDK_SPxxK_3	134	141	PF00069	0.445
MOD_CK1_1	100	106	PF00069	0.520
MOD_CK1_1	110	116	PF00069	0.490
MOD_CK1_1	189	195	PF00069	0.581
MOD_CK1_1	238	244	PF00069	0.582
MOD_CK1_1	291	297	PF00069	0.455
MOD_CK1_1	464	470	PF00069	0.476
MOD_CK1_1	532	538	PF00069	0.474
MOD_CK2_1	16	22	PF00069	0.400
MOD_CK2_1	266	272	PF00069	0.453
MOD_CK2_1	330	336	PF00069	0.460
MOD_CK2_1	353	359	PF00069	0.411
MOD_CK2_1	464	470	PF00069	0.602
MOD_CMANNOS	161	164	PF00535	0.664
MOD_GlcNHglycan	121	124	PF01048	0.732
MOD_GlcNHglycan	167	170	PF01048	0.663
MOD_GlcNHglycan	18	21	PF01048	0.698
MOD_GlcNHglycan	191	194	PF01048	0.651
MOD_GlcNHglycan	263	266	PF01048	0.641
MOD_GlcNHglycan	99	102	PF01048	0.667
MOD_GSK3_1	10	17	PF00069	0.492
MOD_GSK3_1	182	189	PF00069	0.442
MOD_GSK3_1	229	236	PF00069	0.518
MOD_GSK3_1	237	244	PF00069	0.545
MOD_GSK3_1	250	257	PF00069	0.460
MOD_GSK3_1	291	298	PF00069	0.541
MOD_GSK3_1	367	374	PF00069	0.455
MOD_GSK3_1	461	468	PF00069	0.536
MOD_GSK3_1	525	532	PF00069	0.467
MOD_GSK3_1	66	73	PF00069	0.561
MOD_LATS_1	274	280	PF00433	0.439
MOD_LATS_1	351	357	PF00433	0.408
MOD_N-GLC_1	119	124	PF02516	0.634
MOD_N-GLC_1	70	75	PF02516	0.665
MOD_NEK2_1	369	374	PF00069	0.444
MOD_NEK2_1	390	395	PF00069	0.533
MOD_NEK2_1	476	481	PF00069	0.497
MOD_NEK2_1	66	71	PF00069	0.530
MOD_PIKK_1	367	373	PF00454	0.504
MOD_PIKK_1	451	457	PF00454	0.546
MOD_PKA_1	155	161	PF00069	0.419
MOD_PKA_1	222	228	PF00069	0.432
MOD_PKA_1	353	359	PF00069	0.328
MOD_PKA_2	155	161	PF00069	0.501
MOD_PKA_2	222	228	PF00069	0.467
MOD_PKA_2	299	305	PF00069	0.466
MOD_PKA_2	330	336	PF00069	0.490
MOD_PKA_2	353	359	PF00069	0.396
MOD_PKA_2	464	470	PF00069	0.577
MOD_PKA_2	476	482	PF00069	0.479
MOD_PKA_2	66	72	PF00069	0.509
MOD_Plk_1	105	111	PF00069	0.524
MOD_Plk_1	47	53	PF00069	0.426
MOD_Plk_1	470	476	PF00069	0.497
MOD_Plk_2-3	74	80	PF00069	0.445
MOD_Plk_4	222	228	PF00069	0.442
MOD_Plk_4	250	256	PF00069	0.429
MOD_Plk_4	276	282	PF00069	0.481
MOD_Plk_4	330	336	PF00069	0.541
MOD_Plk_4	353	359	PF00069	0.424
MOD_Plk_4	372	378	PF00069	0.372
MOD_Plk_4	385	391	PF00069	0.402
MOD_Plk_4	433	439	PF00069	0.516
MOD_Plk_4	470	476	PF00069	0.497
MOD_Plk_4	48	54	PF00069	0.393
MOD_ProDKin_1	134	140	PF00069	0.461
MOD_ProDKin_1	141	147	PF00069	0.398
MOD_ProDKin_1	183	189	PF00069	0.561
MOD_ProDKin_1	235	241	PF00069	0.477
MOD_ProDKin_1	423	429	PF00069	0.433
MOD_SUMO_for_1	132	135	PF00179	0.419
MOD_SUMO_rev_2	91	97	PF00179	0.539
TRG_DiLeu_BaEn_2	47	53	PF01217	0.388
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.492
TRG_ENDOCYTIC_2	197	200	PF00928	0.556
TRG_ENDOCYTIC_2	377	380	PF00928	0.452
TRG_ENDOCYTIC_2	489	492	PF00928	0.455
TRG_ER_diArg_1	154	156	PF00400	0.417
TRG_ER_diArg_1	494	496	PF00400	0.546
TRG_ER_diArg_1	558	560	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P605	Leptomonas seymouri	35%	100%
A0A1X0NTG4	Trypanosomatidae	24%	100%
A4H941	Leishmania braziliensis	72%	100%
A4HXG6	Leishmania infantum	99%	100%
C9ZP51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AR61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEA2	Leishmania major	91%	100%