MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUI6_LEIDO

TriTrypDb:

LdBPK_171130.1 , LdCL_170017400 , LDHU3_17.1580

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	535	539	PF00656	0.411
CLV_C14_Caspase3-7	641	645	PF00656	0.539
CLV_C14_Caspase3-7	782	786	PF00656	0.389
CLV_MEL_PAP_1	112	118	PF00089	0.648
CLV_NRD_NRD_1	131	133	PF00675	0.581
CLV_NRD_NRD_1	146	148	PF00675	0.559
CLV_NRD_NRD_1	296	298	PF00675	0.611
CLV_NRD_NRD_1	418	420	PF00675	0.645
CLV_NRD_NRD_1	427	429	PF00675	0.559
CLV_NRD_NRD_1	755	757	PF00675	0.469
CLV_PCSK_KEX2_1	131	133	PF00082	0.581
CLV_PCSK_KEX2_1	146	148	PF00082	0.559
CLV_PCSK_KEX2_1	433	435	PF00082	0.586
CLV_PCSK_KEX2_1	755	757	PF00082	0.469
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.586
CLV_PCSK_SKI1_1	671	675	PF00082	0.407
CLV_PCSK_SKI1_1	713	717	PF00082	0.401
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DEG_SCF_TRCP1_1	250	255	PF00400	0.542
DOC_ANK_TNKS_1	56	63	PF00023	0.585
DOC_MAPK_gen_1	146	154	PF00069	0.608
DOC_MAPK_gen_1	433	439	PF00069	0.587
DOC_MAPK_MEF2A_6	794	803	PF00069	0.401
DOC_PP2B_PxIxI_1	489	495	PF00149	0.491
DOC_PP4_FxxP_1	216	219	PF00568	0.637
DOC_PP4_FxxP_1	91	94	PF00568	0.566
DOC_USP7_MATH_1	189	193	PF00917	0.636
DOC_USP7_MATH_1	235	239	PF00917	0.632
DOC_USP7_MATH_1	278	282	PF00917	0.501
DOC_USP7_MATH_1	381	385	PF00917	0.731
DOC_USP7_MATH_1	457	461	PF00917	0.690
DOC_USP7_MATH_1	568	572	PF00917	0.371
DOC_USP7_UBL2_3	429	433	PF12436	0.581
DOC_USP7_UBL2_3	570	574	PF12436	0.361
DOC_WW_Pin1_4	255	260	PF00397	0.619
DOC_WW_Pin1_4	486	491	PF00397	0.509
DOC_WW_Pin1_4	615	620	PF00397	0.346
DOC_WW_Pin1_4	652	657	PF00397	0.475
DOC_WW_Pin1_4	69	74	PF00397	0.796
DOC_WW_Pin1_4	809	814	PF00397	0.443
LIG_14-3-3_CanoR_1	170	175	PF00244	0.654
LIG_14-3-3_CanoR_1	203	209	PF00244	0.634
LIG_14-3-3_CanoR_1	330	336	PF00244	0.646
LIG_14-3-3_CanoR_1	419	424	PF00244	0.676
LIG_14-3-3_CanoR_1	428	437	PF00244	0.657
LIG_14-3-3_CanoR_1	522	528	PF00244	0.515
LIG_14-3-3_CanoR_1	722	730	PF00244	0.386
LIG_APCC_ABBA_1	83	88	PF00400	0.619
LIG_BIR_III_2	396	400	PF00653	0.675
LIG_BRCT_BRCA1_1	301	305	PF00533	0.497
LIG_BRCT_BRCA1_1	581	585	PF00533	0.460
LIG_BRCT_BRCA1_1	617	621	PF00533	0.340
LIG_BRCT_BRCA1_1	686	690	PF00533	0.321
LIG_Clathr_ClatBox_1	801	805	PF01394	0.362
LIG_deltaCOP1_diTrp_1	562	566	PF00928	0.384
LIG_EH1_1	511	519	PF00400	0.408
LIG_EVH1_2	606	610	PF00568	0.471
LIG_FHA_1	108	114	PF00498	0.557
LIG_FHA_1	353	359	PF00498	0.668
LIG_FHA_1	471	477	PF00498	0.502
LIG_FHA_1	586	592	PF00498	0.377
LIG_FHA_1	665	671	PF00498	0.395
LIG_FHA_1	768	774	PF00498	0.441
LIG_FHA_2	406	412	PF00498	0.609
LIG_FHA_2	581	587	PF00498	0.436
LIG_FHA_2	612	618	PF00498	0.422
LIG_Integrin_RGD_1	266	268	PF01839	0.556
LIG_LIR_Apic_2	215	219	PF02991	0.636
LIG_LIR_Apic_2	88	94	PF02991	0.567
LIG_LIR_Gen_1	103	112	PF02991	0.658
LIG_LIR_Gen_1	134	142	PF02991	0.676
LIG_LIR_Gen_1	561	572	PF02991	0.332
LIG_LIR_Gen_1	638	647	PF02991	0.360
LIG_LIR_Gen_1	737	746	PF02991	0.408
LIG_LIR_Gen_1	81	86	PF02991	0.605
LIG_LIR_Nem_3	134	138	PF02991	0.815
LIG_LIR_Nem_3	210	216	PF02991	0.643
LIG_LIR_Nem_3	302	308	PF02991	0.570
LIG_LIR_Nem_3	561	567	PF02991	0.339
LIG_LIR_Nem_3	576	580	PF02991	0.523
LIG_LIR_Nem_3	618	624	PF02991	0.361
LIG_LIR_Nem_3	638	642	PF02991	0.269
LIG_LIR_Nem_3	737	743	PF02991	0.413
LIG_PALB2_WD40_1	559	567	PF16756	0.393
LIG_PDZ_Class_1	817	822	PF00595	0.429
LIG_PTB_Apo_2	76	83	PF02174	0.655
LIG_SH2_CRK	701	705	PF00017	0.355
LIG_SH2_GRB2like	519	522	PF00017	0.443
LIG_SH2_PTP2	630	633	PF00017	0.357
LIG_SH2_STAT5	438	441	PF00017	0.586
LIG_SH2_STAT5	519	522	PF00017	0.443
LIG_SH2_STAT5	6	9	PF00017	0.626
LIG_SH2_STAT5	630	633	PF00017	0.381
LIG_SH2_STAT5	742	745	PF00017	0.389
LIG_SH3_3	39	45	PF00018	0.752
LIG_SH3_3	58	64	PF00018	0.580
LIG_SH3_3	706	712	PF00018	0.383
LIG_SUMO_SIM_anti_2	797	803	PF11976	0.431
LIG_SxIP_EBH_1	766	777	PF03271	0.418
LIG_TRAF2_1	532	535	PF00917	0.432
LIG_TYR_ITIM	699	704	PF00017	0.356
LIG_WRC_WIRS_1	101	106	PF05994	0.669
LIG_WRC_WIRS_1	116	121	PF05994	0.591
LIG_WRC_WIRS_1	213	218	PF05994	0.636
MOD_CK1_1	103	109	PF00069	0.654
MOD_CK1_1	134	140	PF00069	0.740
MOD_CK1_1	141	147	PF00069	0.652
MOD_CK1_1	157	163	PF00069	0.560
MOD_CK1_1	173	179	PF00069	0.797
MOD_CK1_1	212	218	PF00069	0.639
MOD_CK1_1	238	244	PF00069	0.603
MOD_CK1_1	251	257	PF00069	0.591
MOD_CK1_1	258	264	PF00069	0.480
MOD_CK1_1	291	297	PF00069	0.579
MOD_CK1_1	400	406	PF00069	0.712
MOD_CK1_1	529	535	PF00069	0.497
MOD_CK1_1	676	682	PF00069	0.429
MOD_CK1_1	723	729	PF00069	0.381
MOD_CK2_1	405	411	PF00069	0.655
MOD_CK2_1	529	535	PF00069	0.444
MOD_CK2_1	580	586	PF00069	0.400
MOD_CK2_1	611	617	PF00069	0.431
MOD_CK2_1	676	682	PF00069	0.490
MOD_CK2_1	747	753	PF00069	0.431
MOD_CMANNOS	563	566	PF00535	0.314
MOD_Cter_Amidation	417	420	PF01082	0.682
MOD_GlcNHglycan	119	122	PF01048	0.625
MOD_GlcNHglycan	140	143	PF01048	0.647
MOD_GlcNHglycan	149	152	PF01048	0.676
MOD_GlcNHglycan	15	18	PF01048	0.583
MOD_GlcNHglycan	187	190	PF01048	0.616
MOD_GlcNHglycan	191	194	PF01048	0.604
MOD_GlcNHglycan	250	253	PF01048	0.679
MOD_GlcNHglycan	254	257	PF01048	0.662
MOD_GlcNHglycan	290	293	PF01048	0.683
MOD_GlcNHglycan	301	304	PF01048	0.439
MOD_GlcNHglycan	383	386	PF01048	0.600
MOD_GlcNHglycan	388	392	PF01048	0.809
MOD_GlcNHglycan	459	462	PF01048	0.673
MOD_GlcNHglycan	464	467	PF01048	0.653
MOD_GlcNHglycan	483	487	PF01048	0.380
MOD_GlcNHglycan	54	57	PF01048	0.752
MOD_GlcNHglycan	555	558	PF01048	0.426
MOD_GlcNHglycan	678	681	PF01048	0.475
MOD_GlcNHglycan	691	694	PF01048	0.365
MOD_GlcNHglycan	760	763	PF01048	0.420
MOD_GlcNHglycan	9	12	PF01048	0.590
MOD_GSK3_1	103	110	PF00069	0.580
MOD_GSK3_1	133	140	PF00069	0.788
MOD_GSK3_1	185	192	PF00069	0.641
MOD_GSK3_1	199	206	PF00069	0.610
MOD_GSK3_1	248	255	PF00069	0.615
MOD_GSK3_1	397	404	PF00069	0.678
MOD_GSK3_1	424	431	PF00069	0.651
MOD_GSK3_1	468	475	PF00069	0.476
MOD_GSK3_1	482	489	PF00069	0.436
MOD_GSK3_1	495	502	PF00069	0.494
MOD_GSK3_1	558	565	PF00069	0.355
MOD_GSK3_1	611	618	PF00069	0.369
MOD_GSK3_1	672	679	PF00069	0.396
MOD_GSK3_1	685	692	PF00069	0.419
MOD_GSK3_1	720	727	PF00069	0.428
MOD_GSK3_1	747	754	PF00069	0.384
MOD_N-GLC_1	204	209	PF02516	0.516
MOD_N-GLC_1	405	410	PF02516	0.670
MOD_N-GLC_1	424	429	PF02516	0.549
MOD_N-GLC_1	462	467	PF02516	0.581
MOD_N-GLC_1	611	616	PF02516	0.393
MOD_NEK2_1	107	112	PF00069	0.535
MOD_NEK2_1	154	159	PF00069	0.659
MOD_NEK2_1	168	173	PF00069	0.548
MOD_NEK2_1	185	190	PF00069	0.657
MOD_NEK2_1	248	253	PF00069	0.755
MOD_NEK2_1	354	359	PF00069	0.641
MOD_NEK2_1	472	477	PF00069	0.442
MOD_NEK2_1	481	486	PF00069	0.381
MOD_NEK2_1	52	57	PF00069	0.674
MOD_NEK2_1	580	585	PF00069	0.431
MOD_NEK2_1	587	592	PF00069	0.300
MOD_NEK2_1	611	616	PF00069	0.460
MOD_NEK2_1	643	648	PF00069	0.379
MOD_NEK2_1	715	720	PF00069	0.432
MOD_NEK2_2	180	185	PF00069	0.685
MOD_PIKK_1	124	130	PF00454	0.599
MOD_PIKK_1	157	163	PF00454	0.684
MOD_PIKK_1	219	225	PF00454	0.614
MOD_PIKK_1	329	335	PF00454	0.744
MOD_PIKK_1	365	371	PF00454	0.634
MOD_PIKK_1	580	586	PF00454	0.444
MOD_PIKK_1	673	679	PF00454	0.470
MOD_PK_1	297	303	PF00069	0.507
MOD_PK_1	419	425	PF00069	0.662
MOD_PKA_1	131	137	PF00069	0.559
MOD_PKA_1	297	303	PF00069	0.557
MOD_PKA_1	419	425	PF00069	0.640
MOD_PKA_1	428	434	PF00069	0.553
MOD_PKA_2	131	137	PF00069	0.559
MOD_PKA_2	329	335	PF00069	0.750
MOD_PKA_2	381	387	PF00069	0.552
MOD_PKA_2	499	505	PF00069	0.454
MOD_PKA_2	52	58	PF00069	0.671
MOD_PKA_2	521	527	PF00069	0.479
MOD_PKA_2	558	564	PF00069	0.399
MOD_PKA_2	747	753	PF00069	0.545
MOD_Plk_1	204	210	PF00069	0.516
MOD_Plk_1	404	410	PF00069	0.653
MOD_Plk_1	585	591	PF00069	0.315
MOD_Plk_1	611	617	PF00069	0.392
MOD_Plk_1	643	649	PF00069	0.378
MOD_Plk_2-3	405	411	PF00069	0.655
MOD_Plk_4	180	186	PF00069	0.650
MOD_Plk_4	476	482	PF00069	0.382
MOD_Plk_4	568	574	PF00069	0.355
MOD_Plk_4	685	691	PF00069	0.370
MOD_Plk_4	715	721	PF00069	0.416
MOD_Plk_4	78	84	PF00069	0.661
MOD_ProDKin_1	255	261	PF00069	0.621
MOD_ProDKin_1	486	492	PF00069	0.500
MOD_ProDKin_1	615	621	PF00069	0.342
MOD_ProDKin_1	652	658	PF00069	0.474
MOD_ProDKin_1	69	75	PF00069	0.794
MOD_ProDKin_1	809	815	PF00069	0.451
MOD_SUMO_rev_2	778	786	PF00179	0.458
TRG_DiLeu_BaEn_1	797	802	PF01217	0.430
TRG_ENDOCYTIC_2	174	177	PF00928	0.641
TRG_ENDOCYTIC_2	213	216	PF00928	0.576
TRG_ENDOCYTIC_2	5	8	PF00928	0.629
TRG_ENDOCYTIC_2	630	633	PF00928	0.357
TRG_ENDOCYTIC_2	701	704	PF00928	0.353
TRG_ENDOCYTIC_2	717	720	PF00928	0.418
TRG_ER_diArg_1	145	147	PF00400	0.610
TRG_ER_diArg_1	755	757	PF00400	0.419
TRG_ER_diArg_1	774	777	PF00400	0.452
TRG_NES_CRM1_1	268	280	PF08389	0.522
TRG_NES_CRM1_1	795	808	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHP8	Leptomonas seymouri	58%	100%
A0A1X0NU85	Trypanosomatidae	38%	100%
A4H958	Leishmania braziliensis	77%	100%
A4HXI0	Leishmania infantum	100%	100%
E9AR75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE88	Leishmania major	93%	100%