Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUI4_LEIDO

TriTrypDb:

LdBPK_170820.1 , LdCL_170014200 , LDHU3_17.1210

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WUI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.598
CLV_MEL_PAP_1	198	204	PF00089	0.405
CLV_NRD_NRD_1	358	360	PF00675	0.437
CLV_NRD_NRD_1	367	369	PF00675	0.407
CLV_NRD_NRD_1	388	390	PF00675	0.562
CLV_NRD_NRD_1	431	433	PF00675	0.395
CLV_PCSK_FUR_1	365	369	PF00082	0.429
CLV_PCSK_KEX2_1	323	325	PF00082	0.432
CLV_PCSK_KEX2_1	358	360	PF00082	0.424
CLV_PCSK_KEX2_1	367	369	PF00082	0.415
CLV_PCSK_KEX2_1	387	389	PF00082	0.564
CLV_PCSK_KEX2_1	90	92	PF00082	0.450
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.471
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.435
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.434
CLV_PCSK_SKI1_1	266	270	PF00082	0.334
CLV_PCSK_SKI1_1	304	308	PF00082	0.427
CLV_PCSK_SKI1_1	323	327	PF00082	0.413
CLV_PCSK_SKI1_1	336	340	PF00082	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.641
DOC_CKS1_1	30	35	PF01111	0.406
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.419
DOC_MAPK_gen_1	213	223	PF00069	0.548
DOC_MAPK_gen_1	333	343	PF00069	0.610
DOC_MAPK_MEF2A_6	214	223	PF00069	0.540
DOC_MAPK_MEF2A_6	411	418	PF00069	0.633
DOC_PP1_RVXF_1	199	205	PF00149	0.611
DOC_PP1_RVXF_1	302	308	PF00149	0.610
DOC_PP1_RVXF_1	82	89	PF00149	0.566
DOC_PP2B_LxvP_1	130	133	PF13499	0.389
DOC_PP2B_LxvP_1	240	243	PF13499	0.434
DOC_PP2B_LxvP_1	47	50	PF13499	0.380
DOC_PP4_FxxP_1	247	250	PF00568	0.360
DOC_PP4_FxxP_1	280	283	PF00568	0.648
DOC_USP7_MATH_1	120	124	PF00917	0.429
DOC_USP7_MATH_1	169	173	PF00917	0.443
DOC_USP7_MATH_1	227	231	PF00917	0.449
DOC_USP7_UBL2_3	356	360	PF12436	0.681
DOC_WW_Pin1_4	148	153	PF00397	0.413
DOC_WW_Pin1_4	2	7	PF00397	0.642
DOC_WW_Pin1_4	29	34	PF00397	0.414
LIG_14-3-3_CanoR_1	103	109	PF00244	0.558
LIG_14-3-3_CanoR_1	196	204	PF00244	0.573
LIG_14-3-3_CanoR_1	368	374	PF00244	0.719
LIG_14-3-3_CanoR_1	387	392	PF00244	0.783
LIG_Actin_WH2_2	252	268	PF00022	0.420
LIG_APCC_ABBA_1	341	346	PF00400	0.648
LIG_APCC_ABBA_1	51	56	PF00400	0.427
LIG_Clathr_ClatBox_1	176	180	PF01394	0.427
LIG_FHA_1	108	114	PF00498	0.579
LIG_FHA_1	137	143	PF00498	0.403
LIG_FHA_1	180	186	PF00498	0.372
LIG_FHA_1	2	8	PF00498	0.679
LIG_FHA_1	235	241	PF00498	0.395
LIG_FHA_1	260	266	PF00498	0.474
LIG_FHA_1	313	319	PF00498	0.684
LIG_FHA_2	306	312	PF00498	0.627
LIG_FHA_2	388	394	PF00498	0.694
LIG_LIR_Gen_1	190	198	PF02991	0.480
LIG_LIR_Gen_1	75	83	PF02991	0.621
LIG_LIR_Nem_3	102	108	PF02991	0.627
LIG_LIR_Nem_3	190	195	PF02991	0.490
LIG_LIR_Nem_3	75	79	PF02991	0.539
LIG_MYND_1	250	254	PF01753	0.336
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.566
LIG_RPA_C_Insects	86	101	PF08784	0.471
LIG_SH2_SRC	76	79	PF00017	0.465
LIG_SH2_STAP1	238	242	PF00017	0.523
LIG_SH2_STAP1	328	332	PF00017	0.496
LIG_SH2_STAT3	285	288	PF00017	0.584
LIG_SH2_STAT3	54	57	PF00017	0.476
LIG_SH2_STAT5	128	131	PF00017	0.342
LIG_SH2_STAT5	251	254	PF00017	0.340
LIG_SH2_STAT5	76	79	PF00017	0.536
LIG_SH3_3	280	286	PF00018	0.587
LIG_SH3_3	77	83	PF00018	0.468
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.524
LIG_SUMO_SIM_par_1	151	156	PF11976	0.485
LIG_TRAF2_1	398	401	PF00917	0.733
LIG_WRC_WIRS_1	105	110	PF05994	0.589
LIG_WRC_WIRS_1	137	142	PF05994	0.486
MOD_CDK_SPxxK_3	2	9	PF00069	0.550
MOD_CK1_1	107	113	PF00069	0.516
MOD_CK1_1	123	129	PF00069	0.285
MOD_CK1_1	164	170	PF00069	0.624
MOD_CK1_1	172	178	PF00069	0.390
MOD_CK1_1	260	266	PF00069	0.346
MOD_CK1_1	29	35	PF00069	0.567
MOD_CK1_1	379	385	PF00069	0.705
MOD_CK1_1	406	412	PF00069	0.666
MOD_CK2_1	391	397	PF00069	0.730
MOD_CK2_1	406	412	PF00069	0.665
MOD_GlcNHglycan	122	125	PF01048	0.420
MOD_GlcNHglycan	171	174	PF01048	0.628
MOD_GlcNHglycan	259	262	PF01048	0.436
MOD_GlcNHglycan	39	42	PF01048	0.425
MOD_GlcNHglycan	393	397	PF01048	0.783
MOD_GSK3_1	119	126	PF00069	0.181
MOD_GSK3_1	161	168	PF00069	0.626
MOD_GSK3_1	175	182	PF00069	0.360
MOD_GSK3_1	260	267	PF00069	0.334
MOD_GSK3_1	314	321	PF00069	0.601
MOD_GSK3_1	387	394	PF00069	0.753
MOD_GSK3_1	403	410	PF00069	0.636
MOD_N-GLC_1	270	275	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	12	17	PF00069	0.439
MOD_NEK2_1	153	158	PF00069	0.497
MOD_NEK2_1	165	170	PF00069	0.596
MOD_NEK2_1	257	262	PF00069	0.321
MOD_NEK2_1	305	310	PF00069	0.507
MOD_NEK2_1	369	374	PF00069	0.606
MOD_NEK2_1	37	42	PF00069	0.384
MOD_NEK2_1	391	396	PF00069	0.720
MOD_NEK2_2	187	192	PF00069	0.380
MOD_PIKK_1	196	202	PF00454	0.434
MOD_PIKK_1	318	324	PF00454	0.527
MOD_PIKK_1	379	385	PF00454	0.660
MOD_PKA_1	387	393	PF00069	0.575
MOD_PKA_2	387	393	PF00069	0.678
MOD_Plk_4	12	18	PF00069	0.380
MOD_Plk_4	123	129	PF00069	0.324
MOD_Plk_4	136	142	PF00069	0.393
MOD_Plk_4	172	178	PF00069	0.317
MOD_Plk_4	227	233	PF00069	0.333
MOD_Plk_4	264	270	PF00069	0.417
MOD_ProDKin_1	148	154	PF00069	0.513
MOD_ProDKin_1	2	8	PF00069	0.553
MOD_ProDKin_1	29	35	PF00069	0.514
TRG_ENDOCYTIC_2	76	79	PF00928	0.411
TRG_ER_diArg_1	367	369	PF00400	0.565
TRG_ER_diArg_1	386	389	PF00400	0.742
TRG_ER_diArg_1	426	429	PF00400	0.554
TRG_NLS_MonoCore_2	357	362	PF00514	0.608
TRG_NLS_MonoExtN_4	356	363	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N4	Leptomonas seymouri	61%	94%
A0A0S4KHH7	Bodo saltans	36%	90%
A0A1X0NTB3	Trypanosomatidae	48%	100%
A4H918	Leishmania braziliensis	84%	100%
A4HXF0	Leishmania infantum	100%	100%
C9ZP21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AR45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEB8	Leishmania major	98%	100%
V5BFE7	Trypanosoma cruzi	46%	100%