ER membrane protein complex subunit 2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUH2_LEIDO

TriTrypDb:

LdBPK_170230.1 , LdCL_170007800 , LDHU3_17.0440

Length:

317

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, ER Membrane complex EMC2 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WUH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.435
CLV_MEL_PAP_1	91	97	PF00089	0.383
CLV_NRD_NRD_1	297	299	PF00675	0.447
CLV_PCSK_KEX2_1	229	231	PF00082	0.359
CLV_PCSK_KEX2_1	297	299	PF00082	0.448
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.390
CLV_PCSK_SKI1_1	200	204	PF00082	0.315
CLV_PCSK_SKI1_1	26	30	PF00082	0.289
CLV_PCSK_SKI1_1	43	47	PF00082	0.282
CLV_Separin_Metazoa	264	268	PF03568	0.334
DOC_CYCLIN_RxL_1	101	111	PF00134	0.399
DOC_CYCLIN_RxL_1	39	50	PF00134	0.432
DOC_MAPK_gen_1	94	102	PF00069	0.340
DOC_USP7_MATH_1	53	57	PF00917	0.414
DOC_WW_Pin1_4	11	16	PF00397	0.371
LIG_14-3-3_CanoR_1	101	108	PF00244	0.369
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BIR_III_2	180	184	PF00653	0.302
LIG_BRCT_BRCA1_1	241	245	PF00533	0.428
LIG_eIF4E_1	204	210	PF01652	0.406
LIG_eIF4E_1	239	245	PF01652	0.421
LIG_FHA_1	283	289	PF00498	0.390
LIG_FHA_1	301	307	PF00498	0.490
LIG_FHA_1	47	53	PF00498	0.320
LIG_FHA_1	83	89	PF00498	0.413
LIG_FHA_2	12	18	PF00498	0.376
LIG_FHA_2	162	168	PF00498	0.393
LIG_FHA_2	170	176	PF00498	0.300
LIG_FHA_2	182	188	PF00498	0.149
LIG_Integrin_RGD_1	178	180	PF01839	0.409
LIG_LIR_Gen_1	172	181	PF02991	0.459
LIG_LIR_Gen_1	214	225	PF02991	0.326
LIG_LIR_Gen_1	66	76	PF02991	0.296
LIG_LIR_Gen_1	85	95	PF02991	0.205
LIG_LIR_Nem_3	172	176	PF02991	0.341
LIG_LIR_Nem_3	184	188	PF02991	0.251
LIG_LIR_Nem_3	214	220	PF02991	0.425
LIG_LIR_Nem_3	62	68	PF02991	0.289
LIG_LIR_Nem_3	85	90	PF02991	0.385
LIG_NRBOX	190	196	PF00104	0.423
LIG_PTB_Apo_2	187	194	PF02174	0.269
LIG_PTB_Apo_2	210	217	PF02174	0.291
LIG_PTB_Phospho_1	187	193	PF10480	0.264
LIG_PTB_Phospho_1	210	216	PF10480	0.289
LIG_SH2_GRB2like	87	90	PF00017	0.418
LIG_SH2_PTP2	173	176	PF00017	0.312
LIG_SH2_SRC	173	176	PF00017	0.472
LIG_SH2_STAP1	123	127	PF00017	0.378
LIG_SH2_STAP1	239	243	PF00017	0.269
LIG_SH2_STAP1	68	72	PF00017	0.299
LIG_SH2_STAT5	163	166	PF00017	0.320
LIG_SH2_STAT5	173	176	PF00017	0.309
LIG_SH2_STAT5	193	196	PF00017	0.166
LIG_SH2_STAT5	216	219	PF00017	0.328
LIG_SH2_STAT5	312	315	PF00017	0.444
LIG_SH2_STAT5	87	90	PF00017	0.300
LIG_SUMO_SIM_par_1	26	32	PF11976	0.411
MOD_CK1_1	57	63	PF00069	0.458
MOD_CK1_1	6	12	PF00069	0.420
MOD_CK2_1	169	175	PF00069	0.353
MOD_CK2_1	181	187	PF00069	0.307
MOD_CK2_1	57	63	PF00069	0.390
MOD_Cter_Amidation	95	98	PF01082	0.454
MOD_GlcNHglycan	140	143	PF01048	0.286
MOD_GlcNHglycan	270	273	PF01048	0.504
MOD_GlcNHglycan	306	309	PF01048	0.299
MOD_GlcNHglycan	35	38	PF01048	0.435
MOD_GlcNHglycan	56	59	PF01048	0.455
MOD_GSK3_1	300	307	PF00069	0.321
MOD_GSK3_1	53	60	PF00069	0.400
MOD_GSK3_1	96	103	PF00069	0.430
MOD_N-GLC_1	212	217	PF02516	0.475
MOD_N-GLC_1	249	254	PF02516	0.380
MOD_N-GLC_1	82	87	PF02516	0.402
MOD_NEK2_1	244	249	PF00069	0.462
MOD_NEK2_1	90	95	PF00069	0.449
MOD_NEK2_2	292	297	PF00069	0.411
MOD_NEK2_2	96	101	PF00069	0.302
MOD_PIKK_1	237	243	PF00454	0.407
MOD_PIKK_1	244	250	PF00454	0.458
MOD_PIKK_1	280	286	PF00454	0.375
MOD_PKA_2	100	106	PF00069	0.408
MOD_PKA_2	138	144	PF00069	0.300
MOD_PKA_2	33	39	PF00069	0.377
MOD_Plk_1	212	218	PF00069	0.280
MOD_Plk_1	82	88	PF00069	0.398
MOD_Plk_4	169	175	PF00069	0.382
MOD_Plk_4	212	218	PF00069	0.384
MOD_Plk_4	239	245	PF00069	0.386
MOD_Plk_4	82	88	PF00069	0.316
MOD_ProDKin_1	11	17	PF00069	0.364
MOD_SUMO_rev_2	12	21	PF00179	0.369
TRG_ENDOCYTIC_2	123	126	PF00928	0.289
TRG_ENDOCYTIC_2	173	176	PF00928	0.377
TRG_ENDOCYTIC_2	185	188	PF00928	0.229
TRG_ENDOCYTIC_2	68	71	PF00928	0.303
TRG_ENDOCYTIC_2	87	90	PF00928	0.330
TRG_ER_diArg_1	296	298	PF00400	0.447
TRG_NES_CRM1_1	63	77	PF08389	0.347
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX7	Leptomonas seymouri	83%	100%
A0A0S4J0N8	Bodo saltans	42%	100%
A0A1X0NTH4	Trypanosomatidae	55%	100%
A0A3R7KD80	Trypanosoma rangeli	51%	100%
A4H8W1	Leishmania braziliensis	92%	100%
A4HXA8	Leishmania infantum	100%	100%
B0BNG0	Rattus norvegicus	27%	100%
C9ZTV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AQY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q15006	Homo sapiens	27%	100%
Q4QEH6	Leishmania major	97%	100%
Q5E993	Bos taurus	27%	100%
Q5M7J9	Xenopus tropicalis	31%	100%
Q5R882	Pongo abelii	27%	100%
Q6INS3	Xenopus laevis	29%	100%
Q6TGY8	Danio rerio	30%	100%
Q8AVU9	Xenopus laevis	28%	100%
Q9CRD2	Mus musculus	27%	100%
V5B876	Trypanosoma cruzi	51%	100%