VID27_cytoplasmic_protein_putative/Pfam:PF08553

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VID27 cytoplasmic protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUG9_LEIDO

TriTrypDb:

LdBPK_170780.1 , LdCL_170013800 , LDHU3_17.1170

Length:

557

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, VID27 cytoplasmic

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	339	341	PF00675	0.335
CLV_NRD_NRD_1	372	374	PF00675	0.274
CLV_NRD_NRD_1	438	440	PF00675	0.447
CLV_PCSK_SKI1_1	341	345	PF00082	0.332
CLV_PCSK_SKI1_1	382	386	PF00082	0.295
DEG_SPOP_SBC_1	407	411	PF00917	0.371
DEG_SPOP_SBC_1	517	521	PF00917	0.485
DOC_CYCLIN_RxL_1	382	390	PF00134	0.318
DOC_MAPK_gen_1	439	446	PF00069	0.293
DOC_MAPK_JIP1_4	279	285	PF00069	0.335
DOC_MAPK_MEF2A_6	391	399	PF00069	0.271
DOC_PP1_RVXF_1	305	312	PF00149	0.349
DOC_PP4_FxxP_1	108	111	PF00568	0.473
DOC_PP4_FxxP_1	72	75	PF00568	0.430
DOC_USP7_MATH_1	192	196	PF00917	0.399
DOC_USP7_MATH_1	284	288	PF00917	0.409
DOC_USP7_MATH_1	295	299	PF00917	0.365
DOC_USP7_MATH_1	335	339	PF00917	0.391
DOC_USP7_MATH_1	495	499	PF00917	0.414
DOC_USP7_MATH_1	50	54	PF00917	0.453
DOC_USP7_MATH_1	87	91	PF00917	0.484
DOC_WW_Pin1_4	446	451	PF00397	0.386
LIG_14-3-3_CanoR_1	107	111	PF00244	0.412
LIG_14-3-3_CanoR_1	133	139	PF00244	0.329
LIG_14-3-3_CanoR_1	524	531	PF00244	0.424
LIG_14-3-3_CanoR_1	550	555	PF00244	0.525
LIG_APCC_ABBA_1	413	418	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	194	198	PF00533	0.363
LIG_BRCT_BRCA1_1	409	413	PF00533	0.335
LIG_BRCT_BRCA1_1	428	432	PF00533	0.335
LIG_BRCT_BRCA1_1	465	469	PF00533	0.279
LIG_CaM_NSCaTE_8	151	158	PF13499	0.491
LIG_Clathr_ClatBox_1	414	418	PF01394	0.335
LIG_FHA_1	117	123	PF00498	0.470
LIG_FHA_1	133	139	PF00498	0.285
LIG_FHA_1	158	164	PF00498	0.477
LIG_FHA_1	167	173	PF00498	0.437
LIG_FHA_1	241	247	PF00498	0.498
LIG_FHA_1	251	257	PF00498	0.335
LIG_FHA_1	3	9	PF00498	0.524
LIG_FHA_1	36	42	PF00498	0.322
LIG_FHA_1	409	415	PF00498	0.370
LIG_FHA_1	417	423	PF00498	0.327
LIG_FHA_1	473	479	PF00498	0.378
LIG_FHA_1	488	494	PF00498	0.217
LIG_FHA_1	86	92	PF00498	0.525
LIG_FHA_2	138	144	PF00498	0.386
LIG_FHA_2	157	163	PF00498	0.510
LIG_FHA_2	243	249	PF00498	0.335
LIG_FHA_2	384	390	PF00498	0.288
LIG_FHA_2	530	536	PF00498	0.333
LIG_GBD_Chelix_1	309	317	PF00786	0.404
LIG_HCF-1_HBM_1	24	27	PF13415	0.469
LIG_LIR_Apic_2	24	30	PF02991	0.450
LIG_LIR_Apic_2	332	337	PF02991	0.292
LIG_LIR_Apic_2	69	75	PF02991	0.442
LIG_LIR_Apic_2	83	87	PF02991	0.344
LIG_LIR_Gen_1	135	142	PF02991	0.411
LIG_LIR_Gen_1	195	204	PF02991	0.458
LIG_LIR_Gen_1	300	310	PF02991	0.340
LIG_LIR_Gen_1	410	421	PF02991	0.318
LIG_LIR_Gen_1	466	473	PF02991	0.349
LIG_LIR_LC3C_4	231	235	PF02991	0.441
LIG_LIR_Nem_3	135	139	PF02991	0.374
LIG_LIR_Nem_3	140	145	PF02991	0.434
LIG_LIR_Nem_3	148	154	PF02991	0.285
LIG_LIR_Nem_3	195	201	PF02991	0.387
LIG_LIR_Nem_3	300	305	PF02991	0.340
LIG_LIR_Nem_3	410	416	PF02991	0.318
LIG_LIR_Nem_3	466	472	PF02991	0.289
LIG_LIR_Nem_3	90	96	PF02991	0.397
LIG_PCNA_yPIPBox_3	121	133	PF02747	0.374
LIG_SH2_CRK	136	140	PF00017	0.351
LIG_SH2_CRK	152	156	PF00017	0.432
LIG_SH2_CRK	28	32	PF00017	0.483
LIG_SH2_CRK	302	306	PF00017	0.289
LIG_SH2_CRK	334	338	PF00017	0.335
LIG_SH2_CRK	366	370	PF00017	0.271
LIG_SH2_CRK	84	88	PF00017	0.479
LIG_SH2_GRB2like	290	293	PF00017	0.404
LIG_SH2_NCK_1	142	146	PF00017	0.453
LIG_SH2_NCK_1	334	338	PF00017	0.292
LIG_SH2_NCK_1	84	88	PF00017	0.425
LIG_SH2_SRC	142	145	PF00017	0.593
LIG_SH2_SRC	16	19	PF00017	0.559
LIG_SH2_SRC	290	293	PF00017	0.404
LIG_SH2_SRC	421	424	PF00017	0.379
LIG_SH2_SRC	60	63	PF00017	0.456
LIG_SH2_STAT5	154	157	PF00017	0.370
LIG_SH2_STAT5	302	305	PF00017	0.271
LIG_SH2_STAT5	353	356	PF00017	0.349
LIG_SH2_STAT5	366	369	PF00017	0.289
LIG_SH2_STAT5	379	382	PF00017	0.289
LIG_SH2_STAT5	405	408	PF00017	0.271
LIG_SH2_STAT5	421	424	PF00017	0.271
LIG_SH2_STAT5	487	490	PF00017	0.321
LIG_SH2_STAT5	60	63	PF00017	0.440
LIG_SH3_3	88	94	PF00018	0.407
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.374
LIG_SUMO_SIM_par_1	393	398	PF11976	0.321
LIG_SUMO_SIM_par_1	59	67	PF11976	0.483
LIG_TRAF2_1	19	22	PF00917	0.557
LIG_TRAF2_1	207	210	PF00917	0.421
LIG_TYR_ITSM	138	145	PF00017	0.440
LIG_UBA3_1	414	420	PF00899	0.335
MOD_CK1_1	137	143	PF00069	0.416
MOD_CK1_1	178	184	PF00069	0.502
MOD_CK1_1	2	8	PF00069	0.469
MOD_CK1_1	242	248	PF00069	0.335
MOD_CK1_1	300	306	PF00069	0.421
MOD_CK1_1	499	505	PF00069	0.335
MOD_CK1_1	53	59	PF00069	0.609
MOD_CK1_1	85	91	PF00069	0.387
MOD_CK2_1	1	7	PF00069	0.577
MOD_CK2_1	156	162	PF00069	0.538
MOD_CK2_1	204	210	PF00069	0.486
MOD_CK2_1	242	248	PF00069	0.382
MOD_CK2_1	53	59	PF00069	0.504
MOD_GlcNHglycan	1	4	PF01048	0.591
MOD_GlcNHglycan	260	263	PF01048	0.427
MOD_GlcNHglycan	297	300	PF01048	0.365
MOD_GlcNHglycan	358	362	PF01048	0.310
MOD_GlcNHglycan	465	468	PF01048	0.321
MOD_GlcNHglycan	501	504	PF01048	0.626
MOD_GlcNHglycan	508	511	PF01048	0.401
MOD_GlcNHglycan	520	523	PF01048	0.353
MOD_GlcNHglycan	84	87	PF01048	0.436
MOD_GSK3_1	178	185	PF00069	0.556
MOD_GSK3_1	238	245	PF00069	0.416
MOD_GSK3_1	291	298	PF00069	0.399
MOD_GSK3_1	3	10	PF00069	0.401
MOD_GSK3_1	341	348	PF00069	0.297
MOD_GSK3_1	383	390	PF00069	0.295
MOD_GSK3_1	427	434	PF00069	0.392
MOD_GSK3_1	446	453	PF00069	0.352
MOD_GSK3_1	49	56	PF00069	0.615
MOD_GSK3_1	495	502	PF00069	0.335
MOD_GSK3_1	513	520	PF00069	0.237
MOD_GSK3_1	546	553	PF00069	0.538
MOD_N-GLC_1	291	296	PF02516	0.404
MOD_N-GLC_1	53	58	PF02516	0.609
MOD_N-GLC_2	132	134	PF02516	0.313
MOD_N-GLC_2	189	191	PF02516	0.347
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	106	111	PF00069	0.406
MOD_NEK2_1	37	42	PF00069	0.368
MOD_NEK2_1	387	392	PF00069	0.293
MOD_NEK2_1	416	421	PF00069	0.289
MOD_NEK2_1	478	483	PF00069	0.420
MOD_NEK2_1	489	494	PF00069	0.445
MOD_NEK2_1	518	523	PF00069	0.420
MOD_NEK2_1	80	85	PF00069	0.370
MOD_NEK2_2	450	455	PF00069	0.335
MOD_NEK2_2	87	92	PF00069	0.400
MOD_OFUCOSY	479	484	PF10250	0.335
MOD_PIKK_1	175	181	PF00454	0.585
MOD_PIKK_1	346	352	PF00454	0.335
MOD_PIKK_1	496	502	PF00454	0.452
MOD_PKA_2	106	112	PF00069	0.420
MOD_PKA_2	132	138	PF00069	0.335
MOD_PKA_2	270	276	PF00069	0.472
MOD_PKA_2	523	529	PF00069	0.436
MOD_Plk_1	209	215	PF00069	0.415
MOD_Plk_1	250	256	PF00069	0.439
MOD_Plk_1	450	456	PF00069	0.335
MOD_Plk_1	53	59	PF00069	0.655
MOD_Plk_2-3	209	215	PF00069	0.436
MOD_Plk_4	11	17	PF00069	0.381
MOD_Plk_4	134	140	PF00069	0.421
MOD_Plk_4	242	248	PF00069	0.404
MOD_Plk_4	250	256	PF00069	0.404
MOD_Plk_4	270	276	PF00069	0.150
MOD_Plk_4	297	303	PF00069	0.394
MOD_Plk_4	383	389	PF00069	0.271
MOD_Plk_4	409	415	PF00069	0.435
MOD_Plk_4	457	463	PF00069	0.369
MOD_Plk_4	513	519	PF00069	0.549
MOD_ProDKin_1	446	452	PF00069	0.386
MOD_SUMO_for_1	544	547	PF00179	0.435
MOD_SUMO_rev_2	321	331	PF00179	0.423
MOD_SUMO_rev_2	412	422	PF00179	0.340
TRG_ENDOCYTIC_2	136	139	PF00928	0.359
TRG_ENDOCYTIC_2	142	145	PF00928	0.409
TRG_ENDOCYTIC_2	152	155	PF00928	0.253
TRG_ENDOCYTIC_2	28	31	PF00928	0.403
TRG_ENDOCYTIC_2	302	305	PF00928	0.271
TRG_ENDOCYTIC_2	353	356	PF00928	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK8	Leptomonas seymouri	63%	100%
A0A1X0NPH3	Trypanosomatidae	40%	100%
A0A3R7NJV3	Trypanosoma rangeli	42%	100%
A4H914	Leishmania braziliensis	89%	100%
A4HXE6	Leishmania infantum	100%	100%
C9ZUK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AR41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QEC2	Leishmania major	98%	100%
V5BNW8	Trypanosoma cruzi	44%	100%