Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUG6_LEIDO

TriTrypDb:

LdBPK_170940.1 , LdCL_170015400 , LDHU3_17.1360

Length:

514

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.705
CLV_NRD_NRD_1	1	3	PF00675	0.727
CLV_NRD_NRD_1	106	108	PF00675	0.557
CLV_NRD_NRD_1	18	20	PF00675	0.718
CLV_NRD_NRD_1	190	192	PF00675	0.536
CLV_NRD_NRD_1	193	195	PF00675	0.617
CLV_NRD_NRD_1	319	321	PF00675	0.412
CLV_NRD_NRD_1	342	344	PF00675	0.402
CLV_PCSK_FUR_1	106	110	PF00082	0.536
CLV_PCSK_FUR_1	191	195	PF00082	0.697
CLV_PCSK_KEX2_1	106	108	PF00082	0.580
CLV_PCSK_KEX2_1	18	20	PF00082	0.713
CLV_PCSK_KEX2_1	192	194	PF00082	0.613
CLV_PCSK_KEX2_1	3	5	PF00082	0.717
CLV_PCSK_KEX2_1	319	321	PF00082	0.412
CLV_PCSK_KEX2_1	342	344	PF00082	0.402
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.528
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.624
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.693
CLV_PCSK_SKI1_1	133	137	PF00082	0.593
CLV_PCSK_SKI1_1	138	142	PF00082	0.588
CLV_PCSK_SKI1_1	268	272	PF00082	0.586
CLV_PCSK_SKI1_1	3	7	PF00082	0.748
CLV_PCSK_SKI1_1	418	422	PF00082	0.495
CLV_PCSK_SKI1_1	441	445	PF00082	0.539
CLV_PCSK_SKI1_1	495	499	PF00082	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.731
DEG_SPOP_SBC_1	201	205	PF00917	0.673
DEG_SPOP_SBC_1	386	390	PF00917	0.656
DOC_CYCLIN_RxL_1	115	126	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.554
DOC_MAPK_DCC_7	466	475	PF00069	0.518
DOC_MAPK_gen_1	115	124	PF00069	0.541
DOC_MAPK_gen_1	145	153	PF00069	0.533
DOC_MAPK_gen_1	319	326	PF00069	0.384
DOC_MAPK_gen_1	407	416	PF00069	0.408
DOC_MAPK_HePTP_8	463	475	PF00069	0.405
DOC_MAPK_MEF2A_6	466	475	PF00069	0.391
DOC_PP1_RVXF_1	118	125	PF00149	0.568
DOC_PP2B_LxvP_1	510	513	PF13499	0.617
DOC_PP4_FxxP_1	255	258	PF00568	0.555
DOC_PP4_FxxP_1	26	29	PF00568	0.735
DOC_PP4_FxxP_1	318	321	PF00568	0.388
DOC_USP7_MATH_1	116	120	PF00917	0.587
DOC_USP7_MATH_1	201	205	PF00917	0.774
DOC_USP7_MATH_1	209	213	PF00917	0.729
DOC_USP7_MATH_1	264	268	PF00917	0.582
DOC_USP7_MATH_1	281	285	PF00917	0.612
DOC_USP7_MATH_1	29	33	PF00917	0.693
DOC_USP7_MATH_1	294	298	PF00917	0.731
DOC_USP7_MATH_1	304	308	PF00917	0.345
DOC_USP7_MATH_1	386	390	PF00917	0.696
DOC_USP7_UBL2_3	53	57	PF12436	0.782
DOC_WW_Pin1_4	254	259	PF00397	0.546
DOC_WW_Pin1_4	311	316	PF00397	0.473
LIG_14-3-3_CanoR_1	191	201	PF00244	0.662
LIG_14-3-3_CanoR_1	224	230	PF00244	0.553
LIG_14-3-3_CanoR_1	385	395	PF00244	0.609
LIG_14-3-3_CanoR_1	418	424	PF00244	0.420
LIG_APCC_ABBA_1	121	126	PF00400	0.588
LIG_APCC_ABBAyCdc20_2	120	126	PF00400	0.582
LIG_BRCT_BRCA1_1	240	244	PF00533	0.469
LIG_BRCT_BRCA1_1	278	282	PF00533	0.595
LIG_BRCT_BRCA1_1	306	310	PF00533	0.550
LIG_BRCT_BRCA1_1	446	450	PF00533	0.372
LIG_BRCT_BRCA1_1	76	80	PF00533	0.612
LIG_EH_1	77	81	PF12763	0.639
LIG_FHA_1	169	175	PF00498	0.666
LIG_FHA_1	226	232	PF00498	0.687
LIG_FHA_1	264	270	PF00498	0.512
LIG_FHA_1	366	372	PF00498	0.729
LIG_FHA_1	44	50	PF00498	0.702
LIG_FHA_1	460	466	PF00498	0.519
LIG_FHA_2	288	294	PF00498	0.719
LIG_FHA_2	375	381	PF00498	0.703
LIG_FHA_2	425	431	PF00498	0.576
LIG_FHA_2	54	60	PF00498	0.731
LIG_GBD_Chelix_1	481	489	PF00786	0.438
LIG_LIR_Apic_2	23	29	PF02991	0.733
LIG_LIR_Apic_2	316	321	PF02991	0.419
LIG_LIR_Gen_1	139	149	PF02991	0.517
LIG_LIR_Gen_1	307	318	PF02991	0.521
LIG_LIR_Gen_1	457	468	PF02991	0.574
LIG_LIR_Nem_3	139	144	PF02991	0.512
LIG_LIR_Nem_3	241	247	PF02991	0.448
LIG_LIR_Nem_3	279	285	PF02991	0.603
LIG_LIR_Nem_3	338	344	PF02991	0.400
LIG_LIR_Nem_3	457	463	PF02991	0.562
LIG_LIR_Nem_3	95	99	PF02991	0.652
LIG_MYND_1	351	355	PF01753	0.537
LIG_NRBOX	268	274	PF00104	0.585
LIG_Pex14_2	282	286	PF04695	0.648
LIG_SH2_CRK	460	464	PF00017	0.425
LIG_SH2_GRB2like	165	168	PF00017	0.539
LIG_SH2_NCK_1	99	103	PF00017	0.649
LIG_SH2_PTP2	356	359	PF00017	0.505
LIG_SH2_STAT5	146	149	PF00017	0.524
LIG_SH2_STAT5	165	168	PF00017	0.441
LIG_SH2_STAT5	285	288	PF00017	0.647
LIG_SH2_STAT5	356	359	PF00017	0.501
LIG_SH2_STAT5	415	418	PF00017	0.397
LIG_SH2_STAT5	468	471	PF00017	0.429
LIG_SH2_STAT5	509	512	PF00017	0.590
LIG_SH3_2	14	19	PF14604	0.773
LIG_SH3_3	11	17	PF00018	0.708
LIG_SH3_3	91	97	PF00018	0.672
LIG_SH3_CIN85_PxpxPR_1	13	18	PF14604	0.721
LIG_SUMO_SIM_par_1	271	276	PF11976	0.578
LIG_SUMO_SIM_par_1	392	399	PF11976	0.414
LIG_TRAF2_1	102	105	PF00917	0.582
LIG_TRAF2_1	290	293	PF00917	0.644
LIG_TRAF2_1	360	363	PF00917	0.693
LIG_UBA3_1	325	332	PF00899	0.544
MOD_CK1_1	202	208	PF00069	0.736
MOD_CK1_1	257	263	PF00069	0.544
MOD_CK1_1	276	282	PF00069	0.615
MOD_CK1_1	33	39	PF00069	0.699
MOD_CK1_1	369	375	PF00069	0.791
MOD_CK1_1	389	395	PF00069	0.496
MOD_CK1_1	399	405	PF00069	0.356
MOD_CK1_1	424	430	PF00069	0.537
MOD_CK1_1	43	49	PF00069	0.754
MOD_CK1_1	95	101	PF00069	0.612
MOD_CK2_1	287	293	PF00069	0.713
MOD_CK2_1	357	363	PF00069	0.553
MOD_CK2_1	424	430	PF00069	0.525
MOD_CK2_1	433	439	PF00069	0.449
MOD_CK2_1	82	88	PF00069	0.514
MOD_Cter_Amidation	50	53	PF01082	0.700
MOD_GlcNHglycan	215	218	PF01048	0.773
MOD_GlcNHglycan	261	264	PF01048	0.548
MOD_GlcNHglycan	296	299	PF01048	0.715
MOD_GlcNHglycan	359	362	PF01048	0.696
MOD_GlcNHglycan	368	371	PF01048	0.758
MOD_GlcNHglycan	373	376	PF01048	0.470
MOD_GlcNHglycan	401	404	PF01048	0.486
MOD_GlcNHglycan	41	45	PF01048	0.678
MOD_GlcNHglycan	430	433	PF01048	0.638
MOD_GlcNHglycan	485	488	PF01048	0.433
MOD_GlcNHglycan	59	63	PF01048	0.753
MOD_GSK3_1	199	206	PF00069	0.697
MOD_GSK3_1	209	216	PF00069	0.718
MOD_GSK3_1	259	266	PF00069	0.519
MOD_GSK3_1	271	278	PF00069	0.410
MOD_GSK3_1	281	288	PF00069	0.369
MOD_GSK3_1	29	36	PF00069	0.675
MOD_GSK3_1	294	301	PF00069	0.636
MOD_GSK3_1	304	311	PF00069	0.345
MOD_GSK3_1	365	372	PF00069	0.754
MOD_GSK3_1	385	392	PF00069	0.628
MOD_GSK3_1	40	47	PF00069	0.613
MOD_GSK3_1	419	426	PF00069	0.445
MOD_GSK3_1	446	453	PF00069	0.399
MOD_GSK3_1	82	89	PF00069	0.540
MOD_N-GLC_1	33	38	PF02516	0.715
MOD_NEK2_1	238	243	PF00069	0.576
MOD_NEK2_1	273	278	PF00069	0.655
MOD_NEK2_1	309	314	PF00069	0.543
MOD_NEK2_1	414	419	PF00069	0.410
MOD_NEK2_1	423	428	PF00069	0.464
MOD_NEK2_1	444	449	PF00069	0.425
MOD_NEK2_1	450	455	PF00069	0.427
MOD_NEK2_1	459	464	PF00069	0.465
MOD_NEK2_1	58	63	PF00069	0.686
MOD_PIKK_1	324	330	PF00454	0.454
MOD_PIKK_1	332	338	PF00454	0.414
MOD_PIKK_1	421	427	PF00454	0.540
MOD_PIKK_1	450	456	PF00454	0.493
MOD_PIKK_1	65	71	PF00454	0.720
MOD_PK_1	379	385	PF00069	0.640
MOD_PKA_1	192	198	PF00069	0.691
MOD_PKA_2	192	198	PF00069	0.743
MOD_PKA_2	199	205	PF00069	0.741
MOD_PKA_2	294	300	PF00069	0.710
MOD_PKB_1	198	206	PF00069	0.714
MOD_Plk_2-3	433	439	PF00069	0.582
MOD_Plk_4	268	274	PF00069	0.533
MOD_Plk_4	281	287	PF00069	0.604
MOD_Plk_4	313	319	PF00069	0.530
MOD_Plk_4	446	452	PF00069	0.369
MOD_Plk_4	497	503	PF00069	0.475
MOD_ProDKin_1	254	260	PF00069	0.543
MOD_ProDKin_1	311	317	PF00069	0.470
MOD_SUMO_for_1	114	117	PF00179	0.618
MOD_SUMO_rev_2	105	114	PF00179	0.535
MOD_SUMO_rev_2	168	177	PF00179	0.546
MOD_SUMO_rev_2	433	443	PF00179	0.593
MOD_SUMO_rev_2	491	497	PF00179	0.569
TRG_AP2beta_CARGO_1	139	148	PF09066	0.516
TRG_ENDOCYTIC_2	408	411	PF00928	0.410
TRG_ENDOCYTIC_2	460	463	PF00928	0.425
TRG_ER_diArg_1	1	4	PF00400	0.703
TRG_ER_diArg_1	106	109	PF00400	0.613
TRG_ER_diArg_1	17	19	PF00400	0.732
TRG_ER_diArg_1	191	194	PF00400	0.670
TRG_ER_diArg_1	198	201	PF00400	0.718
TRG_ER_diArg_1	318	320	PF00400	0.434
TRG_ER_diArg_1	341	343	PF00400	0.395
TRG_NLS_MonoCore_2	190	195	PF00514	0.678
TRG_NLS_MonoExtN_4	191	196	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD84	Leptomonas seymouri	62%	98%
A0A1X0NST3	Trypanosomatidae	46%	97%
A0A3S5IR66	Trypanosoma rangeli	49%	98%
A4H948	Leishmania braziliensis	80%	100%
A4HXG2	Leishmania infantum	100%	100%
C9ZP42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9AR57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEA6	Leishmania major	93%	100%
V5AQX9	Trypanosoma cruzi	48%	98%