Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUG5_LEIDO

TriTrypDb:

LdBPK_170860.1 , LdCL_170014600 , LDHU3_17.1250

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.538
CLV_C14_Caspase3-7	209	213	PF00656	0.576
CLV_NRD_NRD_1	136	138	PF00675	0.449
CLV_NRD_NRD_1	316	318	PF00675	0.433
CLV_NRD_NRD_1	549	551	PF00675	0.636
CLV_NRD_NRD_1	599	601	PF00675	0.593
CLV_NRD_NRD_1	739	741	PF00675	0.488
CLV_NRD_NRD_1	93	95	PF00675	0.711
CLV_PCSK_KEX2_1	34	36	PF00082	0.411
CLV_PCSK_KEX2_1	549	551	PF00082	0.636
CLV_PCSK_KEX2_1	739	741	PF00082	0.485
CLV_PCSK_KEX2_1	93	95	PF00082	0.706
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.468
CLV_PCSK_SKI1_1	34	38	PF00082	0.396
CLV_PCSK_SKI1_1	412	416	PF00082	0.385
CLV_PCSK_SKI1_1	453	457	PF00082	0.725
CLV_PCSK_SKI1_1	549	553	PF00082	0.586
CLV_PCSK_SKI1_1	561	565	PF00082	0.559
CLV_PCSK_SKI1_1	764	768	PF00082	0.568
CLV_Separin_Metazoa	416	420	PF03568	0.518
DEG_APCC_DBOX_1	738	746	PF00400	0.468
DEG_SPOP_SBC_1	123	127	PF00917	0.757
DEG_SPOP_SBC_1	257	261	PF00917	0.572
DEG_SPOP_SBC_1	582	586	PF00917	0.564
DOC_CKS1_1	221	226	PF01111	0.642
DOC_CKS1_1	3	8	PF01111	0.719
DOC_CKS1_1	404	409	PF01111	0.609
DOC_CKS1_1	562	567	PF01111	0.566
DOC_CYCLIN_RxL_1	152	161	PF00134	0.478
DOC_MAPK_gen_1	137	144	PF00069	0.389
DOC_MAPK_gen_1	278	287	PF00069	0.539
DOC_MAPK_gen_1	317	327	PF00069	0.537
DOC_MAPK_gen_1	549	555	PF00069	0.615
DOC_MAPK_MEF2A_6	137	144	PF00069	0.446
DOC_MAPK_MEF2A_6	19	26	PF00069	0.500
DOC_MAPK_MEF2A_6	293	300	PF00069	0.374
DOC_MAPK_MEF2A_6	320	329	PF00069	0.534
DOC_MAPK_NFAT4_5	19	27	PF00069	0.505
DOC_PP1_RVXF_1	153	160	PF00149	0.493
DOC_PP1_RVXF_1	390	397	PF00149	0.568
DOC_PP2B_LxvP_1	162	165	PF13499	0.421
DOC_PP2B_LxvP_1	782	785	PF13499	0.433
DOC_PP4_FxxP_1	300	303	PF00568	0.371
DOC_PP4_FxxP_1	415	418	PF00568	0.500
DOC_PP4_MxPP_1	1	4	PF00568	0.616
DOC_USP7_MATH_1	123	127	PF00917	0.754
DOC_USP7_MATH_1	166	170	PF00917	0.624
DOC_USP7_MATH_1	258	262	PF00917	0.590
DOC_USP7_MATH_1	312	316	PF00917	0.607
DOC_USP7_MATH_1	350	354	PF00917	0.581
DOC_USP7_MATH_1	355	359	PF00917	0.519
DOC_USP7_MATH_1	463	467	PF00917	0.682
DOC_USP7_MATH_1	582	586	PF00917	0.627
DOC_USP7_MATH_1	645	649	PF00917	0.603
DOC_WW_Pin1_4	178	183	PF00397	0.774
DOC_WW_Pin1_4	2	7	PF00397	0.724
DOC_WW_Pin1_4	220	225	PF00397	0.637
DOC_WW_Pin1_4	262	267	PF00397	0.586
DOC_WW_Pin1_4	346	351	PF00397	0.485
DOC_WW_Pin1_4	403	408	PF00397	0.566
DOC_WW_Pin1_4	44	49	PF00397	0.484
DOC_WW_Pin1_4	453	458	PF00397	0.724
DOC_WW_Pin1_4	561	566	PF00397	0.567
DOC_WW_Pin1_4	650	655	PF00397	0.531
LIG_14-3-3_CanoR_1	155	160	PF00244	0.413
LIG_14-3-3_CanoR_1	392	397	PF00244	0.577
LIG_14-3-3_CanoR_1	419	423	PF00244	0.501
LIG_14-3-3_CanoR_1	647	652	PF00244	0.552
LIG_14-3-3_CanoR_1	694	702	PF00244	0.524
LIG_14-3-3_CanoR_1	746	756	PF00244	0.521
LIG_Actin_WH2_2	410	425	PF00022	0.453
LIG_Actin_WH2_2	556	571	PF00022	0.617
LIG_BIR_III_4	445	449	PF00653	0.637
LIG_BIR_III_4	462	466	PF00653	0.470
LIG_BRCT_BRCA1_1	312	316	PF00533	0.593
LIG_BRCT_BRCA1_1	358	362	PF00533	0.518
LIG_BRCT_BRCA1_2	312	318	PF00533	0.424
LIG_DLG_GKlike_1	155	162	PF00625	0.382
LIG_FHA_1	144	150	PF00498	0.371
LIG_FHA_1	221	227	PF00498	0.769
LIG_FHA_1	236	242	PF00498	0.434
LIG_FHA_1	257	263	PF00498	0.609
LIG_FHA_1	359	365	PF00498	0.401
LIG_FHA_1	512	518	PF00498	0.482
LIG_FHA_2	11	17	PF00498	0.533
LIG_FHA_2	207	213	PF00498	0.581
LIG_FHA_2	404	410	PF00498	0.577
LIG_FHA_2	562	568	PF00498	0.570
LIG_GBD_Chelix_1	480	488	PF00786	0.372
LIG_LIR_Apic_2	297	303	PF02991	0.367
LIG_LIR_Apic_2	401	407	PF02991	0.612
LIG_LIR_Apic_2	559	565	PF02991	0.565
LIG_LIR_Apic_2	665	669	PF02991	0.518
LIG_LIR_Gen_1	13	22	PF02991	0.499
LIG_LIR_Gen_1	158	166	PF02991	0.533
LIG_LIR_Gen_1	29	37	PF02991	0.457
LIG_LIR_Gen_1	501	510	PF02991	0.465
LIG_LIR_LC3C_4	477	482	PF02991	0.486
LIG_LIR_Nem_3	13	18	PF02991	0.503
LIG_LIR_Nem_3	158	162	PF02991	0.486
LIG_LIR_Nem_3	216	222	PF02991	0.604
LIG_LIR_Nem_3	29	33	PF02991	0.319
LIG_LIR_Nem_3	313	319	PF02991	0.468
LIG_LIR_Nem_3	366	370	PF02991	0.428
LIG_LIR_Nem_3	389	394	PF02991	0.655
LIG_LIR_Nem_3	39	43	PF02991	0.329
LIG_LIR_Nem_3	501	505	PF02991	0.465
LIG_LIR_Nem_3	709	713	PF02991	0.365
LIG_MYND_1	375	379	PF01753	0.535
LIG_Pex14_1	387	391	PF04695	0.597
LIG_SH2_CRK	136	140	PF00017	0.472
LIG_SH2_CRK	15	19	PF00017	0.587
LIG_SH2_CRK	219	223	PF00017	0.688
LIG_SH2_CRK	30	34	PF00017	0.337
LIG_SH2_CRK	391	395	PF00017	0.643
LIG_SH2_NCK_1	404	408	PF00017	0.593
LIG_SH2_PTP2	502	505	PF00017	0.354
LIG_SH2_SRC	15	18	PF00017	0.488
LIG_SH2_STAP1	513	517	PF00017	0.490
LIG_SH2_STAP1	713	717	PF00017	0.507
LIG_SH2_STAT5	134	137	PF00017	0.413
LIG_SH2_STAT5	413	416	PF00017	0.411
LIG_SH2_STAT5	502	505	PF00017	0.381
LIG_SH2_STAT5	513	516	PF00017	0.425
LIG_SH2_STAT5	666	669	PF00017	0.515
LIG_SH3_3	1	7	PF00018	0.806
LIG_SH3_3	126	132	PF00018	0.613
LIG_SH3_3	188	194	PF00018	0.722
LIG_SH3_3	195	201	PF00018	0.791
LIG_SH3_3	218	224	PF00018	0.598
LIG_SH3_3	263	269	PF00018	0.498
LIG_SH3_3	300	306	PF00018	0.394
LIG_SH3_3	369	375	PF00018	0.502
LIG_SH3_3	397	403	PF00018	0.552
LIG_SH3_3	634	640	PF00018	0.445
LIG_SH3_3	751	757	PF00018	0.669
LIG_SH3_5	706	710	PF00018	0.409
LIG_SH3_CIN85_PxpxPR_1	7	12	PF14604	0.552
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.457
LIG_SUMO_SIM_anti_2	477	482	PF11976	0.418
LIG_SUMO_SIM_anti_2	501	508	PF11976	0.466
LIG_SUMO_SIM_anti_2	786	793	PF11976	0.503
LIG_SUMO_SIM_par_1	58	64	PF11976	0.462
LIG_SUMO_SIM_par_1	786	793	PF11976	0.494
LIG_SxIP_EBH_1	192	203	PF03271	0.601
LIG_TRAF2_1	213	216	PF00917	0.727
LIG_TRAF2_1	343	346	PF00917	0.451
LIG_TRAF2_1	406	409	PF00917	0.626
LIG_TRAF2_1	436	439	PF00917	0.565
LIG_TRAF2_1	48	51	PF00917	0.487
LIG_TRAF2_1	564	567	PF00917	0.572
LIG_TYR_ITIM	500	505	PF00017	0.448
LIG_TYR_ITSM	11	18	PF00017	0.518
LIG_WRC_WIRS_1	364	369	PF05994	0.492
MOD_CDC14_SPxK_1	181	184	PF00782	0.593
MOD_CDK_SPK_2	7	12	PF00069	0.657
MOD_CDK_SPxK_1	178	184	PF00069	0.592
MOD_CDK_SPxxK_3	650	657	PF00069	0.581
MOD_CK1_1	10	16	PF00069	0.578
MOD_CK1_1	127	133	PF00069	0.548
MOD_CK1_1	167	173	PF00069	0.545
MOD_CK1_1	176	182	PF00069	0.681
MOD_CK1_1	225	231	PF00069	0.683
MOD_CK1_1	235	241	PF00069	0.652
MOD_CK1_1	260	266	PF00069	0.600
MOD_CK1_1	349	355	PF00069	0.658
MOD_CK1_1	356	362	PF00069	0.545
MOD_CK1_1	44	50	PF00069	0.489
MOD_CK1_1	518	524	PF00069	0.548
MOD_CK1_1	650	656	PF00069	0.516
MOD_CK1_1	70	76	PF00069	0.641
MOD_CK2_1	403	409	PF00069	0.569
MOD_CK2_1	501	507	PF00069	0.471
MOD_CK2_1	553	559	PF00069	0.610
MOD_CK2_1	561	567	PF00069	0.574
MOD_CK2_1	569	575	PF00069	0.625
MOD_CK2_1	596	602	PF00069	0.774
MOD_CK2_1	787	793	PF00069	0.443
MOD_Cter_Amidation	547	550	PF01082	0.657
MOD_GlcNHglycan	101	104	PF01048	0.709
MOD_GlcNHglycan	126	129	PF01048	0.723
MOD_GlcNHglycan	175	178	PF01048	0.801
MOD_GlcNHglycan	232	235	PF01048	0.672
MOD_GlcNHglycan	288	291	PF01048	0.367
MOD_GlcNHglycan	312	315	PF01048	0.660
MOD_GlcNHglycan	352	355	PF01048	0.633
MOD_GlcNHglycan	357	361	PF01048	0.563
MOD_GlcNHglycan	546	549	PF01048	0.714
MOD_GlcNHglycan	630	633	PF01048	0.643
MOD_GlcNHglycan	643	646	PF01048	0.658
MOD_GlcNHglycan	682	685	PF01048	0.509
MOD_GlcNHglycan	687	690	PF01048	0.431
MOD_GlcNHglycan	81	84	PF01048	0.659
MOD_GlcNHglycan	90	93	PF01048	0.680
MOD_GSK3_1	123	130	PF00069	0.680
MOD_GSK3_1	164	171	PF00069	0.502
MOD_GSK3_1	178	185	PF00069	0.706
MOD_GSK3_1	256	263	PF00069	0.534
MOD_GSK3_1	272	279	PF00069	0.468
MOD_GSK3_1	301	308	PF00069	0.434
MOD_GSK3_1	346	353	PF00069	0.492
MOD_GSK3_1	373	380	PF00069	0.550
MOD_GSK3_1	511	518	PF00069	0.489
MOD_GSK3_1	641	648	PF00069	0.550
MOD_GSK3_1	783	790	PF00069	0.525
MOD_N-GLC_1	482	487	PF02516	0.526
MOD_NEK2_1	394	399	PF00069	0.520
MOD_NEK2_1	41	46	PF00069	0.597
MOD_NEK2_1	430	435	PF00069	0.500
MOD_NEK2_1	59	64	PF00069	0.253
MOD_NEK2_1	596	601	PF00069	0.656
MOD_NEK2_1	680	685	PF00069	0.553
MOD_NEK2_2	312	317	PF00069	0.602
MOD_NEK2_2	418	423	PF00069	0.576
MOD_NEK2_2	621	626	PF00069	0.608
MOD_PIKK_1	482	488	PF00454	0.374
MOD_PIKK_1	604	610	PF00454	0.735
MOD_PIKK_1	72	78	PF00454	0.570
MOD_PKA_2	277	283	PF00069	0.545
MOD_PKA_2	418	424	PF00069	0.429
MOD_PKA_2	662	668	PF00069	0.510
MOD_Plk_1	474	480	PF00069	0.428
MOD_Plk_1	591	597	PF00069	0.708
MOD_Plk_1	621	627	PF00069	0.640
MOD_Plk_1	778	784	PF00069	0.497
MOD_Plk_2-3	474	480	PF00069	0.499
MOD_Plk_2-3	501	507	PF00069	0.450
MOD_Plk_2-3	787	793	PF00069	0.486
MOD_Plk_4	501	507	PF00069	0.450
MOD_Plk_4	591	597	PF00069	0.531
MOD_Plk_4	662	668	PF00069	0.514
MOD_Plk_4	722	728	PF00069	0.513
MOD_Plk_4	787	793	PF00069	0.486
MOD_ProDKin_1	178	184	PF00069	0.774
MOD_ProDKin_1	2	8	PF00069	0.721
MOD_ProDKin_1	220	226	PF00069	0.639
MOD_ProDKin_1	262	268	PF00069	0.577
MOD_ProDKin_1	346	352	PF00069	0.490
MOD_ProDKin_1	403	409	PF00069	0.559
MOD_ProDKin_1	44	50	PF00069	0.484
MOD_ProDKin_1	453	459	PF00069	0.722
MOD_ProDKin_1	561	567	PF00069	0.568
MOD_ProDKin_1	650	656	PF00069	0.527
MOD_SUMO_rev_2	566	571	PF00179	0.615
TRG_DiLeu_BaEn_1	501	506	PF01217	0.447
TRG_ENDOCYTIC_2	136	139	PF00928	0.430
TRG_ENDOCYTIC_2	15	18	PF00928	0.574
TRG_ENDOCYTIC_2	219	222	PF00928	0.689
TRG_ENDOCYTIC_2	30	33	PF00928	0.340
TRG_ENDOCYTIC_2	391	394	PF00928	0.653
TRG_ENDOCYTIC_2	502	505	PF00928	0.448
TRG_ER_diArg_1	549	551	PF00400	0.708
TRG_ER_diArg_1	738	740	PF00400	0.470
TRG_NES_CRM1_1	711	724	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	733	737	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L1	Leptomonas seymouri	50%	100%
A0A1X0NSU7	Trypanosomatidae	30%	100%
A4H922	Leishmania braziliensis	75%	100%
A4HXF4	Leishmania infantum	99%	100%
C9ZP26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AR49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEB4	Leishmania major	89%	100%