Putative_methyltransferase_putative/Pfam:PF10294

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WUF8_LEIDO

TriTrypDb:

LdBPK_170840.1 , LdCL_170014400 , LDHU3_17.1230

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUF8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.769
CLV_NRD_NRD_1	364	366	PF00675	0.476
CLV_NRD_NRD_1	434	436	PF00675	0.780
CLV_NRD_NRD_1	469	471	PF00675	0.640
CLV_PCSK_FUR_1	432	436	PF00082	0.811
CLV_PCSK_KEX2_1	364	366	PF00082	0.476
CLV_PCSK_KEX2_1	432	434	PF00082	0.778
CLV_PCSK_KEX2_1	469	471	PF00082	0.636
CLV_PCSK_SKI1_1	118	122	PF00082	0.406
CLV_PCSK_SKI1_1	192	196	PF00082	0.607
CLV_Separin_Metazoa	429	433	PF03568	0.684
DEG_Nend_Nbox_1	1	3	PF02207	0.461
DEG_SPOP_SBC_1	229	233	PF00917	0.652
DEG_SPOP_SBC_1	71	75	PF00917	0.470
DOC_ANK_TNKS_1	436	443	PF00023	0.767
DOC_CKS1_1	243	248	PF01111	0.586
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.408
DOC_PP1_RVXF_1	390	396	PF00149	0.424
DOC_PP2B_LxvP_1	210	213	PF13499	0.505
DOC_PP2B_LxvP_1	79	82	PF13499	0.408
DOC_PP4_FxxP_1	425	428	PF00568	0.721
DOC_USP7_MATH_1	154	158	PF00917	0.586
DOC_USP7_MATH_1	213	217	PF00917	0.451
DOC_USP7_MATH_1	223	227	PF00917	0.442
DOC_USP7_MATH_1	229	233	PF00917	0.498
DOC_USP7_MATH_1	30	34	PF00917	0.582
DOC_USP7_MATH_1	352	356	PF00917	0.548
DOC_USP7_MATH_1	418	422	PF00917	0.786
DOC_USP7_MATH_1	455	459	PF00917	0.787
DOC_USP7_MATH_1	71	75	PF00917	0.476
DOC_USP7_UBL2_3	162	166	PF12436	0.473
DOC_WW_Pin1_4	179	184	PF00397	0.694
DOC_WW_Pin1_4	238	243	PF00397	0.648
DOC_WW_Pin1_4	8	13	PF00397	0.465
LIG_14-3-3_CanoR_1	111	121	PF00244	0.342
LIG_14-3-3_CanoR_1	184	190	PF00244	0.659
LIG_14-3-3_CanoR_1	201	207	PF00244	0.426
LIG_14-3-3_CanoR_1	333	343	PF00244	0.522
LIG_14-3-3_CanoR_1	392	401	PF00244	0.453
LIG_14-3-3_CanoR_1	60	70	PF00244	0.408
LIG_BIR_III_2	472	476	PF00653	0.589
LIG_BRCT_BRCA1_1	189	193	PF00533	0.547
LIG_BRCT_BRCA1_1	421	425	PF00533	0.798
LIG_eIF4E_1	268	274	PF01652	0.479
LIG_FHA_1	189	195	PF00498	0.575
LIG_FHA_1	232	238	PF00498	0.633
LIG_FHA_1	323	329	PF00498	0.558
LIG_FHA_1	372	378	PF00498	0.453
LIG_FHA_2	267	273	PF00498	0.373
LIG_FHA_2	274	280	PF00498	0.383
LIG_FHA_2	394	400	PF00498	0.529
LIG_FHA_2	446	452	PF00498	0.763
LIG_Integrin_RGD_1	470	472	PF01839	0.601
LIG_LIR_Apic_2	18	24	PF02991	0.489
LIG_LIR_Apic_2	254	260	PF02991	0.448
LIG_LIR_Apic_2	422	428	PF02991	0.719
LIG_LIR_Gen_1	245	255	PF02991	0.413
LIG_LIR_Gen_1	295	304	PF02991	0.425
LIG_LIR_Gen_1	321	331	PF02991	0.498
LIG_LIR_Gen_1	358	367	PF02991	0.448
LIG_LIR_Gen_1	64	71	PF02991	0.396
LIG_LIR_Nem_3	10	16	PF02991	0.418
LIG_LIR_Nem_3	245	250	PF02991	0.410
LIG_LIR_Nem_3	262	266	PF02991	0.277
LIG_LIR_Nem_3	295	301	PF02991	0.424
LIG_LIR_Nem_3	321	327	PF02991	0.508
LIG_LIR_Nem_3	358	362	PF02991	0.479
LIG_LIR_Nem_3	64	70	PF02991	0.436
LIG_Pex14_2	148	152	PF04695	0.481
LIG_SH2_CRK	257	261	PF00017	0.498
LIG_SH2_PTP2	249	252	PF00017	0.468
LIG_SH2_PTP2	359	362	PF00017	0.473
LIG_SH2_STAT5	249	252	PF00017	0.425
LIG_SH2_STAT5	268	271	PF00017	0.193
LIG_SH2_STAT5	359	362	PF00017	0.448
LIG_SH3_2	428	433	PF14604	0.720
LIG_SH3_3	424	430	PF00018	0.813
LIG_SH3_3	6	12	PF00018	0.422
LIG_SH3_3	79	85	PF00018	0.478
LIG_SUMO_SIM_par_1	226	235	PF11976	0.432
LIG_TRFH_1	67	71	PF08558	0.388
LIG_TYR_ITIM	357	362	PF00017	0.486
LIG_WW_3	429	433	PF00397	0.722
MOD_CDK_SPK_2	179	184	PF00069	0.660
MOD_CDK_SPxK_1	238	244	PF00069	0.536
MOD_CK1_1	205	211	PF00069	0.465
MOD_CK1_1	231	237	PF00069	0.670
MOD_CK1_1	338	344	PF00069	0.568
MOD_CK1_1	355	361	PF00069	0.490
MOD_CK1_1	72	78	PF00069	0.443
MOD_CK2_1	266	272	PF00069	0.382
MOD_CK2_1	338	344	PF00069	0.575
MOD_CK2_1	393	399	PF00069	0.504
MOD_GlcNHglycan	213	216	PF01048	0.541
MOD_GlcNHglycan	340	343	PF01048	0.625
MOD_GlcNHglycan	41	44	PF01048	0.444
MOD_GlcNHglycan	410	413	PF01048	0.721
MOD_GlcNHglycan	421	424	PF01048	0.695
MOD_GlcNHglycan	55	58	PF01048	0.408
MOD_GlcNHglycan	75	78	PF01048	0.233
MOD_GSK3_1	201	208	PF00069	0.481
MOD_GSK3_1	228	235	PF00069	0.567
MOD_GSK3_1	238	245	PF00069	0.616
MOD_GSK3_1	334	341	PF00069	0.628
MOD_GSK3_1	69	76	PF00069	0.451
MOD_N-GLC_1	185	190	PF02516	0.611
MOD_N-GLC_1	31	36	PF02516	0.485
MOD_N-GLC_2	285	287	PF02516	0.389
MOD_NEK2_1	193	198	PF00069	0.537
MOD_NEK2_1	206	211	PF00069	0.381
MOD_NEK2_1	266	271	PF00069	0.382
MOD_NEK2_1	273	278	PF00069	0.379
MOD_NEK2_1	31	36	PF00069	0.457
MOD_NEK2_1	51	56	PF00069	0.332
MOD_PKA_1	433	439	PF00069	0.792
MOD_PKA_2	388	394	PF00069	0.402
MOD_PKA_2	408	414	PF00069	0.710
MOD_PKA_2	433	439	PF00069	0.784
MOD_Plk_1	185	191	PF00069	0.515
MOD_Plk_1	31	37	PF00069	0.405
MOD_Plk_4	155	161	PF00069	0.571
MOD_Plk_4	202	208	PF00069	0.505
MOD_Plk_4	352	358	PF00069	0.555
MOD_ProDKin_1	179	185	PF00069	0.694
MOD_ProDKin_1	238	244	PF00069	0.641
MOD_ProDKin_1	8	14	PF00069	0.463
MOD_SUMO_for_1	218	221	PF00179	0.472
MOD_SUMO_for_1	401	404	PF00179	0.635
MOD_SUMO_rev_2	303	311	PF00179	0.490
TRG_ENDOCYTIC_2	13	16	PF00928	0.433
TRG_ENDOCYTIC_2	249	252	PF00928	0.428
TRG_ENDOCYTIC_2	359	362	PF00928	0.430
TRG_ENDOCYTIC_2	368	371	PF00928	0.463
TRG_ER_diArg_1	392	395	PF00400	0.463
TRG_ER_diArg_1	431	434	PF00400	0.805
TRG_NES_CRM1_1	119	132	PF08389	0.444
TRG_NES_CRM1_1	163	175	PF08389	0.520
TRG_NLS_MonoExtC_3	464	469	PF00514	0.775
TRG_NLS_MonoExtN_4	465	470	PF00514	0.814

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR5	Leptomonas seymouri	59%	100%
A0A1X0NSU1	Trypanosomatidae	40%	100%
A0A422N4P6	Trypanosoma rangeli	41%	100%
A4H920	Leishmania braziliensis	80%	99%
A4HXF2	Leishmania infantum	100%	100%
C9ZP24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AR47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEB6	Leishmania major	93%	100%