HTH La-type RNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUF4_LEIDO

TriTrypDb:

LdBPK_170760.1 , LdCL_170013300 , LDHU3_17.1100

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.652
CLV_C14_Caspase3-7	264	268	PF00656	0.436
CLV_C14_Caspase3-7	30	34	PF00656	0.660
CLV_NRD_NRD_1	140	142	PF00675	0.690
CLV_NRD_NRD_1	279	281	PF00675	0.564
CLV_NRD_NRD_1	60	62	PF00675	0.595
CLV_PCSK_KEX2_1	408	410	PF00082	0.465
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.465
CLV_PCSK_SKI1_1	145	149	PF00082	0.658
CLV_PCSK_SKI1_1	296	300	PF00082	0.466
DEG_APCC_DBOX_1	311	319	PF00400	0.482
DOC_CKS1_1	137	142	PF01111	0.823
DOC_CKS1_1	271	276	PF01111	0.425
DOC_CKS1_1	390	395	PF01111	0.420
DOC_CYCLIN_yClb5_NLxxxL_5	372	381	PF00134	0.406
DOC_MAPK_gen_1	296	305	PF00069	0.432
DOC_MAPK_gen_1	352	360	PF00069	0.473
DOC_MAPK_MEF2A_6	172	180	PF00069	0.465
DOC_MAPK_MEF2A_6	296	305	PF00069	0.377
DOC_USP7_MATH_1	118	122	PF00917	0.662
DOC_USP7_MATH_1	279	283	PF00917	0.527
DOC_USP7_MATH_1	66	70	PF00917	0.593
DOC_WW_Pin1_4	110	115	PF00397	0.756
DOC_WW_Pin1_4	126	131	PF00397	0.720
DOC_WW_Pin1_4	133	138	PF00397	0.707
DOC_WW_Pin1_4	153	158	PF00397	0.447
DOC_WW_Pin1_4	181	186	PF00397	0.753
DOC_WW_Pin1_4	192	197	PF00397	0.603
DOC_WW_Pin1_4	206	211	PF00397	0.681
DOC_WW_Pin1_4	234	239	PF00397	0.592
DOC_WW_Pin1_4	242	247	PF00397	0.604
DOC_WW_Pin1_4	270	275	PF00397	0.470
DOC_WW_Pin1_4	389	394	PF00397	0.464
LIG_14-3-3_CanoR_1	280	287	PF00244	0.630
LIG_14-3-3_CanoR_1	312	316	PF00244	0.454
LIG_14-3-3_CanoR_1	321	329	PF00244	0.417
LIG_14-3-3_CanoR_1	332	337	PF00244	0.271
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_2	151	155	PF00653	0.570
LIG_CSL_BTD_1	235	238	PF09270	0.549
LIG_CtBP_PxDLS_1	157	161	PF00389	0.624
LIG_EVH1_1	212	216	PF00568	0.571
LIG_FHA_1	104	110	PF00498	0.695
LIG_FHA_1	195	201	PF00498	0.605
LIG_FHA_1	24	30	PF00498	0.658
LIG_FHA_1	243	249	PF00498	0.640
LIG_FHA_1	377	383	PF00498	0.502
LIG_FHA_1	41	47	PF00498	0.674
LIG_FHA_2	222	228	PF00498	0.655
LIG_FHA_2	262	268	PF00498	0.428
LIG_FHA_2	28	34	PF00498	0.707
LIG_GBD_Chelix_1	381	389	PF00786	0.411
LIG_LIR_Apic_2	230	235	PF02991	0.618
LIG_LIR_Apic_2	388	393	PF02991	0.367
LIG_LIR_Nem_3	317	322	PF02991	0.523
LIG_MYND_1	210	214	PF01753	0.571
LIG_PAM2_1	146	158	PF00658	0.572
LIG_PAM2_1	227	239	PF00658	0.560
LIG_Pex14_2	287	291	PF04695	0.605
LIG_PTAP_UEV_1	195	200	PF05743	0.607
LIG_SH2_CRK	319	323	PF00017	0.559
LIG_SH2_PTP2	207	210	PF00017	0.600
LIG_SH2_STAP1	368	372	PF00017	0.363
LIG_SH2_STAP1	429	433	PF00017	0.459
LIG_SH2_STAT5	207	210	PF00017	0.600
LIG_SH2_STAT5	410	413	PF00017	0.402
LIG_SH2_STAT5	414	417	PF00017	0.391
LIG_SH3_1	207	213	PF00018	0.597
LIG_SH3_1	232	238	PF00018	0.585
LIG_SH3_2	137	142	PF14604	0.702
LIG_SH3_2	276	281	PF14604	0.467
LIG_SH3_3	134	140	PF00018	0.802
LIG_SH3_3	151	157	PF00018	0.476
LIG_SH3_3	184	190	PF00018	0.636
LIG_SH3_3	193	199	PF00018	0.622
LIG_SH3_3	207	213	PF00018	0.643
LIG_SH3_3	232	238	PF00018	0.597
LIG_SH3_3	268	274	PF00018	0.458
LIG_SH3_3	333	339	PF00018	0.557
LIG_SH3_3	420	426	PF00018	0.577
LIG_SUMO_SIM_anti_2	430	435	PF11976	0.429
LIG_SUMO_SIM_par_1	156	162	PF11976	0.620
LIG_SUMO_SIM_par_1	432	438	PF11976	0.434
LIG_SUMO_SIM_par_1	80	89	PF11976	0.576
LIG_TRAF2_1	114	117	PF00917	0.608
LIG_TRAF2_1	34	37	PF00917	0.521
LIG_TRAF2_1	54	57	PF00917	0.660
LIG_TRAF2_1	65	68	PF00917	0.661
LIG_TRAF2_1	74	77	PF00917	0.547
LIG_UBA3_1	346	354	PF00899	0.426
MOD_CDK_SPK_2	126	131	PF00069	0.674
MOD_CDK_SPK_2	136	141	PF00069	0.626
MOD_CDK_SPxK_1	136	142	PF00069	0.703
MOD_CK1_1	129	135	PF00069	0.725
MOD_CK1_1	136	142	PF00069	0.649
MOD_CK1_1	156	162	PF00069	0.651
MOD_CK1_1	262	268	PF00069	0.492
MOD_Cter_Amidation	406	409	PF01082	0.444
MOD_GlcNHglycan	120	123	PF01048	0.665
MOD_GlcNHglycan	17	20	PF01048	0.691
MOD_GlcNHglycan	229	232	PF01048	0.646
MOD_GlcNHglycan	261	264	PF01048	0.478
MOD_GlcNHglycan	3	6	PF01048	0.630
MOD_GlcNHglycan	385	388	PF01048	0.425
MOD_GSK3_1	129	136	PF00069	0.790
MOD_GSK3_1	221	228	PF00069	0.757
MOD_GSK3_1	23	30	PF00069	0.722
MOD_GSK3_1	257	264	PF00069	0.459
MOD_GSK3_1	36	43	PF00069	0.808
MOD_GSK3_1	385	392	PF00069	0.410
MOD_N-GLC_1	332	337	PF02516	0.476
MOD_N-GLC_1	360	365	PF02516	0.511
MOD_N-GLC_1	375	380	PF02516	0.299
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	165	170	PF00069	0.658
MOD_NEK2_1	287	292	PF00069	0.494
MOD_NEK2_1	418	423	PF00069	0.466
MOD_NEK2_2	311	316	PF00069	0.444
MOD_NEK2_2	327	332	PF00069	0.334
MOD_PIKK_1	376	382	PF00454	0.501
MOD_PK_1	332	338	PF00069	0.468
MOD_PKA_1	219	225	PF00069	0.722
MOD_PKA_1	280	286	PF00069	0.563
MOD_PKA_2	279	285	PF00069	0.570
MOD_PKA_2	311	317	PF00069	0.487
MOD_PKA_2	320	326	PF00069	0.436
MOD_PKA_2	418	424	PF00069	0.511
MOD_Plk_1	240	246	PF00069	0.616
MOD_Plk_1	327	333	PF00069	0.441
MOD_Plk_1	36	42	PF00069	0.572
MOD_Plk_1	55	61	PF00069	0.646
MOD_Plk_1	66	72	PF00069	0.570
MOD_Plk_4	165	171	PF00069	0.627
MOD_Plk_4	36	42	PF00069	0.646
MOD_Plk_4	385	391	PF00069	0.367
MOD_ProDKin_1	110	116	PF00069	0.757
MOD_ProDKin_1	126	132	PF00069	0.721
MOD_ProDKin_1	133	139	PF00069	0.706
MOD_ProDKin_1	153	159	PF00069	0.445
MOD_ProDKin_1	181	187	PF00069	0.752
MOD_ProDKin_1	192	198	PF00069	0.600
MOD_ProDKin_1	206	212	PF00069	0.681
MOD_ProDKin_1	234	240	PF00069	0.591
MOD_ProDKin_1	242	248	PF00069	0.605
MOD_ProDKin_1	270	276	PF00069	0.472
MOD_ProDKin_1	389	395	PF00069	0.471
MOD_SUMO_for_1	130	133	PF00179	0.658
MOD_SUMO_for_1	19	22	PF00179	0.620
MOD_SUMO_for_1	218	221	PF00179	0.674
MOD_SUMO_for_1	78	81	PF00179	0.689
MOD_SUMO_rev_2	262	271	PF00179	0.489
MOD_SUMO_rev_2	416	424	PF00179	0.541
MOD_SUMO_rev_2	56	64	PF00179	0.587
TRG_DiLeu_BaEn_3	80	86	PF01217	0.637
TRG_ENDOCYTIC_2	319	322	PF00928	0.566
TRG_ENDOCYTIC_2	398	401	PF00928	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C3	Leptomonas seymouri	67%	95%
A4H912	Leishmania braziliensis	73%	100%
A4HXE4	Leishmania infantum	99%	100%
E9AR39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEC4	Leishmania major	90%	100%
V5D5C0	Trypanosoma cruzi	34%	100%