Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUD7_LEIDO

TriTrypDb:

LdBPK_170590.1 , LdCL_170011300 , LDHU3_17.0890

Length:

1064

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	495	499	PF00656	0.786
CLV_MEL_PAP_1	125	131	PF00089	0.552
CLV_NRD_NRD_1	447	449	PF00675	0.873
CLV_NRD_NRD_1	563	565	PF00675	0.856
CLV_NRD_NRD_1	60	62	PF00675	0.807
CLV_NRD_NRD_1	642	644	PF00675	0.607
CLV_NRD_NRD_1	75	77	PF00675	0.599
CLV_NRD_NRD_1	90	92	PF00675	0.588
CLV_NRD_NRD_1	990	992	PF00675	0.837
CLV_PCSK_FUR_1	445	449	PF00082	0.813
CLV_PCSK_KEX2_1	447	449	PF00082	0.873
CLV_PCSK_KEX2_1	563	565	PF00082	0.856
CLV_PCSK_KEX2_1	60	62	PF00082	0.807
CLV_PCSK_KEX2_1	642	644	PF00082	0.580
CLV_PCSK_KEX2_1	723	725	PF00082	0.666
CLV_PCSK_KEX2_1	75	77	PF00082	0.599
CLV_PCSK_KEX2_1	90	92	PF00082	0.588
CLV_PCSK_KEX2_1	952	954	PF00082	0.664
CLV_PCSK_KEX2_1	989	991	PF00082	0.835
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.666
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.655
CLV_PCSK_PC7_1	443	449	PF00082	0.837
CLV_PCSK_PC7_1	86	92	PF00082	0.659
CLV_PCSK_SKI1_1	155	159	PF00082	0.615
CLV_PCSK_SKI1_1	221	225	PF00082	0.690
CLV_PCSK_SKI1_1	516	520	PF00082	0.848
CLV_PCSK_SKI1_1	538	542	PF00082	0.673
CLV_PCSK_SKI1_1	662	666	PF00082	0.529
CLV_PCSK_SKI1_1	741	745	PF00082	0.681
CLV_PCSK_SKI1_1	842	846	PF00082	0.668
CLV_PCSK_SKI1_1	888	892	PF00082	0.674
CLV_PCSK_SKI1_1	994	998	PF00082	0.748
DEG_APCC_DBOX_1	758	766	PF00400	0.600
DEG_APCC_DBOX_1	802	810	PF00400	0.680
DEG_SCF_FBW7_1	16	23	PF00400	0.798
DEG_SCF_FBW7_1	465	471	PF00400	0.863
DEG_SPOP_SBC_1	11	15	PF00917	0.790
DEG_SPOP_SBC_1	595	599	PF00917	0.791
DOC_ANK_TNKS_1	747	754	PF00023	0.474
DOC_CKS1_1	465	470	PF01111	0.864
DOC_CKS1_1	624	629	PF01111	0.720
DOC_CYCLIN_RxL_1	152	162	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.644
DOC_MAPK_gen_1	188	196	PF00069	0.640
DOC_MAPK_gen_1	485	494	PF00069	0.858
DOC_MAPK_gen_1	652	660	PF00069	0.444
DOC_MAPK_gen_1	952	959	PF00069	0.653
DOC_MAPK_MEF2A_6	221	228	PF00069	0.686
DOC_PP2B_LxvP_1	309	312	PF13499	0.648
DOC_USP7_MATH_1	1035	1039	PF00917	0.655
DOC_USP7_MATH_1	146	150	PF00917	0.707
DOC_USP7_MATH_1	20	24	PF00917	0.651
DOC_USP7_MATH_1	255	259	PF00917	0.817
DOC_USP7_MATH_1	272	276	PF00917	0.501
DOC_USP7_MATH_1	279	283	PF00917	0.690
DOC_USP7_MATH_1	285	289	PF00917	0.658
DOC_USP7_MATH_1	33	37	PF00917	0.627
DOC_USP7_MATH_1	397	401	PF00917	0.723
DOC_USP7_MATH_1	460	464	PF00917	0.854
DOC_USP7_MATH_1	468	472	PF00917	0.731
DOC_USP7_MATH_1	757	761	PF00917	0.634
DOC_USP7_MATH_1	770	774	PF00917	0.532
DOC_USP7_MATH_1	847	851	PF00917	0.487
DOC_USP7_MATH_1	872	876	PF00917	0.455
DOC_USP7_MATH_1	9	13	PF00917	0.735
DOC_USP7_MATH_1	970	974	PF00917	0.708
DOC_USP7_UBL2_3	952	956	PF12436	0.578
DOC_WW_Pin1_4	1014	1019	PF00397	0.842
DOC_WW_Pin1_4	1058	1063	PF00397	0.721
DOC_WW_Pin1_4	144	149	PF00397	0.731
DOC_WW_Pin1_4	16	21	PF00397	0.676
DOC_WW_Pin1_4	281	286	PF00397	0.824
DOC_WW_Pin1_4	341	346	PF00397	0.832
DOC_WW_Pin1_4	351	356	PF00397	0.674
DOC_WW_Pin1_4	370	375	PF00397	0.543
DOC_WW_Pin1_4	377	382	PF00397	0.781
DOC_WW_Pin1_4	390	395	PF00397	0.555
DOC_WW_Pin1_4	406	411	PF00397	0.637
DOC_WW_Pin1_4	464	469	PF00397	0.862
DOC_WW_Pin1_4	527	532	PF00397	0.860
DOC_WW_Pin1_4	597	602	PF00397	0.846
DOC_WW_Pin1_4	623	628	PF00397	0.704
DOC_WW_Pin1_4	67	72	PF00397	0.804
DOC_WW_Pin1_4	7	12	PF00397	0.739
DOC_WW_Pin1_4	74	79	PF00397	0.715
DOC_WW_Pin1_4	775	780	PF00397	0.761
LIG_14-3-3_CanoR_1	1058	1062	PF00244	0.780
LIG_14-3-3_CanoR_1	128	137	PF00244	0.733
LIG_14-3-3_CanoR_1	22	28	PF00244	0.799
LIG_14-3-3_CanoR_1	47	54	PF00244	0.801
LIG_14-3-3_CanoR_1	684	692	PF00244	0.613
LIG_14-3-3_CanoR_1	695	704	PF00244	0.441
LIG_14-3-3_CanoR_1	759	763	PF00244	0.506
LIG_14-3-3_CanoR_1	910	918	PF00244	0.609
LIG_14-3-3_CanoR_1	994	1004	PF00244	0.845
LIG_Actin_WH2_2	795	812	PF00022	0.571
LIG_Actin_WH2_2	855	872	PF00022	0.581
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BRCT_BRCA1_1	125	129	PF00533	0.698
LIG_Clathr_ClatBox_1	733	737	PF01394	0.675
LIG_EVH1_1	291	295	PF00568	0.850
LIG_FHA_1	1047	1053	PF00498	0.720
LIG_FHA_1	114	120	PF00498	0.719
LIG_FHA_1	304	310	PF00498	0.866
LIG_FHA_1	333	339	PF00498	0.761
LIG_FHA_1	465	471	PF00498	0.760
LIG_FHA_1	598	604	PF00498	0.687
LIG_FHA_1	659	665	PF00498	0.625
LIG_FHA_1	889	895	PF00498	0.679
LIG_FHA_2	470	476	PF00498	0.799
LIG_FHA_2	502	508	PF00498	0.793
LIG_FHA_2	624	630	PF00498	0.716
LIG_FHA_2	745	751	PF00498	0.675
LIG_FHA_2	830	836	PF00498	0.640
LIG_FHA_2	880	886	PF00498	0.567
LIG_GBD_Chelix_1	798	806	PF00786	0.603
LIG_IRF3_LxIS_1	1039	1045	PF10401	0.506
LIG_LIR_Apic_2	142	148	PF02991	0.742
LIG_LIR_Apic_2	305	311	PF02991	0.660
LIG_LIR_Apic_2	357	363	PF02991	0.672
LIG_LIR_Gen_1	156	166	PF02991	0.662
LIG_LIR_Gen_1	234	243	PF02991	0.389
LIG_LIR_Gen_1	320	330	PF02991	0.670
LIG_LIR_Gen_1	343	351	PF02991	0.739
LIG_LIR_Gen_1	656	665	PF02991	0.645
LIG_LIR_Nem_3	156	161	PF02991	0.664
LIG_LIR_Nem_3	234	240	PF02991	0.384
LIG_LIR_Nem_3	288	294	PF02991	0.852
LIG_LIR_Nem_3	320	326	PF02991	0.735
LIG_LIR_Nem_3	343	349	PF02991	0.735
LIG_LIR_Nem_3	656	660	PF02991	0.582
LIG_MYND_1	292	296	PF01753	0.848
LIG_PCNA_yPIPBox_3	707	719	PF02747	0.653
LIG_Pex14_1	237	241	PF04695	0.394
LIG_PTB_Apo_2	508	515	PF02174	0.841
LIG_PTB_Phospho_1	508	514	PF10480	0.843
LIG_RPA_C_Fungi	258	270	PF08784	0.639
LIG_SH2_CRK	1036	1040	PF00017	0.715
LIG_SH2_CRK	346	350	PF00017	0.848
LIG_SH2_CRK	360	364	PF00017	0.613
LIG_SH2_CRK	621	625	PF00017	0.755
LIG_SH2_CRK	657	661	PF00017	0.436
LIG_SH2_SRC	200	203	PF00017	0.675
LIG_SH2_STAP1	115	119	PF00017	0.619
LIG_SH2_STAP1	925	929	PF00017	0.645
LIG_SH2_STAT3	619	622	PF00017	0.769
LIG_SH2_STAT5	115	118	PF00017	0.724
LIG_SH2_STAT5	241	244	PF00017	0.696
LIG_SH2_STAT5	308	311	PF00017	0.865
LIG_SH2_STAT5	346	349	PF00017	0.845
LIG_SH2_STAT5	619	622	PF00017	0.769
LIG_SH3_1	308	314	PF00018	0.647
LIG_SH3_1	621	627	PF00018	0.743
LIG_SH3_3	289	295	PF00018	0.836
LIG_SH3_3	308	314	PF00018	0.587
LIG_SH3_3	371	377	PF00018	0.844
LIG_SH3_3	388	394	PF00018	0.593
LIG_SH3_3	481	487	PF00018	0.849
LIG_SH3_3	5	11	PF00018	0.780
LIG_SH3_3	621	627	PF00018	0.743
LIG_SUMO_SIM_par_1	732	737	PF11976	0.677
LIG_TRAF2_1	179	182	PF00917	0.687
LIG_TRAF2_1	354	357	PF00917	0.630
LIG_TRAF2_1	630	633	PF00917	0.699
LIG_TRAF2_1	882	885	PF00917	0.665
LIG_TRAF2_1	896	899	PF00917	0.346
LIG_TRAF2_2	311	316	PF00917	0.636
LIG_TYR_ITIM	655	660	PF00017	0.542
LIG_WW_2	292	295	PF00397	0.848
LIG_WW_3	253	257	PF00397	0.732
MOD_CDC14_SPxK_1	15	18	PF00782	0.688
MOD_CDK_SPxK_1	12	18	PF00069	0.773
MOD_CDK_SPxK_1	74	80	PF00069	0.808
MOD_CDK_SPxxK_3	406	413	PF00069	0.814
MOD_CK1_1	1017	1023	PF00069	0.582
MOD_CK1_1	117	123	PF00069	0.747
MOD_CK1_1	127	133	PF00069	0.603
MOD_CK1_1	23	29	PF00069	0.581
MOD_CK1_1	275	281	PF00069	0.743
MOD_CK1_1	344	350	PF00069	0.705
MOD_CK1_1	380	386	PF00069	0.865
MOD_CK1_1	393	399	PF00069	0.636
MOD_CK1_1	464	470	PF00069	0.805
MOD_CK1_1	522	528	PF00069	0.737
MOD_CK1_1	529	535	PF00069	0.653
MOD_CK1_1	602	608	PF00069	0.845
MOD_CK1_1	613	619	PF00069	0.777
MOD_CK1_1	683	689	PF00069	0.612
MOD_CK1_1	7	13	PF00069	0.789
MOD_CK1_1	775	781	PF00069	0.643
MOD_CK1_1	84	90	PF00069	0.805
MOD_CK1_1	854	860	PF00069	0.556
MOD_CK1_1	913	919	PF00069	0.645
MOD_CK2_1	144	150	PF00069	0.723
MOD_CK2_1	350	356	PF00069	0.780
MOD_CK2_1	469	475	PF00069	0.716
MOD_CK2_1	501	507	PF00069	0.794
MOD_CK2_1	623	629	PF00069	0.727
MOD_CK2_1	744	750	PF00069	0.658
MOD_CK2_1	758	764	PF00069	0.366
MOD_CK2_1	829	835	PF00069	0.646
MOD_CK2_1	837	843	PF00069	0.500
MOD_CK2_1	879	885	PF00069	0.566
MOD_CK2_1	893	899	PF00069	0.391
MOD_CK2_1	920	926	PF00069	0.501
MOD_Cter_Amidation	561	564	PF01082	0.796
MOD_DYRK1A_RPxSP_1	1058	1062	PF00069	0.718
MOD_DYRK1A_RPxSP_1	390	394	PF00069	0.783
MOD_GlcNHglycan	1006	1009	PF01048	0.788
MOD_GlcNHglycan	1044	1047	PF01048	0.659
MOD_GlcNHglycan	129	132	PF01048	0.695
MOD_GlcNHglycan	257	260	PF01048	0.657
MOD_GlcNHglycan	274	277	PF01048	0.547
MOD_GlcNHglycan	281	284	PF01048	0.741
MOD_GlcNHglycan	287	290	PF01048	0.672
MOD_GlcNHglycan	349	352	PF01048	0.687
MOD_GlcNHglycan	385	388	PF01048	0.811
MOD_GlcNHglycan	395	398	PF01048	0.754
MOD_GlcNHglycan	399	402	PF01048	0.695
MOD_GlcNHglycan	50	53	PF01048	0.797
MOD_GlcNHglycan	524	527	PF01048	0.723
MOD_GlcNHglycan	543	546	PF01048	0.516
MOD_GlcNHglycan	553	556	PF01048	0.736
MOD_GlcNHglycan	685	688	PF01048	0.609
MOD_GlcNHglycan	772	775	PF01048	0.731
MOD_GlcNHglycan	818	823	PF01048	0.644
MOD_GlcNHglycan	853	856	PF01048	0.533
MOD_GlcNHglycan	86	89	PF01048	0.806
MOD_GlcNHglycan	870	873	PF01048	0.493
MOD_GlcNHglycan	912	915	PF01048	0.638
MOD_GlcNHglycan	974	977	PF01048	0.565
MOD_GSK3_1	1004	1011	PF00069	0.791
MOD_GSK3_1	1017	1024	PF00069	0.648
MOD_GSK3_1	1042	1049	PF00069	0.708
MOD_GSK3_1	111	118	PF00069	0.746
MOD_GSK3_1	123	130	PF00069	0.585
MOD_GSK3_1	140	147	PF00069	0.571
MOD_GSK3_1	16	23	PF00069	0.678
MOD_GSK3_1	255	262	PF00069	0.681
MOD_GSK3_1	275	282	PF00069	0.565
MOD_GSK3_1	283	290	PF00069	0.707
MOD_GSK3_1	294	301	PF00069	0.537
MOD_GSK3_1	337	344	PF00069	0.820
MOD_GSK3_1	347	354	PF00069	0.695
MOD_GSK3_1	379	386	PF00069	0.856
MOD_GSK3_1	393	400	PF00069	0.615
MOD_GSK3_1	460	467	PF00069	0.857
MOD_GSK3_1	516	523	PF00069	0.759
MOD_GSK3_1	525	532	PF00069	0.670
MOD_GSK3_1	551	558	PF00069	0.742
MOD_GSK3_1	587	594	PF00069	0.830
MOD_GSK3_1	595	602	PF00069	0.566
MOD_GSK3_1	603	610	PF00069	0.692
MOD_GSK3_1	7	14	PF00069	0.791
MOD_GSK3_1	765	772	PF00069	0.668
MOD_GSK3_1	847	854	PF00069	0.557
MOD_GSK3_1	868	875	PF00069	0.448
MOD_GSK3_1	913	920	PF00069	0.653
MOD_GSK3_1	927	934	PF00069	0.413
MOD_N-GLC_1	303	308	PF02516	0.762
MOD_N-GLC_1	461	466	PF02516	0.763
MOD_N-GLC_1	502	507	PF02516	0.740
MOD_N-GLC_2	667	669	PF02516	0.579
MOD_NEK2_1	1042	1047	PF00069	0.708
MOD_NEK2_1	1052	1057	PF00069	0.583
MOD_NEK2_1	129	134	PF00069	0.693
MOD_NEK2_1	349	354	PF00069	0.663
MOD_NEK2_1	4	9	PF00069	0.773
MOD_NEK2_1	411	416	PF00069	0.754
MOD_NEK2_1	521	526	PF00069	0.856
MOD_NEK2_1	541	546	PF00069	0.515
MOD_NEK2_1	603	608	PF00069	0.674
MOD_NEK2_1	736	741	PF00069	0.674
MOD_NEK2_1	758	763	PF00069	0.504
MOD_NEK2_1	769	774	PF00069	0.548
MOD_NEK2_1	829	834	PF00069	0.672
MOD_PIKK_1	129	135	PF00454	0.692
MOD_PIKK_1	726	732	PF00454	0.673
MOD_PIKK_1	893	899	PF00454	0.617
MOD_PIKK_1	917	923	PF00454	0.546
MOD_PK_1	927	933	PF00069	0.443
MOD_PKA_1	990	996	PF00069	0.785
MOD_PKA_2	1042	1048	PF00069	0.708
MOD_PKA_2	1057	1063	PF00069	0.534
MOD_PKA_2	127	133	PF00069	0.696
MOD_PKA_2	21	27	PF00069	0.801
MOD_PKA_2	255	261	PF00069	0.752
MOD_PKA_2	46	52	PF00069	0.802
MOD_PKA_2	683	689	PF00069	0.618
MOD_PKA_2	758	764	PF00069	0.504
MOD_PKA_2	990	996	PF00069	0.847
MOD_PKB_1	138	146	PF00069	0.716
MOD_PKB_1	886	894	PF00069	0.679
MOD_Plk_1	461	467	PF00069	0.761
MOD_Plk_1	818	824	PF00069	0.644
MOD_Plk_1	902	908	PF00069	0.643
MOD_Plk_1	927	933	PF00069	0.443
MOD_Plk_4	344	350	PF00069	0.739
MOD_Plk_4	461	467	PF00069	0.859
MOD_ProDKin_1	1014	1020	PF00069	0.843
MOD_ProDKin_1	1058	1064	PF00069	0.729
MOD_ProDKin_1	144	150	PF00069	0.723
MOD_ProDKin_1	16	22	PF00069	0.679
MOD_ProDKin_1	281	287	PF00069	0.826
MOD_ProDKin_1	341	347	PF00069	0.831
MOD_ProDKin_1	351	357	PF00069	0.675
MOD_ProDKin_1	370	376	PF00069	0.541
MOD_ProDKin_1	377	383	PF00069	0.780
MOD_ProDKin_1	390	396	PF00069	0.555
MOD_ProDKin_1	406	412	PF00069	0.639
MOD_ProDKin_1	464	470	PF00069	0.864
MOD_ProDKin_1	527	533	PF00069	0.856
MOD_ProDKin_1	597	603	PF00069	0.847
MOD_ProDKin_1	623	629	PF00069	0.700
MOD_ProDKin_1	67	73	PF00069	0.805
MOD_ProDKin_1	7	13	PF00069	0.740
MOD_ProDKin_1	74	80	PF00069	0.714
MOD_ProDKin_1	775	781	PF00069	0.753
MOD_SUMO_for_1	1022	1025	PF00179	0.724
MOD_SUMO_for_1	172	175	PF00179	0.614
MOD_SUMO_for_1	996	999	PF00179	0.740
MOD_SUMO_rev_2	316	323	PF00179	0.776
MOD_SUMO_rev_2	699	709	PF00179	0.647
TRG_DiLeu_BaEn_1	219	224	PF01217	0.693
TRG_DiLeu_BaEn_1	946	951	PF01217	0.672
TRG_DiLeu_BaEn_4	219	225	PF01217	0.692
TRG_DiLeu_BaEn_4	633	639	PF01217	0.690
TRG_DiLeu_BaEn_4	646	652	PF01217	0.430
TRG_DiLeu_BaEn_4	884	890	PF01217	0.614
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.718
TRG_ENDOCYTIC_2	346	349	PF00928	0.742
TRG_ENDOCYTIC_2	657	660	PF00928	0.645
TRG_ENDOCYTIC_2	954	957	PF00928	0.559
TRG_ER_diArg_1	445	448	PF00400	0.814
TRG_ER_diArg_1	491	494	PF00400	0.799
TRG_ER_diArg_1	59	61	PF00400	0.813
TRG_ER_diArg_1	641	643	PF00400	0.612
TRG_ER_diArg_1	831	834	PF00400	0.682
TRG_ER_diArg_1	886	889	PF00400	0.677
TRG_ER_diArg_1	989	991	PF00400	0.691
TRG_NES_CRM1_1	649	663	PF08389	0.610
TRG_NES_CRM1_1	877	893	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	910	915	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H8Z6	Leishmania braziliensis	71%	99%
A4HXC7	Leishmania infantum	100%	100%
E9AR22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QEE1	Leishmania major	90%	100%