Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WUD2_LEIDO

TriTrypDb:

LdBPK_170580.1 , LdCL_170011200 , LDHU3_17.0880

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.782
CLV_C14_Caspase3-7	304	308	PF00656	0.827
CLV_C14_Caspase3-7	315	319	PF00656	0.668
CLV_C14_Caspase3-7	660	664	PF00656	0.812
CLV_NRD_NRD_1	145	147	PF00675	0.754
CLV_NRD_NRD_1	258	260	PF00675	0.754
CLV_NRD_NRD_1	269	271	PF00675	0.614
CLV_NRD_NRD_1	51	53	PF00675	0.779
CLV_NRD_NRD_1	571	573	PF00675	0.709
CLV_NRD_NRD_1	60	62	PF00675	0.656
CLV_NRD_NRD_1	782	784	PF00675	0.608
CLV_NRD_NRD_1	9	11	PF00675	0.769
CLV_PCSK_KEX2_1	145	147	PF00082	0.754
CLV_PCSK_KEX2_1	258	260	PF00082	0.756
CLV_PCSK_KEX2_1	269	271	PF00082	0.612
CLV_PCSK_KEX2_1	51	53	PF00082	0.779
CLV_PCSK_KEX2_1	782	784	PF00082	0.597
CLV_PCSK_KEX2_1	840	842	PF00082	0.813
CLV_PCSK_KEX2_1	9	11	PF00082	0.749
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.813
CLV_PCSK_SKI1_1	230	234	PF00082	0.737
CLV_PCSK_SKI1_1	568	572	PF00082	0.825
CLV_PCSK_SKI1_1	724	728	PF00082	0.778
DEG_Kelch_Keap1_1	791	796	PF01344	0.735
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DEG_SPOP_SBC_1	37	41	PF00917	0.780
DEG_SPOP_SBC_1	481	485	PF00917	0.645
DOC_ANK_TNKS_1	50	57	PF00023	0.738
DOC_CKS1_1	382	387	PF01111	0.866
DOC_CKS1_1	762	767	PF01111	0.846
DOC_MAPK_gen_1	496	504	PF00069	0.645
DOC_MAPK_gen_1	840	846	PF00069	0.818
DOC_MAPK_MEF2A_6	359	367	PF00069	0.843
DOC_PP1_SILK_1	568	573	PF00149	0.827
DOC_PP2B_LxvP_1	23	26	PF13499	0.772
DOC_PP2B_LxvP_1	33	36	PF13499	0.655
DOC_PP2B_LxvP_1	459	462	PF13499	0.731
DOC_PP2B_LxvP_1	78	81	PF13499	0.747
DOC_PP2B_LxvP_1	800	803	PF13499	0.752
DOC_PP4_FxxP_1	371	374	PF00568	0.808
DOC_USP7_MATH_1	108	112	PF00917	0.678
DOC_USP7_MATH_1	138	142	PF00917	0.775
DOC_USP7_MATH_1	185	189	PF00917	0.842
DOC_USP7_MATH_1	204	208	PF00917	0.536
DOC_USP7_MATH_1	244	248	PF00917	0.807
DOC_USP7_MATH_1	263	267	PF00917	0.501
DOC_USP7_MATH_1	298	302	PF00917	0.834
DOC_USP7_MATH_1	354	358	PF00917	0.685
DOC_USP7_MATH_1	36	40	PF00917	0.777
DOC_USP7_MATH_1	374	378	PF00917	0.712
DOC_USP7_MATH_1	392	396	PF00917	0.559
DOC_USP7_MATH_1	481	485	PF00917	0.838
DOC_USP7_MATH_1	535	539	PF00917	0.627
DOC_USP7_MATH_1	551	555	PF00917	0.804
DOC_USP7_MATH_1	625	629	PF00917	0.736
DOC_USP7_MATH_1	86	90	PF00917	0.726
DOC_USP7_MATH_1	91	95	PF00917	0.661
DOC_WW_Pin1_4	126	131	PF00397	0.653
DOC_WW_Pin1_4	200	205	PF00397	0.848
DOC_WW_Pin1_4	206	211	PF00397	0.751
DOC_WW_Pin1_4	21	26	PF00397	0.699
DOC_WW_Pin1_4	268	273	PF00397	0.752
DOC_WW_Pin1_4	293	298	PF00397	0.761
DOC_WW_Pin1_4	308	313	PF00397	0.610
DOC_WW_Pin1_4	376	381	PF00397	0.811
DOC_WW_Pin1_4	38	43	PF00397	0.648
DOC_WW_Pin1_4	388	393	PF00397	0.663
DOC_WW_Pin1_4	490	495	PF00397	0.722
DOC_WW_Pin1_4	545	550	PF00397	0.782
DOC_WW_Pin1_4	599	604	PF00397	0.674
DOC_WW_Pin1_4	618	623	PF00397	0.704
DOC_WW_Pin1_4	640	645	PF00397	0.848
DOC_WW_Pin1_4	669	674	PF00397	0.669
DOC_WW_Pin1_4	676	681	PF00397	0.724
DOC_WW_Pin1_4	739	744	PF00397	0.846
DOC_WW_Pin1_4	751	756	PF00397	0.629
DOC_WW_Pin1_4	758	763	PF00397	0.532
DOC_WW_Pin1_4	766	771	PF00397	0.653
DOC_WW_Pin1_4	833	838	PF00397	0.784
LIG_14-3-3_CanoR_1	168	172	PF00244	0.738
LIG_14-3-3_CanoR_1	187	196	PF00244	0.590
LIG_14-3-3_CanoR_1	258	267	PF00244	0.745
LIG_14-3-3_CanoR_1	332	336	PF00244	0.727
LIG_14-3-3_CanoR_1	393	397	PF00244	0.699
LIG_14-3-3_CanoR_1	61	70	PF00244	0.737
LIG_14-3-3_CanoR_1	637	645	PF00244	0.713
LIG_14-3-3_CanoR_1	658	667	PF00244	0.782
LIG_14-3-3_CanoR_1	684	692	PF00244	0.748
LIG_BIR_III_2	675	679	PF00653	0.782
LIG_BIR_III_2	85	89	PF00653	0.768
LIG_BIR_III_4	450	454	PF00653	0.711
LIG_BRCT_BRCA1_1	553	557	PF00533	0.732
LIG_CtBP_PxDLS_1	743	747	PF00389	0.628
LIG_FHA_1	156	162	PF00498	0.757
LIG_FHA_1	167	173	PF00498	0.709
LIG_FHA_1	328	334	PF00498	0.770
LIG_FHA_1	362	368	PF00498	0.752
LIG_FHA_1	398	404	PF00498	0.750
LIG_FHA_1	497	503	PF00498	0.824
LIG_FHA_1	619	625	PF00498	0.734
LIG_FHA_1	64	70	PF00498	0.745
LIG_FHA_1	795	801	PF00498	0.766
LIG_FHA_1	93	99	PF00498	0.748
LIG_FHA_2	14	20	PF00498	0.778
LIG_FHA_2	158	164	PF00498	0.718
LIG_FHA_2	210	216	PF00498	0.738
LIG_FHA_2	472	478	PF00498	0.605
LIG_FHA_2	487	493	PF00498	0.623
LIG_FHA_2	550	556	PF00498	0.804
LIG_FHA_2	658	664	PF00498	0.813
LIG_FHA_2	670	676	PF00498	0.655
LIG_FHA_2	716	722	PF00498	0.805
LIG_FHA_2	803	809	PF00498	0.791
LIG_FHA_2	822	828	PF00498	0.535
LIG_LIR_Apic_2	370	374	PF02991	0.804
LIG_LIR_Apic_2	693	699	PF02991	0.742
LIG_LIR_Apic_2	764	770	PF02991	0.634
LIG_LIR_Gen_1	424	431	PF02991	0.719
LIG_LIR_Nem_3	424	429	PF02991	0.801
LIG_LIR_Nem_3	554	560	PF02991	0.728
LIG_LIR_Nem_3	653	657	PF02991	0.816
LIG_MAD2	74	82	PF02301	0.715
LIG_PDZ_Class_2	841	846	PF00595	0.818
LIG_SH2_GRB2like	443	446	PF00017	0.762
LIG_SH2_SRC	100	103	PF00017	0.751
LIG_SH2_STAT5	100	103	PF00017	0.751
LIG_SH3_3	1	7	PF00018	0.663
LIG_SH3_3	191	197	PF00018	0.811
LIG_SH3_3	294	300	PF00018	0.764
LIG_SH3_3	379	385	PF00018	0.679
LIG_SH3_3	414	420	PF00018	0.663
LIG_SH3_3	451	457	PF00018	0.771
LIG_SH3_3	597	603	PF00018	0.764
LIG_SH3_3	619	625	PF00018	0.637
LIG_SH3_3	759	765	PF00018	0.764
LIG_SH3_3	796	802	PF00018	0.726
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.756
LIG_UBA3_1	520	525	PF00899	0.654
LIG_WRC_WIRS_1	368	373	PF05994	0.810
MOD_CDC14_SPxK_1	754	757	PF00782	0.716
MOD_CDC14_SPxK_1	769	772	PF00782	0.672
MOD_CDK_SPK_2	378	383	PF00069	0.655
MOD_CDK_SPK_2	388	393	PF00069	0.603
MOD_CDK_SPK_2	618	623	PF00069	0.852
MOD_CDK_SPxK_1	293	299	PF00069	0.754
MOD_CDK_SPxK_1	490	496	PF00069	0.656
MOD_CDK_SPxK_1	751	757	PF00069	0.715
MOD_CDK_SPxK_1	766	772	PF00069	0.670
MOD_CDK_SPxxK_3	376	383	PF00069	0.847
MOD_CDK_SPxxK_3	833	840	PF00069	0.826
MOD_CK1_1	111	117	PF00069	0.775
MOD_CK1_1	126	132	PF00069	0.662
MOD_CK1_1	155	161	PF00069	0.760
MOD_CK1_1	186	192	PF00069	0.757
MOD_CK1_1	209	215	PF00069	0.739
MOD_CK1_1	231	237	PF00069	0.768
MOD_CK1_1	247	253	PF00069	0.551
MOD_CK1_1	301	307	PF00069	0.748
MOD_CK1_1	381	387	PF00069	0.866
MOD_CK1_1	391	397	PF00069	0.690
MOD_CK1_1	408	414	PF00069	0.581
MOD_CK1_1	436	442	PF00069	0.686
MOD_CK1_1	484	490	PF00069	0.726
MOD_CK1_1	506	512	PF00069	0.759
MOD_CK1_1	514	520	PF00069	0.681
MOD_CK1_1	523	529	PF00069	0.608
MOD_CK1_1	544	550	PF00069	0.832
MOD_CK1_1	574	580	PF00069	0.740
MOD_CK1_1	710	716	PF00069	0.728
MOD_CK1_1	751	757	PF00069	0.758
MOD_CK1_1	761	767	PF00069	0.748
MOD_CK1_1	804	810	PF00069	0.752
MOD_CK2_1	209	215	PF00069	0.739
MOD_CK2_1	344	350	PF00069	0.660
MOD_CK2_1	471	477	PF00069	0.658
MOD_CK2_1	486	492	PF00069	0.672
MOD_CK2_1	497	503	PF00069	0.678
MOD_CK2_1	549	555	PF00069	0.811
MOD_CK2_1	715	721	PF00069	0.768
MOD_CK2_1	790	796	PF00069	0.775
MOD_CK2_1	802	808	PF00069	0.701
MOD_CK2_1	821	827	PF00069	0.538
MOD_GlcNHglycan	126	129	PF01048	0.847
MOD_GlcNHglycan	244	247	PF01048	0.756
MOD_GlcNHglycan	249	252	PF01048	0.688
MOD_GlcNHglycan	261	264	PF01048	0.527
MOD_GlcNHglycan	303	306	PF01048	0.742
MOD_GlcNHglycan	322	325	PF01048	0.561
MOD_GlcNHglycan	33	36	PF01048	0.654
MOD_GlcNHglycan	356	359	PF01048	0.679
MOD_GlcNHglycan	394	397	PF01048	0.820
MOD_GlcNHglycan	407	410	PF01048	0.691
MOD_GlcNHglycan	435	438	PF01048	0.823
MOD_GlcNHglycan	463	466	PF01048	0.858
MOD_GlcNHglycan	484	487	PF01048	0.773
MOD_GlcNHglycan	530	533	PF01048	0.697
MOD_GlcNHglycan	573	576	PF01048	0.745
MOD_GlcNHglycan	627	630	PF01048	0.755
MOD_GlcNHglycan	63	66	PF01048	0.786
MOD_GlcNHglycan	638	641	PF01048	0.640
MOD_GlcNHglycan	669	672	PF01048	0.745
MOD_GlcNHglycan	778	781	PF01048	0.839
MOD_GlcNHglycan	88	91	PF01048	0.721
MOD_GSK3_1	129	136	PF00069	0.731
MOD_GSK3_1	157	164	PF00069	0.783
MOD_GSK3_1	167	174	PF00069	0.736
MOD_GSK3_1	175	182	PF00069	0.595
MOD_GSK3_1	183	190	PF00069	0.569
MOD_GSK3_1	200	207	PF00069	0.562
MOD_GSK3_1	209	216	PF00069	0.716
MOD_GSK3_1	220	227	PF00069	0.595
MOD_GSK3_1	259	266	PF00069	0.774
MOD_GSK3_1	327	334	PF00069	0.764
MOD_GSK3_1	344	351	PF00069	0.663
MOD_GSK3_1	374	381	PF00069	0.862
MOD_GSK3_1	38	45	PF00069	0.799
MOD_GSK3_1	387	394	PF00069	0.657
MOD_GSK3_1	429	436	PF00069	0.777
MOD_GSK3_1	469	476	PF00069	0.720
MOD_GSK3_1	480	487	PF00069	0.657
MOD_GSK3_1	488	495	PF00069	0.668
MOD_GSK3_1	511	518	PF00069	0.809
MOD_GSK3_1	519	526	PF00069	0.747
MOD_GSK3_1	541	548	PF00069	0.748
MOD_GSK3_1	562	569	PF00069	0.737
MOD_GSK3_1	595	602	PF00069	0.675
MOD_GSK3_1	613	620	PF00069	0.633
MOD_GSK3_1	636	643	PF00069	0.678
MOD_GSK3_1	703	710	PF00069	0.729
MOD_GSK3_1	756	763	PF00069	0.642
MOD_GSK3_1	766	773	PF00069	0.650
MOD_GSK3_1	790	797	PF00069	0.847
MOD_GSK3_1	9	16	PF00069	0.801
MOD_LATS_1	346	352	PF00433	0.738
MOD_N-GLC_1	403	408	PF02516	0.815
MOD_N-GLC_1	515	520	PF02516	0.689
MOD_N-GLC_1	595	600	PF02516	0.764
MOD_N-GLC_1	667	672	PF02516	0.773
MOD_N-GLC_1	710	715	PF02516	0.758
MOD_N-GLC_1	790	795	PF02516	0.808
MOD_NEK2_1	157	162	PF00069	0.714
MOD_NEK2_1	171	176	PF00069	0.713
MOD_NEK2_1	183	188	PF00069	0.656
MOD_NEK2_1	249	254	PF00069	0.752
MOD_NEK2_1	290	295	PF00069	0.789
MOD_NEK2_1	31	36	PF00069	0.711
MOD_NEK2_1	47	52	PF00069	0.723
MOD_NEK2_1	512	517	PF00069	0.780
MOD_NEK2_1	520	525	PF00069	0.728
MOD_NEK2_1	571	576	PF00069	0.642
MOD_NEK2_1	657	662	PF00069	0.812
MOD_PIKK_1	175	181	PF00454	0.765
MOD_PIKK_1	204	210	PF00454	0.672
MOD_PIKK_1	224	230	PF00454	0.690
MOD_PIKK_1	331	337	PF00454	0.729
MOD_PIKK_1	42	48	PF00454	0.812
MOD_PIKK_1	770	776	PF00454	0.776
MOD_PIKK_1	794	800	PF00454	0.812
MOD_PK_1	566	572	PF00069	0.689
MOD_PKA_1	61	67	PF00069	0.718
MOD_PKA_1	9	15	PF00069	0.755
MOD_PKA_2	167	173	PF00069	0.736
MOD_PKA_2	186	192	PF00069	0.593
MOD_PKA_2	247	253	PF00069	0.753
MOD_PKA_2	298	304	PF00069	0.751
MOD_PKA_2	320	326	PF00069	0.812
MOD_PKA_2	331	337	PF00069	0.693
MOD_PKA_2	392	398	PF00069	0.695
MOD_PKA_2	497	503	PF00069	0.780
MOD_PKA_2	571	577	PF00069	0.625
MOD_PKA_2	60	66	PF00069	0.741
MOD_PKA_2	636	642	PF00069	0.719
MOD_PKA_2	657	663	PF00069	0.814
MOD_PKA_2	756	762	PF00069	0.670
MOD_PKA_2	776	782	PF00069	0.694
MOD_PKA_2	814	820	PF00069	0.707
MOD_PKA_2	9	15	PF00069	0.755
MOD_Plk_1	101	107	PF00069	0.741
MOD_Plk_1	515	521	PF00069	0.691
MOD_Plk_1	595	601	PF00069	0.765
MOD_Plk_1	710	716	PF00069	0.662
MOD_Plk_4	152	158	PF00069	0.833
MOD_Plk_4	167	173	PF00069	0.601
MOD_Plk_4	209	215	PF00069	0.643
MOD_Plk_4	348	354	PF00069	0.775
MOD_Plk_4	515	521	PF00069	0.644
MOD_Plk_4	566	572	PF00069	0.662
MOD_Plk_4	582	588	PF00069	0.667
MOD_ProDKin_1	126	132	PF00069	0.653
MOD_ProDKin_1	200	206	PF00069	0.846
MOD_ProDKin_1	21	27	PF00069	0.697
MOD_ProDKin_1	268	274	PF00069	0.752
MOD_ProDKin_1	293	299	PF00069	0.763
MOD_ProDKin_1	308	314	PF00069	0.609
MOD_ProDKin_1	376	382	PF00069	0.810
MOD_ProDKin_1	38	44	PF00069	0.648
MOD_ProDKin_1	388	394	PF00069	0.663
MOD_ProDKin_1	490	496	PF00069	0.722
MOD_ProDKin_1	545	551	PF00069	0.775
MOD_ProDKin_1	599	605	PF00069	0.673
MOD_ProDKin_1	618	624	PF00069	0.704
MOD_ProDKin_1	640	646	PF00069	0.846
MOD_ProDKin_1	669	675	PF00069	0.671
MOD_ProDKin_1	676	682	PF00069	0.724
MOD_ProDKin_1	739	745	PF00069	0.844
MOD_ProDKin_1	751	757	PF00069	0.632
MOD_ProDKin_1	758	764	PF00069	0.534
MOD_ProDKin_1	766	772	PF00069	0.655
MOD_ProDKin_1	833	839	PF00069	0.781
MOD_SUMO_rev_2	271	279	PF00179	0.750
TRG_ENDOCYTIC_2	443	446	PF00928	0.762
TRG_ER_diArg_1	144	146	PF00400	0.755
TRG_ER_diArg_1	683	686	PF00400	0.675
TRG_ER_diArg_1	781	783	PF00400	0.601
TRG_ER_diArg_1	8	10	PF00400	0.754
TRG_ER_diArg_1	841	844	PF00400	0.737
TRG_NLS_MonoExtN_4	837	844	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H8Z5	Leishmania braziliensis	51%	100%
A4HXC6	Leishmania infantum	100%	100%
E9AR21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	94%
Q4QEE2	Leishmania major	87%	100%