Cystathionine beta-synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cystathionine beta-synthase

Species:

Leishmania donovani

UniProt:

A0A3S7WUC4_LEIDO

TriTrypDb:

LdBPK_170300.1 , LdCL_170008500 , LDHU3_17.0570

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WUC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUC4

Function

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Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	10
GO:0000097	sulfur amino acid biosynthetic process	5	10
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006534	cysteine metabolic process	5	10
GO:0006535	cysteine biosynthetic process from serine	7	10
GO:0006563	L-serine metabolic process	6	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004122	cystathionine beta-synthase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.384
CLV_NRD_NRD_1	142	144	PF00675	0.359
CLV_NRD_NRD_1	247	249	PF00675	0.474
CLV_PCSK_KEX2_1	142	144	PF00082	0.341
CLV_PCSK_SKI1_1	199	203	PF00082	0.341
CLV_PCSK_SKI1_1	253	257	PF00082	0.341
CLV_PCSK_SKI1_1	350	354	PF00082	0.607
DOC_MAPK_DCC_7	200	210	PF00069	0.335
DOC_MAPK_gen_1	145	153	PF00069	0.393
DOC_MAPK_gen_1	53	62	PF00069	0.353

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H0	Leptomonas seymouri	82%	100%
A0A0N0P4U0	Leptomonas seymouri	36%	100%
A0A0S4IP22	Bodo saltans	28%	78%
A0A0S4JDZ7	Bodo saltans	34%	100%
A0A0S4JNJ6	Bodo saltans	65%	95%
A0A1X0NVD2	Trypanosomatidae	71%	100%
A0A1X0P4R1	Trypanosomatidae	38%	100%
A0A3S5H833	Leishmania donovani	36%	100%
A0A422N6U8	Trypanosoma rangeli	75%	96%
A4HPM6	Leishmania braziliensis	35%	100%

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