Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUB5_LEIDO

TriTrypDb:

LdBPK_170390.1 , LdCL_170009400 , LDHU3_17.0660

Length:

136

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	3	7	PF00082	0.344
DOC_MAPK_RevD_3	117	133	PF00069	0.390
DOC_USP7_UBL2_3	128	132	PF12436	0.394
LIG_Clathr_ClatBox_1	119	123	PF01394	0.311
LIG_FHA_1	114	120	PF00498	0.368
LIG_FHA_1	23	29	PF00498	0.607
LIG_FHA_2	25	31	PF00498	0.421
LIG_LIR_LC3C_4	43	47	PF02991	0.348
LIG_PTB_Apo_2	31	38	PF02174	0.392
LIG_PTB_Phospho_1	31	37	PF10480	0.392
LIG_SH2_STAP1	54	58	PF00017	0.356
LIG_SH2_STAT5	37	40	PF00017	0.302
LIG_SUMO_SIM_par_1	118	123	PF11976	0.418
MOD_CK2_1	24	30	PF00069	0.602
MOD_GlcNHglycan	104	107	PF01048	0.578
MOD_GlcNHglycan	42	45	PF01048	0.642
MOD_GlcNHglycan	89	92	PF01048	0.633
MOD_GSK3_1	80	87	PF00069	0.372
MOD_N-GLC_1	107	112	PF02516	0.532
MOD_N-GLC_1	48	53	PF02516	0.593
MOD_NEK2_1	107	112	PF00069	0.311
MOD_NEK2_1	22	27	PF00069	0.599
MOD_NEK2_1	50	55	PF00069	0.291
MOD_Plk_1	107	113	PF00069	0.421
MOD_Plk_1	48	54	PF00069	0.400
MOD_Plk_2-3	118	124	PF00069	0.340
MOD_Plk_2-3	75	81	PF00069	0.341
MOD_Plk_4	107	113	PF00069	0.418
MOD_Plk_4	97	103	PF00069	0.332
MOD_SUMO_rev_2	75	83	PF00179	0.388
TRG_ER_diLys_1	132	136	PF00400	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NT01	Trypanosomatidae	42%	100%
A0A3S5IS80	Trypanosoma rangeli	38%	100%
A4H8X7	Leishmania braziliensis	57%	100%
A4HXA1	Leishmania infantum	100%	100%
C9ZTX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AR03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEG0	Leishmania major	83%	100%
V5B7F7	Trypanosoma cruzi	36%	100%