Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUB2_LEIDO

TriTrypDb:

LdBPK_170370.1 , LdCL_170009200 , LDHU3_17.0640

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WUB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.656
CLV_C14_Caspase3-7	160	164	PF00656	0.611
CLV_NRD_NRD_1	306	308	PF00675	0.657
CLV_NRD_NRD_1	312	314	PF00675	0.571
CLV_NRD_NRD_1	5	7	PF00675	0.664
CLV_NRD_NRD_1	66	68	PF00675	0.503
CLV_PCSK_FUR_1	307	311	PF00082	0.704
CLV_PCSK_FUR_1	75	79	PF00082	0.650
CLV_PCSK_KEX2_1	306	308	PF00082	0.686
CLV_PCSK_KEX2_1	309	311	PF00082	0.676
CLV_PCSK_KEX2_1	312	314	PF00082	0.623
CLV_PCSK_KEX2_1	5	7	PF00082	0.664
CLV_PCSK_KEX2_1	66	68	PF00082	0.595
CLV_PCSK_KEX2_1	77	79	PF00082	0.483
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.562
CLV_PCSK_PC7_1	306	312	PF00082	0.794
DOC_MAPK_gen_1	75	84	PF00069	0.513
DOC_SPAK_OSR1_1	60	64	PF12202	0.482
DOC_USP7_MATH_1	162	166	PF00917	0.614
DOC_USP7_MATH_1	56	60	PF00917	0.494
DOC_WW_Pin1_4	226	231	PF00397	0.740
DOC_WW_Pin1_4	238	243	PF00397	0.654
DOC_WW_Pin1_4	24	29	PF00397	0.704
DOC_WW_Pin1_4	48	53	PF00397	0.642
LIG_14-3-3_CanoR_1	204	214	PF00244	0.654
LIG_14-3-3_CanoR_1	219	226	PF00244	0.758
LIG_14-3-3_CanoR_1	310	316	PF00244	0.644
LIG_BIR_III_2	11	15	PF00653	0.560
LIG_BRCT_BRCA1_1	221	225	PF00533	0.583
LIG_FHA_2	21	27	PF00498	0.755
LIG_FHA_2	241	247	PF00498	0.731
LIG_LIR_Gen_1	59	65	PF02991	0.447
LIG_LIR_Nem_3	323	329	PF02991	0.555
LIG_LIR_Nem_3	59	64	PF02991	0.439
LIG_PDZ_Class_3	325	330	PF00595	0.551
LIG_Pex14_2	61	65	PF04695	0.477
LIG_Rb_pABgroove_1	86	94	PF01858	0.496
LIG_RPA_C_Fungi	55	67	PF08784	0.489
LIG_SH2_SRC	152	155	PF00017	0.657
LIG_SH2_STAP1	152	156	PF00017	0.634
LIG_SH2_STAP1	190	194	PF00017	0.581
LIG_SH2_STAP1	20	24	PF00017	0.632
LIG_SH2_STAT5	90	93	PF00017	0.447
LIG_SH3_3	236	242	PF00018	0.790
LIG_SH3_3	275	281	PF00018	0.811
LIG_SH3_CIN85_PxpxPR_1	282	287	PF14604	0.629
LIG_TRAF2_1	151	154	PF00917	0.728
MOD_CDK_SPxK_1	226	232	PF00069	0.728
MOD_CDK_SPxxK_3	24	31	PF00069	0.640
MOD_CDK_SPxxK_3	48	55	PF00069	0.556
MOD_CK1_1	181	187	PF00069	0.683
MOD_CK1_1	231	237	PF00069	0.728
MOD_CK1_1	240	246	PF00069	0.776
MOD_CK1_1	314	320	PF00069	0.620
MOD_CK1_1	68	74	PF00069	0.607
MOD_CK2_1	240	246	PF00069	0.735
MOD_Cter_Amidation	3	6	PF01082	0.673
MOD_GlcNHglycan	180	183	PF01048	0.740
MOD_GlcNHglycan	185	188	PF01048	0.699
MOD_GlcNHglycan	68	71	PF01048	0.483
MOD_GSK3_1	173	180	PF00069	0.768
MOD_GSK3_1	186	193	PF00069	0.660
MOD_GSK3_1	20	27	PF00069	0.564
MOD_GSK3_1	224	231	PF00069	0.747
MOD_GSK3_1	44	51	PF00069	0.677
MOD_N-GLC_1	163	168	PF02516	0.774
MOD_N-GLC_2	133	135	PF02516	0.407
MOD_N-GLC_2	299	301	PF02516	0.594
MOD_NEK2_1	225	230	PF00069	0.713
MOD_NEK2_1	65	70	PF00069	0.553
MOD_PIKK_1	219	225	PF00454	0.582
MOD_PK_1	263	269	PF00069	0.730
MOD_PK_1	311	317	PF00069	0.615
MOD_PKA_1	311	317	PF00069	0.629
MOD_PKA_1	66	72	PF00069	0.528
MOD_PKA_2	212	218	PF00069	0.698
MOD_PKA_2	231	237	PF00069	0.713
MOD_PKA_2	311	317	PF00069	0.585
MOD_PKA_2	65	71	PF00069	0.530
MOD_PKB_1	309	317	PF00069	0.746
MOD_Plk_1	248	254	PF00069	0.586
MOD_Plk_1	86	92	PF00069	0.471
MOD_Plk_4	86	92	PF00069	0.461
MOD_ProDKin_1	226	232	PF00069	0.745
MOD_ProDKin_1	238	244	PF00069	0.650
MOD_ProDKin_1	24	30	PF00069	0.707
MOD_ProDKin_1	48	54	PF00069	0.636
MOD_SUMO_for_1	76	79	PF00179	0.647
TRG_DiLeu_BaEn_4	142	148	PF01217	0.500
TRG_ER_diArg_1	306	309	PF00400	0.679
TRG_ER_diArg_1	310	313	PF00400	0.648
TRG_ER_diArg_1	65	67	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Y1	Leptomonas seymouri	36%	100%
A4H8X5	Leishmania braziliensis	62%	100%
A4HX99	Leishmania infantum	98%	99%
E9AR01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QEG2	Leishmania major	83%	99%