Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WUA9_LEIDO

TriTrypDb:

LdBPK_170220.1 , LdCL_170007700 , LDHU3_17.0430

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WUA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WUA9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	508	512	PF00656	0.495
CLV_NRD_NRD_1	13	15	PF00675	0.653
CLV_NRD_NRD_1	159	161	PF00675	0.494
CLV_NRD_NRD_1	180	182	PF00675	0.512
CLV_NRD_NRD_1	225	227	PF00675	0.465
CLV_NRD_NRD_1	272	274	PF00675	0.501
CLV_NRD_NRD_1	366	368	PF00675	0.484
CLV_NRD_NRD_1	375	377	PF00675	0.445
CLV_NRD_NRD_1	380	382	PF00675	0.435
CLV_NRD_NRD_1	44	46	PF00675	0.770
CLV_NRD_NRD_1	501	503	PF00675	0.467
CLV_NRD_NRD_1	69	71	PF00675	0.563
CLV_PCSK_KEX2_1	13	15	PF00082	0.719
CLV_PCSK_KEX2_1	179	181	PF00082	0.508
CLV_PCSK_KEX2_1	225	227	PF00082	0.459
CLV_PCSK_KEX2_1	272	274	PF00082	0.449
CLV_PCSK_KEX2_1	366	368	PF00082	0.480
CLV_PCSK_KEX2_1	374	376	PF00082	0.473
CLV_PCSK_KEX2_1	380	382	PF00082	0.449
CLV_PCSK_KEX2_1	43	45	PF00082	0.782
CLV_PCSK_KEX2_1	501	503	PF00082	0.657
CLV_PCSK_KEX2_1	69	71	PF00082	0.563
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.515
CLV_PCSK_PC7_1	176	182	PF00082	0.502
CLV_PCSK_PC7_1	376	382	PF00082	0.583
CLV_PCSK_PC7_1	39	45	PF00082	0.716
CLV_PCSK_SKI1_1	176	180	PF00082	0.429
CLV_PCSK_SKI1_1	186	190	PF00082	0.485
CLV_PCSK_SKI1_1	366	370	PF00082	0.480
CLV_PCSK_SKI1_1	442	446	PF00082	0.411
CLV_PCSK_SKI1_1	463	467	PF00082	0.454
CLV_PCSK_SKI1_1	49	53	PF00082	0.697
CLV_Separin_Metazoa	443	447	PF03568	0.426
DEG_APCC_DBOX_1	491	499	PF00400	0.484
DEG_SPOP_SBC_1	417	421	PF00917	0.688
DOC_ANK_TNKS_1	506	513	PF00023	0.499
DOC_CKS1_1	86	91	PF01111	0.758
DOC_CYCLIN_RxL_1	457	470	PF00134	0.374
DOC_MAPK_gen_1	179	189	PF00069	0.479
DOC_MAPK_gen_1	489	497	PF00069	0.420
DOC_MAPK_gen_1	69	78	PF00069	0.635
DOC_MAPK_MEF2A_6	475	484	PF00069	0.504
DOC_MAPK_MEF2A_6	69	78	PF00069	0.635
DOC_MAPK_RevD_3	486	502	PF00069	0.357
DOC_PP1_RVXF_1	165	172	PF00149	0.403
DOC_PP4_FxxP_1	104	107	PF00568	0.579
DOC_USP7_MATH_1	319	323	PF00917	0.638
DOC_USP7_MATH_1	411	415	PF00917	0.761
DOC_USP7_MATH_1	417	421	PF00917	0.720
DOC_USP7_MATH_1	96	100	PF00917	0.625
DOC_USP7_UBL2_3	161	165	PF12436	0.610
DOC_WW_Pin1_4	115	120	PF00397	0.737
DOC_WW_Pin1_4	299	304	PF00397	0.628
DOC_WW_Pin1_4	384	389	PF00397	0.712
DOC_WW_Pin1_4	420	425	PF00397	0.744
DOC_WW_Pin1_4	81	86	PF00397	0.665
LIG_14-3-3_CanoR_1	111	121	PF00244	0.599
LIG_14-3-3_CanoR_1	13	20	PF00244	0.578
LIG_14-3-3_CanoR_1	192	198	PF00244	0.453
LIG_14-3-3_CanoR_1	216	224	PF00244	0.458
LIG_14-3-3_CanoR_1	294	303	PF00244	0.599
LIG_14-3-3_CanoR_1	346	354	PF00244	0.427
LIG_14-3-3_CanoR_1	81	85	PF00244	0.773
LIG_ActinCP_TwfCPI_2	104	111	PF01115	0.575
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BRCT_BRCA1_1	319	323	PF00533	0.532
LIG_CaM_IQ_9	351	366	PF13499	0.466
LIG_FHA_1	116	122	PF00498	0.701
LIG_FHA_1	191	197	PF00498	0.496
LIG_FHA_1	295	301	PF00498	0.487
LIG_FHA_1	367	373	PF00498	0.514
LIG_FHA_1	430	436	PF00498	0.603
LIG_FHA_1	475	481	PF00498	0.524
LIG_FHA_2	450	456	PF00498	0.582
LIG_LIR_Apic_2	103	107	PF02991	0.569
LIG_LIR_Gen_1	284	292	PF02991	0.424
LIG_LIR_Nem_3	149	154	PF02991	0.386
LIG_LIR_Nem_3	284	288	PF02991	0.404
LIG_LIR_Nem_3	290	295	PF02991	0.411
LIG_RPA_C_Plants	226	237	PF08784	0.526
LIG_SH2_STAT3	295	298	PF00017	0.554
LIG_SH2_STAT5	285	288	PF00017	0.399
LIG_SH3_2	86	91	PF14604	0.629
LIG_SH3_3	386	392	PF00018	0.729
LIG_SH3_3	48	54	PF00018	0.704
LIG_SH3_3	83	89	PF00018	0.712
LIG_TRAF2_1	281	284	PF00917	0.477
LIG_WRC_WIRS_1	101	106	PF05994	0.571
LIG_WW_2	389	392	PF00397	0.618
MOD_CDK_SPxK_1	85	91	PF00069	0.749
MOD_CDK_SPxxK_3	85	92	PF00069	0.628
MOD_CK1_1	122	128	PF00069	0.632
MOD_CK1_1	22	28	PF00069	0.677
MOD_CK1_1	30	36	PF00069	0.693
MOD_CK1_1	302	308	PF00069	0.617
MOD_CK1_1	321	327	PF00069	0.639
MOD_CK1_1	37	43	PF00069	0.701
MOD_CK1_1	419	425	PF00069	0.705
MOD_CK1_1	64	70	PF00069	0.704
MOD_CK1_1	9	15	PF00069	0.664
MOD_CK2_1	215	221	PF00069	0.450
MOD_CK2_1	284	290	PF00069	0.594
MOD_CK2_1	423	429	PF00069	0.666
MOD_CK2_1	449	455	PF00069	0.593
MOD_CK2_1	497	503	PF00069	0.397
MOD_DYRK1A_RPxSP_1	81	85	PF00069	0.571
MOD_GlcNHglycan	1	4	PF01048	0.701
MOD_GlcNHglycan	121	124	PF01048	0.650
MOD_GlcNHglycan	16	19	PF01048	0.668
MOD_GlcNHglycan	21	24	PF01048	0.633
MOD_GlcNHglycan	304	307	PF01048	0.707
MOD_GlcNHglycan	384	387	PF01048	0.584
MOD_GlcNHglycan	411	414	PF01048	0.658
MOD_GlcNHglycan	470	473	PF01048	0.549
MOD_GlcNHglycan	93	96	PF01048	0.686
MOD_GlcNHglycan	98	101	PF01048	0.605
MOD_GSK3_1	115	122	PF00069	0.681
MOD_GSK3_1	22	29	PF00069	0.643
MOD_GSK3_1	290	297	PF00069	0.492
MOD_GSK3_1	298	305	PF00069	0.563
MOD_GSK3_1	30	37	PF00069	0.636
MOD_GSK3_1	315	322	PF00069	0.642
MOD_GSK3_1	409	416	PF00069	0.726
MOD_GSK3_1	418	425	PF00069	0.758
MOD_GSK3_1	493	500	PF00069	0.452
MOD_GSK3_1	60	67	PF00069	0.739
MOD_GSK3_1	68	75	PF00069	0.565
MOD_GSK3_1	76	83	PF00069	0.649
MOD_GSK3_1	9	16	PF00069	0.680
MOD_GSK3_1	96	103	PF00069	0.655
MOD_N-GLC_1	249	254	PF02516	0.522
MOD_N-GLC_1	6	11	PF02516	0.630
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	19	24	PF00069	0.737
MOD_NEK2_1	315	320	PF00069	0.692
MOD_NEK2_1	497	502	PF00069	0.492
MOD_NEK2_1	76	81	PF00069	0.723
MOD_PIKK_1	294	300	PF00454	0.562
MOD_PIKK_1	393	399	PF00454	0.686
MOD_PKA_1	13	19	PF00069	0.609
MOD_PKA_1	366	372	PF00069	0.459
MOD_PKA_1	44	50	PF00069	0.722
MOD_PKA_1	91	97	PF00069	0.631
MOD_PKA_2	13	19	PF00069	0.727
MOD_PKA_2	136	142	PF00069	0.431
MOD_PKA_2	191	197	PF00069	0.516
MOD_PKA_2	215	221	PF00069	0.461
MOD_PKA_2	30	36	PF00069	0.768
MOD_PKA_2	366	372	PF00069	0.446
MOD_PKA_2	44	50	PF00069	0.703
MOD_PKA_2	450	456	PF00069	0.505
MOD_PKA_2	474	480	PF00069	0.537
MOD_PKA_2	68	74	PF00069	0.681
MOD_PKA_2	80	86	PF00069	0.739
MOD_PKB_1	43	51	PF00069	0.718
MOD_PKB_1	518	526	PF00069	0.527
MOD_PKB_1	70	78	PF00069	0.685
MOD_Plk_1	123	129	PF00069	0.569
MOD_Plk_1	205	211	PF00069	0.430
MOD_Plk_1	249	255	PF00069	0.523
MOD_Plk_1	461	467	PF00069	0.424
MOD_Plk_2-3	284	290	PF00069	0.475
MOD_Plk_4	284	290	PF00069	0.475
MOD_Plk_4	476	482	PF00069	0.582
MOD_Plk_4	493	499	PF00069	0.316
MOD_ProDKin_1	115	121	PF00069	0.737
MOD_ProDKin_1	299	305	PF00069	0.637
MOD_ProDKin_1	384	390	PF00069	0.718
MOD_ProDKin_1	420	426	PF00069	0.740
MOD_ProDKin_1	81	87	PF00069	0.667
TRG_DiLeu_BaEn_1	462	467	PF01217	0.496
TRG_DiLeu_BaEn_2	492	498	PF01217	0.355
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.515
TRG_ENDOCYTIC_2	285	288	PF00928	0.399
TRG_ENDOCYTIC_2	289	292	PF00928	0.399
TRG_ER_diArg_1	224	226	PF00400	0.506
TRG_ER_diArg_1	256	259	PF00400	0.513
TRG_ER_diArg_1	277	280	PF00400	0.446
TRG_ER_diArg_1	366	368	PF00400	0.494
TRG_ER_diArg_1	374	376	PF00400	0.465
TRG_ER_diArg_1	379	381	PF00400	0.430
TRG_ER_diArg_1	42	45	PF00400	0.720
TRG_ER_diArg_1	518	521	PF00400	0.541
TRG_ER_diArg_1	69	72	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K9	Leptomonas seymouri	52%	100%
A0A1X0NUG8	Trypanosomatidae	38%	100%
A0A422NFB5	Trypanosoma rangeli	39%	100%
A4H8W0	Leishmania braziliensis	75%	100%
A4HXA7	Leishmania infantum	100%	100%
C9ZTV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEH7	Leishmania major	91%	100%