Sedlin, N-terminal conserved region containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sedlin, N-terminal conserved region containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU90_LEIDO

TriTrypDb:

LdCL_160022700 , LDHU3_16.2100

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WU90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU90

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	7
GO:0009987	cellular process	1	7
GO:0016192	vesicle-mediated transport	4	7
GO:0046907	intracellular transport	3	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.320
CLV_PCSK_KEX2_1	135	137	PF00082	0.219
CLV_PCSK_SKI1_1	82	86	PF00082	0.159
DEG_SPOP_SBC_1	113	117	PF00917	0.384
DOC_CYCLIN_RxL_1	79	89	PF00134	0.371
DOC_PP4_FxxP_1	110	113	PF00568	0.396
DOC_USP7_MATH_1	91	95	PF00917	0.503
LIG_BRCT_BRCA1_1	122	126	PF00533	0.454
LIG_BRCT_BRCA1_1	95	99	PF00533	0.384
LIG_deltaCOP1_diTrp_1	48	57	PF00928	0.359
LIG_EH_1	111	115	PF12763	0.363
LIG_FHA_2	123	129	PF00498	0.381
LIG_FHA_2	51	57	PF00498	0.378
LIG_Integrin_RGD_1	54	56	PF01839	0.171
LIG_LIR_Gen_1	39	47	PF02991	0.454
LIG_LIR_Nem_3	39	44	PF02991	0.466
LIG_LIR_Nem_3	73	78	PF02991	0.359
LIG_MLH1_MIPbox_1	95	99	PF16413	0.384
LIG_Pex14_2	110	114	PF04695	0.445
LIG_SH2_PTP2	75	78	PF00017	0.454
LIG_SH2_STAT5	109	112	PF00017	0.371
LIG_SH2_STAT5	37	40	PF00017	0.331
LIG_SH2_STAT5	71	74	PF00017	0.361
LIG_SH2_STAT5	75	78	PF00017	0.356
LIG_SH3_3	5	11	PF00018	0.186
LIG_SH3_3	59	65	PF00018	0.443
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.380
LIG_WRC_WIRS_1	95	100	PF05994	0.371
MOD_CK1_1	27	33	PF00069	0.376
MOD_CK1_1	39	45	PF00069	0.384
MOD_CK1_1	94	100	PF00069	0.418
MOD_CK2_1	27	33	PF00069	0.491
MOD_GlcNHglycan	21	24	PF01048	0.239
MOD_GlcNHglycan	26	29	PF01048	0.227
MOD_GlcNHglycan	41	44	PF01048	0.291
MOD_GlcNHglycan	72	75	PF01048	0.171
MOD_GSK3_1	66	73	PF00069	0.430
MOD_GSK3_1	93	100	PF00069	0.482
MOD_N-GLC_1	24	29	PF02516	0.175
MOD_NEK2_1	114	119	PF00069	0.384
MOD_NEK2_1	57	62	PF00069	0.491
MOD_Plk_1	128	134	PF00069	0.331
MOD_Plk_4	128	134	PF00069	0.345
MOD_Plk_4	66	72	PF00069	0.527
MOD_Plk_4	94	100	PF00069	0.508
MOD_SUMO_rev_2	88	94	PF00179	0.384
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.454
TRG_ENDOCYTIC_2	37	40	PF00928	0.452
TRG_ENDOCYTIC_2	41	44	PF00928	0.338
TRG_ENDOCYTIC_2	75	78	PF00928	0.359
TRG_ER_diArg_1	135	137	PF00400	0.221
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IQL7	Bodo saltans	42%	80%
A0A1X0NX06	Trypanosomatidae	46%	100%
A0A3R7RIU4	Trypanosoma rangeli	47%	100%
A7RVK7	Nematostella vectensis	24%	90%
C9ZW63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	79%
D3ZVF4	Rattus norvegicus	28%	99%
E2QV03	Canis lupus familiaris	27%	99%
F1SRI0	Sus scrofa	27%	99%
O02173	Caenorhabditis elegans	27%	98%
P0DI81	Homo sapiens	27%	99%
P0DI82	Homo sapiens	27%	99%
Q08CN0	Danio rerio	28%	99%
Q28IG8	Xenopus tropicalis	28%	99%
Q3T0F2	Bos taurus	27%	99%
Q54RV6	Dictyostelium discoideum	24%	100%
Q5RES6	Pongo abelii	27%	99%
Q5ZKP4	Gallus gallus	26%	99%
Q9CQP2	Mus musculus	27%	99%
Q9USZ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9VUZ1	Drosophila melanogaster	25%	99%
V5B4G6	Trypanosoma cruzi	46%	100%