WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU83_LEIDO

TriTrypDb:

LdBPK_161720.1 , LdCL_160022200 , LDHU3_16.2050

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.487
CLV_C14_Caspase3-7	202	206	PF00656	0.741
CLV_C14_Caspase3-7	263	267	PF00656	0.634
CLV_NRD_NRD_1	111	113	PF00675	0.479
CLV_PCSK_KEX2_1	111	113	PF00082	0.479
CLV_PCSK_SKI1_1	111	115	PF00082	0.564
CLV_PCSK_SKI1_1	36	40	PF00082	0.468
CLV_PCSK_SKI1_1	439	443	PF00082	0.596
DEG_SCF_TRCP1_1	21	27	PF00400	0.455
DOC_CKS1_1	223	228	PF01111	0.591
DOC_CKS1_1	249	254	PF01111	0.622
DOC_CKS1_1	59	64	PF01111	0.630
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.570
DOC_MAPK_JIP1_4	190	196	PF00069	0.505
DOC_MAPK_MEF2A_6	4	12	PF00069	0.721
DOC_PP4_FxxP_1	249	252	PF00568	0.661
DOC_USP7_MATH_1	199	203	PF00917	0.688
DOC_USP7_MATH_1	214	218	PF00917	0.551
DOC_USP7_MATH_1	219	223	PF00917	0.656
DOC_USP7_MATH_1	358	362	PF00917	0.720
DOC_USP7_MATH_1	390	394	PF00917	0.768
DOC_USP7_MATH_1	410	414	PF00917	0.539
DOC_USP7_MATH_1	447	451	PF00917	0.597
DOC_USP7_MATH_1	77	81	PF00917	0.389
DOC_WW_Pin1_4	222	227	PF00397	0.667
DOC_WW_Pin1_4	248	253	PF00397	0.653
DOC_WW_Pin1_4	347	352	PF00397	0.742
DOC_WW_Pin1_4	369	374	PF00397	0.633
DOC_WW_Pin1_4	377	382	PF00397	0.700
DOC_WW_Pin1_4	58	63	PF00397	0.662
LIG_14-3-3_CanoR_1	124	133	PF00244	0.535
LIG_14-3-3_CanoR_1	190	195	PF00244	0.598
LIG_14-3-3_CanoR_1	258	263	PF00244	0.565
LIG_14-3-3_CanoR_1	382	389	PF00244	0.716
LIG_14-3-3_CterR_2	449	451	PF00244	0.604
LIG_APCC_ABBA_1	60	65	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	92	96	PF00533	0.418
LIG_EH1_1	435	443	PF00400	0.573
LIG_EVH1_2	252	256	PF00568	0.585
LIG_EVH1_2	353	357	PF00568	0.710
LIG_FHA_1	115	121	PF00498	0.437
LIG_FHA_1	25	31	PF00498	0.509
LIG_FHA_1	278	284	PF00498	0.649
LIG_FHA_1	328	334	PF00498	0.630
LIG_FHA_1	378	384	PF00498	0.746
LIG_FHA_1	5	11	PF00498	0.606
LIG_FHA_2	296	302	PF00498	0.616
LIG_FHA_2	410	416	PF00498	0.628
LIG_GBD_Chelix_1	434	442	PF00786	0.562
LIG_Integrin_isoDGR_2	366	368	PF01839	0.717
LIG_LIR_Gen_1	205	215	PF02991	0.708
LIG_LIR_Gen_1	225	233	PF02991	0.567
LIG_LIR_Nem_3	205	210	PF02991	0.707
LIG_LIR_Nem_3	225	231	PF02991	0.553
LIG_NRBOX	151	157	PF00104	0.474
LIG_Pex14_1	228	232	PF04695	0.543
LIG_SH2_CRK	370	374	PF00017	0.617
LIG_SH2_CRK	403	407	PF00017	0.699
LIG_SH2_NCK_1	370	374	PF00017	0.640
LIG_SH2_STAP1	74	78	PF00017	0.416
LIG_SH3_1	348	354	PF00018	0.722
LIG_SH3_3	348	354	PF00018	0.722
LIG_SH3_3	56	62	PF00018	0.659
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.741
LIG_SUMO_SIM_anti_2	27	35	PF11976	0.539
LIG_SUMO_SIM_par_1	9	16	PF11976	0.621
LIG_TRAF2_1	233	236	PF00917	0.730
LIG_TRAF2_1	413	416	PF00917	0.639
MOD_CDK_SPK_2	377	382	PF00069	0.720
MOD_CK1_1	105	111	PF00069	0.488
MOD_CK1_1	131	137	PF00069	0.396
MOD_CK1_1	179	185	PF00069	0.550
MOD_CK1_1	206	212	PF00069	0.680
MOD_CK1_1	22	28	PF00069	0.542
MOD_CK1_1	222	228	PF00069	0.487
MOD_CK1_1	238	244	PF00069	0.627
MOD_CK1_1	261	267	PF00069	0.570
MOD_CK1_1	300	306	PF00069	0.633
MOD_CK1_1	356	362	PF00069	0.783
MOD_CK1_1	43	49	PF00069	0.514
MOD_CK1_1	6	12	PF00069	0.527
MOD_CK1_1	64	70	PF00069	0.567
MOD_CK2_1	164	170	PF00069	0.424
MOD_CK2_1	278	284	PF00069	0.700
MOD_CK2_1	295	301	PF00069	0.493
MOD_CK2_1	369	375	PF00069	0.633
MOD_CK2_1	409	415	PF00069	0.623
MOD_CK2_1	49	55	PF00069	0.639
MOD_GlcNHglycan	104	107	PF01048	0.649
MOD_GlcNHglycan	201	204	PF01048	0.678
MOD_GlcNHglycan	21	24	PF01048	0.503
MOD_GlcNHglycan	216	219	PF01048	0.587
MOD_GlcNHglycan	27	30	PF01048	0.497
MOD_GlcNHglycan	287	290	PF01048	0.532
MOD_GlcNHglycan	345	348	PF01048	0.694
MOD_GlcNHglycan	360	363	PF01048	0.578
MOD_GlcNHglycan	406	409	PF01048	0.683
MOD_GlcNHglycan	412	415	PF01048	0.614
MOD_GlcNHglycan	55	58	PF01048	0.535
MOD_GSK3_1	124	131	PF00069	0.417
MOD_GSK3_1	164	171	PF00069	0.470
MOD_GSK3_1	199	206	PF00069	0.658
MOD_GSK3_1	235	242	PF00069	0.719
MOD_GSK3_1	24	31	PF00069	0.528
MOD_GSK3_1	248	255	PF00069	0.593
MOD_GSK3_1	318	325	PF00069	0.670
MOD_GSK3_1	339	346	PF00069	0.797
MOD_GSK3_1	353	360	PF00069	0.696
MOD_GSK3_1	377	384	PF00069	0.664
MOD_GSK3_1	39	46	PF00069	0.425
MOD_GSK3_1	49	56	PF00069	0.456
MOD_N-GLC_1	53	58	PF02516	0.566
MOD_NEK2_1	13	18	PF00069	0.618
MOD_NEK2_1	159	164	PF00069	0.472
MOD_NEK2_1	168	173	PF00069	0.429
MOD_NEK2_1	24	29	PF00069	0.390
MOD_NEK2_1	256	261	PF00069	0.643
MOD_NEK2_1	357	362	PF00069	0.686
MOD_NEK2_1	383	388	PF00069	0.692
MOD_NEK2_1	389	394	PF00069	0.611
MOD_NEK2_1	39	44	PF00069	0.356
MOD_NEK2_1	49	54	PF00069	0.411
MOD_NEK2_1	76	81	PF00069	0.377
MOD_NEK2_1	83	88	PF00069	0.384
MOD_NEK2_2	219	224	PF00069	0.650
MOD_NEK2_2	390	395	PF00069	0.729
MOD_NEK2_2	97	102	PF00069	0.455
MOD_OFUCOSY	157	163	PF10250	0.565
MOD_PIKK_1	105	111	PF00454	0.502
MOD_PIKK_1	168	174	PF00454	0.559
MOD_PK_1	258	264	PF00069	0.573
MOD_PKA_1	111	117	PF00069	0.575
MOD_PKA_2	102	108	PF00069	0.614
MOD_PKA_2	111	117	PF00069	0.487
MOD_PKA_2	323	329	PF00069	0.660
MOD_PKA_2	343	349	PF00069	0.709
MOD_PKA_2	381	387	PF00069	0.681
MOD_PKA_2	410	416	PF00069	0.546
MOD_Plk_1	168	174	PF00069	0.464
MOD_Plk_1	300	306	PF00069	0.613
MOD_Plk_1	4	10	PF00069	0.637
MOD_Plk_1	64	70	PF00069	0.490
MOD_Plk_4	128	134	PF00069	0.408
MOD_Plk_4	13	19	PF00069	0.564
MOD_Plk_4	151	157	PF00069	0.570
MOD_Plk_4	252	258	PF00069	0.655
MOD_Plk_4	390	396	PF00069	0.727
MOD_Plk_4	43	49	PF00069	0.566
MOD_Plk_4	437	443	PF00069	0.673
MOD_Plk_4	97	103	PF00069	0.467
MOD_ProDKin_1	222	228	PF00069	0.652
MOD_ProDKin_1	248	254	PF00069	0.648
MOD_ProDKin_1	347	353	PF00069	0.741
MOD_ProDKin_1	369	375	PF00069	0.639
MOD_ProDKin_1	377	383	PF00069	0.702
MOD_ProDKin_1	58	64	PF00069	0.653
TRG_DiLeu_BaEn_1	430	435	PF01217	0.509
TRG_DiLeu_BaEn_2	169	175	PF01217	0.408
TRG_ER_diArg_1	111	113	PF00400	0.577
TRG_ER_diArg_1	333	336	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX30	Leptomonas seymouri	47%	97%
A4H8U0	Leishmania braziliensis	76%	100%
A4HX60	Leishmania infantum	100%	100%
E9AQX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEK3	Leishmania major	90%	100%
V5BMQ6	Trypanosoma cruzi	29%	100%