ADP-ribosylation_factor-like_protein_1/GeneDB:Lmj F.17.0070

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU76_LEIDO

TriTrypDb:

LdBPK_170080.1 , LdCL_170005800 , LDHU3_17.0100

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0005802	trans-Golgi network	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0031984	organelle subcompartment	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

A0A3S7WU76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU76

PDB structure(s): 2x77_A , 2x77_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006622	protein targeting to lysosome	6	1
GO:0006623	protein targeting to vacuole	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.372
CLV_C14_Caspase3-7	86	90	PF00656	0.282
CLV_NRD_NRD_1	119	121	PF00675	0.389
CLV_NRD_NRD_1	18	20	PF00675	0.359
CLV_PCSK_SKI1_1	121	125	PF00082	0.406
DEG_APCC_DBOX_1	119	127	PF00400	0.259
DEG_APCC_DBOX_1	38	46	PF00400	0.305
DEG_SPOP_SBC_1	159	163	PF00917	0.342
DOC_ANK_TNKS_1	180	187	PF00023	0.377
DOC_CYCLIN_RxL_1	19	29	PF00134	0.282

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q3	Leptomonas seymouri	42%	98%
A0A0N0P4P7	Leptomonas seymouri	34%	100%
A0A0N0P633	Leptomonas seymouri	50%	100%
A0A0N0P8D4	Leptomonas seymouri	44%	100%
A0A0N0P8G7	Leptomonas seymouri	23%	87%
A0A0N0P8Z3	Leptomonas seymouri	44%	100%
A0A0N1HS40	Leptomonas seymouri	47%	100%
A0A0N1HTN6	Leptomonas seymouri	92%	99%
A0A0N1I3A9	Leptomonas seymouri	40%	100%
A0A0N1I556	Leptomonas seymouri	53%	100%

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