B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU73_LEIDO

TriTrypDb:

LdBPK_161620.1 , LdCL_160021200 , LDHU3_16.1920

Length:

1150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0031298	replication fork protection complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A0A3S7WU73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU73

Function

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Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006275	regulation of DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1038	1042	PF00656	0.715
CLV_C14_Caspase3-7	1105	1109	PF00656	0.579
CLV_C14_Caspase3-7	728	732	PF00656	0.630
CLV_NRD_NRD_1	1025	1027	PF00675	0.617
CLV_NRD_NRD_1	1028	1030	PF00675	0.615
CLV_NRD_NRD_1	1077	1079	PF00675	0.736
CLV_NRD_NRD_1	1089	1091	PF00675	0.824
CLV_NRD_NRD_1	256	258	PF00675	0.535
CLV_NRD_NRD_1	429	431	PF00675	0.628
CLV_NRD_NRD_1	442	444	PF00675	0.472

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC20	Leptomonas seymouri	64%	100%
A0A422N424	Trypanosoma rangeli	41%	100%
A4H8T1	Leishmania braziliensis	75%	100%
A4HX50	Leishmania infantum	99%	100%
C9ZVU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEL3	Leishmania major	90%	100%
V5BS96	Trypanosoma cruzi	41%	100%

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