Endoplasmic reticulum oxidoreductin, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endoplasmic reticulum oxidoreductin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU69_LEIDO

TriTrypDb:

LdBPK_161630.1 , LdCL_160021300 , LDHU3_16.1950

Length:

443

Annotations

Annotations by Jardim et al.

Oxidoreductase, endoplasmic reticulum oxidoreductin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 4
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	13
GO:0016020	membrane	2	13
GO:0031090	organelle membrane	3	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S7WU69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU69

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13
GO:0034975	protein folding in endoplasmic reticulum	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0015035	protein-disulfide reductase activity	3	13
GO:0015036	disulfide oxidoreductase activity	4	13
GO:0016491	oxidoreductase activity	2	13
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	13
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	13
GO:0016972	thiol oxidase activity	5	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.233
CLV_PCSK_KEX2_1	263	265	PF00082	0.319
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.393
CLV_PCSK_SKI1_1	144	148	PF00082	0.369
CLV_PCSK_SKI1_1	213	217	PF00082	0.403
CLV_PCSK_SKI1_1	290	294	PF00082	0.344
CLV_PCSK_SKI1_1	320	324	PF00082	0.345
CLV_PCSK_SKI1_1	45	49	PF00082	0.600
CLV_PCSK_SKI1_1	70	74	PF00082	0.476
CLV_PCSK_SKI1_1	86	90	PF00082	0.327
DEG_APCC_DBOX_1	212	220	PF00400	0.425
DEG_Nend_UBRbox_4	1	3	PF02207	0.567
DEG_ODPH_VHL_1	265	277	PF01847	0.369
DEG_SCF_FBW7_1	135	141	PF00400	0.447
DOC_CKS1_1	135	140	PF01111	0.425
DOC_CYCLIN_RxL_1	210	217	PF00134	0.431
DOC_CYCLIN_RxL_1	408	416	PF00134	0.367
DOC_CYCLIN_yClb5_NLxxxL_5	404	413	PF00134	0.345
DOC_MAPK_DCC_7	144	152	PF00069	0.369
DOC_MAPK_HePTP_8	8	20	PF00069	0.579
DOC_MAPK_MEF2A_6	11	20	PF00069	0.529
DOC_MAPK_MEF2A_6	3	10	PF00069	0.499
DOC_MAPK_MEF2A_6	30	39	PF00069	0.604
DOC_PP1_RVXF_1	409	416	PF00149	0.425
DOC_PP1_SILK_1	209	214	PF00149	0.447
DOC_USP7_MATH_1	138	142	PF00917	0.437
DOC_USP7_MATH_1	41	45	PF00917	0.470
DOC_USP7_MATH_1	439	443	PF00917	0.533
DOC_USP7_UBL2_3	375	379	PF12436	0.425
DOC_WW_Pin1_4	134	139	PF00397	0.402
DOC_WW_Pin1_4	236	241	PF00397	0.311
DOC_WW_Pin1_4	25	30	PF00397	0.491
DOC_WW_Pin1_4	327	332	PF00397	0.324
DOC_WW_Pin1_4	58	63	PF00397	0.560
DOC_WW_Pin1_4	79	84	PF00397	0.376
LIG_14-3-3_CanoR_1	395	399	PF00244	0.453
LIG_14-3-3_CanoR_1	78	82	PF00244	0.443
LIG_APCC_ABBA_1	265	270	PF00400	0.415
LIG_BRCT_BRCA1_1	288	292	PF00533	0.369
LIG_BRCT_BRCA1_1	329	333	PF00533	0.291
LIG_BRCT_BRCA1_1	81	85	PF00533	0.347
LIG_deltaCOP1_diTrp_1	153	158	PF00928	0.345
LIG_eIF4E_1	98	104	PF01652	0.327
LIG_FHA_1	109	115	PF00498	0.425
LIG_FHA_1	292	298	PF00498	0.433
LIG_FHA_1	376	382	PF00498	0.310
LIG_FHA_1	48	54	PF00498	0.561
LIG_FHA_1	67	73	PF00498	0.378
LIG_FHA_2	104	110	PF00498	0.385
LIG_FHA_2	203	209	PF00498	0.463
LIG_FHA_2	307	313	PF00498	0.327
LIG_FHA_2	330	336	PF00498	0.311
LIG_FHA_2	49	55	PF00498	0.560
LIG_LIR_Apic_2	178	183	PF02991	0.325
LIG_LIR_Apic_2	229	235	PF02991	0.425
LIG_LIR_Gen_1	166	174	PF02991	0.312
LIG_LIR_Nem_3	166	170	PF02991	0.312
LIG_LIR_Nem_3	82	88	PF02991	0.330
LIG_MLH1_MIPbox_1	81	85	PF16413	0.393
LIG_NRBOX	211	217	PF00104	0.393
LIG_Pex14_1	189	193	PF04695	0.298
LIG_SH2_CRK	180	184	PF00017	0.327
LIG_SH2_CRK	247	251	PF00017	0.429
LIG_SH2_NCK_1	247	251	PF00017	0.447
LIG_SH2_PTP2	167	170	PF00017	0.311
LIG_SH2_STAT5	167	170	PF00017	0.306
LIG_SH2_STAT5	276	279	PF00017	0.350
LIG_SH2_STAT5	57	60	PF00017	0.514
LIG_SH2_STAT5	84	87	PF00017	0.371
LIG_SH3_3	143	149	PF00018	0.449
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.573
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.425
LIG_SUMO_SIM_anti_2	401	408	PF11976	0.302
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.395
LIG_SxIP_EBH_1	343	354	PF03271	0.447
LIG_TRAF2_1	205	208	PF00917	0.408
MOD_CDC14_SPxK_1	239	242	PF00782	0.333
MOD_CDK_SPK_2	25	30	PF00069	0.477
MOD_CDK_SPxK_1	236	242	PF00069	0.333
MOD_CDK_SPxxK_3	79	86	PF00069	0.376
MOD_CK1_1	291	297	PF00069	0.330
MOD_CK1_1	425	431	PF00069	0.543
MOD_CK2_1	103	109	PF00069	0.385
MOD_CK2_1	118	124	PF00069	0.419
MOD_CK2_1	169	175	PF00069	0.425
MOD_CK2_1	202	208	PF00069	0.373
MOD_CK2_1	329	335	PF00069	0.313
MOD_CK2_1	58	64	PF00069	0.491
MOD_CMANNOS	155	158	PF00535	0.345
MOD_GlcNHglycan	106	109	PF01048	0.234
MOD_GlcNHglycan	180	183	PF01048	0.327
MOD_GlcNHglycan	216	219	PF01048	0.298
MOD_GlcNHglycan	91	94	PF01048	0.433
MOD_GSK3_1	130	137	PF00069	0.330
MOD_GSK3_1	138	145	PF00069	0.424
MOD_GSK3_1	207	214	PF00069	0.354
MOD_GSK3_1	25	32	PF00069	0.615
MOD_GSK3_1	291	298	PF00069	0.376
MOD_GSK3_1	394	401	PF00069	0.438
MOD_GSK3_1	99	106	PF00069	0.378
MOD_N-GLC_1	250	255	PF02516	0.326
MOD_N-GLC_1	356	361	PF02516	0.294
MOD_N-GLC_1	48	53	PF02516	0.485
MOD_N-GLC_2	110	112	PF02516	0.345
MOD_NEK2_1	103	108	PF00069	0.393
MOD_NEK2_1	219	224	PF00069	0.298
MOD_NEK2_1	286	291	PF00069	0.340
MOD_NEK2_1	322	327	PF00069	0.319
MOD_NEK2_1	356	361	PF00069	0.425
MOD_NEK2_1	413	418	PF00069	0.328
MOD_NEK2_1	48	53	PF00069	0.610
MOD_NEK2_2	250	255	PF00069	0.425
MOD_NEK2_2	279	284	PF00069	0.455
MOD_OFUCOSY	105	112	PF10250	0.367
MOD_PK_1	422	428	PF00069	0.324
MOD_PKA_2	394	400	PF00069	0.441
MOD_PKA_2	77	83	PF00069	0.447
MOD_Plk_1	118	124	PF00069	0.449
MOD_Plk_1	207	213	PF00069	0.447
MOD_Plk_1	250	256	PF00069	0.330
MOD_Plk_1	295	301	PF00069	0.359
MOD_Plk_1	306	312	PF00069	0.278
MOD_Plk_1	356	362	PF00069	0.301
MOD_Plk_1	6	12	PF00069	0.596
MOD_Plk_2-3	118	124	PF00069	0.369
MOD_Plk_2-3	394	400	PF00069	0.447
MOD_Plk_4	12	18	PF00069	0.583
MOD_Plk_4	142	148	PF00069	0.431
MOD_Plk_4	207	213	PF00069	0.403
MOD_Plk_4	227	233	PF00069	0.116
MOD_Plk_4	295	301	PF00069	0.390
MOD_Plk_4	402	408	PF00069	0.345
MOD_Plk_4	68	74	PF00069	0.448
MOD_Plk_4	99	105	PF00069	0.407
MOD_ProDKin_1	134	140	PF00069	0.402
MOD_ProDKin_1	236	242	PF00069	0.311
MOD_ProDKin_1	25	31	PF00069	0.492
MOD_ProDKin_1	327	333	PF00069	0.324
MOD_ProDKin_1	58	64	PF00069	0.559
MOD_ProDKin_1	79	85	PF00069	0.376
TRG_DiLeu_BaEn_1	402	407	PF01217	0.298
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.393
TRG_ENDOCYTIC_2	167	170	PF00928	0.311
TRG_ENDOCYTIC_2	87	90	PF00928	0.338
TRG_ENDOCYTIC_2	98	101	PF00928	0.270
TRG_ER_diArg_1	42	45	PF00400	0.606
TRG_ER_diArg_1	438	441	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ4	Leptomonas seymouri	75%	100%
A0A0S4JAH9	Bodo saltans	34%	92%
A0A0S4JHX0	Bodo saltans	39%	89%
A0A1X0P0B6	Trypanosomatidae	51%	99%
A0A422NE38	Trypanosoma rangeli	52%	97%
A4H8T2	Leishmania braziliensis	86%	100%
A4HX51	Leishmania infantum	100%	100%
A5PJN2	Bos taurus	31%	95%
B1H1F9	Xenopus tropicalis	29%	93%
B6CVD7	Sus scrofa	32%	95%
C9ZVU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AQW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O74401	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	95%
Q03103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	79%
Q4QEL2	Leishmania major	95%	100%
Q6DD71	Xenopus laevis	29%	95%
Q75BB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	81%
Q7SEY9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	66%
Q7T3D1	Danio rerio	29%	91%
Q7X9I4	Arabidopsis thaliana	31%	94%
Q7YTU4	Caenorhabditis elegans	28%	93%
Q86YB8	Homo sapiens	29%	95%
Q8NIP5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	79%
Q8R180	Mus musculus	31%	95%
Q8R2E9	Mus musculus	29%	95%
Q8R4A1	Rattus norvegicus	31%	95%
Q96HE7	Homo sapiens	31%	95%
Q9C7S7	Arabidopsis thaliana	33%	94%
Q9V3A6	Drosophila melanogaster	27%	92%
Q9Y7P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	78%
V5BI75	Trypanosoma cruzi	51%	100%