Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7WU64_LEIDO

TriTrypDb:

LdBPK_161570.1 , LdCL_160020700 , LDHU3_16.1860

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WU64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU64

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	20
GO:0007018	microtubule-based movement	3	20
GO:0009987	cellular process	1	20

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0003774	cytoskeletal motor activity	1	20
GO:0003777	microtubule motor activity	2	20
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	20
GO:0005515	protein binding	2	20
GO:0005524	ATP binding	5	20
GO:0008017	microtubule binding	5	20
GO:0008092	cytoskeletal protein binding	3	20
GO:0015631	tubulin binding	4	20
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	20
GO:0030554	adenyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032559	adenyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20
GO:0043167	ion binding	2	20
GO:0043168	anion binding	3	20
GO:0097159	organic cyclic compound binding	2	20
GO:0097367	carbohydrate derivative binding	2	20
GO:0140657	ATP-dependent activity	1	20
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.277
CLV_C14_Caspase3-7	507	511	PF00656	0.503
CLV_NRD_NRD_1	170	172	PF00675	0.239
CLV_NRD_NRD_1	2	4	PF00675	0.716
CLV_NRD_NRD_1	384	386	PF00675	0.468
CLV_NRD_NRD_1	524	526	PF00675	0.383
CLV_NRD_NRD_1	811	813	PF00675	0.507
CLV_NRD_NRD_1	833	835	PF00675	0.618
CLV_NRD_NRD_1	844	846	PF00675	0.574
CLV_NRD_NRD_1	857	859	PF00675	0.493
CLV_PCSK_KEX2_1	2	4	PF00082	0.567
CLV_PCSK_KEX2_1	495	497	PF00082	0.517
CLV_PCSK_KEX2_1	524	526	PF00082	0.561
CLV_PCSK_KEX2_1	811	813	PF00082	0.555
CLV_PCSK_KEX2_1	833	835	PF00082	0.601
CLV_PCSK_KEX2_1	844	846	PF00082	0.574
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.538
CLV_PCSK_SKI1_1	146	150	PF00082	0.302
CLV_PCSK_SKI1_1	246	250	PF00082	0.237
CLV_PCSK_SKI1_1	313	317	PF00082	0.265
CLV_PCSK_SKI1_1	352	356	PF00082	0.237
CLV_PCSK_SKI1_1	387	391	PF00082	0.373
CLV_PCSK_SKI1_1	435	439	PF00082	0.451
CLV_PCSK_SKI1_1	448	452	PF00082	0.413
CLV_PCSK_SKI1_1	811	815	PF00082	0.649
CLV_Separin_Metazoa	209	213	PF03568	0.305
DEG_APCC_DBOX_1	810	818	PF00400	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.492
DOC_CYCLIN_RxL_1	246	254	PF00134	0.242
DOC_MAPK_MEF2A_6	8	17	PF00069	0.528
DOC_MAPK_RevD_3	157	172	PF00069	0.272
DOC_MIT_MIM_1	543	551	PF04212	0.366
DOC_PP4_FxxP_1	115	118	PF00568	0.385
DOC_PP4_FxxP_1	238	241	PF00568	0.385
DOC_SPAK_OSR1_1	806	810	PF12202	0.363
DOC_USP7_MATH_1	140	144	PF00917	0.272
DOC_USP7_MATH_1	194	198	PF00917	0.313
DOC_USP7_MATH_1	284	288	PF00917	0.320
DOC_USP7_MATH_1	504	508	PF00917	0.521
DOC_USP7_MATH_1	67	71	PF00917	0.316
DOC_USP7_MATH_1	73	77	PF00917	0.262
DOC_WW_Pin1_4	329	334	PF00397	0.353
DOC_WW_Pin1_4	839	844	PF00397	0.535
LIG_14-3-3_CanoR_1	139	148	PF00244	0.291
LIG_14-3-3_CanoR_1	171	177	PF00244	0.288
LIG_14-3-3_CanoR_1	225	230	PF00244	0.248
LIG_14-3-3_CanoR_1	307	312	PF00244	0.253
LIG_14-3-3_CanoR_1	503	513	PF00244	0.537
LIG_14-3-3_CanoR_1	52	56	PF00244	0.241
LIG_14-3-3_CanoR_1	547	555	PF00244	0.463
LIG_14-3-3_CanoR_1	564	573	PF00244	0.455
LIG_14-3-3_CanoR_1	586	592	PF00244	0.401
LIG_14-3-3_CanoR_1	725	731	PF00244	0.313
LIG_Actin_WH2_2	192	208	PF00022	0.200
LIG_Actin_WH2_2	760	778	PF00022	0.376
LIG_APCC_ABBA_1	157	162	PF00400	0.294
LIG_APCC_ABBAyCdc20_2	387	393	PF00400	0.363
LIG_APCC_ABBAyCdc20_2	448	454	PF00400	0.501
LIG_BRCT_BRCA1_1	181	185	PF00533	0.237
LIG_Clathr_ClatBox_1	229	233	PF01394	0.253
LIG_eIF4E_1	452	458	PF01652	0.449
LIG_FHA_1	147	153	PF00498	0.311
LIG_FHA_1	182	188	PF00498	0.344
LIG_FHA_1	190	196	PF00498	0.337
LIG_FHA_1	310	316	PF00498	0.279
LIG_FHA_1	324	330	PF00498	0.365
LIG_FHA_1	425	431	PF00498	0.511
LIG_FHA_1	515	521	PF00498	0.420
LIG_FHA_1	719	725	PF00498	0.523
LIG_FHA_1	763	769	PF00498	0.329
LIG_FHA_1	834	840	PF00498	0.606
LIG_FHA_2	121	127	PF00498	0.279
LIG_FHA_2	234	240	PF00498	0.240
LIG_FHA_2	25	31	PF00498	0.277
LIG_FHA_2	426	432	PF00498	0.435
LIG_FHA_2	436	442	PF00498	0.497
LIG_FHA_2	612	618	PF00498	0.693
LIG_FHA_2	626	632	PF00498	0.614
LIG_FHA_2	640	646	PF00498	0.450
LIG_FHA_2	654	660	PF00498	0.466
LIG_FHA_2	668	674	PF00498	0.399
LIG_FHA_2	682	688	PF00498	0.626
LIG_FHA_2	696	702	PF00498	0.430
LIG_GBD_Chelix_1	526	534	PF00786	0.524
LIG_KLC1_Yacidic_2	158	162	PF13176	0.253
LIG_LIR_Apic_2	113	118	PF02991	0.385
LIG_LIR_Apic_2	236	241	PF02991	0.385
LIG_LIR_Gen_1	111	118	PF02991	0.314
LIG_LIR_Gen_1	182	193	PF02991	0.296
LIG_LIR_Gen_1	197	205	PF02991	0.318
LIG_LIR_Gen_1	454	462	PF02991	0.539
LIG_LIR_Gen_1	78	89	PF02991	0.262
LIG_LIR_Gen_1	791	800	PF02991	0.581
LIG_LIR_Nem_3	111	115	PF02991	0.294
LIG_LIR_Nem_3	162	168	PF02991	0.232
LIG_LIR_Nem_3	182	188	PF02991	0.296
LIG_LIR_Nem_3	197	201	PF02991	0.318
LIG_LIR_Nem_3	388	394	PF02991	0.382
LIG_LIR_Nem_3	454	458	PF02991	0.545
LIG_LIR_Nem_3	78	84	PF02991	0.262
LIG_LIR_Nem_3	791	796	PF02991	0.591
LIG_MYND_1	241	245	PF01753	0.385
LIG_NRBOX	310	316	PF00104	0.294
LIG_PCNA_PIPBox_1	231	240	PF02747	0.237
LIG_PCNA_yPIPBox_3	301	315	PF02747	0.283
LIG_Pex14_1	379	383	PF04695	0.528
LIG_Pex14_2	53	57	PF04695	0.285
LIG_PTB_Apo_2	131	138	PF02174	0.385
LIG_PTB_Apo_2	743	750	PF02174	0.345
LIG_PTB_Phospho_1	743	749	PF10480	0.342
LIG_SH2_CRK	793	797	PF00017	0.367
LIG_SH2_GRB2like	737	740	PF00017	0.383
LIG_SH2_GRB2like	744	747	PF00017	0.328
LIG_SH2_NCK_1	793	797	PF00017	0.404
LIG_SH2_PTP2	16	19	PF00017	0.441
LIG_SH2_SRC	744	747	PF00017	0.351
LIG_SH2_STAP1	150	154	PF00017	0.385
LIG_SH2_STAP1	498	502	PF00017	0.461
LIG_SH2_STAT3	737	740	PF00017	0.383
LIG_SH2_STAT5	112	115	PF00017	0.251
LIG_SH2_STAT5	150	153	PF00017	0.265
LIG_SH2_STAT5	16	19	PF00017	0.476
LIG_SH2_STAT5	160	163	PF00017	0.184
LIG_SH2_STAT5	318	321	PF00017	0.291
LIG_SH2_STAT5	383	386	PF00017	0.437
LIG_SH2_STAT5	744	747	PF00017	0.481
LIG_SH2_STAT5	773	776	PF00017	0.378
LIG_SH3_3	42	48	PF00018	0.260
LIG_SH3_3	81	87	PF00018	0.385
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.332
LIG_SUMO_SIM_par_1	230	236	PF11976	0.297
LIG_SUMO_SIM_par_1	281	287	PF11976	0.253
LIG_SUMO_SIM_par_1	325	332	PF11976	0.385
LIG_TRAF2_1	123	126	PF00917	0.297
LIG_TRAF2_1	610	613	PF00917	0.450
LIG_TRAF2_1	614	617	PF00917	0.473
LIG_TRAF2_1	628	631	PF00917	0.451
LIG_TRAF2_1	642	645	PF00917	0.465
LIG_TRAF2_1	656	659	PF00917	0.464
LIG_TRAF2_1	670	673	PF00917	0.400
LIG_TRAF2_1	684	687	PF00917	0.446
LIG_TRAF2_1	698	701	PF00917	0.460
LIG_TRAF2_1	75	78	PF00917	0.272
LIG_UBA3_1	809	816	PF00899	0.407
LIG_WRC_WIRS_1	112	117	PF05994	0.393
LIG_WRC_WIRS_1	211	216	PF05994	0.253
MOD_CDK_SPK_2	839	844	PF00069	0.513
MOD_CDK_SPxK_1	839	845	PF00069	0.536
MOD_CDK_SPxxK_3	329	336	PF00069	0.215
MOD_CK1_1	108	114	PF00069	0.274
MOD_CK1_1	120	126	PF00069	0.322
MOD_CK1_1	309	315	PF00069	0.264
MOD_CK1_1	323	329	PF00069	0.257
MOD_CK1_1	341	347	PF00069	0.322
MOD_CK2_1	120	126	PF00069	0.297
MOD_CK2_1	152	158	PF00069	0.309
MOD_CK2_1	284	290	PF00069	0.259
MOD_CK2_1	329	335	PF00069	0.385
MOD_CK2_1	38	44	PF00069	0.237
MOD_CK2_1	425	431	PF00069	0.446
MOD_CK2_1	513	519	PF00069	0.449
MOD_CK2_1	564	570	PF00069	0.465
MOD_CK2_1	607	613	PF00069	0.601
MOD_CK2_1	625	631	PF00069	0.610
MOD_CK2_1	639	645	PF00069	0.500
MOD_CK2_1	653	659	PF00069	0.475
MOD_CK2_1	667	673	PF00069	0.432
MOD_CK2_1	681	687	PF00069	0.486
MOD_CK2_1	695	701	PF00069	0.414
MOD_CK2_1	716	722	PF00069	0.415
MOD_CK2_1	726	732	PF00069	0.360
MOD_CK2_1	847	853	PF00069	0.715
MOD_GlcNHglycan	107	110	PF01048	0.271
MOD_GlcNHglycan	142	145	PF01048	0.336
MOD_GlcNHglycan	152	155	PF01048	0.347
MOD_GlcNHglycan	24	30	PF01048	0.370
MOD_GlcNHglycan	39	43	PF01048	0.409
MOD_GlcNHglycan	548	551	PF01048	0.470
MOD_GlcNHglycan	617	621	PF01048	0.516
MOD_GlcNHglycan	631	635	PF01048	0.512
MOD_GlcNHglycan	645	649	PF01048	0.478
MOD_GlcNHglycan	659	663	PF01048	0.489
MOD_GlcNHglycan	673	677	PF01048	0.446
MOD_GlcNHglycan	687	691	PF01048	0.418
MOD_GlcNHglycan	69	72	PF01048	0.385
MOD_GlcNHglycan	701	705	PF01048	0.462
MOD_GlcNHglycan	73	76	PF01048	0.388
MOD_GSK3_1	117	124	PF00069	0.275
MOD_GSK3_1	146	153	PF00069	0.340
MOD_GSK3_1	179	186	PF00069	0.407
MOD_GSK3_1	210	217	PF00069	0.284
MOD_GSK3_1	221	228	PF00069	0.301
MOD_GSK3_1	323	330	PF00069	0.306
MOD_GSK3_1	593	600	PF00069	0.514
MOD_GSK3_1	607	614	PF00069	0.622
MOD_GSK3_1	625	632	PF00069	0.575
MOD_GSK3_1	639	646	PF00069	0.517
MOD_GSK3_1	653	660	PF00069	0.473
MOD_GSK3_1	667	674	PF00069	0.666
MOD_GSK3_1	67	74	PF00069	0.363
MOD_GSK3_1	681	688	PF00069	0.557
MOD_GSK3_1	695	702	PF00069	0.418
MOD_GSK3_1	835	842	PF00069	0.689
MOD_LATS_1	170	176	PF00433	0.297
MOD_N-GLC_1	278	283	PF02516	0.259
MOD_N-GLC_1	307	312	PF02516	0.240
MOD_N-GLC_1	338	343	PF02516	0.350
MOD_N-GLC_1	749	754	PF02516	0.402
MOD_NEK2_1	135	140	PF00069	0.382
MOD_NEK2_1	214	219	PF00069	0.310
MOD_NEK2_1	306	311	PF00069	0.278
MOD_NEK2_1	327	332	PF00069	0.318
MOD_NEK2_1	38	43	PF00069	0.442
MOD_NEK2_1	615	620	PF00069	0.477
MOD_NEK2_1	629	634	PF00069	0.484
MOD_NEK2_1	643	648	PF00069	0.480
MOD_NEK2_1	657	662	PF00069	0.456
MOD_NEK2_1	671	676	PF00069	0.398
MOD_NEK2_1	685	690	PF00069	0.507
MOD_NEK2_1	699	704	PF00069	0.468
MOD_NEK2_1	792	797	PF00069	0.400
MOD_PIKK_1	121	127	PF00454	0.237
MOD_PIKK_1	585	591	PF00454	0.462
MOD_PIKK_1	73	79	PF00454	0.286
MOD_PK_1	172	178	PF00069	0.332
MOD_PK_1	822	828	PF00069	0.457
MOD_PK_1	852	858	PF00069	0.434
MOD_PKA_1	833	839	PF00069	0.695
MOD_PKA_2	296	302	PF00069	0.170
MOD_PKA_2	306	312	PF00069	0.280
MOD_PKA_2	51	57	PF00069	0.242
MOD_PKA_2	546	552	PF00069	0.498
MOD_PKA_2	585	591	PF00069	0.403
MOD_PKA_2	833	839	PF00069	0.774
MOD_PKB_1	295	303	PF00069	0.385
MOD_Plk_1	278	284	PF00069	0.259
MOD_Plk_1	307	313	PF00069	0.240
MOD_Plk_1	338	344	PF00069	0.332
MOD_Plk_1	38	44	PF00069	0.298
MOD_Plk_1	593	599	PF00069	0.619
MOD_Plk_1	611	617	PF00069	0.653
MOD_Plk_1	625	631	PF00069	0.724
MOD_Plk_1	639	645	PF00069	0.682
MOD_Plk_1	653	659	PF00069	0.629
MOD_Plk_1	667	673	PF00069	0.595
MOD_Plk_1	681	687	PF00069	0.624
MOD_Plk_1	695	701	PF00069	0.569
MOD_Plk_1	749	755	PF00069	0.410
MOD_Plk_1	822	828	PF00069	0.482
MOD_Plk_1	852	858	PF00069	0.724
MOD_Plk_2-3	716	722	PF00069	0.397
MOD_Plk_4	152	158	PF00069	0.280
MOD_Plk_4	194	200	PF00069	0.325
MOD_Plk_4	225	231	PF00069	0.262
MOD_Plk_4	278	284	PF00069	0.288
MOD_Plk_4	323	329	PF00069	0.315
MOD_ProDKin_1	329	335	PF00069	0.353
MOD_ProDKin_1	839	845	PF00069	0.536
MOD_SUMO_for_1	472	475	PF00179	0.468
MOD_SUMO_rev_2	818	824	PF00179	0.570
MOD_SUMO_rev_2	853	861	PF00179	0.505
TRG_ENDOCYTIC_2	112	115	PF00928	0.255
TRG_ENDOCYTIC_2	16	19	PF00928	0.327
TRG_ENDOCYTIC_2	198	201	PF00928	0.257
TRG_ENDOCYTIC_2	452	455	PF00928	0.530
TRG_ENDOCYTIC_2	793	796	PF00928	0.419
TRG_ER_diArg_1	1	3	PF00400	0.736
TRG_ER_diArg_1	17	20	PF00400	0.267
TRG_ER_diArg_1	260	263	PF00400	0.237
TRG_ER_diArg_1	523	525	PF00400	0.386
TRG_ER_diArg_1	810	812	PF00400	0.486
TRG_ER_diArg_1	843	845	PF00400	0.719
TRG_NES_CRM1_1	543	556	PF08389	0.468
TRG_NLS_MonoExtN_4	48	53	PF00514	0.337
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	844	848	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H5	Leptomonas seymouri	27%	73%
A0A0N1IH46	Leptomonas seymouri	72%	100%
A0A0S4IR67	Bodo saltans	27%	100%
A0A0S4JFN9	Bodo saltans	28%	100%
A0A1X0NDZ3	Trypanosomatidae	30%	77%
A0A1X0NP27	Trypanosomatidae	32%	100%
A0A1X0NPH9	Trypanosomatidae	26%	93%
A0A1X0P0C2	Trypanosomatidae	55%	100%
A0A3Q8IBS7	Leishmania donovani	27%	100%
A0A3Q8IDT2	Leishmania donovani	100%	71%
A0A3Q8IG23	Leishmania donovani	28%	73%
A0A3Q8IHG6	Leishmania donovani	32%	100%
A0A3R7KM83	Trypanosoma rangeli	30%	78%
A0A3R7RD86	Trypanosoma rangeli	54%	100%
A0A3S5H5N6	Leishmania donovani	25%	100%
A0A3S5H759	Leishmania donovani	27%	81%
A0A3S5IRH3	Trypanosoma rangeli	26%	100%
A4H8S6	Leishmania braziliensis	80%	100%
A4HIP0	Leishmania braziliensis	26%	72%
A4HSQ9	Leishmania infantum	25%	100%
A4HX45	Leishmania infantum	87%	92%
A4HYA2	Leishmania infantum	27%	77%
A4I4V2	Leishmania infantum	32%	100%
A4I562	Leishmania infantum	27%	100%
A4I5Y7	Leishmania infantum	28%	73%
C9ZVU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	76%
E9AEA0	Leishmania major	32%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AQW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P33176	Homo sapiens	27%	90%
Q0DV28	Oryza sativa subsp. japonica	30%	91%
Q4Q0P7	Leishmania major	22%	100%
Q4Q6Y4	Leishmania major	28%	72%
Q4Q7F9	Leishmania major	28%	71%
Q4QEL8	Leishmania major	89%	94%
Q5R706	Pongo abelii	29%	100%
Q5W7C6	Oryza sativa subsp. japonica	29%	82%
Q9SV36	Arabidopsis thaliana	28%	82%
V5B325	Trypanosoma cruzi	31%	100%
V5BMP0	Trypanosoma cruzi	58%	100%
V5DNV9	Trypanosoma cruzi	27%	77%