CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU54_LEIDO

TriTrypDb:

LdBPK_161580.1 , LdCL_160020800 , LDHU3_16.1880

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WU54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU54

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008483	transaminase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016769	transferase activity, transferring nitrogenous groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.720
CLV_MEL_PAP_1	629	635	PF00089	0.440
CLV_NRD_NRD_1	241	243	PF00675	0.636
CLV_NRD_NRD_1	269	271	PF00675	0.470
CLV_NRD_NRD_1	292	294	PF00675	0.678
CLV_PCSK_FUR_1	267	271	PF00082	0.526
CLV_PCSK_FUR_1	559	563	PF00082	0.488
CLV_PCSK_KEX2_1	160	162	PF00082	0.518
CLV_PCSK_KEX2_1	241	243	PF00082	0.633
CLV_PCSK_KEX2_1	269	271	PF00082	0.461
CLV_PCSK_KEX2_1	292	294	PF00082	0.638
CLV_PCSK_KEX2_1	50	52	PF00082	0.657
CLV_PCSK_KEX2_1	561	563	PF00082	0.515
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.518
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.638
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.619
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.515
CLV_PCSK_SKI1_1	201	205	PF00082	0.740
CLV_PCSK_SKI1_1	277	281	PF00082	0.750
CLV_PCSK_SKI1_1	294	298	PF00082	0.527
CLV_PCSK_SKI1_1	410	414	PF00082	0.473
CLV_PCSK_SKI1_1	480	484	PF00082	0.480
CLV_PCSK_SKI1_1	520	524	PF00082	0.509
CLV_PCSK_SKI1_1	574	578	PF00082	0.349
DEG_APCC_DBOX_1	200	208	PF00400	0.653
DEG_APCC_KENBOX_2	444	448	PF00400	0.399
DEG_Nend_UBRbox_4	1	3	PF02207	0.597
DEG_SPOP_SBC_1	64	68	PF00917	0.564
DOC_CYCLIN_RxL_1	550	560	PF00134	0.414
DOC_CYCLIN_RxL_1	9	19	PF00134	0.495
DOC_MAPK_DCC_7	445	454	PF00069	0.490
DOC_MAPK_DCC_7	469	479	PF00069	0.351
DOC_MAPK_gen_1	292	299	PF00069	0.628
DOC_MAPK_MEF2A_6	160	167	PF00069	0.515
DOC_MAPK_MEF2A_6	249	257	PF00069	0.470
DOC_MAPK_MEF2A_6	292	299	PF00069	0.628
DOC_MAPK_MEF2A_6	445	454	PF00069	0.542
DOC_MAPK_MEF2A_6	520	529	PF00069	0.434
DOC_PP2B_LxvP_1	14	17	PF13499	0.497
DOC_USP7_MATH_1	275	279	PF00917	0.700
DOC_USP7_MATH_1	352	356	PF00917	0.722
DOC_USP7_MATH_1	357	361	PF00917	0.700
DOC_USP7_MATH_1	450	454	PF00917	0.392
DOC_USP7_MATH_1	615	619	PF00917	0.534
DOC_USP7_UBL2_3	480	484	PF12436	0.534
DOC_USP7_UBL2_3	601	605	PF12436	0.527
DOC_WW_Pin1_4	16	21	PF00397	0.565
DOC_WW_Pin1_4	320	325	PF00397	0.697
DOC_WW_Pin1_4	96	101	PF00397	0.710
LIG_14-3-3_CanoR_1	134	140	PF00244	0.706
LIG_14-3-3_CanoR_1	354	360	PF00244	0.735
LIG_14-3-3_CanoR_1	401	407	PF00244	0.469
LIG_14-3-3_CanoR_1	513	517	PF00244	0.405
LIG_14-3-3_CanoR_1	520	526	PF00244	0.471
LIG_Actin_WH2_2	226	243	PF00022	0.567
LIG_Actin_WH2_2	464	482	PF00022	0.506
LIG_BRCT_BRCA1_1	66	70	PF00533	0.530
LIG_FAT_LD_1	250	258	PF03623	0.502
LIG_FHA_1	127	133	PF00498	0.708
LIG_FHA_1	344	350	PF00498	0.562
LIG_FHA_1	39	45	PF00498	0.552
LIG_FHA_1	425	431	PF00498	0.476
LIG_FHA_1	481	487	PF00498	0.456
LIG_FHA_1	509	515	PF00498	0.472
LIG_FHA_1	56	62	PF00498	0.673
LIG_FHA_1	568	574	PF00498	0.392
LIG_FHA_1	590	596	PF00498	0.369
LIG_FHA_1	614	620	PF00498	0.481
LIG_FHA_2	115	121	PF00498	0.608
LIG_FHA_2	123	129	PF00498	0.516
LIG_FHA_2	179	185	PF00498	0.581
LIG_FHA_2	223	229	PF00498	0.525
LIG_FHA_2	373	379	PF00498	0.361
LIG_FHA_2	403	409	PF00498	0.348
LIG_LIR_Gen_1	152	163	PF02991	0.569
LIG_LIR_Gen_1	393	404	PF02991	0.401
LIG_LIR_LC3C_4	483	488	PF02991	0.489
LIG_LIR_Nem_3	152	158	PF02991	0.610
LIG_LIR_Nem_3	393	399	PF02991	0.387
LIG_Pex14_2	151	155	PF04695	0.625
LIG_PTB_Apo_2	145	152	PF02174	0.649
LIG_RPA_C_Fungi	351	363	PF08784	0.523
LIG_SH2_CRK	472	476	PF00017	0.491
LIG_SH2_PTP2	463	466	PF00017	0.360
LIG_SH2_STAP1	369	373	PF00017	0.518
LIG_SH2_STAT3	628	631	PF00017	0.426
LIG_SH2_STAT5	219	222	PF00017	0.452
LIG_SH2_STAT5	463	466	PF00017	0.360
LIG_SH2_STAT5	628	631	PF00017	0.412
LIG_SH3_1	321	327	PF00018	0.660
LIG_SH3_3	14	20	PF00018	0.585
LIG_SH3_3	321	327	PF00018	0.740
LIG_SH3_3	84	90	PF00018	0.496
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.523
LIG_SUMO_SIM_par_1	128	133	PF11976	0.665
LIG_SUMO_SIM_par_1	21	27	PF11976	0.508
LIG_SUMO_SIM_par_1	370	375	PF11976	0.384
LIG_SUMO_SIM_par_1	591	598	PF11976	0.406
LIG_TYR_ITIM	577	582	PF00017	0.355
LIG_UBA3_1	473	480	PF00899	0.499
LIG_WRC_WIRS_1	437	442	PF05994	0.463
MOD_CDC14_SPxK_1	99	102	PF00782	0.764
MOD_CDK_SPxK_1	96	102	PF00069	0.759
MOD_CK1_1	119	125	PF00069	0.588
MOD_CK1_1	135	141	PF00069	0.488
MOD_CK1_1	147	153	PF00069	0.496
MOD_CK1_1	186	192	PF00069	0.578
MOD_CK1_1	27	33	PF00069	0.549
MOD_CK1_1	282	288	PF00069	0.752
MOD_CK1_1	309	315	PF00069	0.667
MOD_CK1_1	320	326	PF00069	0.764
MOD_CK1_1	328	334	PF00069	0.693
MOD_CK1_1	34	40	PF00069	0.690
MOD_CK1_1	355	361	PF00069	0.743
MOD_CK1_1	532	538	PF00069	0.464
MOD_CK1_1	618	624	PF00069	0.525
MOD_CK2_1	178	184	PF00069	0.580
MOD_CK2_1	402	408	PF00069	0.421
MOD_CK2_1	416	422	PF00069	0.335
MOD_CK2_1	49	55	PF00069	0.722
MOD_GlcNHglycan	114	117	PF01048	0.704
MOD_GlcNHglycan	133	137	PF01048	0.419
MOD_GlcNHglycan	188	191	PF01048	0.670
MOD_GlcNHglycan	277	280	PF01048	0.724
MOD_GlcNHglycan	36	39	PF01048	0.692
MOD_GlcNHglycan	385	388	PF01048	0.598
MOD_GlcNHglycan	488	491	PF01048	0.461
MOD_GlcNHglycan	67	70	PF01048	0.649
MOD_GlcNHglycan	75	78	PF01048	0.606
MOD_GSK3_1	112	119	PF00069	0.728
MOD_GSK3_1	122	129	PF00069	0.590
MOD_GSK3_1	147	154	PF00069	0.610
MOD_GSK3_1	199	206	PF00069	0.654
MOD_GSK3_1	240	247	PF00069	0.586
MOD_GSK3_1	27	34	PF00069	0.551
MOD_GSK3_1	275	282	PF00069	0.721
MOD_GSK3_1	309	316	PF00069	0.680
MOD_GSK3_1	357	364	PF00069	0.652
MOD_GSK3_1	450	457	PF00069	0.502
MOD_GSK3_1	508	515	PF00069	0.487
MOD_GSK3_1	609	616	PF00069	0.458
MOD_GSK3_1	618	625	PF00069	0.462
MOD_N-GLC_1	112	117	PF02516	0.660
MOD_N-GLC_1	142	147	PF02516	0.624
MOD_N-GLC_1	199	204	PF02516	0.647
MOD_N-GLC_1	207	212	PF02516	0.636
MOD_N-GLC_1	343	348	PF02516	0.744
MOD_N-GLC_1	390	395	PF02516	0.522
MOD_N-GLC_1	435	440	PF02516	0.402
MOD_N-GLC_1	589	594	PF02516	0.372
MOD_N-GLC_1	595	600	PF02516	0.413
MOD_NEK2_1	114	119	PF00069	0.630
MOD_NEK2_1	142	147	PF00069	0.574
MOD_NEK2_1	149	154	PF00069	0.560
MOD_NEK2_1	183	188	PF00069	0.542
MOD_NEK2_1	203	208	PF00069	0.679
MOD_NEK2_1	29	34	PF00069	0.683
MOD_NEK2_1	306	311	PF00069	0.620
MOD_NEK2_1	350	355	PF00069	0.742
MOD_NEK2_1	372	377	PF00069	0.359
MOD_NEK2_1	397	402	PF00069	0.559
MOD_NEK2_1	416	421	PF00069	0.391
MOD_NEK2_1	508	513	PF00069	0.447
MOD_NEK2_1	514	519	PF00069	0.399
MOD_NEK2_1	521	526	PF00069	0.404
MOD_NEK2_1	557	562	PF00069	0.385
MOD_NEK2_1	595	600	PF00069	0.436
MOD_NEK2_1	633	638	PF00069	0.447
MOD_NEK2_1	73	78	PF00069	0.531
MOD_NEK2_2	450	455	PF00069	0.397
MOD_PIKK_1	277	283	PF00454	0.727
MOD_PIKK_1	424	430	PF00454	0.517
MOD_PIKK_1	609	615	PF00454	0.433
MOD_PKA_2	101	107	PF00069	0.627
MOD_PKA_2	126	132	PF00069	0.739
MOD_PKA_2	240	246	PF00069	0.593
MOD_PKA_2	355	361	PF00069	0.757
MOD_PKA_2	512	518	PF00069	0.468
MOD_Plk_1	119	125	PF00069	0.548
MOD_Plk_1	142	148	PF00069	0.657
MOD_Plk_1	183	189	PF00069	0.522
MOD_Plk_1	199	205	PF00069	0.563
MOD_Plk_1	306	312	PF00069	0.634
MOD_Plk_1	328	334	PF00069	0.693
MOD_Plk_1	343	349	PF00069	0.690
MOD_Plk_1	390	396	PF00069	0.506
MOD_Plk_1	435	441	PF00069	0.415
MOD_Plk_1	508	514	PF00069	0.515
MOD_Plk_1	589	595	PF00069	0.371
MOD_Plk_2-3	128	134	PF00069	0.670
MOD_Plk_2-3	390	396	PF00069	0.472
MOD_Plk_4	101	107	PF00069	0.658
MOD_Plk_4	178	184	PF00069	0.541
MOD_Plk_4	249	255	PF00069	0.455
MOD_Plk_4	306	312	PF00069	0.650
MOD_Plk_4	344	350	PF00069	0.785
MOD_Plk_4	450	456	PF00069	0.530
MOD_Plk_4	514	520	PF00069	0.429
MOD_Plk_4	589	595	PF00069	0.398
MOD_ProDKin_1	16	22	PF00069	0.564
MOD_ProDKin_1	320	326	PF00069	0.695
MOD_ProDKin_1	96	102	PF00069	0.712
MOD_SUMO_rev_2	47	52	PF00179	0.620
MOD_SUMO_rev_2	499	503	PF00179	0.581
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.559
TRG_ENDOCYTIC_2	139	142	PF00928	0.623
TRG_ENDOCYTIC_2	369	372	PF00928	0.414
TRG_ENDOCYTIC_2	463	466	PF00928	0.360
TRG_ENDOCYTIC_2	579	582	PF00928	0.357
TRG_ER_diArg_1	240	242	PF00400	0.640
TRG_ER_diArg_1	266	269	PF00400	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX36	Leptomonas seymouri	53%	100%
A0A0S4IMR2	Bodo saltans	34%	96%
A0A1X0P052	Trypanosomatidae	39%	100%
A0A3R7K490	Trypanosoma rangeli	36%	100%
A4H8S7	Leishmania braziliensis	74%	100%
A4HX46	Leishmania infantum	100%	100%
C9ZVU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEL7	Leishmania major	93%	100%
V5BS91	Trypanosoma cruzi	41%	100%