Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU53_LEIDO

TriTrypDb:

LdBPK_161440.1 , LdCL_160019400 , LDHU3_16.1720

Length:

108

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.676
CLV_NRD_NRD_1	85	87	PF00675	0.621
CLV_PCSK_KEX2_1	84	86	PF00082	0.595
CLV_PCSK_SKI1_1	77	81	PF00082	0.584
DEG_APCC_DBOX_1	85	93	PF00400	0.575
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.589
DOC_MAPK_DCC_7	84	94	PF00069	0.742
DOC_MAPK_HePTP_8	64	76	PF00069	0.567
DOC_MAPK_MEF2A_6	101	108	PF00069	0.843
DOC_MAPK_MEF2A_6	67	76	PF00069	0.561
DOC_PP2B_LxvP_1	72	75	PF13499	0.575
DOC_WW_Pin1_4	100	105	PF00397	0.837
LIG_BIR_II_1	1	5	PF00653	0.853
LIG_FHA_1	101	107	PF00498	0.850
LIG_FHA_2	93	99	PF00498	0.807
LIG_MYND_1	87	91	PF01753	0.807
LIG_PDZ_Class_2	103	108	PF00595	0.802
LIG_SUMO_SIM_par_1	90	96	PF11976	0.721
LIG_UBA3_1	71	77	PF00899	0.559
MOD_CK2_1	92	98	PF00069	0.781
MOD_GlcNHglycan	43	47	PF01048	0.658
MOD_GlcNHglycan	95	98	PF01048	0.834
MOD_NEK2_2	62	67	PF00069	0.667
MOD_Plk_1	62	68	PF00069	0.589
MOD_Plk_4	35	41	PF00069	0.490
MOD_ProDKin_1	100	106	PF00069	0.838
TRG_DiLeu_BaEn_1	102	107	PF01217	0.842
TRG_DiLeu_BaEn_2	15	21	PF01217	0.760
TRG_ER_diArg_1	84	86	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX0	Leptomonas seymouri	73%	100%
A0A1X0NZ50	Trypanosomatidae	58%	86%
A0A3R7N3A0	Trypanosoma rangeli	69%	86%
A4H8R5	Leishmania braziliensis	85%	100%
A4HX33	Leishmania infantum	100%	100%
C9ZVW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	83%
E9AQU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QEN0	Leishmania major	95%	100%